Rongtuan Lin

Rongtuan Lin

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The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.

Cell Host Microbe 2019 Sep;26(3):369-384.e8

Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.08.010DOI Listing
September 2019

Activation of Mast Cells Promote ANKA Infection in Murine Model.

Front Cell Infect Microbiol 2019 10;9:322. Epub 2019 Sep 10.

Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.

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http://dx.doi.org/10.3389/fcimb.2019.00322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747038PMC
September 2019

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders.

Front Oncol 2019 2;9:719. Epub 2019 Aug 2.

Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research, Israel-Canada (IMRIC), Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.3389/fonc.2019.00719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688159PMC
August 2019

UBXN3B positively regulates STING-mediated antiviral immune responses.

Nat Commun 2018 06 13;9(1):2329. Epub 2018 Jun 13.

Department of Microbiology and Immunology, New York Medical College, 15 Dana Road, Valhalla, NY, 10595, USA.

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http://dx.doi.org/10.1038/s41467-018-04759-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998066PMC
June 2018

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.

Viruses 2017 10 3;9(10). Epub 2017 Oct 3.

Department of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada.

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http://dx.doi.org/10.3390/v9100287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691638PMC
October 2017

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity.

Mol Ther 2017 08 17;25(8):1900-1916. Epub 2017 May 17.

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Division of Experimental Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542709PMC
August 2017

Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity.

Front Immunol 2016 3;7:662. Epub 2017 Jan 3.

Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, QC, Canada; Division of Experimental Medicine, McGill University, Montreal, QC, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2016.00662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206486PMC
January 2017

RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways.

Inflamm Cell Signal 2017 Jan;4(1):e1491

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA; Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, 8000 Aarhus C DENMARK.

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http://dx.doi.org/10.14800/ics.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298905PMC
January 2017

RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection.

J Virol 2016 10 29;90(20):9406-19. Epub 2016 Sep 29.

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada Department of Microbiology & Immunology, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1128/JVI.00748-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044816PMC
October 2016

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal Repeat.

J Virol 2016 10 29;90(20):9338-49. Epub 2016 Sep 29.

Department of Biology, University of Winnipeg, Winnipeg, Manitoba, Canada Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

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http://dx.doi.org/10.1128/JVI.01503-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044829PMC
October 2016

Kaposi's Sarcoma-Associated Herpesvirus Reduces Cellular Myeloid Differentiation Primary-Response Gene 88 (MyD88) Expression via Modulation of Its RNA.

J Virol 2016 01 14;90(1):180-8. Epub 2015 Oct 14.

School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, USA

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http://dx.doi.org/10.1128/JVI.02342-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702530PMC
January 2016

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Eur J Immunol 2015 12 12;45(12):3386-403. Epub 2015 Oct 12.

Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London, UK.

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http://dx.doi.org/10.1002/eji.201545794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833184PMC
December 2015

Nlrp6 regulates intestinal antiviral innate immunity.

Science 2015 Nov 22;350(6262):826-30. Epub 2015 Oct 22.

Section of Infectious Diseases, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06510, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.

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http://dx.doi.org/10.1126/science.aab3145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927078PMC
November 2015

Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells.

Growth Horm IGF Res 2015 Oct 20;25(5):253-61. Epub 2015 Jul 20.

Dept of Medicine, McGill University and the McGill University Health Center, Canada; Dept of Surgery, McGill University and the McGill University Health Center, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2015.07.008DOI Listing
October 2015

NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.

Eur J Immunol 2015 Mar 23;45(3):758-72. Epub 2014 Dec 23.

Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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http://dx.doi.org/10.1002/eji.201344412DOI Listing
March 2015

HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells.

PLoS Pathog 2014 Dec 18;10(12):e1004575. Epub 2014 Dec 18.

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada; VGTI Florida, Port St. Lucie, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270795PMC
December 2014

Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB.

Invest New Drugs 2014 Apr 23;32(2):227-34. Epub 2013 Oct 23.

Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, 3755 Cote-Ste-Catherine, Rd., Montreal, QC, H3T 1E2, Canada.

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http://dx.doi.org/10.1007/s10637-013-0040-yDOI Listing
April 2014

Intact type I Interferon production and IRF7 function in sooty mangabeys.

PLoS Pathog 2013 29;9(8):e1003597. Epub 2013 Aug 29.

Divison of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757038PMC
March 2014

Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

J Virol 2013 Dec 18;87(23):12814-27. Epub 2013 Sep 18.

Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China.

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http://dx.doi.org/10.1128/JVI.02355-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838156PMC
December 2013

SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.

J Mol Biol 2013 Dec 23;425(24):4981-94. Epub 2013 Oct 23.

Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2.

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http://dx.doi.org/10.1016/j.jmb.2013.10.022DOI Listing
December 2013

ELF4 is critical for induction of type I interferon and the host antiviral response.

Nat Immunol 2013 Dec 3;14(12):1237-46. Epub 2013 Nov 3.

Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/ni.2756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939855PMC
December 2013

Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.

Mol Ther 2013 Nov 28;21(11):2043-53. Epub 2013 Aug 28.

Department of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/mt.2013.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831042PMC
November 2013

Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.

Cell Host Microbe 2013 Oct;14(4):422-34

Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.chom.2013.09.009DOI Listing
October 2013

UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.

Cell Rep 2013 Apr 28;3(4):1057-70. Epub 2013 Mar 28.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707122PMC
April 2013

Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression.

PLoS One 2012 7;7(6):e38336. Epub 2012 Jun 7.

Centre National de la Recherche Scientifique-FRE3235, Paris Descartes University, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369917PMC
December 2012

Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.

J Virol 2012 Apr 1;86(7):3528-40. Epub 2012 Feb 1.

Institut für Klinische und Molekulare Virologie, Universitätsklinikum, Friedrich Alexander Universität, Erlangen, Germany.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.06713-11
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http://dx.doi.org/10.1128/JVI.06713-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302539PMC
April 2012

Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants.

Chem Biol Drug Des 2012 Mar 11;79(3):300-12. Epub 2012 Jan 11.

Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1111/j.1747-0285.2011.01290.xDOI Listing
March 2012

IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.

J Virol 2012 Jan 9;86(2):726-37. Epub 2011 Nov 9.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.05989-11
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http://dx.doi.org/10.1128/JVI.05989-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255812PMC
January 2012

Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.

J Virol 2011 Nov 10;85(21):11079-89. Epub 2011 Aug 10.

Molecular Virology and Viral Immunology Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.05098-11
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http://dx.doi.org/10.1128/JVI.05098-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194975PMC
November 2011

Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-γ-mediated tumor elimination.

Mol Cancer Res 2011 Oct 4;9(10):1356-65. Epub 2011 Aug 4.

Department of Biochemistry, Chosun University School of Medicine, Dong-Gu, Gwang-ju 501-759, Korea.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0185DOI Listing
October 2011

Bioactivity determination of native and variant forms of therapeutic interferons.

J Biomed Biotechnol 2011 3;2011:174615. Epub 2011 Mar 3.

Biologics and Genetic Therapies Directorate, Health Canada, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9.

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http://dx.doi.org/10.1155/2011/174615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051158PMC
July 2011

Tom70 imports antiviral immunity to the mitochondria.

Cell Res 2010 Sep 13;20(9):971-3. Epub 2010 Jul 13.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1038/cr.2010.113DOI Listing
September 2010

STING-ing the antiviral pathway.

J Mol Cell Biol 2010 Jun 18;2(3):110-2. Epub 2009 Dec 18.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/jmcb/mjp048DOI Listing
June 2010

The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}.

Mol Endocrinol 2009 Dec 23;23(12):2013-25. Epub 2009 Oct 23.

Department of Medicine, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1210/me.2009-0197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419122PMC
December 2009

Functional analysis of a dominant negative mutation of interferon regulatory factor 5.

PLoS One 2009 11;4(5):e5500. Epub 2009 May 11.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677155PMC
September 2009

Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.

J Biol Chem 2009 Aug 22;284(33):21797-809. Epub 2009 Jun 22.

Unit of Hepacivirus and Innate Immunity, Laboratory of Viral Genomics and Vaccination, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1074/jbc.M109.018275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755906PMC
August 2009

Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.

Mol Cell Biol 2009 Jun 6;29(12):3435-50. Epub 2009 Apr 6.

UPR 2228-CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints-Pères, Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1128/MCB.01805-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698742PMC
June 2009

Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.

Mol Cell Biol 2009 Jun 20;29(12):3401-12. Epub 2009 Apr 20.

Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste. Catherine, Montreal, Quebec, Canada H3T 1E2.

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http://dx.doi.org/10.1128/MCB.00880-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698723PMC
June 2009

Targeting dendritic cell signaling to regulate the response to immunization.

Blood 2008 Mar 7;111(6):3050-61. Epub 2008 Jan 7.

Infection and Immunity, University College London, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-11-12
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http://dx.doi.org/10.1182/blood-2007-11-122408DOI Listing
March 2008

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.

J Biol Chem 2007 Nov 30;282(44):32208-21. Epub 2007 Aug 30.

Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704870200
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http://dx.doi.org/10.1074/jbc.M704870200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756044PMC
November 2007

Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection.

Virology 2007 Aug 23;365(1):20-33. Epub 2007 Apr 23.

Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.virol.2007.03.011DOI Listing
August 2007

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.

Nat Immunol 2007 Jun 29;8(6):592-600. Epub 2007 Apr 29.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada.

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http://dx.doi.org/10.1038/ni1465DOI Listing
June 2007

Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.

J Immunol 2007 Jan;178(1):253-61

Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.4049/jimmunol.178.1.253DOI Listing
January 2007

Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.

Biochem Pharmacol 2006 Nov 31;72(11):1477-84. Epub 2006 Jul 31.

Lady Davis Institute for Medical Research-Jewish General Hospital, Department of Microbiology & Immunology, McGill University, Montreal, Canada H3T 1E2.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520600390
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http://dx.doi.org/10.1016/j.bcp.2006.06.030DOI Listing
November 2006

Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages.

Cancer Res 2006 Nov;66(21):10576-85

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1279DOI Listing
November 2006

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

J Immunol 2006 Aug;177(4):2527-35

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montréal, Québec, Canada.

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http://dx.doi.org/10.4049/jimmunol.177.4.2527DOI Listing
August 2006

Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production.

J Immunol 2006 Jun;176(11):7051-61

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

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http://dx.doi.org/10.4049/jimmunol.176.11.7051DOI Listing
June 2006

Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.

J Biol Chem 2006 Feb 27;281(8):4856-66. Epub 2005 Dec 27.

UPR 2228-CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints-Pères, Université Paris V, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1074/jbc.M506812200DOI Listing
February 2006

MasterCARD: a priceless link to innate immunity.

Trends Mol Med 2006 Feb 6;12(2):53-6. Epub 2006 Jan 6.

Lady Davis Institute for Medical Research--Jewish General Hospital, Department of Microbiology & Immunology, McGill University, Montreal, QC, H3T 1E2, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S147149140500270
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http://dx.doi.org/10.1016/j.molmed.2005.12.003DOI Listing
February 2006

Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.

J Biol Chem 2006 Jan 23;281(4):2095-103. Epub 2005 Nov 23.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M510326200DOI Listing
January 2006

Inhibition of the interferon antiviral response by hepatitis C virus.

Expert Rev Clin Immunol 2006 Jan;2(1):49-58

McGill University, Lady Davis Institute for Medical Research - Jewish General Hospital, Department of Microbiology & Immunology, McGill University, Montreal, H3T 1E2, Canada.

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2.1.49
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http://dx.doi.org/10.1586/1744666X.2.1.49DOI Listing
January 2006

IRF-3 releases its inhibitions.

Structure 2005 Sep;13(9):1235-6

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http://dx.doi.org/10.1016/j.str.2005.08.001DOI Listing
September 2005

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

J Virol 2005 Jul;79(14):9180-91

McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste. Catherine, Montreal, Quebec, Canada H3T1E2.

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http://dx.doi.org/10.1128/JVI.79.14.9180-9191.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168763PMC
July 2005

Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.

FEBS J 2005 Jun;272(12):3120-31

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04726.xDOI Listing
June 2005

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.

J Biol Chem 2005 Jan 19;280(4):3088-95. Epub 2004 Nov 19.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M408452200DOI Listing
January 2005

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.

J Virol 2005 Jan;79(1):124-31

Terry Fox Molecular Oncology Group, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.

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http://dx.doi.org/10.1128/JVI.79.1.124-131.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538702PMC
January 2005

A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions.

Oncogene 2004 Jul;23(34):5770-80

Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/sj.onc.1207707DOI Listing
July 2004

Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.

Ann N Y Acad Sci 2003 Dec;1010:237-48

Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1196/annals.1299.042DOI Listing
December 2003

Triggering the interferon antiviral response through an IKK-related pathway.

Science 2003 May 17;300(5622):1148-51. Epub 2003 Apr 17.

Lady Davis Institute for Medical Research-Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1126/science.1081315DOI Listing
May 2003

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

J Biol Chem 2003 Mar 10;278(11):9441-7. Epub 2003 Jan 10.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology & Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M209851200DOI Listing
March 2003

Super-activated interferon-regulatory factors can enhance plasmid immunization.

Vaccine 2003 Mar;21(13-14):1363-70

Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ont., Canada L8N 3Z5.

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http://dx.doi.org/10.1016/s0264-410x(02)00694-1DOI Listing
March 2003

Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines.

Oncogene 2003 Feb;22(7):964-73

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/sj.onc.1206270DOI Listing
February 2003

Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.

Oncogene 2002 Oct;21(44):6751-65

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1038/sj.onc.1205843DOI Listing
October 2002

In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.

Cancer Res 2002 Sep;62(18):5148-52

Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, 3755 Cote-Ste.-Catherine Road, Montreal, Quebec H3T-1E2, Canada.

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September 2002

Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.

J Virol 2002 Apr;76(8):3659-69

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136070PMC
http://dx.doi.org/10.1128/jvi.76.8.3659-3669.2002DOI Listing
April 2002

Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.

J Mol Biol 2002 Mar;316(5):1009-22

UPR 2228-CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints-Pères, Université Paris V, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.

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http://dx.doi.org/10.1006/jmbi.2001.5401DOI Listing
March 2002

Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function.

J Interferon Cytokine Res 2002 Jan;22(1):49-58

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Medicine, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1089/107999002753452656DOI Listing
January 2002