Rongzhen Xu

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Rongzhen Xu

Publications by authors named "Rongzhen Xu"

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41Publications

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Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a.

Oncotarget 2017 Sep 24;8(43):75050-75064. Epub 2017 Aug 24.

Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.

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September 2017

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

Cancer Cell 2017 07;32(1):115-128.e7

Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. Electronic address:

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July 2017

4-Chlorbenzoyl Berbamine, a Novel Derivative of the Natural Product Berbamine, Potently Inhibits the Growth of Human Myeloma Cells by Modulating the NF-κB and JNK Signalling Pathways.

Cancer Invest 2016 Nov 21;34(10):496-505. Epub 2016 Oct 21.

a Department of Hematology , The Second Affiliated Hospital of Zhejiang University of Medicine , Hangzhou , Zhejiang , China.

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November 2016

Corrigendum to 'Ca/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer' [Cancer Lett. 344 (1), 119-128; March 1, 2014].

Cancer Lett 2016 Oct 1;380(2):609-610. Epub 2016 Aug 1.

Department of Respiratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

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October 2016

Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation.

Neurosci Bull 2016 Apr 7;32(2):145-52. Epub 2016 Mar 7.

Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

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April 2016

Identification of a novel RNA giant nuclear body in cancer cells.

Oncotarget 2016 Jan;7(4):4724-34

Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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January 2016

Leukemia stem cells: the root of chronic myeloid leukemia.

Protein Cell 2015 Jun 10;6(6):403-12. Epub 2015 Mar 10.

Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Department of Hematology, Zhejiang University, Hangzhou, 310009, China.

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June 2015

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.

Oncotarget 2015 Jun;6(17):15111-21

Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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June 2015

Ca2+/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells.

Oncotarget 2015 Jun;6(18):16069-83

Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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June 2015

[Triptolide induces apoptosis of human acute T lymphocytic leukemia Jurkat cells via inhibiting transcription of human endogenous retrovirus HERV-K Np9 gene].

Nan Fang Yi Ke Da Xue Xue Bao 2015 May;35(5):702-6

Department of Hematology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.E-mail:

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May 2015

GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.

PLoS One 2014 22;9(4):e93567. Epub 2014 Apr 22.

Division of Molecular Diabetes Research, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.

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January 2015

The application of dual-energy computed tomography in the diagnosis of acute gouty arthritis.

Clin Rheumatol 2014 Jul 18;33(7):975-9. Epub 2014 Apr 18.

Department of Rheumatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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July 2014

RETRACTED: Ca(2+)/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer.

Cancer Lett 2014 03 1;344(1):119-128. Epub 2013 Nov 1.

Department of Respiratory Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

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March 2014

Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II.

Mol Cancer Ther 2013 Oct 19;12(10):2067-77. Epub 2013 Aug 19.

Corresponding Authors: Wendong Huang, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010.

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October 2013

[CaMKIIγ promotes in vitro and in vivo growth of colorectal cancer cells by upregulating nuclear factor-κB signaling pathway].

Nan Fang Yi Ke Da Xue Xue Bao 2013 May;33(5):649-53

School of Medicine, Zhejiang University, Hangzhou, China.

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May 2013

CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.

Blood 2012 Dec 16;120(24):4829-39. Epub 2012 Oct 16.

Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Hangzhou, China.

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December 2012

Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.

J Hepatol 2012 Nov 21;57(5):1004-12. Epub 2012 Jun 21.

Irell & Manella Graduate School of Biological Sciences, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, United States.

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November 2012

Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity.

Eur J Med Chem 2012 Aug 7;54:867-72. Epub 2012 May 7.

Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou 310027, PR China.

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August 2012

Expression patterns of non-coding spliced transcripts from human endogenous retrovirus HERV-H elements in colon cancer.

PLoS One 2012 6;7(1):e29950. Epub 2012 Jan 6.

Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

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May 2012

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Mol Endocrinol 2012 May 2;26(5):775-85. Epub 2012 Apr 2.

Division of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.

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May 2012

miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice.

Hepatology 2010 Dec 26;52(6):2148-57. Epub 2010 Oct 26.

Division of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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December 2010

Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft.

Acta Biochim Biophys Sin (Shanghai) 2010 Nov;42(11):827-33

Department of Cardiothoracic Surgery, Second Affiliated Hospital, Zhejiang University, Hangzhou, China.

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November 2010

The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers.

Int J Cancer 2010 Oct;127(8):1833-43

Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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October 2010

High prevalence and genetic diversity of HCV among HIV-1 infected people from various high-risk groups in China.

PLoS One 2010 May 27;5(5):e10631. Epub 2010 May 27.

Key Laboratory of AIDS Immunology of Ministry of Health, No 1 Hospital of China Medical University, Shenyang, Liaoning, China.

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May 2010

Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors.

Toxicology 2010 Jan 14;268(1-2):19-24. Epub 2009 Nov 14.

Department of Hematology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.

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January 2010

A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G.

J Virol 2009 Sep 17;83(17):8674-82. Epub 2009 Jun 17.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

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September 2009

Berbamine derivatives: a novel class of compounds for anti-leukemia activity.

Eur J Med Chem 2009 Aug 23;44(8):3293-8. Epub 2009 Feb 23.

College of Pharmaceutical Sciences, Zhejiang University, Zijin Campus, Hangzhou, China.

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August 2009

Identification of a novel human endogenous retrovirus and promoter activity of its 5' U3.

Biochem Biophys Res Commun 2009 May 14;382(2):468-72. Epub 2009 Mar 14.

Cancer Institute, Second Affiliated Hospital, and Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou, China.

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May 2009

Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.

PLoS One 2008 17;3(12):e3963. Epub 2008 Dec 17.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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March 2009

Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.

J Mol Biol 2008 Sep 28;381(4):1000-11. Epub 2008 Jun 28.

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Zhejiang, China.

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September 2008

Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression.

Cell Microbiol 2008 Jan 1;10(1):112-21. Epub 2007 Aug 1.

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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January 2008

Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.

Hepatology 2007 Dec;46(6):1810-20

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, China.

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December 2007

Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia.

Authors:
Rongzhen Xu

Cell Res 2007 Apr;17(4):295-7

Department of Hematology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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April 2007

Cell-specific regulation of APOBEC3F by interferons.

Acta Biochim Biophys Sin (Shanghai) 2007 Apr;39(4):297-304

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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April 2007

A simple, rapid, and sensitive integrated protein microarray for simultaneous detection of multiple antigens and antibodies of five human hepatitis viruses (HBV, HCV, HDV, HEV, and HGV).

Anal Biochem 2007 Mar 29;362(1):69-75. Epub 2006 Dec 29.

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou 310009, China.

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March 2007

STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha.

J Immunol 2006 Oct;177(7):4530-40

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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October 2006

Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F.

J Virol 2006 Mar;80(6):3112-5

Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, China.

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March 2006

Berbamine: a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity.

Leuk Res 2006 Jan 14;30(1):17-23. Epub 2005 Jul 14.

Department of Hematology, Second Affiliated Hospital, Hangzhou, Zhejiang Province 310009,China.

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January 2006

Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.

Blood 2005 Nov 19;106(9):3142-9. Epub 2005 Jul 19.

Department of Hematology, Second Affiliated Hospital, School of Medicine, Cancer Institute, Zhejiang University, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310009, China.

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November 2005