Publications by authors named "Ron Smits"

67Publications

Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers.

Oncogene 2020 04 26;39(17):3458-3472. Epub 2020 Feb 26.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41388-020-1232-5DOI Listing
April 2020

Upregulated β-catenin signaling does not affect survival of pancreatic cancer cells during dual inhibition of GSK3B and HDAC.

Pancreatology 2020 04 24;20(3):558-561. Epub 2019 Dec 24.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2019.12.019DOI Listing
April 2020

Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes.

Gastroenterology 2020 03 17;158(4):1029-1043.e10. Epub 2019 Dec 17.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.11.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179799PMC
March 2020

Wnt/β-Catenin Signaling in Liver Cancers.

Cancers (Basel) 2019 Jul 2;11(7). Epub 2019 Jul 2.

State Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 211198, China.

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http://dx.doi.org/10.3390/cancers11070926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679127PMC
July 2019

Bacterial biofilms as a potential contributor to mucinous colorectal cancer formation.

Biochim Biophys Acta Rev Cancer 2019 08 12;1872(1):74-79. Epub 2019 Jun 12.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2019.05.009DOI Listing
August 2019

Activated Signaling Pathways and Targeted Therapies in Desmoid-Type Fibromatosis: A Literature Review.

Front Oncol 2019 17;9:397. Epub 2019 May 17.

Department of Medical Oncology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fonc.2019.00397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534064PMC
May 2019

HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.

Carcinogenesis 2019 12;40(12):1514-1524

Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgz038DOI Listing
December 2019

Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues.

Lab Invest 2019 03 30;99(3):445-446. Epub 2019 Jan 30.

Departments of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41374-018-0183-8DOI Listing
March 2019

Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling.

Mol Cancer Res 2019 02 26;17(2):521-531. Epub 2018 Sep 26.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0054DOI Listing
February 2019

A novel tissue-based ß-catenin gene and immunohistochemical analysis to exclude familial adenomatous polyposis among children with hepatoblastoma tumors.

Pediatr Blood Cancer 2018 06 15;65(6):e26991. Epub 2018 Feb 15.

Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/pbc.26991
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http://dx.doi.org/10.1002/pbc.26991DOI Listing
June 2018

Erratum to: Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

J Gastroenterol 2018 04;53(4):576-577

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00535-017-1392-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828004PMC
April 2018

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.

Gastroenterology 2017 10 14;153(4):1133-1147. Epub 2017 Jul 14.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.006DOI Listing
October 2017

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.

Cell Rep 2017 05;19(6):1202-1213

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 28049 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Universidad Autónoma de Madrid, 28049 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.036DOI Listing
May 2017

Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

J Gastroenterol 2017 Apr 29;52(4):419-431. Epub 2016 Dec 29.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, Netherlands.

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http://dx.doi.org/10.1007/s00535-016-1299-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357489PMC
April 2017

Bacterial Biofilms in Colorectal Cancer Initiation and Progression.

Trends Mol Med 2017 01 13;23(1):18-30. Epub 2016 Dec 13.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.11.004DOI Listing
January 2017

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

J Exp Med 2017 01 15;214(1):143-163. Epub 2016 Dec 15.

Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich, University Hospital Grosshadern, 81377 Munich, Germany

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http://dx.doi.org/10.1084/jem.20160675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206496PMC
January 2017

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling.

Neoplasia 2016 Dec 13;18(12):711-723. Epub 2016 Nov 13.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110474PMC
December 2016

Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders.

Mol Cell Biol 2016 11 22;36(21):2728-2741. Epub 2016 Aug 22.

Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji Okazaki, Aichi 444-8787, Japan Department of Physiological Sciences, School of Life Sciences, SOKENDAI; (The Graduate University for Advanced Studies), Okazaki 444-8787, Japan.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00139-16
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http://dx.doi.org/10.1128/MCB.00139-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064219PMC
November 2016

Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration.

Eur J Cancer 2016 10 11;66:34-46. Epub 2016 Aug 11.

Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.020DOI Listing
October 2016

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.

Histochem Cell Biol 2016 Oct 31;146(4):445-55. Epub 2016 May 31.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037145PMC
http://dx.doi.org/10.1007/s00418-016-1453-4DOI Listing
October 2016

Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.

Cell Cycle 2016 06 6;15(12):1631-42. Epub 2016 May 6.

a Institute for Research in Immunology and Cancer, Université de Montréal , Montreal , Quebec , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1183851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934081PMC
June 2016

Fasting protects against the side effects of irinotecan but preserves its anti-tumor effect in Apc15lox mutant mice.

Cell Cycle 2015 8;14(14):2333-9. Epub 2015 May 8.

a Department of Surgery ; Erasmus University Medical Center ; Rotterdam , the Netherlands.

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http://dx.doi.org/10.1080/15384101.2015.1044170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613178PMC
April 2016

Disturbed balance between SOX2 and CDX2 in human vitelline duct anomalies and intestinal duplications.

Virchows Arch 2013 May 9;462(5):515-22. Epub 2013 Apr 9.

Department of Pediatric Surgery, of the Erasmus MC, PO Box 2040, 3000, CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00428-013-1405-5DOI Listing
May 2013

GNAS is not involved in gastrointestinal tumour formation in Peutz-Jeghers syndrome.

Fam Cancer 2013 Sep;12(3):581-2

Department of Gastroenterology and Hepatology, Erasmus Medical University Centre, Room L-463, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10689-013-9602-6DOI Listing
September 2013

Restriction of intestinal stem cell expansion and the regenerative response by YAP.

Nature 2013 Jan 25;493(7430):106-10. Epub 2012 Nov 25.

Stem Cell Program and Department of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature11693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536889PMC
January 2013

Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.

Med Mol Morphol 2012 Jun 22;45(3):161-7. Epub 2012 Sep 22.

Department of Anatomy I, Fujita Health University School of Medicine, Aichi, Japan.

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http://dx.doi.org/10.1007/s00795-011-0553-4DOI Listing
June 2012

Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice.

Dev Biol 2012 Sep 9;369(1):91-100. Epub 2012 Jun 9.

Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ydbio.2012.06.007DOI Listing
September 2012

The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.

Med Mol Morphol 2011 Dec 17;44(4):207-12. Epub 2011 Dec 17.

Department of Anatomy I, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

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http://dx.doi.org/10.1007/s00795-010-0529-9DOI Listing
December 2011

Colorectal cancers choosing sides.

Biochim Biophys Acta 2011 Dec 10;1816(2):219-31. Epub 2011 Aug 10.

Centro de Investigação de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Prof. Lima Basto 1099-023 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.bbcan.2011.07.005DOI Listing
December 2011

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice.

Mol Cell Endocrinol 2011 Jul 1;341(1-2):48-54. Epub 2011 Jun 1.

Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.mce.2011.05.026DOI Listing
July 2011

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.

Gut 2011 Sep 9;60(9):1204-12. Epub 2011 Feb 9.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, room L-63, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/gut.2010.233460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152867PMC
September 2011

Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors.

Mol Carcinog 2011 Jan;50(1):8-15

Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics (MPIMG), Berlin, Germany.

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http://dx.doi.org/10.1002/mc.20692DOI Listing
January 2011

A new conditional Apc-mutant mouse model for colorectal cancer.

Carcinogenesis 2010 May 22;31(5):946-52. Epub 2010 Feb 22.

Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgq046DOI Listing
May 2010

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.

PLoS Genet 2009 Jul 3;5(7):e1000547. Epub 2009 Jul 3.

Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1000547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697381PMC
July 2009

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

Curr Biol 2006 Nov;16(22):2259-64

Department of Cell Biology and Genetics, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cub.2006.09.065DOI Listing
November 2006

Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers.

Genes Chromosomes Cancer 2003 Oct;38(2):177-86

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/gcc.10268
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http://dx.doi.org/10.1002/gcc.10268DOI Listing
October 2003

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.

Nat Genet 2002 Dec 11;32(4):594-605. Epub 2002 Nov 11.

Center for Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratory, Wassenaarseweg 72, 2333 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ng1045DOI Listing
December 2002

Cancer biology. A matter of dosage.

Science 2002 Oct;298(5594):761-3

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1126/science.1077707DOI Listing
October 2002

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

Hum Mol Genet 2002 Jun;11(13):1549-60

Centro de Investigação de Patobiologia Molecular-CIPM, Instituto Português de Oncologia Francisco Gentil, 1093 Lisbon, Portugal.

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http://dx.doi.org/10.1093/hmg/11.13.1549DOI Listing
June 2002