Ron Bose

Ron Bose

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Ron Bose

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Imaging of HER2 with [Zr]pertuzumab in Response to T-DM1 Therapy.

Cancer Biother Radiopharm 2019 May 24;34(4):209-217. Epub 2019 Jan 24.

1 Department of Radiology, The University of Alabama at Birmingham, Birmingham, Alabama.

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https://www.liebertpub.com/doi/10.1089/cbr.2018.2654
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http://dx.doi.org/10.1089/cbr.2018.2654DOI Listing
May 2019

Reply to J.J. Tao et al.

J Clin Oncol 2018 08 1;36(23):2451. Epub 2018 Jun 1.

John D. Hainsworth, Sarah Cannon Research Institute; Tennessee Oncology, PLLC, Nashville, TN; Funda Meric-Bernstam, The University of Texas MD Anderson Cancer Center, Houston, TX; Charles Swanton, Francis Crick Institute, London, United Kingdom; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Genentech, South San Francisco, CA; David R. Spigel, Sarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, TN; Christopher Sweeney, Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA; Howard Burris, Sarah Cannon Research Institute; Tennessee Oncology, PLLC, Nashville, TN; Ron Bose, Washington University School of Medicine, St Louis, MO; Bongin Yoo, Alisha Stein, and Mary Beattie, Genentech, South San Francisco, CA; and Razelle Kurzrock, Moores Cancer Center, University of California, San Diego, San Diego, CA.

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http://dx.doi.org/10.1200/JCO.2018.78.6392DOI Listing
August 2018

Targeted Therapy for Advanced Solid Tumors on the Basis of Molecular Profiles: Results From MyPathway, an Open-Label, Phase IIa Multiple Basket Study.

J Clin Oncol 2018 02 10;36(6):536-542. Epub 2018 Jan 10.

John D. Hainsworth, David R. Spigel, and Howard Burris, Sarah Cannon Research Institute; Tennessee Oncology, Nashville, TN; Funda Meric-Bernstam, University of Texas MD Anderson Cancer Center, Houston, TX; Charles Swanton, Francis Crick Institute, London, United Kingdom; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Christopher Sweeney, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Ron Bose, Washington University School of Medicine, St Louis, MO; Bongin Yoo, Alisha Stein, and Mary Beattie, Genentech, South San Francisco; and Razelle Kurzrock, Moores Cancer Center, University of California San Diego, San Diego, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.3780DOI Listing
February 2018

Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data.

PLoS One 2013 27;8(6):e67980. Epub 2013 Jun 27.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America ; Computational and Systems Biology Program, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067980PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694871PMC
October 2017

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types.

Sci Rep 2017 07 25;7(1):6418. Epub 2017 Jul 25.

Division of Oncology, Department of Medicine, Washington University School of Medicine, 660S Euclid Ave, St. Louis, MO, 63110, USA.

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http://www.nature.com/articles/s41598-017-06366-x
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http://dx.doi.org/10.1038/s41598-017-06366-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527104PMC
July 2017

Efficient sortase-mediated N-terminal labeling of TEV protease cleaved recombinant proteins.

Anal Biochem 2017 03 11;521:55-58. Epub 2017 Jan 11.

Division of Oncology, Department of Medicine, Washington University School of Medicine, Campus Box 8076, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303137PMC
March 2017

Unsupervised detection of cancer driver mutations with parsimony-guided learning.

Nat Genet 2016 10 12;48(10):1288-94. Epub 2016 Sep 12.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ng.3658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328615PMC
October 2016

Prognostic and Predictive Biomarkers of Endocrine Responsiveness for Estrogen Receptor Positive Breast Cancer.

Adv Exp Med Biol 2016 ;882:125-54

Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, 320A Cullen, MS 600, 77030, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-3-319-22909-6_5DOI Listing
August 2016

Genomic Characterization of Primary Invasive Lobular Breast Cancer.

J Clin Oncol 2016 06 29;34(16):1872-81. Epub 2016 Feb 29.

Christine Desmedt, Gabriele Zoppoli, Denis Larsimont, Debora Fumagalli, David Brown, Françoise Rothé, Delphine Vincent, Naima Kheddoumi, Ghizlane Rouas, Samira Majjaj, Sylvain Brohée, Roberto Salgado, Martine Piccart-Gebhart, and Christos Sotiriou, Institut Jules Bordet; Christine Galant, Cliniques Universitaires Saint Luc, Brussels; Peter Van Loo, University of Leuven; Thomas Van Brussel and Diether Lambrechts, VIB Vesalius Research Center, Leuven, Belgium; Gabriele Zoppoli, University of Genoa and Istituto di Ricerca a Carattere Clinico-Scientifico San Martino-National Cancer Institute, Genoa; Giancarlo Pruneri, Patrick Maisonneuve, and Giuseppe Viale, European Institute of Oncology; Marco Fornili and Elia Biganzoli, University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Gunes Gundem and Peter J. Campbell, Wellcome Trust Sanger Institute, Cambridgeshire; Peter Van Loo, The Francis Crick Institute, London, United Kingdom; Ron Bose, Washington University School of Medicine, St Louis, MO; Otto Metzger, Dana-Farber Cancer Institute, Boston, MA; and François Bertucci, Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1200/JCO.2015.64.0334DOI Listing
June 2016

Statistically identifying tumor suppressors and oncogenes from pan-cancer genome-sequencing data.

Bioinformatics 2015 Nov 25;31(22):3561-8. Epub 2015 Jul 25.

Division of Oncology, Department of Medicine, Washington University School of Medicine.

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http://dx.doi.org/10.1093/bioinformatics/btv430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757952PMC
November 2015

HER2 missense mutations have distinct effects on oncogenic signaling and migration.

Proc Natl Acad Sci U S A 2015 Nov 27;112(45):E6205-14. Epub 2015 Oct 27.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218;

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http://dx.doi.org/10.1073/pnas.1516853112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653184PMC
November 2015

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.

Mol Cell Biol 2015 Sep 29;35(17):3083-102. Epub 2015 Jun 29.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA Department of Chemistry, University of California, Berkeley, Berkeley, California, USA Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00248-15
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http://dx.doi.org/10.1128/MCB.00248-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525312PMC
September 2015

HER2-Mutated Breast Cancer Responds to Treatment With Single-Agent Neratinib, a Second-Generation HER2/EGFR Tyrosine Kinase Inhibitor.

J Natl Compr Canc Netw 2015 Sep;13(9):1061-4

From the Department of Oncology, Kaplan Medical Center, Rehovot, Israel; Section of Breast Oncology, Division of Oncology, Department of Medicine, Siteman Cancer Center, and Washington University School of Medicine, St. Louis, Missouri; and Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas. From the Department of Oncology, Kaplan Medical Center, Rehovot, Israel; Section of Breast Oncology, Division of Oncology, Department of Medicine, Siteman Cancer Center, and Washington University School of Medicine, St. Louis, Missouri; and Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas. From the Department of Oncology, Kaplan Medical Center, Rehovot, Israel; Section of Breast Oncology, Division of Oncology, Department of Medicine, Siteman Cancer Center, and Washington University School of Medicine, St. Louis, Missouri; and Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.

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http://www.jnccn.org/content/13/9/1061.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701428PMC
http://dx.doi.org/10.6004/jnccn.2015.0131DOI Listing
September 2015

HER2 activating mutations are targets for colorectal cancer treatment.

Cancer Discov 2015 Aug;5(8):832-41

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527087PMC
August 2015

Tissue phosphoproteomics with PolyMAC identifies potential therapeutic targets in a transgenic mouse model of HER2 positive breast cancer.

Electrophoresis 2014 Dec 12;35(24):3463-9. Epub 2014 Jun 12.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1002/elps.201400022
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http://dx.doi.org/10.1002/elps.201400022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193948PMC
December 2014

DGIdb: mining the druggable genome.

Nat Methods 2013 Dec 13;10(12):1209-10. Epub 2013 Oct 13.

1] The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [3].

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http://dx.doi.org/10.1038/nmeth.2689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851581PMC
December 2013

Incorporating genomics into breast cancer clinical trials and care.

Clin Cancer Res 2013 Dec;19(23):6371-9

Authors' Affiliation: Section of Breast Oncology, Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0837DOI Listing
December 2013

Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.

J Biol Chem 2013 Aug 10;288(35):25254-64. Epub 2013 Jul 10.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M113.474882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757188PMC
August 2013

A neu view of invasive lobular breast cancer.

Authors:
Ron Bose

Clin Cancer Res 2013 Jul 28;19(13):3331-3. Epub 2013 May 28.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700640PMC
July 2013

Activating HER2 mutations in HER2 gene amplification negative breast cancer.

Cancer Discov 2013 Feb 7;3(2):224-37. Epub 2012 Dec 7.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570596PMC
February 2013

Using multigene tests to select treatment for early-stage breast cancer.

J Natl Compr Canc Netw 2013 Feb;11(2):174-82; quiz 182

Division of Oncology, Department of Medicine, Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.6004/jnccn.2013.0025DOI Listing
February 2013

Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers.

Mol Cell Proteomics 2013 Jan 25;12(1):180-93. Epub 2012 Oct 25.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/mcp.M112.020115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536899PMC
January 2013

Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.

Mol Cell Proteomics 2012 Aug 12;11(8):355-69. Epub 2012 Apr 12.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/mcp.M111.015750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412967PMC
August 2012

Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

J Biol Chem 2010 Mar 18;285(10):7035-44. Epub 2009 Dec 18.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M109.096032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844153PMC
March 2010

The ErbB kinase domain: structural perspectives into kinase activation and inhibition.

Exp Cell Res 2009 Feb 15;315(4):649-58. Epub 2008 Aug 15.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.yexcr.2008.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668223PMC
February 2009

Mechanism of activation and inhibition of the HER4/ErbB4 kinase.

Structure 2008 Mar;16(3):460-7

Department of Biophysics & Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.str.2007.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858219PMC
March 2008

Human Proteinpedia enables sharing of human protein data.

Authors:
Suresh Mathivanan Mukhtar Ahmed Natalie G Ahn Hainard Alexandre Ramars Amanchy Philip C Andrews Joel S Bader Brian M Balgley Marcus Bantscheff Keiryn L Bennett Erik Björling Blagoy Blagoev Ron Bose Samir K Brahmachari Alma S Burlingame Xosé R Bustelo Gerard Cagney Greg T Cantin Helene L Cardasis Julio E Celis Raghothama Chaerkady Feixia Chu Philip A Cole Catherine E Costello Robert J Cotter David Crockett James P DeLany Angelo M De Marzo Leroi V DeSouza Eric W Deutsch Eric Dransfield Gerard Drewes Arnaud Droit Michael J Dunn Kojo Elenitoba-Johnson Rob M Ewing Jennifer Van Eyk Vitor Faca Jayson Falkner Xiangming Fang Catherine Fenselau Daniel Figeys Pierre Gagné Cecilia Gelfi Kris Gevaert Jeffrey M Gimble Florian Gnad Renu Goel Pavel Gromov Samir M Hanash William S Hancock H C Harsha Gerald Hart Faith Hays Fuchu He Prashantha Hebbar Kenny Helsens Heiko Hermeking Winston Hide Karin Hjernø Denis F Hochstrasser Oliver Hofmann David M Horn Ralph H Hruban Nieves Ibarrola Peter James Ole N Jensen Pia Hønnerup Jensen Peter Jung Kumaran Kandasamy Indu Kheterpal Reiko F Kikuno Ulrike Korf Roman Körner Bernhard Kuster Min-Seok Kwon Hyoung-Joo Lee Young-Jin Lee Michael Lefevre Minna Lehvaslaiho Pierre Lescuyer Fredrik Levander Megan S Lim Christian Löbke Joseph A Loo Matthias Mann Lennart Martens Juan Martinez-Heredia Mark McComb James McRedmond Alexander Mehrle Rajasree Menon Christine A Miller Harald Mischak S Sujatha Mohan Riaz Mohmood Henrik Molina Michael F Moran James D Morgan Robert Moritz Martine Morzel David C Muddiman Anuradha Nalli J Daniel Navarro Thomas A Neubert Osamu Ohara Rafael Oliva Gilbert S Omenn Masaaki Oyama Young-Ki Paik Kyla Pennington Rainer Pepperkok Balamurugan Periaswamy Emanuel F Petricoin Guy G Poirier T S Keshava Prasad Samuel O Purvine B Abdul Rahiman Prasanna Ramachandran Y L Ramachandra Robert H Rice Jens Rick Ragna H Ronnholm Johanna Salonen Jean-Charles Sanchez Thierry Sayd Beerelli Seshi Kripa Shankari Shi Jun Sheng Vivekananda Shetty K Shivakumar Richard J Simpson Ravi Sirdeshmukh K W Michael Siu Jeffrey C Smith Richard D Smith David J States Sumio Sugano Matthew Sullivan Giulio Superti-Furga Maarit Takatalo Visith Thongboonkerd Jonathan C Trinidad Mathias Uhlen Joël Vandekerckhove Julian Vasilescu Timothy D Veenstra José-Manuel Vidal-Taboada Mauno Vihinen Robin Wait Xiaoyue Wang Stefan Wiemann Billy Wu Tao Xu John R Yates Jun Zhong Ming Zhou Yunping Zhu Petra Zurbig Akhilesh Pandey

Nat Biotechnol 2008 Feb;26(2):164-7

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http://dx.doi.org/10.1038/nbt0208-164DOI Listing
February 2008

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Nature 2007 Nov;450(7170):741-4

Department of Molecular and Cell Biology, and Howard Hughes Medical Institute, California Institute for Quantitative Sciences, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature05998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561764PMC
November 2007

Protein tyrosine kinase-substrate interactions.

Curr Opin Struct Biol 2006 Dec 7;16(6):668-75. Epub 2006 Nov 7.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.sbi.2006.10.012DOI Listing
December 2006

Phosphoproteomic analysis of Her2/neu signaling and inhibition.

Proc Natl Acad Sci U S A 2006 Jun 19;103(26):9773-8. Epub 2006 Jun 19.

Department of Pharmacology, McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0603948103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502529PMC
June 2006