Ronald L Hayes

Ronald L Hayes

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Ronald L Hayes

Ronald L Hayes

Publications by authors named "Ronald L Hayes"

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Intracranial Pressure Monitoring in Experimental Traumatic Brain Injury: Implications for Clinical Management.

J Neurotrauma 2019 Feb 25. Epub 2019 Feb 25.

1 Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1089/neu.2018.6145DOI Listing
February 2019

Exploratory study of sport-related concussion effects on peripheral micro-RNA expression.

Brain Inj 2019 31;33(4):1-7. Epub 2019 Jan 31.

d Department of Community Health and Family Medicine , University of Florida , Gainesville , FL , USA.

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http://dx.doi.org/10.1080/02699052.2019.1573379DOI Listing
January 2019

Concussion BASICS III: Serum biomarker changes following sport-related concussion.

Neurology 2018 12 7;91(23):e2133-e2143. Epub 2018 Nov 7.

From the Departments of Clinical and Health Psychology (B.M.A., R.M.B., A.M.S., G.H.), Neurology (R.M.B., S.T.D., J.R.C.), and Community Health and Family Medicine (J.R.C.), and University Athletic Association (J.K.B., D.N.D., J.R.C.), University of Florida, Gainesville; and Banyan Biomarkers, Inc. (R.L.H.), Alachua, FL.

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http://dx.doi.org/10.1212/WNL.0000000000006617DOI Listing
December 2018

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.

Mol Neurobiol 2018 03 13;55(3):2174-2184. Epub 2017 Mar 13.

Departments of Psychiatry & Neuroscience, Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Gainesville, FL, 32611, USA.

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http://dx.doi.org/10.1007/s12035-017-0424-7DOI Listing
March 2018

Operation Brain Trauma Therapy: 2016 Update.

Mil Med 2018 03;183(suppl_1):303-312

Brain Trauma Neuroprotection and Neurorestoration Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500.

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http://dx.doi.org/10.1093/milmed/usx184DOI Listing
March 2018

Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Mol Neurobiol 2018 01;55(1):898-900

Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s12035-017-0764-3DOI Listing
January 2018

Prospective Assessment of Acute Blood Markers of Brain Injury in Sport-Related Concussion.

J Neurotrauma 2017 11 4;34(22):3134-3142. Epub 2017 Aug 4.

1 Department of Neurosurgery, Medical College of Wisconsin , Milwaukee, Wisconsin.

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http://dx.doi.org/10.1089/neu.2017.5046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678359PMC
November 2017

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.

Front Neurol 2016 22;7:198. Epub 2016 Nov 22.

Program for Neurotrauma, Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Program for Neurotrauma, Neuroproteomics and Biomarkers Research, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.3389/fneur.2016.00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118702PMC
November 2016

Finding effective biomarkers for pediatric traumatic brain injury.

Brain Circ 2016 Jul-Sep;2(3):129-132. Epub 2016 Oct 18.

Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.4103/2394-8108.192518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126274PMC
October 2016

Biomarkers.

Handb Clin Neurol 2015 ;127:245-65

Banyan Biomarkers Inc., Alachua, FL, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97804445289260
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http://dx.doi.org/10.1016/B978-0-444-52892-6.00016-7DOI Listing
August 2016

Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients.

Sci Rep 2016 Apr 14;6:24588. Epub 2016 Apr 14.

Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.

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http://www.nature.com/articles/srep24588
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http://dx.doi.org/10.1038/srep24588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830936PMC
April 2016

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar 10;33(6):513-22. Epub 2015 Dec 10.

11 Department of Applied Neurobiology and Combat Casualty Care Research Program for Brain Trauma & Neuroprotection Research, Walter Reed Army Institute of Research , Silver Spring, Maryland.

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http://dx.doi.org/10.1089/neu.2015.4113DOI Listing
March 2016

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar 20;33(6):567-80. Epub 2016 Jan 20.

1 Brain Trauma Neuroprotection/Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, Maryland.

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http://dx.doi.org/10.1089/neu.2015.4130DOI Listing
March 2016

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar;33(6):538-52

9 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.4116DOI Listing
March 2016

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar;33(6):523-37

1 Brain Trauma Neuroprotection/Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, Maryland.

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http://dx.doi.org/10.1089/neu.2015.4115DOI Listing
March 2016

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar;33(6):553-66

10 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.4122DOI Listing
March 2016

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

J Neurotrauma 2016 Mar;33(6):581-94

1 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2015.4131DOI Listing
March 2016

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Mol Neurobiol 2015 Aug 2;52(1):696-709. Epub 2014 Oct 2.

Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA,

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http://dx.doi.org/10.1007/s12035-014-8898-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383741PMC
August 2015

Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.

J Neurotrauma 2015 Aug 14;32(16):1179-89. Epub 2015 May 14.

2 Department of Neurological Surgery, University of California at Davis , Davis, California.

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http://dx.doi.org/10.1089/neu.2015.3873DOI Listing
August 2015

Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury.

Neurocrit Care 2015 Feb;22(1):52-64

Department of Emergency Medicine, Orlando Regional Medical Center, 86 W. Underwood (S-200), Orlando, FL, 32806, USA,

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http://dx.doi.org/10.1007/s12028-014-0028-2DOI Listing
February 2015

Serum biomarkers predict acute symptom burden in children after concussion: a preliminary study.

J Neurotrauma 2014 Jun 8;31(11):1072-5. Epub 2014 Apr 8.

1 Division of Emergency Medicine, Boston Children's Hospital , Boston, Massachusetts.

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http://dx.doi.org/10.1089/neu.2013.3265DOI Listing
June 2014

A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke.

Brain Res Bull 2014 Mar 26;102:46-56. Epub 2014 Feb 26.

Xuanwu-Banyan Biomarker Research and Assay Center, Beijing 100053, China; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1016/j.brainresbull.2014.02.005DOI Listing
March 2014

Different expression of ubiquitin C-terminal hydrolase-L1 and αII-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.

Brain Res 2013 Dec 16;1540:84-91. Epub 2013 Oct 16.

Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Xuanwu-Banyan Biomarker Research and Assay Center, Beijing 100053, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00068993130132
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http://dx.doi.org/10.1016/j.brainres.2013.09.051DOI Listing
December 2013

Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.

Acta Neurochir Suppl 2013 ;118:77-81

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/978-3-7091-1434-6_13DOI Listing
August 2013

Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats.

Toxicol Sci 2012 Nov 12;130(1):158-67. Epub 2012 Jul 12.

Banyan Biomarkers. Inc., 13400 Progress Blvd, Alachua, Florida 32615, USA.

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http://dx.doi.org/10.1093/toxsci/kfs224DOI Listing
November 2012

Serum concentrations of ubiquitin C-terminal hydrolase-L1 and αII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI.

J Neurotrauma 2012 Jan;29(1):162-7

Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15224, USA.

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http://dx.doi.org/10.1089/neu.2011.1989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253308PMC
January 2012

Protein biomarkers for traumatic and ischemic brain injury: from bench to bedside.

Transl Stroke Res 2011 Dec 7;2(4):455-62. Epub 2011 Dec 7.

Center of Innovative Research, Banyan Biomarkers Inc, 12085 Research Drive, Alachua, FL, 32615, USA.

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http://dx.doi.org/10.1007/s12975-011-0137-6DOI Listing
December 2011

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.

J Trauma 2011 Jul;71(1 Suppl):S15-24

Safar Center for Resuscitation Research, Department of Critical Care Medicine and Anesthesiology, Pediatrics, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.

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http://dx.doi.org/10.1097/TA.0b013e31822117feDOI Listing
July 2011

Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids.

J Neurotrauma 2011 Jun 8;28(6):861-70. Epub 2011 Apr 8.

Virginia Commonwealth University, Pharmacotherapy & Outcomes Sciences and Neurosurgery, Richmond, Virginia 23298-0533, USA.

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http://dx.doi.org/10.1089/neu.2010.1564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113451PMC
June 2011

Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research.

PM R 2011 Jun;3(6 Suppl 1):S139-47

Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193414821100104
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http://dx.doi.org/10.1016/j.pmrj.2011.02.012DOI Listing
June 2011

Translating biomarkers research to clinical care: applications and issues for rehabilomics.

PM R 2011 Jun;3(6 Suppl 1):S31-8

Critical Care Medicine, Neurological Surgery and Pediatrics, Children's Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, 4401 Penn Ave, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1016/j.pmrj.2011.03.016DOI Listing
June 2011

Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.

ASN Neuro 2011 Feb 16;3(1):e00051. Epub 2011 Feb 16.

Center of Innovative Research, Banyan Biomarkers Inc., 12085 Research Drive, Alachua, FL 32615, USA.

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http://dx.doi.org/10.1042/AN20100012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040574PMC
February 2011

Blood-based diagnostics of traumatic brain injuries.

Expert Rev Mol Diagn 2011 Jan;11(1):65-78

Banyan Biomarkers, Inc., 12085 Research Drive, Alachua, FL 32615, USA.

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http://dx.doi.org/10.1586/erm.10.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063529PMC
January 2011

Systems biology and theranostic approach to drug discovery and development to treat traumatic brain injury.

Methods Mol Biol 2010 ;662:317-29

Center of Innovative Research, Banyan Biomarkers, Inc., Alachua, FL, USA.

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http://dx.doi.org/10.1007/978-1-60761-800-3_16DOI Listing
December 2010

Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure.

J Trauma 2010 Oct;69(4):795-804

Center of Innovative Research, Banyan Biomarkers, Inc, Alachua, Florida 32615, USA.

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http://dx.doi.org/10.1097/TA.0b013e3181bbd885DOI Listing
October 2010

Neuroproteomics: a biochemical means to discriminate the extent and modality of brain injury.

J Neurotrauma 2010 Oct 9;27(10):1837-52. Epub 2010 Oct 9.

Department of Anatomy, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-0709, USA.

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http://dx.doi.org/10.1089/neu.2010.1374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953930PMC
October 2010

Traumatic brain injury biomarkers: from pipeline to diagnostic assay development.

Methods Mol Biol 2009 ;566:293-302

Research and Development Department, Banyan Biomarkers Inc., Alachua, FL, USA.

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http://dx.doi.org/10.1007/978-1-59745-562-6_19DOI Listing
February 2010

Translation of neurological biomarkers to clinically relevant platforms.

Methods Mol Biol 2009 ;566:303-13

Clinical Department, Banyan Biomarkers Inc., Alachua, FL, USA.

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http://dx.doi.org/10.1007/978-1-59745-562-6_20DOI Listing
February 2010

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.

BMC Neurosci 2010 Feb 18;11:21. Epub 2010 Feb 18.

Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute of the University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1186/1471-2202-11-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836363PMC
February 2010

Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways.

Apoptosis 2009 Nov;14(11):1289-98

Center of Innovative Research, Banyan Biomarkers Inc., Alachua, FL 32615, USA.

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http://dx.doi.org/10.1007/s10495-009-0405-zDOI Listing
November 2009

P43/pro-EMAPII: a potential biomarker for discriminating traumatic versus ischemic brain injury.

J Neurotrauma 2009 Aug;26(8):1295-305

Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1089/neu.2008.0811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850301PMC
August 2009

Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study.

Acta Neurochir (Wien) 2008 Oct 9;150(10):1019-31; discussion 1031. Epub 2008 Sep 9.

Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Viale Regina Margherita n. 59, 98121 Messina, Italy.

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http://link.springer.com/10.1007/s00701-008-0021-7
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http://dx.doi.org/10.1007/s00701-008-0021-7DOI Listing
October 2008

Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation.

Proteomics Clin Appl 2008 Oct 26;2(10-11):1467-83. Epub 2008 Aug 26.

Center of Neuroproteomics and Biomarker Research, Departments of Psychiatry, University of Florida, College of Medicine and McKnight Brain Institute, Gainesville, FL, USA.

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http://dx.doi.org/10.1002/prca.200800011DOI Listing
October 2008

Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury.

Biochem Biophys Res Commun 2008 Sep 16;373(4):478-81. Epub 2008 May 16.

Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.05.031DOI Listing
September 2008

Use of biomarkers for diagnosis and management of traumatic brain injury patients.

Expert Opin Med Diagn 2008 Aug;2(8):937-45

Director of Academic Clinical Research Orlando Regional Medical Center, Department of Emergency Medicine, 86 W. Underwood (S-200), Orlando, FL 32806, USA +1 407 237 6329 ; +1 407 649 3083 ;

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http://dx.doi.org/10.1517/17530059.2.8.937DOI Listing
August 2008

Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.

J Neurochem 2008 Mar 22;104(5):1404-14. Epub 2007 Nov 22.

Department of Psychiatry, Centers for Neuroproteomics and Biomarker Research and Traumatic Brain Injury Studies at the McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610-0256, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05086.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584683PMC
March 2008