Ronald E Bontrop

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Rijswijk, The Netherlands; Department of Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address:

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October 2018

Cell Type and Species-specific Patterns in Neuronal and Non-neuronal Methylomes of Human and Chimpanzee Cortices.

Authors:

Julia Böck Christian W Remmele Marcus Dittrich Tobias Müller Ivanela Kondova Stephan Persengiev Ronald E Bontrop Carsten P Ade Theo F J Kraus Armin Giese Nady El Hajj Eberhard Schneider Thomas Haaf

Cereb Cortex 2018 10;28(10):3724-3739

Institute of Human Genetics, Julius Maximilians University Würzburg, Würzburg, Germany.

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October 2018

Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018.

Authors:

Keith T Ballingall Ronald E Bontrop Shirley A Ellis Unni Grimholt John A Hammond Chak-Sum Ho Jim Kaufman Lorna J Kennedy Giuseppe Maccari Donald Miller James Robinson Steven G E Marsh

Immunogenetics 2018 11 24;70(10):625-632. Epub 2018 Jul 24.

Anthony Nolan Research Institute, London, UK.

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November 2018

IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era.

Authors:

Giuseppe Maccari James Robinson Ronald E Bontrop Nel Otting Natasja G de Groot Chak-Sum Ho Keith T Ballingall Steven G E Marsh John A Hammond

Immunogenetics 2018 11 19;70(10):619-623. Epub 2018 Jul 19.

The Pirbright Institute, Woking, Surrey, UK.

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November 2018

Nomenclature for the KIR of non-human species.

Authors:

James Robinson Lisbeth A Guethlein Giuseppe Maccari Jeroen Blokhuis Benjamin N Bimber Natasja G de Groot Nicholas D Sanderson Laurent Abi-Rached Lutz Walter Ronald E Bontrop John A Hammond Steven G E Marsh Peter Parham

Immunogenetics 2018 09 4;70(9):571-583. Epub 2018 Jun 4.

Department of Structural Biology and Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, CA, USA.

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September 2018

Human and Rhesus Macaque Haplotypes Defined by Their Transcriptomes.

Authors:

Jesse Bruijnesteijn Marit K H van der Wiel Wendy T N Swelsen Nel Otting Annemiek J M de Vos-Rouweler Diënne Elferink Gaby G Doxiadis Frans H J Claas Neubury M Lardy Natasja G de Groot Ronald E Bontrop

J Immunol 2018 03 22;200(5):1692-1701. Epub 2018 Jan 22.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, the Netherlands;

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March 2018

A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics.

Authors:

Natasja G de Groot Corrine M C Heijmans Arnoud H de Ru George M C Janssen Jan W Drijfhout Nel Otting Christelle Vangenot Gaby G M Doxiadis Frits Koning Peter A van Veelen Ronald E Bontrop

J Immunol 2017 11 11;199(10):3679-3690. Epub 2017 Oct 11.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, the Netherlands.

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November 2017

AIDS in chimpanzees: the role of MHC genes.

Authors:

Natasja G de Groot Corinne M C Heijmans Ronald E Bontrop

Immunogenetics 2017 08 10;69(8-9):499-509. Epub 2017 Jul 10.

Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ, Rijswijk, The Netherlands.

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August 2017

Foreword: Immunogenetics special issue 2017.

Authors:

Ronald E Bontrop

Immunogenetics 2017 08;69(8-9):479-480

Biomedical Primate Research Center, PO Box 3306, 2280, Rijswijk, GH, Netherlands.

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August 2017

Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific alleles.

Authors:

Ivanela Kondova Gerco Braskamp Peter J Heidt Wim Collignon Tom Haaksma Nanine de Groot Nel Otting Gaby Doxiadis Susan V Westmoreland Eric J Vallender Ronald E Bontrop

Primate Biol 2017 22;4(1):117-125. Epub 2017 Jun 22.

Department of Comparative Genetics, Biomedical Primate Research Centre, 2288 GJ Rijswijk, the Netherlands.

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June 2017

Limited MHC class I intron 2 repertoire variation in bonobos.

Authors:

Natasja G de Groot Corrine M C Heijmans Philippe Helsen Nel Otting Zjef Pereboom Jeroen M G Stevens Ronald E Bontrop

Immunogenetics 2017 10 16;69(10):677-688. Epub 2017 Jun 16.

Biomedical Primate Research Centre, Department of Comparative Genetics & Refinement, Rijswijk, The Netherlands.

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October 2017

Two Orangutan Species Have Evolved Different Alleles and Haplotypes.

Authors:

Lisbeth A Guethlein Paul J Norman Corinne M C Heijmans Natasja G de Groot Hugo G Hilton Farbod Babrzadeh Laurent Abi-Rached Ronald E Bontrop Peter Parham

J Immunol 2017 04 6;198(8):3157-3169. Epub 2017 Mar 6.

Department of Structural Biology, Stanford University, Stanford, CA 94305;

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April 2017

Major histocompatibility complex haplotyping and long-amplicon allele discovery in cynomolgus macaques from Chinese breeding facilities.

Authors:

Julie A Karl Michael E Graham Roger W Wiseman Katelyn E Heimbruch Samantha M Gieger Gaby G M Doxiadis Ronald E Bontrop David H O'Connor

Immunogenetics 2017 04 11;69(4):211-229. Epub 2017 Jan 11.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.

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April 2017

IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.

Authors:

Giuseppe Maccari James Robinson Keith Ballingall Lisbeth A Guethlein Unni Grimholt Jim Kaufman Chak-Sum Ho Natasja G de Groot Paul Flicek Ronald E Bontrop John A Hammond Steven G E Marsh

Nucleic Acids Res 2017 01 28;45(D1):D860-D864. Epub 2016 Nov 28.

Anthony Nolan Research Institute (ANRI), Royal Free Hospital, London, NW3 2QG, UK

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January 2017

The orthologs of HLA-DQ and -DP genes display abundant levels of variability in macaque species.

Authors:

Nel Otting Marit K H van der Wiel Nanine de Groot Annemiek J M de Vos-Rouweler Natasja G de Groot Gaby G M Doxiadis Roger W Wiseman David H O'Connor Ronald E Bontrop

Immunogenetics 2017 Feb 22;69(2):87-99. Epub 2016 Oct 22.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands.

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February 2017

Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans.

Authors:

Natasja G de Groot Corrine M C Heijmans Marit K H van der Wiel Jeroen H Blokhuis Arend Mulder Lisbeth A Guethlein Gaby G M Doxiadis Frans H J Claas Peter Parham Ronald E Bontrop

J Immunol 2016 Jan 18;196(2):750-8. Epub 2015 Dec 18.

Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, the Netherlands; Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, the Netherlands.

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January 2016

Co-evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity.

Authors:

Natasja G de Groot Jeroen H Blokhuis Nel Otting Gaby G M Doxiadis Ronald E Bontrop

Immunol Rev 2015 Sep;267(1):228-45

Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.

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September 2015

High diversity of MIC genes in non-human primates.

Authors:

Alice Meyer Raphael Carapito Louise Ott Mirjana Radosavljevic Philippe Georgel Erin J Adams Peter Parham Ronald E Bontrop Antoine Blancher Seiamak Bahram

Immunogenetics 2014 Oct 31;66(9-10):581-7. Epub 2014 Jul 31.

Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, Plateforme GENOMAX, LabEx Transplantex, Centre de Recherche d'Immunologie et d'Hématologie. Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, 4 Rue Kirschleger, 67085, Strasbourg, France.

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October 2014

Differential recombination dynamics within the MHC of macaque species.

Authors:

Nanine de Groot Gaby G M Doxiadis Nel Otting Annemiek J M de Vos-Rouweler Ronald E Bontrop

Immunogenetics 2014 Oct 17;66(9-10):535-44. Epub 2014 Jun 17.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands.

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October 2014

Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection.

Authors:

Babs E Verstrepen Ernst J Verschoor Zahra C Fagrouch Petra Mooij Natasja G de Groot Ronald E Bontrop Willy M Bogers Jonathan L Heeney Gerrit Koopman

PLoS One 2014 16;9(4):e95103. Epub 2014 Apr 16.

Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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June 2015

Widespread differences in cortex DNA methylation of the "language gene" CNTNAP2 between humans and chimpanzees.

Authors:

Eberhard Schneider Nady El Hajj Steven Richter Justin Roche-Santiago Indrajit Nanda Werner Schempp Peter Riederer Bianca Navarro Ronald E Bontrop Ivanela Kondova Claus Jürgen Scholz Thomas Haaf

Epigenetics 2014 Apr 16;9(4):533-45. Epub 2014 Jan 16.

Institute for Human Genetics; Julius Maximilian University; Würzburg, Germany.

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April 2014

DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge.

Authors:

Gerrit Koopman Niels Beenhakker Ivonne Nieuwenhuis Gaby Doxiadis Petra Mooij Jan W Drijfhout Josef Koestler Tomas Hanke Zahra Fagrouch Ernst J Verschoor Ronald E Bontrop Ralf Wagner Willy M J M Bogers Cornelis J M Melief

AIDS 2013 Nov;27(18):2841-51

aDepartment of Virology bDepartment of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk cDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands dUniversity of Regensburg, Regensburg, Germany eThe Jenner Institute, University of Oxford, Oxford, UK fISA Pharmaceuticals, Leiden, the Netherlands.

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November 2013

Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques.

Authors:

Natasja G de Groot Corrine M C Heijmans Arnoud H de Ru Chopie Hassan Nel Otting Gaby G M Doxiadis Frits Koning Peter A van Veelen Ronald E Bontrop

Immunogenetics 2013 Dec 17;65(12):897-900. Epub 2013 Sep 17.

Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ, Rijswijk, The Netherlands,

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December 2013

The repertoire of MHC class I genes in the common marmoset: evidence for functional plasticity.

Authors:

Marit K van der Wiel Nel Otting Natasja G de Groot Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2013 Dec 10;65(12):841-9. Epub 2013 Sep 10.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands.

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December 2013

Evolution and diversity of copy number variation in the great ape lineage.

Authors:

Peter H Sudmant John Huddleston Claudia R Catacchio Maika Malig Ladeana W Hillier Carl Baker Kiana Mohajeri Ivanela Kondova Ronald E Bontrop Stephan Persengiev Francesca Antonacci Mario Ventura Javier Prado-Martinez Tomas Marques-Bonet Evan E Eichler

Genome Res 2013 Sep 3;23(9):1373-82. Epub 2013 Jul 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98105, USA.

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September 2013

Great ape genetic diversity and population history.

Authors:

Javier Prado-Martinez Peter H Sudmant Jeffrey M Kidd Heng Li Joanna L Kelley Belen Lorente-Galdos Krishna R Veeramah August E Woerner Timothy D O'Connor Gabriel Santpere Alexander Cagan Christoph Theunert Ferran Casals Hafid Laayouni Kasper Munch Asger Hobolth Anders E Halager Maika Malig Jessica Hernandez-Rodriguez Irene Hernando-Herraez Kay Prüfer Marc Pybus Laurel Johnstone Michael Lachmann Can Alkan Dorina Twigg Natalia Petit Carl Baker Fereydoun Hormozdiari Marcos Fernandez-Callejo Marc Dabad Michael L Wilson Laurie Stevison Cristina Camprubí Tiago Carvalho Aurora Ruiz-Herrera Laura Vives Marta Mele Teresa Abello Ivanela Kondova Ronald E Bontrop Anne Pusey Felix Lankester John A Kiyang Richard A Bergl Elizabeth Lonsdorf Simon Myers Mario Ventura Pascal Gagneux David Comas Hans Siegismund Julie Blanc Lidia Agueda-Calpena Marta Gut Lucinda Fulton Sarah A Tishkoff James C Mullikin Richard K Wilson Ivo G Gut Mary Katherine Gonder Oliver A Ryder Beatrice H Hahn Arcadi Navarro Joshua M Akey Jaume Bertranpetit David Reich Thomas Mailund Mikkel H Schierup Christina Hvilsom Aida M Andrés Jeffrey D Wall Carlos D Bustamante Michael F Hammer Evan E Eichler Tomas Marques-Bonet

Nature 2013 Jul 3;499(7459):471-5. Epub 2013 Jul 3.

Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, PRBB, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.

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July 2013

Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.

Authors:

Gaby G M Doxiadis Nanine de Groot Nel Otting Annemiek J M de Vos-Rouweler Maria J Bolijn Corrine M C Heijmans Natasja G de Groot Marit K H van der Wiel Edmond J Remarque Christelle Vangenot José M Nunes Alicia Sanchez-Mazas Ronald E Bontrop

Immunogenetics 2013 Aug 29;65(8):569-84. Epub 2013 May 29.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.

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August 2013

The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind's future?

Authors:

Natasja G de Groot Ronald E Bontrop

Retrovirology 2013 May 24;10:53. Epub 2013 May 24.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.

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May 2013

Evaluation of IL-28B polymorphisms and serum IP-10 in hepatitis C infected chimpanzees.

Authors:

Babs E Verstrepen Natasja G de Groot Zwier M A Groothuismink Ernst J Verschoor Rik A de Groen Willy M Bogers Harry L A Janssen Petra Mooij Ronald E Bontrop Gerrit Koopman Andre Boonstra

PLoS One 2012 30;7(10):e46645. Epub 2012 Oct 30.

Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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May 2013

Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1.

Authors:

Stephan Persengiev Ivanela Kondova Ronald E Bontrop

J Nucleic Acids 2012 3;2012:672536. Epub 2012 Oct 3.

Department of Medical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.

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October 2012

Evolution of HLA-DRB genes.

Authors:

Gaby G M Doxiadis Ilka Hoof Nanine de Groot Ronald E Bontrop

Mol Biol Evol 2012 Dec 23;29(12):3843-53. Epub 2012 Jul 23.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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December 2012

Multilocus definition of MHC haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).

Authors:

Nel Otting Nanine de Groot Annemiek J M de Vos-Rouweler Annet Louwerse Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2012 Oct 8;64(10):755-65. Epub 2012 Jul 8.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands.

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October 2012

Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species.

Authors:

Natasja G de Groot Nel Otting James Robinson Antoine Blancher Bernard A P Lafont Steven G E Marsh David H O'Connor Takashi Shiina Lutz Walter David I Watkins Ronald E Bontrop

Immunogenetics 2012 Aug 18;64(8):615-31. Epub 2012 Apr 18.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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August 2012

Genomic tools for evolution and conservation in the chimpanzee: Pan troglodytes ellioti is a genetically distinct population.

Authors:

Rory Bowden Tammie S MacFie Simon Myers Garrett Hellenthal Eric Nerrienet Ronald E Bontrop Colin Freeman Peter Donnelly Nicholas I Mundy

PLoS Genet 2012 1;8(3):e1002504. Epub 2012 Mar 1.

Department of Statistics, University of Oxford, Oxford, United Kingdom.

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September 2012

The Impact of MicroRNAs on Brain Aging and Neurodegeneration.

Authors:

Stephan P Persengiev Ivanela I Kondova Ronald E Bontrop

Curr Gerontol Geriatr Res 2012 18;2012:359369. Epub 2012 Jan 18.

Department of Complex Genetics, Division of Medical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.

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August 2012

A comparative analysis of viral peptides presented by contemporary human and chimpanzee MHC class I molecules.

Authors:

Hanneke W M van Deutekom Ilka Hoof Ronald E Bontrop Can Keşmir

J Immunol 2011 Dec 31;187(11):5995-6001. Epub 2011 Oct 31.

Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands.

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December 2011

DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome.

Authors:

Gaby G M Doxiadis Annemiek J M de Vos-Rouweler Nanine de Groot Nel Otting Ronald E Bontrop

Immunogenetics 2012 Jan 30;64(1):31-7. Epub 2011 Jul 30.

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.

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January 2012

The extreme plasticity of killer cell Ig-like receptor (KIR) haplotypes differentiates rhesus macaques from humans.

Authors:

Jeroen H Blokhuis Marit K van der Wiel Gaby G M Doxiadis Ronald E Bontrop

Eur J Immunol 2011 Sep 4;41(9):2719-28. Epub 2011 Aug 4.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg, Rijswijk, The Netherlands.

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September 2011

Genomic plasticity of the MHC class I A region in rhesus macaques: extensive haplotype diversity at the population level as revealed by microsatellites.

Authors:

Gaby G M Doxiadis Nanine de Groot Nel Otting Jeroen H Blokhuis Ronald E Bontrop

Immunogenetics 2011 Feb 15;63(2):73-83. Epub 2010 Oct 15.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288, Rijswijk, The Netherlands.

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February 2011

No difference in Gag and Env immune-response profiles between vaccinated and non-vaccinated rhesus macaques that control immunodeficiency virus replication.

Authors:

Ivonne Nieuwenhuis Niels Beenhakker Willy M J M Bogers Nel Otting Ronald E Bontrop Patrice Dubois Petra Mooij Jonathan L Heeney Gerrit Koopman

J Gen Virol 2010 Dec 8;91(Pt 12):2974-84. Epub 2010 Sep 8.

Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands.

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December 2010

AIDS-protective HLA-B27/B57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz.

Authors:

Natasja G de Groot Corrine M C Heijmans Yvonne M Zoet Arnoud H de Ru Frank A Verreck Peter A van Veelen Jan W Drijfhout Gaby G M Doxiadis Edmond J Remarque Ilias I N Doxiadis Jon J van Rood Frits Koning Ronald E Bontrop

Proc Natl Acad Sci U S A 2010 Aug 9;107(34):15175-80. Epub 2010 Aug 9.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.

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August 2010

Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis.

Authors:

Stephan Persengiev Ivanela Kondova Nel Otting Arnulf H Koeppen Ronald E Bontrop

Neurobiol Aging 2011 Dec 6;32(12):2316.e17-27. Epub 2010 May 6.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Center, Rijswijk, The Netherlands.

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December 2011

The mosaic of KIR haplotypes in rhesus macaques.

Authors:

Jeroen H Blokhuis Marit K van der Wiel Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2010 May 5;62(5):295-306. Epub 2010 Mar 5.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288GJ, Rijswijk, The Netherlands.

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May 2010

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.

Authors:

Trevelyan R Menheniott Anthony J Peterson Louise O'Connor Kai Syin Lee Anastasia Kalantzis Ivanela Kondova Ronald E Bontrop Katrina M Bell Andrew S Giraud

Gastroenterology 2010 May 4;138(5):1823-35. Epub 2010 Feb 4.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.

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May 2010

Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force.

Authors:

Gaby G M Doxiadis Nanine de Groot Natasja G de Groot Gabriëlle Rotmans Annemiek J M de Vos-Rouweler Ronald E Bontrop

Immunogenetics 2010 Mar 4;62(3):137-47. Epub 2010 Feb 4.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.

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March 2010

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.

Authors:

Simon Myers Rory Bowden Afidalina Tumian Ronald E Bontrop Colin Freeman Tammie S MacFie Gil McVean Peter Donnelly

Science 2010 Feb 31;327(5967):876-9. Epub 2009 Dec 31.

Department of Statistics, Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK.

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February 2010

Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).

Authors:

Nel Otting Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2009 Dec 24;61(11-12):745-53. Epub 2009 Nov 24.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ, Rijswijk, The Netherlands.

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December 2009

The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.

Authors:

Natasja G de Groot Corrine M C Heijmans Nanine de Groot Gaby G M Doxiadis Nel Otting Ronald E Bontrop

Mol Immunol 2009 Dec 2;47(2-3):381-9. Epub 2009 Oct 2.

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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December 2009

Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin.

Authors:

Jeroen H Blokhuis Marit K van der Wiel Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2009 Jul 9;61(7):503-12. Epub 2009 Jun 9.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 139, Rijswijk, 2288 GJ, The Netherlands.

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July 2009

Correlated evolution of nucleotide substitution rates and allelic variation in Mhc-DRB lineages of primates.

Authors:

László Z Garamszegi Natasja G de Groot Ronald E Bontrop

BMC Evol Biol 2009 Apr 12;9:73. Epub 2009 Apr 12.

Department of Biology, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.

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April 2009

Compound evolutionary history of the rhesus macaque MHC class I B region revealed by microsatellite analysis and localization of retroviral sequences.

Authors:

Gaby G M Doxiadis Corrine M C Heijmans Maxime Bonhomme Nel Otting Brigitte Crouau-Roy Ronald E Bontrop

PLoS One 2009 27;4(1):e4287. Epub 2009 Jan 27.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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May 2009

A splice site mutation converts an inhibitory killer cell Ig-like receptor into an activating one.

Authors:

Jeroen H Blokhuis Gaby G M Doxiadis Ronald E Bontrop

Mol Immunol 2009 Feb 18;46(4):640-8. Epub 2008 Nov 18.

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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February 2009

Genomic plasticity of the immune-related Mhc class I B region in macaque species.

Authors:

Maxime Bonhomme Gaby G M Doxiadis Corrine M C Heijmans Virginie Vervoort Nel Otting Ronald E Bontrop Brigitte Crouau-Roy

BMC Genomics 2008 Oct 30;9:514. Epub 2008 Oct 30.

Université Paul Sabatier, Laboratoire Evolution et Diversité Biologique UMR5174 UPS/CNRS, 118 Route de Narbonne, Toulouse 31062 cedex 9, France.

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October 2008

Comparative genetics of a highly divergent DRB microsatellite in different macaque species.

Authors:

Nanine de Groot Gaby G M Doxiadis Annemiek J M de Vos-Rouweler Natasja G de Groot Ernst J Verschoor Ronald E Bontrop

Immunogenetics 2008 Dec 28;60(12):737-48. Epub 2008 Oct 28.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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December 2008

A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin.

Authors:

Nel Otting Corrine M C Heijmans Marit van der Wiel Natasja G de Groot Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2008 Sep 11;60(9):507-14. Epub 2008 Jul 11.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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September 2008

Impact of endogenous intronic retroviruses on major histocompatibility complex class II diversity and stability.

Authors:

Gaby G M Doxiadis Nanine de Groot Ronald E Bontrop

J Virol 2008 Jul 30;82(13):6667-77. Epub 2008 Apr 30.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands.

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July 2008

Reshuffling of ancient peptide binding motifs between HLA-DRB multigene family members: old wine served in new skins.

Authors:

Gaby G M Doxiadis Nanine de Groot Natasja G de Groot Ilias I N Doxiadis Ronald E Bontrop

Mol Immunol 2008 May;45(10):2743-51

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, Rijswijk, The Netherlands.

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May 2008

Pinpointing a selective sweep to the chimpanzee MHC class I region by comparative genomics.

Authors:

Natasja G de Groot Corrine M C Heijmans Nanine de Groot Nel Otting Annemiek J M de Vos-Rouweller Edmond J Remarque Maxime Bonhomme Gaby G M Doxiadis Brigitte Crouau-Roy Ronald E Bontrop

Mol Ecol 2008 Apr 10;17(8):2074-88. Epub 2008 Mar 10.

Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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April 2008

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.

Authors:

Barbara Royer Dinesh C Soares Paul N Barlow Ronald E Bontrop Patrice Roll Andrée Robaglia-Schlupp Antoine Blancher Anthony Levasseur Pierre Cau Pierre Pontarotti Pierre Szepetowski

BMC Genet 2007 Oct 18;8:72. Epub 2007 Oct 18.

INSERM UMR 491, Université de la Méditerranée, 13385 Marseille, Cedex 5, France.

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October 2007

A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques.

Authors:

Gaby G M Doxiadis Nanine de Groot Frans H J Claas Ilias I N Doxiadis Jon J van Rood Ronald E Bontrop

Proc Natl Acad Sci U S A 2007 May 14;104(21):8907-12. Epub 2007 May 14.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.

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May 2007

MHC class I A region diversity and polymorphism in macaque species.

Authors:

Nel Otting Annemiek J M de Vos-Rouweler Corrine M C Heijmans Natasja G de Groot Gaby G M Doxiadis Ronald E Bontrop

Immunogenetics 2007 May 3;59(5):367-75. Epub 2007 Mar 3.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.

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May 2007

An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2.

Authors:

Mark J Kwakkenbos Mourad Matmati Ole Madsen Walter Pouwels YongYi Wang Ronald E Bontrop Peter J Heidt Robert M Hoek Jörg Hamann

FASEB J 2006 Dec 26;20(14):2582-4. Epub 2006 Oct 26.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands.

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December 2006

Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions.

Authors:

Ronald E Bontrop

Hum Immunol 2006 Jun 3;67(6):388-97. Epub 2006 Apr 3.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, GH Rijswijk, The Netherlands.

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June 2006

Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.

Authors:

Gaby G M Doxiadis Marit K H van der Wiel Herbert P M Brok Natasja G de Groot Nel Otting Bert A 't Hart Jon J van Rood Ronald E Bontrop

Proc Natl Acad Sci U S A 2006 Apr 31;103(15):5864-8. Epub 2006 Mar 31.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.

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April 2006

Extensive sharing of MHC class II alleles between rhesus and cynomolgus macaques.

Authors:

Gaby G M Doxiadis Annemiek J M Rouweler Natasja G de Groot Annet Louwerse Nel Otting Ernst J Verschoor Ronald E Bontrop

Immunogenetics 2006 May 10;58(4):259-68. Epub 2006 Feb 10.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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May 2006

ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005.

Authors:

Shirley A Ellis Ronald E Bontrop Doug F Antczak Keith Ballingall Christopher J Davies Jim Kaufman Lorna J Kennedy James Robinson Douglas M Smith Michael J Stear Rene J M Stet Matthew J Waller Lutz Walter Steven G E Marsh

Immunogenetics 2006 Jan 3;57(12):953-8. Epub 2006 Jan 3.

Immunology Division, Institute for Animal Health, Compton, RG20 7NN, UK.

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January 2006

Modeling human arthritic diseases in nonhuman primates.

Authors:

Michel P M Vierboom Margreet Jonker Ronald E Bontrop Bert 't Hart

Arthritis Res Ther 2005 9;7(4):145-54. Epub 2005 Jun 9.

Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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April 2006

Nomenclature for Factors of the HLA System, 2004.

Authors:

Steven G E Marsh Ekkehard D Albert Walter F Bodmer Ronald E Bontrop Bo Dupont Henry A Erlich Daniel E Geraghty John A Hansen Carolyn K Hurley Bernard Mach Wolfgang R Mayr Peter Parham Effie W Petersdorf Takehiko Sasazuki Geziena M Th Schreuder Jack L Strominger Arne Svejgaard Paul I Terasaki John Trowsdale

Hum Immunol 2005 May 3;66(5):571-636. Epub 2005 Mar 3.

Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, United Kingdom.

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May 2005

Microsatellite typing of the rhesus macaque MHC region.

Authors:

M Cecilia T Penedo Ronald E Bontrop Corrine M C Heijmans Nel Otting Riet Noort Annemiek J M Rouweler Nanine de Groot Natasja G de Groot Thea Ward Gaby G M Doxiadis

Immunogenetics 2005 May 5;57(3-4):198-209. Epub 2005 Apr 5.

Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

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May 2005

MHC polymorphism: AIDS susceptibility in non-human primates.

Authors:

Ronald E Bontrop David I Watkins

Trends Immunol 2005 Apr;26(4):227-33

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P.O Box 3306, 2280 GH Rijswijk, The Netherlands.

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April 2005

Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans.

Authors:

Natasja G de Groot Christian A Garcia Ernst J Verschoor Gaby G M Doxiadis Steven G E Marsh Nel Otting Ronald E Bontrop

Mol Biol Evol 2005 Jun 9;22(6):1375-85. Epub 2005 Mar 9.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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June 2005

Comparison of fine-scale recombination rates in humans and chimpanzees.

Authors:

Wendy Winckler Simon R Myers Daniel J Richter Robert C Onofrio Gavin J McDonald Ronald E Bontrop Gilean A T McVean Stacey B Gabriel David Reich Peter Donnelly David Altshuler

Science 2005 Apr 10;308(5718):107-11. Epub 2005 Feb 10.

Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.

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April 2005

Unparalleled complexity of the MHC class I region in rhesus macaques.

Authors:

Nel Otting Corrine M C Heijmans Riet C Noort Natasja G de Groot Gaby G M Doxiadis Jon J van Rood David I Watkins Ronald E Bontrop

Proc Natl Acad Sci U S A 2005 Feb 21;102(5):1626-31. Epub 2005 Jan 21.

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands.

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February 2005

A prevalent POLG CAG microsatellite length allele in humans and African great apes.

Mamm Genome 2004 Jun;15(6):492-502

Institute of Medical Technology and Tampere University Hospital, University of Tampere, FIN-33014, Finland.

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June 2004

Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenes.

Authors:

Nanine de Groot Gaby G Doxiadis Natasja G De Groot Nel Otting Corrine Heijmans Annemiek J M Rouweler Ronald E Bontrop

J Immunol 2004 May;172(10):6152-7

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

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May 2004

Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populations.

Authors:

Gaby G M Doxiadis Nel Otting Natasja G de Groot Nanine de Groot Annemiek J M Rouweler Riet Noort Ernst J Verschoor Ilja Bontjer Ronald E Bontrop

Immunogenetics 2003 Nov 18;55(8):540-51. Epub 2003 Oct 18.

Department of Comparative Genetics and Refinement and Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands.

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November 2003