Rosa Bacchetta

Rosa Bacchetta

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Rosa Bacchetta

Rosa Bacchetta

Publications by authors named "Rosa Bacchetta"

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Treatment with rapamycin can restore regulatory T-cell function in IPEX patients.

J Allergy Clin Immunol 2019 Dec 23. Epub 2019 Dec 23.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.11.043DOI Listing
December 2019

APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells.

Front Immunol 2018 25;9:881. Epub 2018 May 25.

Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University, Stanford, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.00881
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http://dx.doi.org/10.3389/fimmu.2018.00881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980965PMC
July 2019

The autoimmune targets in IPEX are dominated by gut epithelial proteins.

J Allergy Clin Immunol 2019 Jul 23;144(1):327-330.e8. Epub 2019 Apr 23.

Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193038
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http://dx.doi.org/10.1016/j.jaci.2019.02.031DOI Listing
July 2019

Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked.

Front Immunol 2018 29;9:544. Epub 2018 Mar 29.

Department of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885158PMC
May 2019

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome.

Front Immunol 2019 12;10:753. Epub 2019 Apr 12.

Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473200PMC
April 2019

Role of human forkhead box P3 in early thymic maturation and peripheral T-cell homeostasis.

J Allergy Clin Immunol 2018 12 27;142(6):1909-1921.e9. Epub 2018 Apr 27.

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.03.015DOI Listing
December 2018

Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency.

J Allergy Clin Immunol 2018 12;142(6):1679-1695

Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, Calif; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.10.026DOI Listing
December 2018

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.

Immunity 2018 12;49(6):1004-1019

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, 17176 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183052
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http://dx.doi.org/10.1016/j.immuni.2018.12.001DOI Listing
December 2018

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.

Ann N Y Acad Sci 2018 04 25;1417(1):5-22. Epub 2016 Feb 25.

Department of Pediatrics, Division of Pediatric Stem Cells, Transplantation and Regenerative Medicine, Stanford University Medical School, Stanford, California.

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http://dx.doi.org/10.1111/nyas.13011DOI Listing
April 2018

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired.

J Allergy Clin Immunol 2018 01 6;141(1):202-213.e8. Epub 2017 Jul 6.

Division of Stem Cell Transplantation and Regenerative Medicine at Stanford University, and Department of Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.05.045DOI Listing
January 2018

Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry.

J Immunol 2018 01 27;200(1):336-346. Epub 2017 Nov 27.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.4049/jimmunol.1701025DOI Listing
January 2018

Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction.

Clin Immunol 2017 10 14;183:273-277. Epub 2017 Sep 14.

University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.09.011DOI Listing
October 2017

Forkhead-Box-P3 Gene Transfer in Human CD4 T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy.

Front Immunol 2017 12;8:1282. Epub 2017 Oct 12.

Department of Stem Cell Transplantation and Regenerative Medicine, Division of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643480PMC
October 2017

Gene/cell therapy approaches for Immune Dysregulation Polyendocrinopathy Enteropathy X-linked syndrome.

Curr Gene Ther 2014 ;14(6):422-8

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20131, Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443799PMC
http://dx.doi.org/10.2174/1566523214666141001123828DOI Listing
July 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies.

Nat Rev Gastroenterol Hepatol 2015 May 17;12(5):293-302. Epub 2015 Mar 17.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Paris Descartes Hôpital Necker Enfants Malades, 149 Rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1038/nrgastro.2015.44DOI Listing
May 2015

Identification of STAT5A and STAT5B target genes in human T cells.

PLoS One 2014 30;9(1):e86790. Epub 2014 Jan 30.

Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086790PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907443PMC
December 2014

Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.

Curr Top Microbiol Immunol 2014 ;380:39-68

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy,

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http://dx.doi.org/10.1007/978-3-662-43492-5_3DOI Listing
November 2014

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT.

Bone Marrow Transplant 2014 Nov 11;49(11):1400-1404. Epub 2014 Aug 11.

San Raffaele Telethon Institute for Gene Therapy (HSRTIGET), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/bmt.2014.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222814PMC
November 2014

Regulatory T cells and their roles in immune dysregulation and allergy.

Immunol Res 2014 May;58(2-3):358-68

Division of Pediatric Immunology and Allergy, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s12026-014-8512-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161462PMC
May 2014

Forkhead box P3: the peacekeeper of the immune system.

Int Rev Immunol 2014 Mar 19;33(2):129-45. Epub 2013 Dec 19.

1Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3109/08830185.2013.863303DOI Listing
March 2014

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.

Sci Transl Med 2013 Dec;5(215):215ra174

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30073
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http://dx.doi.org/10.1126/scitranslmed.3007320DOI Listing
December 2013

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

Nat Med 2013 Jun 28;19(6):739-46. Epub 2013 Apr 28.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/nm.3179DOI Listing
June 2013

Gene therapy for primary immunodeficiencies: Part 2.

Curr Opin Immunol 2012 Oct 18;24(5):585-91. Epub 2012 Aug 18.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.coi.2012.07.012DOI Listing
October 2012

Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunity.

Front Immunol 2012 31;3:211. Epub 2012 Jul 31.

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute Milan, Italy ; Vita Salute San Raffaele University Milan, Italy.

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http://dx.doi.org/10.3389/fimmu.2012.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459184PMC
October 2012

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells.

Eur J Immunol 2011 Jun 13;41(6):1652-62. Epub 2011 May 13.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://doi.wiley.com/10.1002/eji.201041120
Publisher Site
http://dx.doi.org/10.1002/eji.201041120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116154PMC
June 2011

Clinical tolerance in allogeneic hematopoietic stem cell transplantation.

Immunol Rev 2011 May;241(1):145-63

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells, Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01010.xDOI Listing
May 2011

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.

Eur J Immunol 2011 Apr 14;41(4):1120-31. Epub 2011 Mar 14.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/eji.201040909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107421PMC
April 2011

Methods for in vitro generation of human type 1 regulatory T cells.

Methods Mol Biol 2011 ;677:31-46

Department of Regenerative Medicine, San Raffaele Telethon Institute for Gene Therapy HSR, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-60761-869-0_3DOI Listing
February 2011

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.

J Allergy Clin Immunol 2010 Dec 30;126(6):1242-51. Epub 2010 Oct 30.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491001342
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http://dx.doi.org/10.1016/j.jaci.2010.09.001DOI Listing
December 2010

Molecular regulation of cellular immunity by FOXP3.

Adv Exp Med Biol 2009 ;665:30-46

Department of Surgery, University of British Columbia, Vancouver, Canada.

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May 2010

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.

Blood 2009 Nov 8;114(19):4138-41. Epub 2009 Sep 8.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 58-20132 Milan, Italy.

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http://dx.doi.org/10.1182/blood-2009-04-214593DOI Listing
November 2009

CD4+ T-regulatory cells: toward therapy for human diseases.

Immunol Rev 2008 Jun;223:391-421

Department of Surgery, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00634.xDOI Listing
June 2008

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells.

Methods Mol Biol 2007 ;380:83-105

San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-59745-395-0_6DOI Listing
April 2008

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

Int Immunol 2008 Mar 12;20(3):421-31. Epub 2008 Feb 12.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/intimm/dxn002DOI Listing
March 2008

Immunological lessons learnt from patients transplanted with fully mismatched stem cells.

Immunol Res 2007 ;38(1-3):201-9

Department of Transplantation and Clinical Immunology, Claude Bernard University and Edouard Herriot Hospital, Lyon, France.

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http://dx.doi.org/10.1007/s12026-007-0002-6DOI Listing
January 2008

Role of regulatory T cells and FOXP3 in human diseases.

J Allergy Clin Immunol 2007 Aug;120(2):227-35; quiz 236-7

San Raffaele Telethon Institute for Gene Therapy, Milano, Italy.

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http://dx.doi.org/10.1016/j.jaci.2007.06.023DOI Listing
August 2007

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Int Immunol 2007 Apr 27;19(4):345-54. Epub 2007 Feb 27.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada.

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http://dx.doi.org/10.1093/intimm/dxm014DOI Listing
April 2007

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

Immunol Rev 2006 Aug;212:28-50

San Raffaele Telethon Institute for Gene therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00420.xDOI Listing
August 2006

Tr1 cells: from discovery to their clinical application.

Semin Immunol 2006 Apr 7;18(2):120-7. Epub 2006 Feb 7.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, Milano 20132, Italy.

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http://dx.doi.org/10.1016/j.smim.2006.01.007DOI Listing
April 2006

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

J Clin Invest 2005 Nov 6;115(11):3276-84. Epub 2005 Oct 6.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1172/JCI24685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242190PMC
November 2005

CD4+ regulatory T cells: mechanisms of induction and effector function.

Autoimmun Rev 2005 Nov;4(8):491-6

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina, 58, Milan I-20132, Italy.

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http://dx.doi.org/10.1016/j.autrev.2005.04.005DOI Listing
November 2005

Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation.

Curr Opin Hematol 2005 Nov;12(6):451-6

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy.

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http://dx.doi.org/10.1097/01.moh.0000177826.41262.0aDOI Listing
November 2005

Reappraisal of in utero stem cell transplantation based on long-term results.

Fetal Diagn Ther 2004 Jul-Aug;19(4):305-12

Department of Transplantation and Clinical Immunology, Claude Bernard University, Lyon, and Department of Obstetrics, Paris University, Paris, France.

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http://dx.doi.org/10.1159/000077957DOI Listing
January 2005

The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.

Int Arch Allergy Immunol 2002 Dec;129(4):263-76

San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

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http://dx.doi.org/10.1159/000067596DOI Listing
December 2002