Ronald L Horst

Ronald L Horst

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Ronald L Horst

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Oral 25-Hydroxycholecalciferol Acts as an Agonist in the Duodenum of Mice and as Modeled in Cultured Human HT-29 and Caco2 Cells.

J Nutr 2019 Oct 26. Epub 2019 Oct 26.

Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.

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http://dx.doi.org/10.1093/jn/nxz261DOI Listing
October 2019

Localization of the 1,25-dihydroxyvitamin d-mediated response in the intestines of mice.

J Steroid Biochem Mol Biol 2019 02 17;186:56-60. Epub 2018 Sep 17.

Department of Biomedical Sciences, Iowa State University, 1800 Christensen Drive, Ames, Iowa, 50011, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342631PMC
February 2019

Association of 25-Hydroxyvitamin D with Liver Cancer Incidence and Chronic Liver Disease Mortality in Finnish Male Smokers of the ATBC Study.

Cancer Epidemiol Biomarkers Prev 2018 09 2;27(9):1075-1082. Epub 2018 May 2.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148352PMC
September 2018

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D-3--Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Drug Metab Dispos 2018 04 17;46(4):367-379. Epub 2018 Jan 17.

Departments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.)

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http://dx.doi.org/10.1124/dmd.117.078428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829543PMC
April 2018

Simplified 25-Hydroxyvitamin D Standardization and Optimization in Dried Blood Spots by LC-MS/MS.

J AOAC Int 2017 Sep 11;100(5):1328-1336. Epub 2017 May 11.

National Institutes of Health, Office of Dietary Supplements, Vitamin D Standardization Program, 6100 Executive Blvd, Room 3B01, Bethesda, MD 20892.

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http://dx.doi.org/10.5740/jaoacint.17-0086DOI Listing
September 2017

Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.

Endocr Relat Cancer 2016 Apr 27;23(4):251-64. Epub 2016 Jan 27.

Department of Medicine-EndocrinologyStanford University School of Medicine, Stanford, CA, USA Stanford Cancer InstituteStanford University School of Medicine, Stanford, CA, USA

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http://dx.doi.org/10.1530/ERC-15-0557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889430PMC
April 2016

Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism.

J Invest Dermatol 2015 Dec 27;135(12):3125-3132. Epub 2015 Jul 27.

Department of Medicine, Calcium Research Laboratory and the Centre for Translational Biology, McGill University Health Centre Montreal, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.297DOI Listing
December 2015

Combination of oral vitamin D3 with photodynamic therapy enhances tumor cell death in a murine model of cutaneous squamous cell carcinoma.

Photochem Photobiol 2014 Sep-Oct;90(5):1126-35. Epub 2014 May 26.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH; Department of Dermatology, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1111/php.12286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186664PMC
September 2015

Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D.

Mol Cancer Ther 2015 Aug 1;14(8):1951-61. Epub 2015 May 1.

Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549392PMC
August 2015

Vitamin D-binding protein and pancreatic cancer: a nested case-control study.

Am J Clin Nutr 2015 Jun 22;101(6):1206-15. Epub 2015 Apr 22.

From the Nutritional Epidemiology Branch (MRP and RZS-S) and the Radiation Epidemiology Branch (DMF), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; the Departments of Epidemiology and Biostatistics and Exercise Science, Milken Institute School of Public Health, George Washington University, Washington, DC (KR); the Clinical Support Laboratory, Leidos Biomedical Research Inc./Frederick National Laboratory for Cancer Research, Frederick, MD (WK and HR); and Heartland Assays Inc., Iowa State University, Ames, IA (RLH).

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http://dx.doi.org/10.3945/ajcn.114.096016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441803PMC
June 2015

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

Endocrinology 2014 Jun 18;155(6):2052-63. Epub 2014 Mar 18.

Departments of Pharmaceutics (Z.W., T.W., K.E.T.) and Medicinal Chemistry (M.S.), University of Washington, Seattle, Washington 98195-7610; Faculty of Pharmacy (T.H.), Osaka Ohtani University, Tondabayashi, Osaka 584-8540, Japan; Department of Pharmacokinetics and Drug Metabolism (L.Z.D.), Amgen, Seattle, Washington 98119; Department of Biomedical Sciences (N.J.K., J.P.G.), College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011; Heartland Assays, LLC (R.L.H.), Ames, Iowa 50010; and Department of Pharmaceutical Sciences (A.S.C., E.G.S.), St Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1210/en.2013-2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020929PMC
June 2014

Serum 25(OH) vitamin D concentration changes after Roux-en-Y gastric bypass surgery.

Obesity (Silver Spring) 2013 Dec 13;21(12):E599-606. Epub 2013 Jun 13.

Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, Saint Paul, Minnesota, USA.

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http://dx.doi.org/10.1002/oby.20464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731401PMC
December 2013

Vitamin D4 in mushrooms.

PLoS One 2012 3;7(8):e40702. Epub 2012 Aug 3.

Biochemistry Department, Virginia Tech, Blacksburg, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411670PMC
February 2013

Effects of vitamin D(3) -enriched diet on egg yolk vitamin D(3) content and yolk quality.

J Food Sci 2013 Feb 18;78(2):C178-83. Epub 2013 Jan 18.

Dept. of Food Science and Human Nutrition, Iowa State Univ., Ames, IA 50011, USA.

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http://dx.doi.org/10.1111/1750-3841.12032DOI Listing
February 2013

Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites.

Kidney Int 2012 Nov 27;82(10):1061-70. Epub 2012 Jun 27.

Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

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http://dx.doi.org/10.1038/ki.2012.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461248PMC
November 2012

Rickets: case series and diagnostic review of hypovitaminosis D in swine.

J Vet Diagn Invest 2012 Nov 18;24(6):1137-44. Epub 2012 Sep 18.

Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA.

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http://dx.doi.org/10.1177/1040638712461487DOI Listing
November 2012

Importance of apical membrane delivery of 1,25-dihydroxyvitamin D3 to vitamin D-responsive gene expression in the colon.

Am J Physiol Gastrointest Liver Physiol 2012 Oct 26;303(7):G870-8. Epub 2012 Jul 26.

2048 VET MED, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA.

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http://dx.doi.org/10.1152/ajpgi.00149.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347747PMC
October 2012

Pre-diagnostic circulating vitamin D and risk of melanoma in men.

PLoS One 2012 25;7(4):e35112. Epub 2012 Apr 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035112PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338826PMC
September 2012

Serum vitamin D and risk of bladder cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening trial.

Cancer Epidemiol Biomarkers Prev 2012 Jul 23;21(7):1222-5. Epub 2012 May 23.

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-12-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392360PMC
July 2012

Intraindividual variation in plasma 25-hydroxyvitamin D measures 5 years apart among postmenopausal women.

Cancer Epidemiol Biomarkers Prev 2012 Jun 20;21(6):916-24. Epub 2012 Apr 20.

Department of Social and Preventive Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214-8001, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-12-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372646PMC
June 2012

Serum 25-hydroxyvitamin D and risk of lung cancer in male smokers: a nested case-control study.

PLoS One 2011 10;6(6):e20796. Epub 2011 Jun 10.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020796PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112221PMC
November 2011

Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study.

Cancer Epidemiol Biomarkers Prev 2011 Sep 22;20(9):1850-60. Epub 2011 Jul 22.

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Suite 320, Bethesda, MD 20982, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188814PMC
September 2011

Vitamin D mushrooms: comparison of the composition of button mushrooms (Agaricus bisporus) treated postharvest with UVB light or sunlight.

J Agric Food Chem 2011 Aug 25;59(16):8724-32. Epub 2011 Jul 25.

Cantox Health Sciences International, an Intertek Company, Mississauga, Ontario, Canada.

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http://dx.doi.org/10.1021/jf201255bDOI Listing
August 2011

Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in Finnish men.

Cancer Epidemiol Biomarkers Prev 2011 Jun 28;20(6):1178-84. Epub 2011 Apr 28.

Yale School of Public Health, Department ofChronic Disease Epidemiology, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111816PMC
June 2011

Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II.

Breast Cancer Res 2011 May 11;13(3):R50. Epub 2011 May 11.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/bcr2880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218936PMC
May 2011

Prevalence of subclinical hypocalcemia in dairy herds.

Vet J 2011 Apr;188(1):122-4

Periparturient Diseases of Cattle Research Unit, USDA-Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA.

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http://dx.doi.org/10.1016/j.tvjl.2010.03.025DOI Listing
April 2011

Vitamin D(3) is more potent than vitamin D(2) in humans.

J Clin Endocrinol Metab 2011 Mar 22;96(3):E447-52. Epub 2010 Dec 22.

Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA.

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http://dx.doi.org/10.1210/jc.2010-2230DOI Listing
March 2011

Serum 25-hydroxyvitamin D and risks of colon and rectal cancer in Finnish men.

Am J Epidemiol 2011 Mar 19;173(5):499-508. Epub 2011 Jan 19.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/aje/kwq398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105436PMC
March 2011

Serum vitamin D and risk of bladder cancer.

Cancer Res 2010 Nov 26;70(22):9218-23. Epub 2010 Oct 26.

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982924PMC
November 2010

Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis.

FEBS J 2010 Oct 20;277(19):3999-4009. Epub 2010 Aug 20.

Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Imizu, Toyama, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07791.xDOI Listing
October 2010

Exogenous versus endogenous recovery of 25-hydroxyvitamins D2 and D3 in human samples using high-performance liquid chromatography and the DiaSorin LIAISON Total-D Assay.

Authors:
Ronald L Horst

J Steroid Biochem Mol Biol 2010 Jul 7;121(1-2):180-2. Epub 2010 Mar 7.

Heartland Assays Inc., 2325 North Loop Dr., Suite 6300, Ames, IA 50010, United States.

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http://dx.doi.org/10.1016/j.jsbmb.2010.03.010DOI Listing
July 2010

The impact of delayed blood centrifuging, choice of collection tube, and type of assay on 25-hydroxyvitamin D concentrations.

Cancer Causes Control 2010 Apr 18;21(4):643-8. Epub 2009 Dec 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Mailstop 7238, Rockville, MD 20852, USA.

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http://link.springer.com/10.1007/s10552-009-9485-x
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http://dx.doi.org/10.1007/s10552-009-9485-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849301PMC
April 2010

Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Cancer Epidemiol Biomarkers Prev 2010 Apr 23;19(4):927-31. Epub 2010 Mar 23.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8109, Bethesda, MD 20892-7240, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-1121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857993PMC
April 2010

Plasma 25-hydroxyvitamin D levels and the risk of colorectal cancer: the multiethnic cohort study.

Cancer Epidemiol Biomarkers Prev 2010 Jan;19(1):130-4

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804026PMC
January 2010

Vitamin D3 distribution and status in the body.

J Am Coll Nutr 2009 Jun;28(3):252-6

Creighton University, 601 N. 30 St., Suite 4841, Omaha, NE 68131, USA.

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http://dx.doi.org/10.1080/07315724.2009.10719779DOI Listing
June 2009

Analyzing vitamin D in foods and supplements: methodologic challenges.

Am J Clin Nutr 2008 Aug;88(2):554S-557S

Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, US Department of Agriculture, Beltsville, USA.

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http://dx.doi.org/10.1093/ajcn/88.2.554SDOI Listing
August 2008

Serum vitamin D concentration and prostate cancer risk: a nested case-control study.

J Natl Cancer Inst 2008 Jun 27;100(11):796-804. Epub 2008 May 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/jnci/djn152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703748PMC
June 2008

The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going.

J Steroid Biochem Mol Biol 2007 Mar 2;103(3-5):473-6. Epub 2007 Jan 2.

Departments of Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2006.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892844PMC
March 2007

Neutrophil extracellular trap formation by bovine neutrophils is not inhibited by milk.

Vet Immunol Immunopathol 2006 Sep 27;113(1-2):248-55. Epub 2006 Jun 27.

Periparturient Diseases of Cattle Research Unit, National Animal Disease Center, Ames, IA 50010, USA.

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http://dx.doi.org/10.1016/j.vetimm.2006.05.004DOI Listing
September 2006

Adapting to the transition between gestation and lactation: differences between rat, human and dairy cow.

J Mammary Gland Biol Neoplasia 2005 Apr;10(2):141-56

National Animal Disease Center, United States Department of Agriculture, Ames, Iowa, 50010, USA.

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http://dx.doi.org/10.1007/s10911-005-5397-xDOI Listing
April 2005

Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk.

J Biol Chem 2004 Oct 9;279(41):42369-73. Epub 2004 Aug 9.

Periparturient Diseases of Cattle Research Unit, United States Department of Agriculture-Agriculture Research Service, National Animal Disease Center, Ames, Iowa 50010, USA.

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http://dx.doi.org/10.1074/jbc.M407788200DOI Listing
October 2004

Characterization of Cos-7 cells overexpressing the rat secretory pathway Ca2+-ATPase.

Am J Physiol Cell Physiol 2004 Jan 10;286(1):C164-9. Epub 2003 Sep 10.

Periparturient Diseases of Cattle Research Unit, U.S. Department of Agriculture-Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA.

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http://dx.doi.org/10.1152/ajpcell.00065.2003DOI Listing
January 2004

Effect of mastectomy on milk fever, energy, and vitamins A, E, and beta-carotene status at parturition.

J Dairy Sci 2002 Jun;85(6):1427-36

National Animal Disease Center, USDA-ARS, Ames, IA 50010, USA.

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http://dx.doi.org/10.3168/jds.S0022-0302(02)74210-0DOI Listing
June 2002