Ronald P Taylor

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs.

Authors:

Antibodies (Basel) 2020 Oct 28;9(4). Epub 2020 Oct 28.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

View Article and Find Full Text PDF

October 2020

How Do mAbs Make Use of Complement to Kill Cancer Cells? The Role of Ca.

Authors:

Ronald P Taylor Margaret A Lindorfer

Antibodies (Basel) 2020 Sep 4;9(3). Epub 2020 Sep 4.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

View Article and Find Full Text PDF

September 2020

Clearance of amyloid-beta with bispecific antibody constructs bound to erythrocytes.

Authors:

Ronald P Taylor Margaret A Lindorfer John P Atkinson

Alzheimers Dement (N Y) 2020 27;6(1):e12067. Epub 2020 Aug 27.

Department of Medicine and Division of Rheumatology Washington University St. Louis Missouri USA.

View Article and Find Full Text PDF

August 2020

Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome.

Authors:

Yuzhou Zhang Robin A Kremsdorf C John Sperati Kammi J Henriksen Mari Mori Renee X Goodfellow Gabriella R Pitcher Cindy L Benson Nicolo Ghiringhelli Borsa Ronald P Taylor Carla M Nester Richard J H Smith

Kidney Int 2020 11 12;98(5):1265-1274. Epub 2020 Jun 12.

Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. Electronic address:

View Article and Find Full Text PDF

November 2020

C3(H2O) prevents rescue of complement-mediated C3 glomerulopathy in Cfh-/- Cfd-/- mice.

Authors:

Yuzhou Zhang Adam Keenan Dao-Fu Dai Kristofer S May Emily E Anderson Margaret A Lindorfer John B Henrich Gabriella R Pitcher Ronald P Taylor Richard Jh Smith

JCI Insight 2020 05 7;5(9). Epub 2020 May 7.

Molecular Otolaryngology and Renal Research Laboratories, and.

View Article and Find Full Text PDF

May 2020

DuoHexaBody-CD37, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.

Authors:

Simone C Oostindie Hilma J van der Horst Laurens P Kil Kristin Strumane Marije B Overdijk Edward N van den Brink Jeroen H N van den Brakel Hendrik J Rademaker Berris van Kessel Juliette van den Noort Martine E D Chamuleau Tuna Mutis Margaret A Lindorfer Ronald P Taylor Janine Schuurman Paul W H I Parren Frank J Beurskens Esther C W Breij

Blood Cancer J 2020 04 28;10(3):30. Epub 2020 Apr 28.

Genmab, Utrecht, The Netherlands.

View Article and Find Full Text PDF

April 2020

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Nat Immunol 2019 Nov;20(11):1556

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article and Find Full Text PDF

November 2019

'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Nat Immunol 2019 11;20(11):1409-1413

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article and Find Full Text PDF

November 2019

Complement C1r serine protease contributes to kidney fibrosis.

Authors:

Sandhya Xavier Ranjit K Sahu Sai Vineela Bontha Valeria Mass Ronald P Taylor Judit Megyesi Nicole M Thielens Didier Portilla

Am J Physiol Renal Physiol 2019 11 11;317(5):F1293-F1304. Epub 2019 Sep 11.

Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia.

View Article and Find Full Text PDF

November 2019

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Authors:

Sunita Gulati Frank J Beurskens Bart-Jan de Kreuk Marcel Roza Bo Zheng Rosane B DeOliveira Jutamas Shaughnessy Nancy A Nowak Ronald P Taylor Marina Botto Xianbao He Robin R Ingalls Trent M Woodruff Wen-Chao Song Janine Schuurman Peter A Rice Sanjay Ram

PLoS Biol 2019 06 19;17(6):e3000323. Epub 2019 Jun 19.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

View Article and Find Full Text PDF

June 2019

Null donors favor prepared immunologists.

Authors:

Ronald P Taylor

Blood 2019 03;133(13):1389-1390

University of Virginia School of Medicine.

View Article and Find Full Text PDF

March 2019

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

Authors:

Simone C Oostindie Hilma J van der Horst Margaret A Lindorfer Erika M Cook Jillian C Tupitza Clive S Zent Richard Burack Karl R VanDerMeid Kristin Strumane Martine E D Chamuleau Tuna Mutis Rob N de Jong Janine Schuurman Esther C W Breij Frank J Beurskens Paul W H I Parren Ronald P Taylor

Haematologica 2019 09 21;104(9):1841-1852. Epub 2019 Feb 21.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, USA

View Article and Find Full Text PDF

September 2019

Critical role of C5a in sickle cell disease.

Authors:

Gregory M Vercellotti Agustin P Dalmasso Terry R Schaid Julia Nguyen Chunsheng Chen Marna E Ericson Fuad Abdulla Trevor Killeen Margaret A Lindorfer Ronald P Taylor John D Belcher

Am J Hematol 2019 03 3;94(3):327-337. Epub 2019 Jan 3.

Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota.

View Article and Find Full Text PDF

March 2019

Mechanisms of Complement-Mediated Damage in Hematological Disorders.

Authors:

Ronald P Taylor Margaret A Lindorfer

Semin Hematol 2018 07 14;55(3):118-123. Epub 2018 Feb 14.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA.

View Article and Find Full Text PDF

July 2018

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

Authors:

Diana Jalal Brandon Renner Jennifer Laskowski Erik Stites James Cooper Karissa Valente Zhiying You Loni Perrenoud Moglie Le Quintrec Ismaeel Muhamed Uwe Christians Jelena Klawitter Margaret A Lindorfer Ronald P Taylor V Michael Holers Joshua M Thurman

J Am Heart Assoc 2018 07 13;7(14). Epub 2018 Jul 13.

Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO.

View Article and Find Full Text PDF

July 2018

Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Nat Immunol 2017 09;18(10):1173

View Article and Find Full Text PDF

September 2017

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Nat Immunol 2017 Aug 12;18(8):889-898. Epub 2017 Jun 12.

Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA.

View Article and Find Full Text PDF

August 2017

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.

Authors:

Ronald P Taylor Margaret A Lindorfer Erika M Cook Frank J Beurskens Janine Schuurman Paul W H I Parren Clive S Zent Karl R VanDerMeid Richard Burack Masashi Mizuno B Paul Morgan

Clin Immunol 2017 08 31;181:24-28. Epub 2017 May 31.

Division of Infection & Immunity, School of Medicine, Cardiff University, United Kingdom.

View Article and Find Full Text PDF

August 2017

Neutrophils: positive or negative?

Authors:

Ronald P Taylor

Blood 2017 05;129(19):2596-2597

UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE.

View Article and Find Full Text PDF

May 2017

Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Authors:

Sandhya Xavier Ranjit K Sahu Susan G Landes Jing Yu Ronald P Taylor Srinivas Ayyadevara Judit Megyesi William B Stallcup Jeremy S Duffield Edimara S Reis John D Lambris Didier Portilla

Am J Physiol Renal Physiol 2017 03 4;312(3):F516-F532. Epub 2017 Jan 4.

Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia;

View Article and Find Full Text PDF

March 2017

Publications by authors named "Ronald P Taylor"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: