Ron H Mathijssen

Ron H Mathijssen

Ron H Mathijssen

Ron H Mathijssen

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The influence of single-nucleotide polymorphisms on overall survival and toxicity in cabazitaxel-treated patients with metastatic castration-resistant prostate cancer.

Cancer Chemother Pharmacol 2020 Mar 1;85(3):547-553. Epub 2020 Jan 1.

Department of Medical Oncology, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00280-019-04011-0DOI Listing
March 2020

Cost-Neutral Optimization of Pazopanib Exposure by Splitting Intake Moments: A Prospective Pharmacokinetic Study in Cancer Patients.

Clin Pharmacokinet 2020 Feb 4. Epub 2020 Feb 4.

Division of Medical Oncology, Department of Clinical Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-020-00863-5DOI Listing
February 2020

Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.

Pharmacogenomics J 2019 10 4;19(5):473-479. Epub 2019 Feb 4.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41397-019-0079-zDOI Listing
October 2019

p16 status and choice of chemotherapy in the KEYNOTE-040 study.

Lancet 2019 10;394(10206):1322-1323

Erasmus MC Cancer Institute, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(19)31260-7DOI Listing
October 2019

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

Pharm Res 2019 Oct 15;36(12):163. Epub 2019 Oct 15.

Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1007/s11095-019-2697-1DOI Listing
October 2019

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine.

Eur J Clin Pharmacol 2019 Sep 7;75(9):1309-1318. Epub 2019 Jun 7.

Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-019-02704-2DOI Listing
September 2019

Quantification of the tyrosine kinase inhibitor erlotinib in human scalp hair by liquid chromatography-tandem mass spectrometry: Pitfalls for clinical application.

J Pharm Biomed Anal 2019 Aug 17;172:175-182. Epub 2019 Apr 17.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jpba.2019.04.031DOI Listing
August 2019

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence.

J Clin Oncol 2019 Aug 18;37(22):1980-1981. Epub 2019 Jun 18.

C. Louwrens Braal, PharmD, Erasmus University Medical Center, Rotterdam, the Netherlands; Jos H. Beijnen, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; Stijn L.W. Koolen, PhD, PharmD and Esther Oomen-de Hoop, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Neeltje Steeghs, MD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Agnes Jager, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Alwin D.R. Huitema, PharmD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; and Ron H.J. Mathijssen, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.19.00418DOI Listing
August 2019

Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment.

J Immunother Cancer 2019 07 12;7(1):182. Epub 2019 Jul 12.

Department of Internal Medicine, Division of Nephrology and Transplantation, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40425-019-0653-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626432PMC
July 2019

Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance-Letter.

Clin Cancer Res 2019 05;25(10):3192

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-19-0164DOI Listing
May 2019

Quantification of afatinib, alectinib, crizotinib and osimertinib in human plasma by liquid chromatography/triple-quadrupole mass spectrometry; focusing on the stability of osimertinib.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 11;1113:37-44. Epub 2019 Mar 11.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jchromb.2019.03.011DOI Listing
April 2019

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how? - Authors' reply.

Lancet Oncol 2019 Feb;20(2):e67

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30010-5DOI Listing
February 2019

Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer.

Cancers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers11020173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406317PMC
February 2019

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

Eur J Cancer 2019 Jan 11;107:60-67. Epub 2018 Dec 11.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183147
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http://dx.doi.org/10.1016/j.ejca.2018.11.010DOI Listing
January 2019

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

Pharm Res 2019 Jan 7;36(2):33. Epub 2019 Jan 7.

Department of Pharmacy &Pharmacology, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1007/s11095-018-2563-6DOI Listing
January 2019

Clinically relevant drug interactions with multikinase inhibitors: a review.

Ther Adv Med Oncol 2019 4;11:1758835918818347. Epub 2019 Jan 4.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1758835918818347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322107PMC
January 2019

Self-reported quality of life and hope in phase-I trial participants: An observational prospective cohort study.

Eur J Cancer Care (Engl) 2018 Nov 4;27(6):e12908. Epub 2018 Sep 4.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/ecc.12908DOI Listing
November 2018

Sunitinib-induced blood pressure rise does not involve aldosterone: observations in a patient after bilateral adrenalectomy.

J Hypertens 2018 11;36(11):2279-2280

Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center.

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http://Insights.ovid.com/crossref?an=00004872-201811000-0002
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http://dx.doi.org/10.1097/HJH.0000000000001894DOI Listing
November 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

Lancet Oncol 2018 11 19;19(11):1459-1467. Epub 2018 Oct 19.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183068
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http://dx.doi.org/10.1016/S1470-2045(18)30686-7DOI Listing
November 2018

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants.

Genes (Basel) 2018 Nov 28;9(12). Epub 2018 Nov 28.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.3390/genes9120585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316498PMC
November 2018

Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics.

Clin Pharmacokinet 2018 10;57(10):1229-1254

Department of Medical Oncology, Erasmus MC Cancer Institute, 's-Gravendijkwal 230, 3015, Rotterdam, The Netherlands.

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http://link.springer.com/10.1007/s40262-018-0644-7
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http://dx.doi.org/10.1007/s40262-018-0644-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132501PMC
October 2018

Development of an Enzyme-Linked Immune Sorbent Assay to Measure Nivolumab and Pembrolizumab Serum Concentrations.

Ther Drug Monit 2018 10;40(5):596-601

Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1097/FTD.0000000000000534DOI Listing
October 2018

Tamoxifen-induced fatty liver disease in a Caucasian patient.

Breast Cancer Res Treat 2018 Aug 7;171(1):243-244. Epub 2018 May 7.

Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-018-4817-8DOI Listing
August 2018

Development and validation of an analytical method for regorafenib and its metabolites in mouse plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jul 5;1090:43-51. Epub 2018 May 5.

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.jchromb.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991487PMC
July 2018

Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial.

Clin Pharmacokinet 2018 05;57(5):637-644

Department of Medical Oncology and Clinical Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s40262-017-0582-9
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http://dx.doi.org/10.1007/s40262-017-0582-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904242PMC
May 2018

Factors Affecting the Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer.

JAMA Oncol 2018 02;4(2):263-264

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2016.7019DOI Listing
February 2018

Bioanalytical methods for the quantification of hydromorphone, fentanyl, norfentanyl, morphine, morphine-3ß-glucuronide and morphine-6ß-glucuronide in human plasma.

J Pharm Biomed Anal 2018 Feb 17;149:475-481. Epub 2017 Nov 17.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpba.2017.11.035DOI Listing
February 2018

Understanding how coping strategies and quality of life maintain hope in patients deliberating phase I trial participation.

Psychooncology 2018 01 26;27(1):163-170. Epub 2017 Jul 26.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1002/pon.4487
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http://dx.doi.org/10.1002/pon.4487DOI Listing
January 2018

Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma.

J Clin Endocrinol Metab 2017 08;102(8):2922-2929

Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands.

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http://dx.doi.org/10.1210/jc.2016-4025DOI Listing
August 2017

A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients.

Clin Pharmacokinet 2017 07;56(7):733-746

Department of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-016-0471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488155PMC
July 2017

Tyrosine Kinase Inhibitors and Proton Pump Inhibitors: An Evaluation of Treatment Options.

Clin Pharmacokinet 2017 07;56(7):683-688

Department of Medical Oncology, Erasmus MC Cancer InstituteErasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-016-0503-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488129PMC
July 2017

Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

Pharmacogenet Genomics 2017 06;27(6):227-231

aHereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO) bOncology Department, Hospital Universitario 12 de Octubre cSpanish Oncology Genitourinary Group (SOGUG) dISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain eDepartment of Clinical Pharmacy and Toxicology fDepartment of Medical Oncology gDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden hDepartment of Medical Oncology, VU University Medical Center, Amsterdam iDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands jDepartment of Solid Tumour Oncology, Cleveland Clinic Foundation (CCF) Taussig Cancer Institute, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000280DOI Listing
June 2017

Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure.

Clin Pharmacokinet 2017 03;56(3):305-310

Department of Medical Oncology, Erasmus MC Cancer Institute, PO Box 5201, 3008 AE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-016-0441-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315737PMC
March 2017

Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients.

Clin Pharmacokinet 2017 03;56(3):293-303

Department of Pharmacy and Pharmacology, Netherlands Cancer Institute-Antoni van Leeuwenhoek and MC Slotervaart, Louwesweg 6, PO Box 90440, 1006 BK, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-016-0443-yDOI Listing
March 2017

A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients.

Br J Clin Pharmacol 2017 02 29;83(2):294-313. Epub 2016 Oct 29.

Dept of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, Netherlands.

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http://dx.doi.org/10.1111/bcp.13129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237702PMC
February 2017

Nivolumab for Squamous-Cell Cancer of Head and Neck.

N Engl J Med 2017 02;376(6):595-6

Erasmus MC Cancer Institute, Rotterdam, the Netherlands

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http://dx.doi.org/10.1056/NEJMc1615565DOI Listing
February 2017

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients.

Clin Cancer Res 2016 Dec 28;22(23):5738-5746. Epub 2016 Jul 28.

Department of Medical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1255DOI Listing
December 2016

Individualized Tamoxifen Dose Escalation-Letter.

Clin Cancer Res 2016 12;22(24):6300

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1967DOI Listing
December 2016

Reply to N. Singh et al.

J Clin Oncol 2016 11 31;34(33):4054. Epub 2016 Oct 31.

Roelof Wouter Frederik van Leeuwen, Erasmus University Medical Center and Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands; Teun van Gelder, Erasmus University Medical Center, Rotterdam, the Netherlands; Joachim G. Aerts, Erasmus Medical Center Cancer Institute, Rotterdam, and Amphia Hospital, Breda, the Netherlands; and Ron H.J. Mathijssen, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2016.68.9356DOI Listing
November 2016

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS.

Bioanalysis 2016 10;8(2):123-34. Epub 2015 Dec 10.

Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://www.future-science.com/doi/10.4155/bio.15.235
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http://dx.doi.org/10.4155/bio.15.235DOI Listing
September 2016

Opioid treatment failure in cancer patients: the role of clinical and genetic factors.

Pharmacogenomics 2016 08 29;17(13):1391-403. Epub 2016 Jul 29.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs-2016-0082DOI Listing
August 2016

Predicting paclitaxel-induced neutropenia using the DMET platform.

Pharmacogenomics 2015 12;16(11):1231-41. Epub 2015 Aug 12.

Department of Clinical Chemistry, Erasmus University Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.15.68DOI Listing
June 2016

Treatment with subcutaneous and transdermal fentanyl: results from a population pharmacokinetic study in cancer patients.

Eur J Clin Pharmacol 2016 Apr 14;72(4):459-67. Epub 2016 Jan 14.

Department of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-015-2005-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792338PMC
April 2016

Influence of the Acidic Beverage Cola on the Absorption of Erlotinib in Patients With Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 Apr 8;34(12):1309-14. Epub 2016 Feb 8.

Roelof W.F. van Leeuwen, Robert Peric, Koen G.A.M. Hussaarts, Emma Kienhuis, Nikki S. IJzerman, Peter de Bruijn, Cor van der Leest, Bronno van der Holt, Joachim G. Aerts, and Ron H.J. Mathijssen, Erasmus MC Cancer Institute; Roelof W.F. van Leeuwen and Teun van Gelder, Erasmus University Medical Center, Rotterdam; Cor van der Leest and Joachim G. Aerts, Amphia Hospital, Breda; Henk Codrington, Haga Hospital, the Hague; and Jeroen S. Kloover, Elisabeth-Tweesteden Hospital, Tilburg, the Netherlands.

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http://ascopubs.org/doi/10.1200/JCO.2015.65.2560
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http://dx.doi.org/10.1200/JCO.2015.65.2560DOI Listing
April 2016

Macrocytosis as a potential parameter associated with survival after tyrosine kinase inhibitor treatment.

Eur J Cancer 2016 Mar 1;56:101-106. Epub 2016 Feb 1.

Dept of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.12.019DOI Listing
March 2016

miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway.

Mol Cancer 2015 Nov 17;14:196. Epub 2015 Nov 17.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12943-015-0464-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650519PMC
November 2015

CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.

Eur Urol 2015 Oct 27;68(4):621-9. Epub 2015 Apr 27.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands; Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.04.018DOI Listing
October 2015

A Systematic Review of Prospective Studies Reporting Adverse Events of Commonly Used Opioids for Cancer-Related Pain: A Call for the Use of Standardized Outcome Measures.

J Pain 2015 Oct 5;16(10):935-46. Epub 2015 Jun 5.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jpain.2015.05.006DOI Listing
October 2015

Development and validation of an UPLC-MS/MS method for the quantification of tamoxifen and its main metabolites in human scalp hair.

J Pharm Biomed Anal 2015 Oct 12;114:416-25. Epub 2015 Jun 12.

Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpba.2015.06.018DOI Listing
October 2015

Lysosomal Sequestration Determines Intracellular Imatinib Levels.

Mol Pharmacol 2015 Sep 24;88(3):477-87. Epub 2015 Jun 24.

Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (H.B., A.T.D., S.Se., A.W.M.B., P.B., S.Sl., R.H.J.M., E.A.C.W.); Department of Human Genetics, Catholic University Leuven and University Hospitals, Leuven, Belgium (M.D.-R.); Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan (T.T.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.)

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http://dx.doi.org/10.1124/mol.114.097451DOI Listing
September 2015

4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes.

Br J Clin Pharmacol 2015 Sep 12;80(3):560-8. Epub 2015 Aug 12.

Department of Clinical Chemistry, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015CE, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/bcp.12707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574840PMC
September 2015

Greater Sensitivity of Blood Pressure Than Renal Toxicity to Tyrosine Kinase Receptor Inhibition With Sunitinib.

Hypertension 2015 Sep 20;66(3):543-9. Epub 2015 Jul 20.

From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (S.L., M.H.W.K., F.M.M.S., A.H.J.D., A.H.v.d.M.); Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (H.J.B.); Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands (M.H.W.K.); Department of Pathology, Reinier de Graaf Gasthuis, Delft, The Netherlands (F.M.M.S.); Department of Pathology, Herlev University Hospital, Herlev, Denmark (A.H.); Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands (M.C.C.-v.G.); and Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands (S.S., R.H.JM.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05435DOI Listing
September 2015

Inter-patient variability in docetaxel pharmacokinetics: A review.

Cancer Treat Rev 2015 Jul 7;41(7):605-13. Epub 2015 May 7.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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July 2015

Pharmacokinetically based dosing of weekly paclitaxel to reduce drug-related neurotoxicity based on a single sample strategy.

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Individualization of tamoxifen therapy: much more than just CYP2D6 genotyping.

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http://dx.doi.org/10.1016/j.ctrv.2015.01.002DOI Listing
March 2015