Roman Sasik

Roman Sasik

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Roman Sasik

Roman Sasik

Publications by authors named "Roman Sasik"

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42Publications

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Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.

Cell Rep 2019 Jul;28(4):1103-1116.e4

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.073DOI Listing
July 2019

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

Cell 2019 Apr 4;177(3):572-586.e22. Epub 2019 Apr 4.

Department of Pharmacology, University of California, San Diego School of Medicine, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA; Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193027
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http://dx.doi.org/10.1016/j.cell.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711371PMC
April 2019

E47 Governs the MYC-CDKN1B/p27-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16 and Wild-Type p53.

Cell Mol Gastroenterol Hepatol 2018 16;6(2):181-198. Epub 2018 May 16.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.

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http://dx.doi.org/10.1016/j.jcmgh.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039985PMC
May 2018

Distinct gene signatures predict insulin resistance in young mice with high fat diet-induced obesity.

Physiol Genomics 2018 03 8;50(3):144-157. Epub 2018 Jan 8.

Department of Pediatrics, University of California at San Diego , La Jolla, California.

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http://dx.doi.org/10.1152/physiolgenomics.00045.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899230PMC
March 2018

Proinflammatory Dual Receptor T Cells in Chronic Graft-versus-Host Disease.

Biol Blood Marrow Transplant 2017 Nov 24;23(11):1852-1860. Epub 2017 Jul 24.

Department of Pathology, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682197PMC
November 2017

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Cancer Discov 2016 08 13;6(8):870-85. Epub 2016 May 13.

Moores Cancer Center, University of California, San Diego, La Jolla, California. Department of Pathology, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091937PMC
August 2016

Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes.

PLoS One 2014 26;9(11):e113765. Epub 2014 Nov 26.

Departments of Pathology and Medicine, University of California San Diego, La Jolla, California, United States of America; Department of Pathology, Immunology, and Microbiology, University of California Davis, Davis, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113765PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245998PMC
July 2015

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.

Haematologica 2015 Jul 10;100(7):945-54. Epub 2015 Apr 10.

Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA CLL Research Consortium, and Department of Medicine, University of California, San Diego, La Jolla, CA, USA

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http://dx.doi.org/10.3324/haematol.2014.122069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486229PMC
July 2015

The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes.

PLoS One 2014 1;9(5):e96577. Epub 2014 May 1.

Department of Pediatrics (Cardiology), University of California San Diego, La Jolla, California, United States of America; Rady Children's Hospital San Diego, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006892PMC
June 2015

The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.

FASEB J 2015 May 28;29(5):1859-68. Epub 2015 Jan 28.

*Department of Pediatrics (Cardiology), Department of Pediatrics and School of Pharmacy, Pediatrics Diabetes Research Center, Departments of Pediatrics and Cellular and Molecular Medicine, and Department of Medicine, University of California, San Diego, La Jolla, California, USA; Computational Science Research Center and Biomedical Informatics Research Center, San Diego State University, San Diego, California, USA; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA; **Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany; and Rady Children's Hospital, San Diego, California, USA

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http://dx.doi.org/10.1096/fj.14-257808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771066PMC
May 2015

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling.

J Mol Cell Cardiol 2015 Feb 13;79:133-44. Epub 2014 Nov 13.

Department of Pediatrics (Cardiology), University of California San Diego, United States; Rady Children's Hospital San Diego, United States; Institute for Engineering in Medicine, University of California San Diego, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302020PMC
February 2015

A degenerative retinal process in HIV-associated non-infectious retinopathy.

PLoS One 2013 17;8(9):e74712. Epub 2013 Sep 17.

Jacobs Retina Center at the Shiley Eye Center, University of California San Diego, Department of Ophthalmology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074712PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775801PMC
June 2014

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.

Nat Genet 2014 Mar 2;46(3):245-52. Epub 2014 Feb 2.

1] Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California, USA. [2] Sanford Consortium for Regenerative Medicine, La Jolla, California, USA. [3] Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA. [4] Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.2889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267534PMC
March 2014

Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila.

PLoS One 2013 24;8(4):e61773. Epub 2013 Apr 24.

Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061773PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634835PMC
December 2013

The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia.

Mol Carcinog 2009 Jan;48(1):38-44

Centre de Recherche du Centre Hospitalier Université Laval, Centre de Génomique, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1002/mc.20454DOI Listing
January 2009

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.

Int Immunol 2009 Jan 9;21(1):81-93. Epub 2008 Dec 9.

Actimis Pharmaceuticals, Inc., 10835 Road to the Cure, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1093/intimm/dxn127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638841PMC
January 2009

Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition.

Cancer Res 2008 Oct;68(19):8085-93

Department of Medicine, Moores Cancer Center, The Laboratory of Immunology, University of California, La Jolla, California92093-0815, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1014DOI Listing
October 2008

KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity.

J Immunol 2008 Jul;181(1):256-64

Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0815, USA.

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http://dx.doi.org/10.4049/jimmunol.181.1.256DOI Listing
July 2008

R5 and X4 HIV viruses differentially modulate host gene expression in resting CD4+ T cells.

AIDS Res Hum Retroviruses 2008 Mar;24(3):485-93

Infectious Disease Research Center, CHUL Research Center and Laval University, Québec, Canada.

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http://dx.doi.org/10.1089/aid.2007.0120DOI Listing
March 2008

Pathway and gene ontology based analysis of gene expression in a rat model of cerebral ischemic tolerance.

Brain Res 2007 Oct 7;1177:103-23. Epub 2007 Aug 7.

Department of Anesthesiology, University of California, San Diego, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.07.047DOI Listing
October 2007

A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay.

J Virol Methods 2006 Oct 28;137(1):125-33. Epub 2006 Jul 28.

Department of Pathology, University of California San Diego, La Jolla, CA 92093-0679, USA.

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http://dx.doi.org/10.1016/j.jviromet.2006.06.019DOI Listing
October 2006

Methamphetamine stimulates interferon inducible genes in HIV infected brain.

J Neuroimmunol 2005 Dec 24;170(1-2):158-71. Epub 2005 Oct 24.

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01655728050038
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http://dx.doi.org/10.1016/j.jneuroim.2005.09.009DOI Listing
December 2005

Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia.

Proc Natl Acad Sci U S A 2005 Oct 13;102(43):15533-8. Epub 2005 Oct 13.

Center for Behavioral Genomics, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0507666102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266138PMC
October 2005

Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages.

AIDS Res Hum Retroviruses 2004 Nov;20(11):1210-22

Department of Pathology, University of California San Diego, La Jolla, California 92093-0679, USA.

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http://dx.doi.org/10.1089/aid.2004.20.1210DOI Listing
November 2004

A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.

Proc Natl Acad Sci U S A 2004 Oct 27;101(40):14461-6. Epub 2004 Sep 27.

Department of Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0405786101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521940PMC
October 2004

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.

Proc Natl Acad Sci U S A 2004 Jul 15;101(30):10995-1000. Epub 2004 Jul 15.

Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093, USA.

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http://dx.doi.org/10.1073/pnas.0404073101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC503732PMC
July 2004