Roman K Thomas

Roman K Thomas

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Roman K Thomas

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Resistance Mechanisms to AZD9291 and Rociletinib-Response.

Clin Cancer Res 2017 07;23(14):3967-3968

Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0948DOI Listing
July 2017

The tumour suppressor CYLD regulates the p53 DNA damage response.

Nat Commun 2016 08 26;7:12508. Epub 2016 Aug 26.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Centre for Molecular Medicine (CMMC), University of Cologne, Joseph-Stelzmann-Straβe 26, Cologne 50931, Germany.

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http://dx.doi.org/10.1038/ncomms12508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007442PMC
August 2016

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.

J Thorac Oncol 2015 Jun;10(6):e40-3

*Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Köln Bonn, Institute of Pathology, University Hospital of Cologne, Cologne, Germany; ‡Department of Translational Genomics, Center for Integrated Oncology Köln Bonn, University of Cologne, Cologne, Germany; §Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ‖Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ¶Center for Integrated Oncology Köln Bonn, Institute of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; and #Institute of Hematopathology Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000503DOI Listing
June 2015

Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer.

Clin Cancer Res 2015 May 11;21(9):1989-94. Epub 2014 Dec 11.

Department of Translational Genomics and Pathology, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0854DOI Listing
May 2015

Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort.

J Clin Oncol 2015 Mar 9;33(9):992-9. Epub 2015 Feb 9.

Julien Mazières, Damien Rouvière, and Julie D. Milia, Hôpital Larrey, Centre Hospitalier Universitaire, Université Paul Sabatier; Thomas Filleron, Institut Universitaire du Cancer, Toulouse; Gérard Zalcman, Centre Hospitalier Universitaire, Université de Caen-Basse Normandie, Caen; Pamela Biondani and Benjamin Besse, Gustave Roussy, Villejuif; Fabrice Barlesi, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille; Hervé Léna, Centre Hospitalier Universitaire, Rennes; Isabelle Monnet, Centre Hospitalier Intercommunal de Créteil, Créteil; Luc Thiberville, Centre Hospitalier Universitaire, Rouen; Nicolas Pecuchet, Institut Curie, Paris, France; Lucio Crinò, Medica-Azienda Ospedaliera, Perugia; Federico Cappuzzo, Istituto Toscano Tumori, Ospedale Civile, Livorno, Italy; Anne-Marie C. Dingemans, Maastricht University Medical Center, Maastricht; Egbert F. Smit, VU University Medical Center, Amsterdam, the Netherlands; Sacha I. Rothschild, University Hospital Basel, Medical Oncology, Basel; Christian Spirig, Klinik St Anna; Joachim Diebold and Oliver Gautschi, Cantonal Hospital Luzern, Lucerne, Switzerland; Rafal Dziadziuszko, Gdansk Medical University, Gdansk, Poland; Jurgen Wolf and Roman K. Thomas, Center of Integrated Oncology Köln-Bonn, University Hospital Cologne, University of Cologne; Frauke Leenders and Roman K. Thomas, University of Cologne; Johannes M. Heuckmann, Blackfield AG, Cologne, Germany.

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http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.58
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http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.58
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.58.3302
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http://dx.doi.org/10.1200/JCO.2014.58.3302DOI Listing
March 2015

PD-L1 expression in small cell neuroendocrine carcinomas.

Eur J Cancer 2015 Feb 9;51(3):421-6. Epub 2015 Jan 9.

Institute of Pathology, University Hospital Cologne, Cologne, Germany; Center for Integrated Oncology (CIO) Cologne/Bonn, Germany.

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http://dx.doi.org/10.1016/j.ejca.2014.12.006DOI Listing
February 2015

Identification and further development of potent TBK1 inhibitors.

ACS Chem Biol 2015 Jan;10(1):289-98

Department of Chemistry and Chemical Biology, Technical University of Dortmund , Otto-Hahn-Straße 6, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/cb500908dDOI Listing
January 2015

Era of comprehensive cancer genome analyses.

J Clin Oncol 2014 Dec 10;32(36):4029-30. Epub 2014 Nov 10.

University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1200/JCO.2014.58.4375DOI Listing
December 2014

CGARS: cancer genome analysis by rank sums.

Bioinformatics 2014 May 9;30(9):1295-6. Epub 2014 Jan 9.

Department of Translational Genomics, Department of Pathology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btu011DOI Listing
May 2014

CD74-NRG1 fusions in lung adenocarcinoma.

Cancer Discov 2014 Apr 27;4(4):415-22. Epub 2014 Jan 27.

1Department of Translational Genomics; 2Department I of Internal Medicine; 3Laboratory of Translational Cancer Genomics; 4Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn; 5Center for Molecular Medicine Cologne (CMMC); 6Cologne Center for Genomics (CCG); 7Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); 8Department of Pathology, University Hospital Medical Center, University of Cologne; 9Blackfield AG; 10Max Planck Institute for Neurological Research; 11Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH; 12Institute of Human Genetics, Cologne; 13Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Berlin; 14Department of Prostate Cancer Research, Institute of Pathology; 15Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn; 16Institute of Pathology; 17Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena; 18Institute for Pathology Bad Berka, Bad Berka, Germany;19Division of Molecular Oncology, Aichi Cancer Center Research Institute; 20Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; Departments of 21Surgery and22Pathology, St. Vincent's Hospital; 23Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;24Department of Pathology, 25CHU Grenoble Institut National de la Santé et de la Recherche Medicale (INSERM) U823, Institute Albert Bonniot, Grenoble-Alpes University, Grenoble, France; 26Laboratory of Oncology IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 27Laboratory for Molecular Medicine and Biotechnology, University Campus Bio-Medico, Rome, Italy; 28Center for the Biology of Disease, VIB, Leuven; and 29Oncology Discovery, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0633DOI Listing
April 2014

Overcoming drug resistance in ALK-rearranged lung cancer.

Authors:
Roman K Thomas

N Engl J Med 2014 Mar;370(13):1250-1

From the Departments of Translational Genomics and Pathology, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1056/NEJMe1316173DOI Listing
March 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0323DOI Listing
February 2014

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

J Med Chem 2013 Jul 10;56(14):5757-72. Epub 2013 Jul 10.

Department of Chemistry and Chemical Biology, Technical University of Dortmund, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/jm4004076DOI Listing
July 2013

Lessons learned from lung cancer genomics: the emerging concept of individualized diagnostics and treatment.

J Clin Oncol 2013 May 15;31(15):1858-65. Epub 2013 Apr 15.

Center of Integrated Oncology Köln-Bonn, University of Cologne, Weyertal 115b, 50931 Cologne, Germany.

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http://dx.doi.org/10.1200/JCO.2012.45.9867DOI Listing
May 2013

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.

J Clin Invest 2013 Apr;123(4):1732-40

Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1172/JCI65385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613914PMC
April 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ng.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915822PMC
October 2012

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

Clin Cancer Res 2012 Sep 21;18(17):4682-90. Epub 2012 Aug 21.

Department of Translational Genomics, University of Cologne, c/o MPI for Neurological Research, Gleueler Str. 50, 50931 Cologne, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3260DOI Listing
September 2012

Epidermal growth factor receptor (EGFR) signaling and covalent EGFR inhibition in lung cancer.

J Clin Oncol 2012 Sep 20;30(27):3417-20. Epub 2012 Aug 20.

Technical University Dortmund, Dortmund, Germany.

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http://ascopubs.org/doi/10.1200/JCO.2012.43.1825
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http://dx.doi.org/10.1200/JCO.2012.43.1825DOI Listing
September 2012

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

Clin Cancer Res 2011 Dec 26;17(23):7394-401. Epub 2011 Sep 26.

Max Planck Institute for Neurological Research, Klaus-Joachim-Zülch Laboratories of the Max Planck Society, Köln, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382103PMC
December 2011

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors.

Cancer Res 2011 Jul 25;71(14):4920-31. Epub 2011 May 25.

Departments of Medicine and Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138877PMC
July 2011

Cytohesins are cytoplasmic ErbB receptor activators.

Cell 2010 Oct;143(2):201-11

LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://hss.ulb.uni-bonn.de/2011/2583/2583a.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741001059
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http://dx.doi.org/10.1016/j.cell.2010.09.011DOI Listing
October 2010

Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling.

PLoS One 2010 Jan 27;5(1):e8919. Epub 2010 Jan 27.

Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, Max Planck Society, Köln, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008919PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811738PMC
January 2010

Systematically linking drug susceptibility to cancer genome aberrations.

Cell Cycle 2009 Nov 27;8(22):3652-6. Epub 2009 Nov 27.

Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, Köln, Germany.

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http://www.tandfonline.com/doi/abs/10.4161/cc.8.22.9936
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http://dx.doi.org/10.4161/cc.8.22.9936DOI Listing
November 2009

Standardized high-throughput evaluation of cell-based compound screens.

BMC Bioinformatics 2008 Nov 12;9:475. Epub 2008 Nov 12.

Institute of Medical Statistics, Informatics and Epidemiology, University of Köln, Köln, Germany.

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http://dx.doi.org/10.1186/1471-2105-9-475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639430PMC
November 2008

Somatic mutations affect key pathways in lung adenocarcinoma.

Nature 2008 Oct;455(7216):1069-75

The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1038/nature07423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694412PMC
October 2008

The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD.

Int J Cancer 2006 Oct;119(7):1738-40

Institute for Cell Biology (Tumor Research), University of Duisburg-Essen, Medical School, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.22010DOI Listing
October 2006

A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing.

Cancer Lett 2006 Aug 19;239(2):227-33. Epub 2005 Sep 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.08.007DOI Listing
August 2006

Genomic approaches to lung cancer.

Clin Cancer Res 2006 Jul;12(14 Pt 2):4384s-4391s

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-0098DOI Listing
July 2006

Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.

Clin Cancer Res 2005 Nov;11(22):8186-94

Molecular Tumor Biology and Tumor Immunology, Department I for Internal Medicine, Center for Molecular Medicine Cologne, University of Cologne, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0224DOI Listing
November 2005

Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine.

Blood 2005 Sep 24;106(6):2018-25. Epub 2005 May 24.

Molecular Tumor Biology and Tumor Immunology Clinic I for Internal Medicine, University of Cologne, Joseph-Stelzmann Str 9/Haus 16, 50931 Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2005-02-0642DOI Listing
September 2005

Problems and promises of targeted therapy for Hodgkin's lymphoma.

Nat Clin Pract Oncol 2005 Jan;2(1):2-3

The Burnham Institute, San Diego, CA, USA.

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http://dx.doi.org/10.1038/ncponc0073DOI Listing
January 2005