Publications


Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a.
Oncotarget 2017 Sep 24;8(43):75050-75064. Epub 2017 Aug 24.
Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Cancer Cell 2017 Jul;32(1):115-128.e7
Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. Electronic address:

4-Chlorbenzoyl Berbamine, a Novel Derivative of the Natural Product Berbamine, Potently Inhibits the Growth of Human Myeloma Cells by Modulating the NF-κB and JNK Signalling Pathways.
Cancer Invest 2016 Nov 21;34(10):496-505. Epub 2016 Oct 21.
a Department of Hematology , The Second Affiliated Hospital of Zhejiang University of Medicine , Hangzhou , Zhejiang , China.

Corrigendum to 'Ca/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer' [Cancer Lett. 344 (1), 119-128; March 1, 2014].
Cancer Lett 2016 Oct 1;380(2):609-610. Epub 2016 Aug 1.
Department of Respiratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation.
Neurosci Bull 2016 Apr 7;32(2):145-52. Epub 2016 Mar 7.
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Identification of a novel RNA giant nuclear body in cancer cells.
Oncotarget 2016 Jan;7(4):4724-34
Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.
Oncotarget 2015 Jun;6(17):15111-21
Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II.
Mol Cancer Ther 2013 Oct 19;12(10):2067-77. Epub 2013 Aug 19.
Corresponding Authors: Wendong Huang, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010.

CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.
Blood 2012 Dec 16;120(24):4829-39. Epub 2012 Oct 16.
Department of Hematology, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Hangzhou, China.

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.
Mol Endocrinol 2012 May 2;26(5):775-85. Epub 2012 Apr 2.
Division of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.


Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.
Blood 2005 Nov 19;106(9):3142-9. Epub 2005 Jul 19.
Department of Hematology, Second Affiliated Hospital, School of Medicine, Cancer Institute, Zhejiang University, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310009, China.

RETRACTED: Ca(2+)/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer.
Cancer Lett 2014 03 1;344(1):119-128. Epub 2013 Nov 1.
Department of Respiratory Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.
PLoS One 2014 22;9(4):e93567. Epub 2014 Apr 22.
Division of Molecular Diabetes Research, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.

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