Rongqing Zhang

Rongqing Zhang

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A basic protein, N25, from a mollusk modifies calcium carbonate morphology and shell biomineralization.

J Biol Chem 2019 Apr 9. Epub 2019 Apr 9.

School of Life Sciences, Tsinghua University, China.

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http://dx.doi.org/10.1074/jbc.RA118.007338DOI Listing
April 2019

Transcription factor Pf-Rel regulates expression of matrix protein genes Prismalin-14 and MSI60 in the pearl oyster Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 16. Epub 2019 Apr 16.

Protein Science Laboratory of the Ministry of Education, School of Life Science, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1093/abbs/gmz031DOI Listing
April 2019

Shell repair and the potential microbial causal in a shell disease of the pearl oyster Pinctada fucata.

Fish Shellfish Immunol 2019 Mar 19;86:934-941. Epub 2018 Dec 19.

MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China; Department of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, 314000, China. Electronic address:

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http://dx.doi.org/10.1016/j.fsi.2018.12.032DOI Listing
March 2019

Establishment of a high throughput-screening system for nucleoside deoxyribosyltransferase II mutant enzymes with altered substrate specificity.

J Biosci Bioeng 2019 Feb 23. Epub 2019 Feb 23.

Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2019.01.002DOI Listing
February 2019

Transcriptional regulation of the matrix protein Shematrin-2 during shell formation in pearl oyster.

J Biol Chem 2018 11 3;293(46):17803-17816. Epub 2018 Oct 3.

From the Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084 and

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http://dx.doi.org/10.1074/jbc.RA118.005281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240880PMC
November 2018

The Microstructure, Proteomics and Crystallization of the Limpet Teeth.

Proteomics 2018 Oct 5;18(19):e1800194. Epub 2018 Sep 5.

Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1002/pmic.201800194DOI Listing
October 2018

Cloning, characterization and functional analysis of an Alveoline-like protein in the shell of Pinctada fucata.

Sci Rep 2018 Aug 16;8(1):12258. Epub 2018 Aug 16.

Protein Science Laboratory of the Ministry of Education, School of Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41598-018-29743-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095885PMC
August 2018

Hemocytes in the extrapallial space of Pinctada fucata are involved in immunity and biomineralization.

Sci Rep 2018 Mar 15;8(1):4657. Epub 2018 Mar 15.

MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41598-018-22961-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854705PMC
March 2018

Amorphous calcium carbonate: A precursor phase for aragonite in shell disease of the pearl oyster.

Biochem Biophys Res Commun 2018 02 8;497(1):102-107. Epub 2018 Feb 8.

Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing, 100084, China; Department of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, 314000, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.02.031DOI Listing
February 2018

fam20C participates in the shell formation in the pearl oyster, Pinctada fucata.

Sci Rep 2018 Feb 23;8(1):3563. Epub 2018 Feb 23.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41598-018-21797-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824888PMC
February 2018

Studies of the cryopreservation condition of Gymnocypris przewalskii spermatozoa.

Anim Reprod Sci 2018 Jan 7;188:13-20. Epub 2017 Nov 7.

State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, China. Electronic address:

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http://dx.doi.org/10.1016/j.anireprosci.2017.10.021DOI Listing
January 2018

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors.

Cancer Res 2017 09 31;77(18):5107-5117. Epub 2017 Jul 31.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0917DOI Listing
September 2017

Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.

Biochim Biophys Acta Mol Basis Dis 2017 08 26;1863(8):1973-1983. Epub 2016 Oct 26.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.10.021DOI Listing
August 2017

OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.

Biochim Biophys Acta Mol Basis Dis 2017 08 4;1863(8):1951-1961. Epub 2016 Nov 4.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.004DOI Listing
August 2017

The receptor genes PfBMPR1B and PfBAMBI are involved in regulating shell biomineralization in the pearl oyster Pinctada fucata.

Sci Rep 2017 08 23;7(1):9219. Epub 2017 Aug 23.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://www.nature.com/articles/s41598-017-10011-y
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http://dx.doi.org/10.1038/s41598-017-10011-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569090PMC
August 2017

Influencing Mechanism of Ocean Acidification on Byssus Performance in the Pearl Oyster Pinctada fucata.

Environ Sci Technol 2017 Jul 24;51(13):7696-7706. Epub 2017 Jun 24.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.est.7b02132DOI Listing
July 2017

A Novel Matrix Protein, PfY2, Functions as a Crucial Macromolecule during Shell Formation.

Sci Rep 2017 07 20;7(1):6021. Epub 2017 Jul 20.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://www.nature.com/articles/s41598-017-06375-w
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http://dx.doi.org/10.1038/s41598-017-06375-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519542PMC
July 2017

Identification and expression characterization of three Wnt signaling genes in pearl oyster (Pinctada fucata).

Comp Biochem Physiol B Biochem Mol Biol 2016 Jun-Jul;196-197:92-101. Epub 2016 Mar 8.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Science, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.cbpb.2016.03.003DOI Listing
February 2017

Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells' Survival and Proliferation In Vivo.

Biomed Res Int 2016 21;2016:1363902. Epub 2016 Jun 21.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.1155/2016/1363902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932172PMC
February 2017

Pf-Sp8/9, a novel member of the specificity protein family in Pinctada fucata, potentially participates in biomineralization.

J Struct Biol 2016 11 10;196(2):119-126. Epub 2016 May 10.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2016.05.002DOI Listing
November 2016

Cloning and mineralization-related functions of the calponin gene in Chlamys farreri.

Comp Biochem Physiol B Biochem Mol Biol 2016 Nov 1;201:53-8. Epub 2016 Jul 1.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Department of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China. Electronic address:

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http://dx.doi.org/10.1016/j.cbpb.2016.06.008DOI Listing
November 2016

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

Diabetologia 2016 11 10;59(11):2435-2447. Epub 2016 Aug 10.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.

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http://dx.doi.org/10.1007/s00125-016-4070-9DOI Listing
November 2016

Ca Mediates the Self-Assembly of the Foot Proteins of Pinctada fucata from the Nanoscale to the Microscale.

Biomacromolecules 2016 10 15;17(10):3347-3355. Epub 2016 Sep 15.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University , Beijing 100084 China.

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http://dx.doi.org/10.1021/acs.biomac.6b01125DOI Listing
October 2016

PDE5 inhibitors protect against post-infarction heart failure.

Front Biosci (Landmark Ed) 2016 06 1;21:1194-210. Epub 2016 Jun 1.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China,

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June 2016

The transcription factor Pf-POU3F4 regulates expression of the matrix protein genes Aspein and Prismalin-14 in pearl oyster (Pinctada fucata).

FEBS J 2016 05 6;283(10):1962-78. Epub 2016 Apr 6.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Science, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1111/febs.13716DOI Listing
May 2016

Amorphous calcium carbonate precipitation by cellular biomineralization in mantle cell cultures of Pinctada fucata.

PLoS One 2014 18;9(11):e113150. Epub 2014 Nov 18.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236139PMC
April 2016

The Effect of NF-κB Signalling Pathway on Expression and Regulation of Nacrein in Pearl Oyster, Pinctada fucata.

PLoS One 2015 9;10(7):e0131711. Epub 2015 Jul 9.

Institute of Marine Biotechnology, School of Life Science, Tsinghua University, Beijing, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131711PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497715PMC
April 2016

Dual Roles of the Lysine-Rich Matrix Protein (KRMP)-3 in Shell Formation of Pearl Oyster, Pinctada fucata.

PLoS One 2015 10;10(7):e0131868. Epub 2015 Jul 10.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131868PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498902PMC
April 2016

Hemocytes participate in calcium carbonate crystal formation, transportation and shell regeneration in the pearl oyster Pinctada fucata.

Fish Shellfish Immunol 2016 Apr 23;51:263-270. Epub 2016 Feb 23.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.fsi.2016.02.027DOI Listing
April 2016

Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation.

Immunol Lett 2016 Feb 8;170:7-14. Epub 2015 Dec 8.

Department of Cardiovasology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

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http://dx.doi.org/10.1016/j.imlet.2015.12.003DOI Listing
February 2016

Interactive Effects of Seawater Acidification and Elevated Temperature on the Transcriptome and Biomineralization in the Pearl Oyster Pinctada fucata.

Environ Sci Technol 2016 Feb 13;50(3):1157-65. Epub 2016 Jan 13.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.est.5b05107DOI Listing
February 2016

Luteolin alleviates post-infarction cardiac dysfunction by up-regulating autophagy through Mst1 inhibition.

J Cell Mol Med 2016 Jan 5;20(1):147-56. Epub 2015 Nov 5.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1111/jcmm.12714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717847PMC
January 2016

Low dose tunicamycin enhances atherosclerotic plaque stability by inducing autophagy.

Biochem Pharmacol 2016 Jan 23;100:51-60. Epub 2015 Nov 23.

Department of Cardiology, Xijing Hospital, The Fourth Military Medial University, Xi'an, Shaanxi 710032, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.11.020DOI Listing
January 2016

Lin28a protects against diabetic cardiomyopathy via the PKA/ROCK2 pathway.

Biochem Biophys Res Commun 2016 Jan 25;469(1):29-36. Epub 2015 Nov 25.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.11.065DOI Listing
January 2016

Transcriptome and biomineralization responses of the pearl oyster Pinctada fucata to elevated CO2 and temperature.

Sci Rep 2016 Jan 6;6:18943. Epub 2016 Jan 6.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/srep18943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702168PMC
January 2016

Ghrelin improves functional survival of engrafted adipose-derived mesenchymal stem cells in ischemic heart through PI3K/Akt signaling pathway.

Biomed Res Int 2015 24;2015:858349. Epub 2015 Mar 24.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China ; Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.1155/2015/858349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387976PMC
December 2015

Heterogeneous distribution of dye-labelled biomineralizaiton proteins in calcite crystals.

Sci Rep 2015 Dec 17;5:18338. Epub 2015 Dec 17.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084 China.

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http://dx.doi.org/10.1038/srep18338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682127PMC
December 2015

Cloning and identification of a YY-1 homolog as a potential transcription factor from Pinctada fucata.

Gene 2015 Nov 4;572(1):108-115. Epub 2015 Jul 4.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2015.07.003DOI Listing
November 2015

Interactive effects of seawater acidification and elevated temperature on biomineralization and amino acid metabolism in the mussel Mytilus edulis.

J Exp Biol 2015 Nov 28;218(Pt 22):3623-31. Epub 2015 Sep 28.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China

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http://dx.doi.org/10.1242/jeb.126748DOI Listing
November 2015

In-depth proteomic analysis of shell matrix proteins of Pinctada fucata.

Sci Rep 2015 Nov 26;5:17269. Epub 2015 Nov 26.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084 China.

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http://dx.doi.org/10.1038/srep17269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660305PMC
November 2015

Extensible byssus of Pinctada fucata: Ca(2+)-stabilized nanocavities and a thrombospondin-1 protein.

Sci Rep 2015 Oct 8;5:15018. Epub 2015 Oct 8.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084 China.

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http://dx.doi.org/10.1038/srep15018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597212PMC
October 2015

The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization.

Sci Rep 2015 Sep 25;5:14408. Epub 2015 Sep 25.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/srep14408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585884PMC
September 2015

Calcium carbonate mineralization mediated by in vitro cultured mantle cells from Pinctada fucata.

Biochem Biophys Res Commun 2015 Aug 12;463(4):1053-8. Epub 2015 Jun 12.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.057DOI Listing
August 2015

cfMSP-1, an extremely acidic matrix protein involved in shell formation of the scallop Chlamys farreri.

Comp Biochem Physiol B Biochem Mol Biol 2015 Jul 28;185:34-41. Epub 2015 Mar 28.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10964959150004
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http://dx.doi.org/10.1016/j.cbpb.2015.03.004DOI Listing
July 2015

Morphology and classification of hemocytes in Pinctada fucata and their responses to ocean acidification and warming.

Fish Shellfish Immunol 2015 Jul 14;45(1):194-202. Epub 2015 Apr 14.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.fsi.2015.04.006DOI Listing
July 2015

Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway.

J Cell Mol Med 2015 Jun 16;19(6):1174-82. Epub 2015 Feb 16.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1111/jcmm.12369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459833PMC
June 2015

Microarray: a global analysis of biomineralization-related gene expression profiles during larval development in the pearl oyster, Pinctada fucata.

BMC Genomics 2015 Apr 19;16:325. Epub 2015 Apr 19.

Institute of Marine Biotechnology, Collaborative Innovation Center of Deep Sea Biology, School of Life Science, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1186/s12864-015-1524-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445274PMC
April 2015

A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy.

Biochim Biophys Acta 2015 Feb 27;1852(2):319-31. Epub 2014 May 27.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.05.017DOI Listing
February 2015

Enzymatic synthesis of 2'-deoxyuridine by whole cell catalyst co-expressing uridine phosphorylase and thymidine phosphorylase through auto-induction system.

J Biosci Bioeng 2014 Dec 6;118(6):723-7. Epub 2014 Jun 6.

School of Life Sciences, Tsinghua University, Beijing 100084, China; Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.jbiosc.2014.05.005DOI Listing
December 2014

Cloning and characterization of the shell matrix protein Shematrin in scallop Chlamys farreri.

Acta Biochim Biophys Sin (Shanghai) 2014 Aug 7;46(8):709-19. Epub 2014 Jul 7.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1093/abbs/gmu054DOI Listing
August 2014

A novel acidic matrix protein, PfN44, stabilizes magnesium calcite to inhibit the crystallization of aragonite.

J Biol Chem 2014 Jan 3;289(5):2776-87. Epub 2013 Dec 3.

From the Institute of Marine Biotechnology, School of Life Sciences and.

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http://dx.doi.org/10.1074/jbc.M113.504027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908410PMC
January 2014

Characterization of the Zhikong scallop (Chlamys farreri) mantle transcriptome and identification of biomineralization-related genes.

Mar Biotechnol (NY) 2013 Dec 17;15(6):706-15. Epub 2013 Jul 17.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s10126-013-9517-0DOI Listing
December 2013

Structural characterization of amorphous calcium carbonate-binding protein: an insight into the mechanism of amorphous calcium carbonate formation.

Biochem J 2013 Jul;453(2):179-86

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1042/BJ20130285DOI Listing
July 2013

FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease.

PLoS One 2012 14;7(8):e42900. Epub 2012 Aug 14.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an City, Shaanxi Province, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042900PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419247PMC
May 2013

Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism.

Diabetes 2013 May 30;62(5):1697-708. Epub 2013 Jan 30.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

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http://dx.doi.org/10.2337/db12-1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636622PMC
May 2013

S1P1 and S1P3 are potential markers of cardiac microangiopathy in diabetes.

Med Hypotheses 2012 Aug 15;79(2):168-70. Epub 2012 May 15.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an City, Shaanxi Province, China.

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http://dx.doi.org/10.1016/j.mehy.2012.04.025DOI Listing
August 2012

Novel basic protein, PfN23, functions as key macromolecule during nacre formation.

J Biol Chem 2012 May 13;287(19):15776-85. Epub 2012 Mar 13.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1074/jbc.M112.341594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346131PMC
May 2012

The role of matrix proteins in the control of nacreous layer deposition during pearl formation.

Proc Biol Sci 2012 Mar 7;279(1730):1000-7. Epub 2011 Sep 7.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, People's Republic of China.

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http://dx.doi.org/10.1098/rspb.2011.1661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259940PMC
March 2012

Improved synthesis of 2'-deoxyadenosine and 5-methyluridine by Escherichia coli using an auto-induction system.

World J Microbiol Biotechnol 2012 Feb 14;28(2):721-7. Epub 2011 Sep 14.

School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s11274-011-0868-2DOI Listing
February 2012

Transformation of prednisolone to a 20β-hydroxy prednisolone compound by Streptomyces roseochromogenes TS79.

Appl Microbiol Biotechnol 2011 Nov 14;92(4):727-35. Epub 2011 Jun 14.

School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1007/s00253-011-3382-4DOI Listing
November 2011

Identification of genes directly involved in shell formation and their functions in pearl oyster, Pinctada fucata.

PLoS One 2011 1;6(7):e21860. Epub 2011 Jul 1.

Institute of Marine Biotechnology, School of Life Science, Tsinghua University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128620PMC
November 2011

Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells.

Antioxid Redox Signal 2011 Oct 26;15(7):1769-78. Epub 2011 Apr 26.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University,15 Changle West Road, Xi’an, China.

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http://dx.doi.org/10.1089/ars.2010.3764DOI Listing
October 2011

A new method to extract matrix proteins directly from the secretion of the mollusk mantle and the role of these proteins in shell biomineralization.

Mar Biotechnol (NY) 2011 Oct 29;13(5):981-91. Epub 2011 Jan 29.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://link.springer.com/10.1007/s10126-011-9362-y
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October 2011

Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes.

Mol Cell Biochem 2011 Jul 2;353(1-2):305-13. Epub 2011 Apr 2.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China.

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http://link.springer.com/10.1007/s11010-011-0799-0
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http://dx.doi.org/10.1007/s11010-011-0799-0DOI Listing
July 2011

Effects and mechanisms of ghrelin on cardiac microvascular endothelial cells in rats.

Cell Biol Int 2011 Feb;35(2):135-40

*Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, Shaanxi 710032, Peoples Republic of China.

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http://dx.doi.org/10.1042/CBI20100139DOI Listing
February 2011

Pinctada fucata mantle gene 3 (PFMG3) promotes differentiation in mouse osteoblasts (MC3T3-E1).

Comp Biochem Physiol B Biochem Mol Biol 2011 Feb 23;158(2):173-80. Epub 2010 Nov 23.

Protein Science Key Laboratory of the Ministry of Education, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.cbpb.2010.11.004DOI Listing
February 2011

A possible mechanism for the formation of annual growth lines in bivalve shells.

Sci China Life Sci 2011 Feb 14;54(2):175-80. Epub 2011 Feb 14.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1007/s11427-010-4132-zDOI Listing
February 2011

Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation.

Inflamm Res 2011 Jan 23;60(1):37-45. Epub 2010 Jul 23.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032 Shaanxi, China.

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http://dx.doi.org/10.1007/s00011-010-0232-2DOI Listing
January 2011

A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.

Microvasc Res 2010 Jul 14;80(1):158-65. Epub 2010 Jan 14.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

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http://dx.doi.org/10.1016/j.mvr.2010.01.003DOI Listing
July 2010

Cloning and characterization of the activin like receptor 1 homolog (Pf-ALR1) in the pearl oyster, Pinctada fucata.

Comp Biochem Physiol B Biochem Mol Biol 2010 Jul 10;156(3):158-67. Epub 2010 Mar 10.

Institute of Marine Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.cbpb.2010.02.012DOI Listing
July 2010

A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats.

Apoptosis 2010 Apr;15(4):488-98

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

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http://dx.doi.org/10.1007/s10495-009-0439-2DOI Listing
April 2010

Calcineurin plays an important role in the shell formation of pearl oyster (Pinctada fucata).

Mar Biotechnol (NY) 2010 Feb 11;12(1):100-10. Epub 2009 Jul 11.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1007/s10126-009-9204-3DOI Listing
February 2010

Calcineurin mediates the immune response of hemocytes through NF-kappaB signaling pathway in pearl oyster (Pinctada fucata).

Fish Shellfish Immunol 2010 Feb 5;28(2):253-60. Epub 2009 Nov 5.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://linkinghub.elsevier.com/retrieve/pii/S105046480900355
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http://dx.doi.org/10.1016/j.fsi.2009.11.001DOI Listing
February 2010

The structure-function relationship of MSI7, a matrix protein from pearl oyster Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2009 Nov;41(11):955-62

Department of Biological Science and Biotechnology, Institute of Marine Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1093/abbs/gmp086DOI Listing
November 2009

Identification and comparison of amorphous calcium carbonate-binding protein and acetylcholine-binding protein in the abalone, Haliotis discus hannai.

Mar Biotechnol (NY) 2009 Sep-Oct;11(5):596-607. Epub 2009 Jan 13.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s10126-008-9176-8DOI Listing
October 2009

Cloning, characterization and immunolocalization of two subunits of calcineurin from pearl oyster (Pinctada fucata).

Comp Biochem Physiol B Biochem Mol Biol 2009 May 22;153(1):43-53. Epub 2009 Jan 22.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1016/j.cbpb.2009.01.008DOI Listing
May 2009

Cloning and characterization of Prisilkin-39, a novel matrix protein serving a dual role in the prismatic layer formation from the oyster Pinctada fucata.

J Biol Chem 2009 Apr 19;284(16):10841-54. Epub 2009 Feb 19.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, and Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China.

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http://www.jbc.org/content/284/16/10841.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M808357200
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http://dx.doi.org/10.1074/jbc.M808357200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667771PMC
April 2009

The extra C-terminal tail is involved in the conformation, stability changes and the N/C-domain interactions of the calmodulin-like protein from pearl oyster Pinctada fucata.

Biochim Biophys Acta 2008 Nov 11;1784(11):1514-23. Epub 2008 Jul 11.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.bbapap.2008.06.021DOI Listing
November 2008

Immunolocalization of matrix proteins in nacre lamellae and their in vivo effects on aragonitic tablet growth.

J Struct Biol 2008 Oct 3;164(1):33-40. Epub 2008 Jun 3.

Department of Biological Sciences and Biotechnology, Institute of Marine Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.jsb.2008.05.009DOI Listing
October 2008

Characterization of calcium deposition and shell matrix protein secretion in primary mantle tissue culture from the marine pearl oyster Pinctada fucata.

Mar Biotechnol (NY) 2008 Jul-Aug;10(4):457-65. Epub 2008 Mar 25.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1007/s10126-008-9081-1DOI Listing
September 2008

Culture of outer epithelial cells from mantle tissue to study shell matrix protein secretion for biomineralization.

Cell Tissue Res 2008 Sep 1;333(3):493-501. Epub 2008 Jul 1.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s00441-008-0609-5DOI Listing
September 2008

Significance of the C-terminal globular domain and the extra tail of the calmodulin-like protein (Pinctada fucata) in subcellular localization and protein-protein interaction.

Cell Biol Int 2008 Aug 10;32(8):920-7. Epub 2008 Apr 10.

Institute of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Haidian, Beijing 100084, PR China.

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http://dx.doi.org/10.1016/j.cellbi.2008.04.007DOI Listing
August 2008

The inner-shell film: an immediate structure participating in pearl oyster shell formation.

Chembiochem 2008 May;9(7):1093-9

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1002/cbic.200700553DOI Listing
May 2008

Cloning and expression pattern of a Smad3 homolog from the pearl oyster, Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2008 Mar;40(3):244-52

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1111/j.1745-7270.2008.00399.xDOI Listing
March 2008

Cloning and characterization of a heterogeneous nuclear ribonucleoprotein homolog from pearl oyster, Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2007 Dec;39(12):955-63

Institute of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1111/j.1745-7270.2007.00341.xDOI Listing
December 2007

N40, a novel nonacidic matrix protein from pearl oyster nacre, facilitates nucleation of aragonite in vitro.

Biomacromolecules 2007 Nov 12;8(11):3597-601. Epub 2007 Oct 12.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, and Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1021/bm0701494DOI Listing
November 2007

Biomineralization: functions of calmodulin-like protein in the shell formation of pearl oyster.

Biochim Biophys Acta 2007 Sep 17;1770(9):1338-44. Epub 2007 Jul 17.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.bbagen.2007.06.018DOI Listing
September 2007

Different effects of Pb(2+) and Cu(2+) on immune and antioxidant enzyme activities in the mantle of Pinctada fucata.

Environ Toxicol Pharmacol 2007 Sep 19;24(2):122-8. Epub 2007 Apr 19.

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.

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http://dx.doi.org/10.1016/j.etap.2007.04.002DOI Listing
September 2007

Cloning, characterization, and expression patterns of three sarco/endoplasmic reticulum Ca2+-ATPase isoforms from pearl oyster (Pinctada fucata).

Acta Biochim Biophys Sin (Shanghai) 2007 Sep;39(9):722-30

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1111/j.1745-7270.2007.00330.xDOI Listing
September 2007

Cloning, characterization and expression analysis of calcium channel beta subunit from pearl oyster (Pinctada fucata).

J Biosci Bioeng 2007 Jul;104(1):47-54

Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1263/jbb.104.47DOI Listing
July 2007

Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice.

Pharmazie 2007 Jun;62(6):439-44

Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China.

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June 2007