Ronald P J Oude Elferink

Ronald P J Oude Elferink

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Publications by authors named "Ronald P J Oude Elferink"

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Overexpression of carbamoyl-phosphate synthase 1 significantly improves ureagenesis of human liver HepaRG cells only when cultured under shaking conditions.

Mitochondrion 2019 Jul 22;47:298-308. Epub 2019 Feb 22.

Amsterdam UMC, University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, AG&M, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands; Amsterdam UMC, University of Amsterdam, Surgical Laboratory, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2019.02.005DOI Listing
July 2019

Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.

Hepatology 2019 May 28. Epub 2019 May 28.

Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.30792DOI Listing
May 2019

HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity.

Cell Physiol Biochem 2018 15;48(5):2189-2204. Epub 2018 Aug 15.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center (AMC), Amsterdam, the Netherlands.

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http://dx.doi.org/10.1159/000492560DOI Listing
September 2018

Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.

Biochim Biophys Acta Mol Basis Dis 2018 04 28;1864(4 Pt B):1232-1239. Epub 2017 Sep 28.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.022DOI Listing
April 2018

Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes.

Hepatol Commun 2018 03 9;2(3):299-312. Epub 2018 Feb 9.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center University of Amsterdam Amsterdam the Netherlands.

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http://doi.wiley.com/10.1002/hep4.1140
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http://dx.doi.org/10.1002/hep4.1140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831026PMC
March 2018

Na -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice.

Hepatology 2018 Mar 24. Epub 2018 Mar 24.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, AMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/hep.29888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175374PMC
March 2018

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β.

Cell Mol Gastroenterol Hepatol 2018 Mar 28;5(3):223-237. Epub 2017 Nov 28.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X173016
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http://dx.doi.org/10.1016/j.jcmgh.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904037PMC
March 2018

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.

Hepatology 2017 08 19;66(2):542-554. Epub 2017 Jun 19.

Department of Gastroenterology & Hepatology and Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/hep.29029
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http://dx.doi.org/10.1002/hep.29029DOI Listing
August 2017

The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.

Dig Dis 2017 1;35(3):217-223. Epub 2017 Mar 1.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000450914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516404PMC
May 2017

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

Gastroenterology 2017 04 5;152(5):1126-1138.e6. Epub 2017 Jan 5.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2016.12.037DOI Listing
April 2017

Erratum to: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.

Cell Mol Life Sci 2017 04;74(7):1365

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00018-017-2475-3DOI Listing
April 2017

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.

Cell Mol Life Sci 2017 02 14;74(4):715-730. Epub 2016 Sep 14.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00018-016-2360-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272906PMC
February 2017

Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.

Drug Metab Dispos 2017 01 25;45(1):56-67. Epub 2016 Oct 25.

Department of Experimental Surgery (V.A.M., R.A.F.M.C., R.H.), and the Tytgat Institute for Liver and Intestinal Research, Academic Medical Center (V.A.M., D.R.W., R.P.J.O.E., R.A.F.M.C., R.H.), Amsterdam, the Netherlands; and Biopredic International, Saint-Grégoire, France (V.S.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.116.072603
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http://dx.doi.org/10.1124/dmd.116.072603DOI Listing
January 2017

Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice.

Biochim Biophys Acta 2016 Nov 27;1862(11):2054-2062. Epub 2016 Jul 27.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105, BK, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.07.012DOI Listing
November 2016

The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.

Biochim Biophys Acta 2016 09 11;1863(9):2280-8. Epub 2016 Jun 11.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.06.005DOI Listing
September 2016

ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes.

Hepatology 2016 07 6;64(1):161-74. Epub 2016 Apr 6.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.28522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266587PMC
July 2016

Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders.

J Pediatr Gastroenterol Nutr 2016 Apr;62(4):530-5

*Department of Medicine I, Friedrich-Alexander-University of Erlangen, Erlangen, Germany †Tytgat Institute for Liver and Intestinal Research and Department of Hepatology & Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands ‡Pediatric Hepatology Unit and National Reference Centre for Biliary Atresia, DHU Hepatinov, CHU Bicêtre, Assistance Publique-Hôpitaux de Paris, University Paris-Sud, Paris, and Inserm UMR-S1174, Orsay, France §Department of Surgery, University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/MPG.0000000000001044DOI Listing
April 2016

Enteroendocrine cells are a potential source of serum autotaxin in men.

Biochim Biophys Acta 2016 04 14;1862(4):696-704. Epub 2016 Jan 14.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.012DOI Listing
April 2016

ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.

Dig Dis 2015 27;33(3):314-8. Epub 2015 May 27.

Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000371665DOI Listing
March 2016

MRP2 in cholestasis: Putting down the anchor.

J Hepatol 2015 Dec 3;63(6):1309-10. Epub 2015 Oct 3.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2015.09.020DOI Listing
December 2015

Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review.

Clin Rev Allergy Immunol 2015 Jun;48(2-3):182-91

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12016-014-8423-1DOI Listing
June 2015

IgG4-associated cholangitis: a comprehensive review.

Clin Rev Allergy Immunol 2015 Jun;48(2-3):198-206

Department of Gastroenterology and Hepatology and Tytgat Institute of Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Meibergdreef 9, room G4-216, 1105 AZ, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s12016-014-8430-2
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http://dx.doi.org/10.1007/s12016-014-8430-2DOI Listing
June 2015

Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy.

J Hepatol 2015 Apr 5;62(4):897-904. Epub 2014 Nov 5.

Tytgat Institute for Liver and Intestinal Research and Department of Hepatology & Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.10.041DOI Listing
April 2015

Advances in pathogenesis and management of pruritus in cholestasis.

Dig Dis 2014 14;32(5):637-45. Epub 2014 Jul 14.

Department of Medicine 1, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1159/000360518DOI Listing
March 2015

[Risks of intrahepatic cholestasis of pregnancy].

Ned Tijdschr Geneeskd 2014 ;158:A7713

Academisch Medisch Centrum, Amsterdam.

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March 2015

Lysophosphatidic acid and signaling in sensory neurons.

Biochim Biophys Acta 2015 Jan 16;1851(1):61-5. Epub 2014 Sep 16.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center Amsterdam, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbalip.2014.09.004DOI Listing
January 2015

Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.

Lab Invest 2014 Oct 28;94(10):1103-13. Epub 2014 Jul 28.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2014.102DOI Listing
October 2014

ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.

Arterioscler Thromb Vasc Biol 2014 Sep 26;34(9):1985-9. Epub 2014 Jun 26.

From the Division of Molecular Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands (R.S.J., S.M., D.S., P.B., K.v.d.W.); Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (S.D., R.P.J.O.E.); Institute of Enzymology, RCNS, Hungarian Academy of Sciences, Budapest, Hungary (F.S., A.V.); Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands (A.P., A.A.B.); and Netherlands Institute for Neuroscience, Amsterdam, The Netherlands (A.A.B.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743317PMC
September 2014

Receptors, cells and circuits involved in pruritus of systemic disorders.

Biochim Biophys Acta 2014 Jul 22;1842(7):869-92. Epub 2014 Feb 22.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2014.02.007DOI Listing
July 2014

Pruritus in cholestasis: facts and fiction.

Hepatology 2014 Jul 29;60(1):399-407. Epub 2014 May 29.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.26909DOI Listing
July 2014

Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts.

Biochim Biophys Acta 2014 Jun 19;1840(6):1765-70. Epub 2013 Dec 19.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2013.12.015DOI Listing
June 2014

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation.

Front Physiol 2014 10;5:42. Epub 2014 Feb 10.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2014.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918592PMC
June 2014

Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses.

Eur J Immunol 2014 May 11;44(5):1341-51. Epub 2014 Mar 11.

Center for Applied Medical Research (CIMA), Clinic and School of Medicine University of Navarra, Pamplona, Spain; CIBERehd, the "Carlos III" Institute of Health, Madrid, Spain.

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http://doi.wiley.com/10.1002/eji.201344218
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http://dx.doi.org/10.1002/eji.201344218DOI Listing
May 2014

FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model.

Biochim Biophys Acta 2014 May 15;1842(5):739-46. Epub 2014 Feb 15.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.02.004DOI Listing
May 2014

Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice.

Biochim Biophys Acta 2013 Jun 14;1832(6):697-704. Epub 2013 Feb 14.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2013.02.005DOI Listing
June 2013

Advances in pathogenesis and treatment of pruritus.

Clin Liver Dis 2013 May 20;17(2):319-29. Epub 2012 Dec 20.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, G4-216, PO Box 22600, Amsterdam NL-1100 DD, The Netherlands.

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http://dx.doi.org/10.1016/j.cld.2012.11.006DOI Listing
May 2013

Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity.

Hepatology 2013 Apr 18;57(4):1509-17. Epub 2013 Jan 18.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.26133DOI Listing
April 2013

P4 ATPases: flippases in health and disease.

Int J Mol Sci 2013 Apr 11;14(4):7897-922. Epub 2013 Apr 11.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/ijms14047897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645723PMC
April 2013

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions.

Hepatology 2012 Oct;56(4):1391-400

Tytgat Institute for Liver and Intestinal Research, Department of gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.25748DOI Listing
October 2012

Oral availability of cefadroxil depends on ABCC3 and ABCC4.

Drug Metab Dispos 2012 Mar 13;40(3):515-21. Epub 2011 Dec 13.

AMC Tytgat Institute, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.1124/dmd.111.041731DOI Listing
March 2012

[Pruritus in liver disease. Pathogenesis and treatment].

Ned Tijdschr Geneeskd 2011 ;155(52):A4045

Tytgat Instituut voor Lever- en Gastrointestinaal Onderzoek en afd. Maag-, Darm-, Leverziekten, Academisch Medisch Centrum, Amsterdam, the Netherlands.

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February 2012

The molecular mechanism of cholestatic pruritus.

Dig Dis 2011 17;29(1):66-71. Epub 2011 Jun 17.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000324131DOI Listing
October 2011

Pathophysiology and current management of pruritus in liver disease.

Clin Res Hepatol Gastroenterol 2011 Feb;35(2):89-97

Tytgat Institute for liver and intestinal research, Department of gastroenterology and hepatology, Academic Medical Center, S1-164, University of Amsterdam, Meibergdreef 69-71, NL-1105 BK Amsterdam, The Netherlands.

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February 2011

The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.

Hepatology 2010 Oct;52(4):1489-96

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.23810DOI Listing
October 2010

Lysophosphatidic acid is a potential mediator of cholestatic pruritus.

Gastroenterology 2010 Sep 19;139(3):1008-18, 1018.e1. Epub 2010 Jun 19.

Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2010.05.009DOI Listing
September 2010

Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein.

J Pharmacol Exp Ther 2010 Jul 13;334(1):78-86. Epub 2010 Apr 13.

Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.110.16699
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http://dx.doi.org/10.1124/jpet.110.166991DOI Listing
July 2010

P4 ATPases--the physiological relevance of lipid flipping transporters.

FEBS Lett 2010 Jul 7;584(13):2708-16. Epub 2010 May 7.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2010.04.071DOI Listing
July 2010

Progressive familial intrahepatic cholestasis type 1.

Semin Liver Dis 2010 May 26;30(2):117-24. Epub 2010 Apr 26.

Tytgat Institute of Liver and Gastrointestinal Research and Department of Gastroenterology and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1055/s-0030-1253221DOI Listing
May 2010

Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3)(-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3)(-) exchange.

Hepatology 2010 Mar;51(3):891-902

Division of Gene Therapy and Hepatology-Liver Unit, CIMA, CUN, and School of Medicine, University of Navarra, and Ciberehd, Pamplona, Spain.

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http://doi.wiley.com/10.1002/hep.23403
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http://dx.doi.org/10.1002/hep.23403DOI Listing
March 2010

Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria.

FASEB J 2009 Oct 29;23(10):3470-81. Epub 2009 Jun 29.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), VU University Amsterdam, van der Boechorststraat 7, Amsterdam, Netherlands 1081 BT.

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http://www.fasebj.org/doi/10.1096/fj.08-122598
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http://dx.doi.org/10.1096/fj.08-122598DOI Listing
October 2009

Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.

Hepatology 2009 Oct;50(4):1263-72

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.23112DOI Listing
October 2009

Primary biliary cirrhosis.

Semin Immunopathol 2009 Sep 15;31(3):283-307. Epub 2009 Jul 15.

Department of Gastroenterology & Hepatology/Liver Center, Academic Medical Center, G4-213, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00281-009-0164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758170PMC
September 2009

Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.

Drug Metab Dispos 2009 Aug 14;37(8):1698-702. Epub 2009 May 14.

Liver Center, Academic Medical Center, Meibergdreef 69-71, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1124/dmd.108.026146DOI Listing
August 2009

P4 ATPases - lipid flippases and their role in disease.

Biochim Biophys Acta 2009 Jul 27;1791(7):628-35. Epub 2009 Feb 27.

AMC Liver Center, Academic Medical Center, University of Amsterdam, Meibergdreef 69-71, 1105BK Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900062
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http://dx.doi.org/10.1016/j.bbalip.2009.02.008DOI Listing
July 2009

Localization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodents.

J Exp Zool B Mol Dev Evol 2009 Jun;312B(4):375-87

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/jez.b.21267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142622PMC
June 2009

Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats.

Eur J Pharmacol 2009 Jun 7;613(1-3):119-27. Epub 2009 Apr 7.

Department of Pharmacology and Toxicology, Children's Research Center, University of Arizona, Tucson, AZ 85721, USA

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http://dx.doi.org/10.1016/j.ejphar.2009.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739623PMC
June 2009

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

J Biol Chem 2009 Apr 19;284(15):9947-54. Epub 2009 Feb 19.

AMC Liver Center, Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M808667200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665118PMC
April 2009

Intrahepatic cholestasis of pregnancy: when should you look further?

World J Gastroenterol 2009 Mar;15(9):1126-9

Victorian Liver Transplant Unit, Austin Hospital, Melbourne 3084, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655184PMC
http://dx.doi.org/10.3748/wjg.15.1126DOI Listing
March 2009

Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices.

World J Gastroenterol 2009 Mar;15(11):1359-66

Liver Center, Academic Medical Center of University of Amsterdam, Meibergdreef 69/71, 1105 BK Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658838PMC
http://dx.doi.org/10.3748/wjg.15.1359DOI Listing
March 2009

Pathogenesis and treatment of pruritus in cholestasis.

Drugs 2008 ;68(15):2163-82

Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.2165/00003495-200868150-00006DOI Listing
January 2009

New light on anion exchangers in primary biliary cirrhosis.

J Hepatol 2008 Dec 7;49(6):881-3. Epub 2008 Oct 7.

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http://dx.doi.org/10.1016/j.jhep.2008.09.010DOI Listing
December 2008

Regulation of direct transintestinal cholesterol excretion in mice.

Am J Physiol Gastrointest Liver Physiol 2008 Jul 29;295(1):G203-G208. Epub 2008 May 29.

AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajpgi.90231.2008DOI Listing
July 2008

Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.

Gastroenterology 2008 Jun 8;134(7):2091-100. Epub 2008 Mar 8.

AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2008.02.097DOI Listing
June 2008

Activation of cyclic AMP Signaling in Ae2-deficient mouse fibroblasts.

J Biol Chem 2008 May 4;283(18):12146-53. Epub 2008 Mar 4.

Academic Medical Center Liver Center, Academic Medical Center, University of Amsterdam, 1105 BK, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M710590200DOI Listing
May 2008

Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.

Gastroenterology 2008 May 14;134(5):1482-93. Epub 2008 Feb 14.

Division of Gene Therapy and Hepatology, CIMA, Clínica Universitaria and School of Medicine, University of Navarra, and CIBERehd, Pamplona, Spain.

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http://dx.doi.org/10.1053/j.gastro.2008.02.020DOI Listing
May 2008

Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver.

J Hepatol 2008 Feb 17;48(2):266-75. Epub 2007 Dec 17.

Department of Surgery (Surgical Laboratory; IWO-1-172), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2007.09.018DOI Listing
February 2008

Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial.

Pediatr Res 2007 Dec;62(6):725-30

Department of Pediatrics, Pediatric Gastroenterology, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1203/PDR.0b013e3181598cc5DOI Listing
December 2007

Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

Gastroenterology 2007 Sep 20;133(3):967-75. Epub 2007 Jun 20.

AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2007.06.019DOI Listing
September 2007

Intestinal bile salt absorption in Atp8b1 deficient mice.

J Hepatol 2007 Jul 7;47(1):114-22. Epub 2007 Mar 7.

AMC Liver Center, Academic Medical Center, Room S1-166, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2007.02.011DOI Listing
July 2007