Ronald Wetzel

Ronald Wetzel

UNVERIFIED PROFILE

Are you Ronald Wetzel?   Register this Author

Register author
Ronald Wetzel

Ronald Wetzel

Publications by authors named "Ronald Wetzel"

Are you Ronald Wetzel?   Register this Author

84Publications

1196Reads

15Profile Views

An Aggregate Weight-Normalized Thioflavin-T Measurement Scale for Characterizing Polymorphic Amyloids and Assembly Intermediates.

Methods Mol Biol 2018 ;1777:121-144

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7811-3_6DOI Listing
February 2019

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease.

Neurobiol Dis 2018 12 30;120:126-138. Epub 2018 Aug 30.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Pittsburgh Institute for Neurodegenerative Diseases (PIND), University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186178PMC
December 2018

RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.

J Biol Chem 2018 01 7;293(4):1353-1362. Epub 2017 Dec 7.

From the Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M117.808402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787811PMC
January 2018

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.

PLoS One 2016 6;11(6):e0155747. Epub 2016 Jun 6.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155747PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894636PMC
August 2017

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Nat Commun 2017 05 24;8:15462. Epub 2017 May 24.

Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458082PMC
May 2017

Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation.

J Mol Biol 2017 01 13;429(2):308-323. Epub 2016 Dec 13.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2016.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286556PMC
January 2017

Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway.

Nat Commun 2016 08 22;7:12419. Epub 2016 Aug 22.

Structural Biology Department, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/ncomms12419
Publisher Site
http://dx.doi.org/10.1038/ncomms12419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996947PMC
August 2016

Fluorescence Correlation Spectroscopy: A Tool to Study Protein Oligomerization and Aggregation In Vitro and In Vivo.

Methods Mol Biol 2016 ;1345:67-87

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 5th Avenue, Pittsburgh, PA, 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2978-8_5DOI Listing
July 2016

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core.

Proc Natl Acad Sci U S A 2016 Feb 1;113(6):1546-51. Epub 2016 Feb 1.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1521933113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760812PMC
February 2016

C-Terminal Threonine Reduces Aβ43 Amyloidogenicity Compared with Aβ42.

J Mol Biol 2016 Jan 26;428(2 Pt A):274-291. Epub 2015 Jun 26.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2015.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691432PMC
January 2016

Huntington disease.

Nat Rev Dis Primers 2015 04 23;1:15005. Epub 2015 Apr 23.

Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2015.5DOI Listing
April 2015

Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.

Biochim Biophys Acta 2015 Jan 16;1852(1):61-9. Epub 2014 Oct 16.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Pittsburgh Institute for Neurodegenerative Diseases (PIND), University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2014.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268122PMC
January 2015

Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.

Biochemistry 2014 Oct 16;53(42):6653-66. Epub 2014 Oct 16.

Department of Structural Biology, University of Pittsburgh School of Medicine , Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15260, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi501010qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211650PMC
October 2014

Aggregation behavior of chemically synthesized, full-length huntingtin exon1.

Biochemistry 2014 Jun 12;53(24):3897-907. Epub 2014 Jun 12.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania 15260, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi500300cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075985PMC
June 2014

Biophysical underpinnings of the repeat length dependence of polyglutamine amyloid formation.

J Biol Chem 2014 Apr 4;289(15):10254-60. Epub 2014 Mar 4.

From the Department of Structural Biology and the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C114.552943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036150PMC
April 2014

Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.

Biopolymers 2014 Mar;102(2):206-21

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.22470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010528PMC
March 2014

D-polyglutamine amyloid recruits L-polyglutamine monomers and kills cells.

J Mol Biol 2014 Feb 28;426(4):816-29. Epub 2013 Nov 28.

Department of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2013.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910295PMC
February 2014

A serendipitous survey of prediction algorithms for amyloidogenicity.

Biopolymers 2013 Nov;100(6):780-9

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA, 15260.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.22305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918212PMC
November 2013

Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.

FEBS Lett 2013 Jun 10;587(11):1638-43. Epub 2013 Apr 10.

University at Albany, State University of New York, Albany, NY 12222, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2013.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685276PMC
June 2013

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

J Mol Biol 2012 Nov 18;424(1-2):1-14. Epub 2012 Sep 18.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2012.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488119PMC
November 2012

Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence.

Authors:
Ronald Wetzel

J Mol Biol 2012 Aug 27;421(4-5):466-90. Epub 2012 Jan 27.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2012.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362671PMC
August 2012

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.

Biochemistry 2012 Apr 20;51(13):2706-16. Epub 2012 Mar 20.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi3000929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394396PMC
April 2012

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

J Mol Biol 2012 Feb 9;415(5):881-99. Epub 2011 Dec 9.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2011.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568928PMC
February 2012

Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates.

J Mol Biol 2012 Feb 9;415(5):900-17. Epub 2011 Dec 9.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2011.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267848PMC
February 2012

Assays for studying nucleated aggregation of polyglutamine proteins.

Methods 2011 Mar 11;53(3):246-54. Epub 2011 Jan 11.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2011.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057327PMC
March 2011

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent.

Nat Struct Mol Biol 2011 Mar 13;18(3):328-36. Epub 2011 Feb 13.

Structural Biology Department, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075957PMC
March 2011

The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.

J Am Chem Soc 2011 Mar 7;133(12):4558-66. Epub 2011 Mar 7.

Department of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja110715fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109494PMC
March 2011

Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice.

J Biol Chem 2010 Nov 25;285(47):36945-57. Epub 2010 Aug 25.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M110.127738
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.127738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978623PMC
November 2010

Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.

J Mol Biol 2010 Aug 18;401(3):503-17. Epub 2010 Jun 18.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002228361000639
Publisher Site
http://dx.doi.org/10.1016/j.jmb.2010.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919579PMC
August 2010

Structural variations in the cross-beta core of amyloid beta fibrils revealed by deep UV resonance Raman spectroscopy.

J Am Chem Soc 2010 May;132(18):6324-8

Department of Chemistry University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja909074jDOI Listing
May 2010

Soluble and mature amyloid fibrils in drusen deposits.

Invest Ophthalmol Vis Sci 2010 Mar 5;51(3):1304-10. Epub 2009 Nov 5.

Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.09-4207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840723PMC
March 2010

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Neuron 2009 Dec;64(6):828-40

Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2009.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807408PMC
December 2009

The impact of ataxin-1-like histidine insertions on polyglutamine aggregation.

Protein Eng Des Sel 2009 Aug 18;22(8):469-78. Epub 2009 Jun 18.

Department of Structural Biology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/peds/article-lookup/doi/10.1093/pro
Publisher Site
http://dx.doi.org/10.1093/protein/gzp023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719497PMC
August 2009

Structures of Abeta-related peptide--monoclonal antibody complexes.

Biochemistry 2009 Jun;48(23):5210-7

Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi9001216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720063PMC
June 2009

In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence.

J Biol Chem 2007 Dec 17;282(50):36736-43. Epub 2007 Oct 17.

Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M703682200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892112PMC
December 2007

Amyloid adhesins are abundant in natural biofilms.

Environ Microbiol 2007 Dec;9(12):3077-90

Department of Biotechnology, Aalborg University, Sohngaardsholmvej 57, DK-9000, Aalborg, Denmark.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1462-2920.2007.01418.x
Publisher Site
http://dx.doi.org/10.1111/j.1462-2920.2007.01418.xDOI Listing
December 2007

Molecular basis for passive immunotherapy of Alzheimer's disease.

Proc Natl Acad Sci U S A 2007 Oct 25;104(40):15659-64. Epub 2007 Sep 25.

Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0705888104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994138PMC
October 2007

A triaxial probe for on-line proteolysis coupled with hydrogen/deuterium exchange-electrospray mass spectrometry.

J Am Soc Mass Spectrom 2007 Feb 30;18(2):208-17. Epub 2006 Oct 30.

Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996-1600, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jasms.2006.09.011DOI Listing
February 2007

Polymorphism in the intermediates and products of amyloid assembly.

Curr Opin Struct Biol 2007 Feb 23;17(1):48-57. Epub 2007 Jan 23.

Department of Structural Biology, University of Pittsburgh School of Medicine, 2046 Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0959440X0700008
Publisher Site
http://dx.doi.org/10.1016/j.sbi.2007.01.007DOI Listing
February 2007

Plasticity of amyloid fibrils.

Biochemistry 2007 Jan;46(1):1-10

Graduate School of Medicine, University of Tennessee, Knoxville Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0620959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526019PMC
January 2007

Hydrogen/deuterium exchange mass spectrometry analysis of protein aggregates.

Methods Enzymol 2006 ;413:140-66

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S007668790613008
Publisher Site
http://dx.doi.org/10.1016/S0076-6879(06)13008-6DOI Listing
November 2006

Analysis of amyloid fibril structure by scanning cysteine mutagenesis.

Methods Enzymol 2006 ;413:182-98

University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(06)13010-4DOI Listing
November 2006

Screening for modulators of aggregation with a microplate elongation assay.

Methods Enzymol 2006 ;413:313-25

University of Tennessee Medical Center-Graduate School of Medicine, Knoxville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(06)13016-5DOI Listing
November 2006

Imaging polyglutamine deposits in brain tissue.

Methods Enzymol 2006 ;412:106-22

Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(06)12008-XDOI Listing
November 2006

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions.

Proc Natl Acad Sci U S A 2006 Nov 30;103(45):16764-9. Epub 2006 Oct 30.

Department of Biomedical Engineering, Washington University, One Brookings Drive, Box 1097, St. Louis, MO 63130, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0608175103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1629004PMC
November 2006

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.

Proc Natl Acad Sci U S A 2006 Sep 15;103(39):14367-72. Epub 2006 Sep 15.

Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-4260, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0602348103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599969PMC
September 2006

Amyloid fibrils--common threads in the natural history of proteins.

Authors:
Ronald Wetzel

Acc Chem Res 2006 Sep;39(9):567

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ar0681934DOI Listing
September 2006

Hydrogen/deuterium exchange mass spectrometry--a window into amyloid structure.

Acc Chem Res 2006 Sep;39(9):584-93

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ar050057wDOI Listing
September 2006

Kinetics and thermodynamics of amyloid fibril assembly.

Authors:
Ronald Wetzel

Acc Chem Res 2006 Sep;39(9):671-9

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ar050069hDOI Listing
September 2006

Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange--mass spectrometry with on-line proteolytic fragmentation.

J Mol Biol 2006 Aug 12;361(4):785-95. Epub 2006 Jul 12.

Graduate School of Medicine University of Tennessee, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002228360600810
Publisher Site
http://dx.doi.org/10.1016/j.jmb.2006.06.066DOI Listing
August 2006

Nucleation of huntingtin aggregation in cells.

Authors:
Ronald Wetzel

Nat Chem Biol 2006 Jun;2(6):297-8

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio0606-297DOI Listing
June 2006

Alanine scanning mutagenesis of Abeta(1-40) amyloid fibril stability.

J Mol Biol 2006 Apr 30;357(4):1283-94. Epub 2006 Jan 30.

Graduate School of Medicine, R221, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2006.01.041DOI Listing
April 2006

Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils.

J Biol Chem 2006 Jan 1;281(2):993-1000. Epub 2005 Nov 1.

Graduate School of Medicine, University of Tennessee, Knoxville, 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M505091200DOI Listing
January 2006

Oligoproline effects on polyglutamine conformation and aggregation.

J Mol Biol 2006 Jan 9;355(3):524-35. Epub 2005 Nov 9.

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2005.10.053DOI Listing
January 2006

Polyglutamine homopolymers having 8-45 residues form slablike beta-crystallite assemblies.

Proteins 2005 Nov;61(2):398-411

Biology Department, Boston College, Chestnut Hill, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.20602DOI Listing
November 2005

polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction.

Proc Natl Acad Sci U S A 2005 Oct 17;102(43):15400-5. Epub 2005 Oct 17.

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0501651102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266079PMC
October 2005

Thermodynamics of A beta(1-40) amyloid fibril elongation.

Biochemistry 2005 Sep;44(38):12709-18

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi050927hDOI Listing
September 2005

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.

Proc Natl Acad Sci U S A 2005 Aug 2;102(32):11402-7. Epub 2005 Aug 2.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0503634102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183566PMC
August 2005

Structural properties of Abeta protofibrils stabilized by a small molecule.

Proc Natl Acad Sci U S A 2005 May 9;102(20):7115-20. Epub 2005 May 9.

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0408582102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1091746PMC
May 2005

Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy.

Biochemistry 2005 Mar;44(11):4434-41

Department of Biochemistry and Cellular and Molecular Biology, the Center of Excellence for Structural Biology, University of Tennessee-Knoxville, Knoxville, Tennessee 37996-0840, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi048292u
Publisher Site
http://dx.doi.org/10.1021/bi048292uDOI Listing
March 2005

An intersheet packing interaction in A beta fibrils mapped by disulfide cross-linking.

Biochemistry 2004 Dec;43(49):15310-7

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi048019sDOI Listing
December 2004

Molecular modeling of the core of Abeta amyloid fibrils.

Proteins 2004 Nov;57(2):357-64

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.20222DOI Listing
November 2004

Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor.

FASEB J 2004 May 4;18(7):923-5. Epub 2004 Mar 4.

University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.03-1238fjeDOI Listing
May 2004

Kinetic analysis of beta-amyloid fibril elongation.

Anal Biochem 2004 May;328(1):67-75

Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2004.01.014DOI Listing
May 2004

Seeding specificity in amyloid growth induced by heterologous fibrils.

J Biol Chem 2004 Apr 29;279(17):17490-9. Epub 2004 Jan 29.

Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M311300200DOI Listing
April 2004

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

Mol Cell 2004 Apr;14(1):95-104

Department of Cell Biology, 240 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1097-2765(04)00151-0DOI Listing
April 2004

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis.

J Mol Biol 2004 Jan;335(3):833-42

Graduate School of Medicine, R221, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2003.11.008DOI Listing
January 2004

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange.

Biochemistry 2003 Dec;42(48):14092-8

Graduate School of Medicine, University of Tennessee, 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0357816DOI Listing
December 2003

An assay for characterizing in vitro the kinetics of polyglutamine aggregation.

Methods Mol Biol 2003 ;217:295-303

Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-330-5:295DOI Listing
April 2003

Enhanced correction methods for hydrogen exchange-mass spectrometric studies of amyloid fibrils.

Protein Sci 2003 Mar;12(3):635-43

Graduate School of Medicine, University of Tennessee Medical Center, University of Tennessee, Knoxville, Tennessee 37996-1600, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1110/ps.0225703
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312450PMC
http://dx.doi.org/10.1110/ps.0225703DOI Listing
March 2003

Mutational analysis of the structural organization of polyglutamine aggregates.

Proc Natl Acad Sci U S A 2002 Dec 20;99(26):17014-9. Epub 2002 Nov 20.

Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.252523899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139261PMC
December 2002

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells.

Hum Mol Genet 2002 Nov;11(23):2905-17

Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/11.23.2905DOI Listing
November 2002

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation.

Proc Natl Acad Sci U S A 2002 Sep 19;99(18):11884-9. Epub 2002 Aug 19.

Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.182276099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129363PMC
September 2002

Ideas of order for amyloid fibril structure.

Authors:
Ronald Wetzel

Structure 2002 Aug;10(8):1031-6

Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0969-2126(02)00809-2DOI Listing
August 2002

Amyloid-like features of polyglutamine aggregates and their assembly kinetics.

Biochemistry 2002 Jun;41(23):7391-9

Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi011772qDOI Listing
June 2002

Conformational Abs recognizing a generic amyloid fibril epitope.

Proc Natl Acad Sci U S A 2002 Feb 29;99(3):1485-90. Epub 2002 Jan 29.

Graduate School of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.022662599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122217PMC
February 2002