Roman Hajek

Roman Hajek

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Roman Hajek

Roman Hajek

Publications by authors named "Roman Hajek"

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Single agent daratumumab in advanced multiple myeloma possesses significant efficacy even in an unselected "real-world" population.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Nov 6. Epub 2018 Nov 6.

Department of Haematooncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Czech Republic.

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November 2018

Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma.

Front Immunol 2018 16;9:2431. Epub 2018 Nov 16.

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czechia.

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November 2018

HILIC/ESI-MS determination of gangliosides and other polar lipid classes in renal cell carcinoma and surrounding normal tissues.

Anal Bioanal Chem 2018 Oct 28;410(25):6585-6594. Epub 2018 Jul 28.

Faculty of Chemical Technology, Department of Analytical Chemistry, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.

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October 2018

The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma.

Anticancer Res 2018 Sep;38(9):5087-5092

Laboratory for Tumor Biology and Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Innsbruck Medical University, Innsbruck, Austria.

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September 2018

From open packing to negative wound pressure therapy: A critical overview of deep sternal wound infection treatment strategies after cardiac surgery.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Sep 14. Epub 2018 Sep 14.

Centre for Cardiovascular and Transplant Surgery, Brno, Czech Republic.

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September 2018

The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets.

PLoS One 2018 10;13(8):e0202045. Epub 2018 Aug 10.

Laboratory for Tumor Biology & Angiogenesis, Department of Internal Medicine V (Hematology and Medical Oncology), Medical University of Innsbruck, Innsbruck, Austria.

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August 2018

Venetoclax: A new wave in hematooncology.

Exp Hematol 2018 05 2;61:10-25. Epub 2018 Mar 2.

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.

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May 2018

The start of a new wave: Developments in proteasome inhibition in multiple myeloma.

Eur J Haematol 2018 Mar 30. Epub 2018 Mar 30.

University Hospital Ostrava, Ostrava, Czech Republic.

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March 2018

Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection.

Eur J Haematol 2017 Dec 10;99(6):469-478. Epub 2017 Oct 10.

Department of Clinical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.

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December 2017

PD-1/PD-L1 inhibitors in haematological malignancies: update 2017.

Immunology 2017 11 4;152(3):357-371. Epub 2017 Aug 4.

Department of Haemato-oncology, University Hospital Ostrava, Ostrava, Czech Republic.

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November 2017

Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Characterization of Gangliosides in Biological Samples.

Anal Chem 2017 Nov 3;89(22):12425-12432. Epub 2017 Nov 3.

Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice , Studentská 573, 53210 Pardubice, Czech Republic.

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November 2017

Deregulated expression of long non-coding RNA UCA1 in multiple myeloma.

Eur J Haematol 2017 Sep 29;99(3):223-233. Epub 2017 Jun 29.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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September 2017

High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma.

PLoS One 2017 20;12(7):e0181487. Epub 2017 Jul 20.

Department of Internal Medicine V (Hematology and Medical Oncology), Innsbruck Medical University, Anichstr. 35, Innsbruck, Austria.

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September 2017

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma.

Oncotarget 2017 Aug 21;8(34):56243-56254. Epub 2017 Apr 21.

Department of Internal Medicine V, Hematology and Medical Oncology, Innsbruck Medical University, Innsbruck, Austria.

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August 2017

Activity of aldehyde dehydrogenase in B-cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors.

Eur J Haematol 2017 Jan 9;98(1):19-25. Epub 2016 Jun 9.

Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.

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January 2017

Health-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.

J Clin Oncol 2016 11;34(32):3921-3930

A. Keith Stewart, Mayo Clinic, Scottsdale, AZ; Meletios A. Dimopoulos, Alexandra Hospital, Athens, Greece; Tamás Masszi, St. István and St. László Hospital, Semmelweis University, Budapest, Hungary; Ivan Špička, General University Hospital in Prague, Prague; Roman Hájek, University Hospital Brno and University of Ostrava, Brno, Czech Republic; Albert Oriol, Institut Català d'Oncologia, Institut Josep Carreras, Hospital Germans Trias i Pujol; Laura Rosiñol, Hospital Clínic de Barcelona, Barcelona; Jesus F. San-Miguel, Clinica Universidad de Navarra/El Centro de Investigacíon Médica Aplicada, Instituto de Investigacíon Sanitaria de Navarra, Pamplona, Spain; David S. Siegel, John Theurer Cancer Center at Hackensack University, Hackensack, NJ; Ruben Niesvizky, Weill Cornell Medical College, New York, NY; Andrzej J. Jakubowiak, University of Chicago Medicine, Chicago, IL; Heinz Ludwig, Wilhelminen Cancer Research Institute, Wilheminenspital, Vienna, Austria; Jacqui Buchanan, Xinqun Yang, Biao Xing, Naseem Zojwalla, and Margaret Tonda, Onyx Pharmaceuticals, South San Francisco, CA; Kim Cocks, KCStats Consultancy, Leeds, United Kingdom; Philippe Moreau, University of Nantes, Nantes, France; and Antonio Palumbo, University of Torino, Torino, Italy.

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November 2016

Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview.

Gene 2016 Oct 7;591(2):490-8. Epub 2016 Jun 7.

Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.

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October 2016

Cytogenetics in multiple myeloma patients progressing into extramedullary disease.

Eur J Haematol 2016 Jul 19;97(1):93-100. Epub 2015 Oct 19.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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July 2016

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma.

PLoS One 2015 21;10(9):e0137294. Epub 2015 Sep 21.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic; Department of Hematooncology, Faculty of Medicine University of Ostrava and University Hospital Ostrava, Ostrava, Czech Republic.

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May 2016

The effect of continuous elimination methods on the hemostatic profile of a cardiac surgery patient monitored using thromboelastography.

Int J Artif Organs 2016 May 15;39(3):106-13. Epub 2016 Apr 15.

Department of Biomedicine and Statistics, Faculty of Medicine and Dentistry, Palacky University, Olomouc - Czech Republic.

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May 2016

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma.

J Transl Med 2016 05 28;14(1):150. Epub 2016 May 28.

Department of Haematooncology, Faculty of Medicine, University of Ostrava, Dvořákova 7, 702 00, Ostrava, Czech Republic.

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May 2016

Monoclonal antibodies - A new era in the treatment of multiple myeloma.

Blood Rev 2016 Mar 24;30(2):101-10. Epub 2015 Aug 24.

Department of Hematooncology, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava, Czech Republic; Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic. Electronic address:

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March 2016

Hydrophilic interaction liquid chromatography-mass spectrometry of (lyso)phosphatidic acids, (lyso)phosphatidylserines and other lipid classes.

J Chromatogr A 2016 Mar 29;1439:65-73. Epub 2016 Jan 29.

Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Czech Republic. Electronic address:

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March 2016

Multicentered patient-based evidence of the role of free light chain ratio normalization in multiple myeloma disease relapse.

Eur J Haematol 2016 Feb 21;96(2):119-27. Epub 2015 Apr 21.

4th Department of Medicine - Hematology, Charles University Hospital and Faculty of Medicine Hradec, Králové, Czech Republic.

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February 2016

Centrosome amplification and clonal evolution in multiple myeloma: Short review.

Crit Rev Oncol Hematol 2016 Feb 2;98:116-21. Epub 2015 Nov 2.

Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.

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February 2016

Detection of tumor-specific marker for minimal residual disease in multiple myeloma patients.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Dec 23;159(4):554-61. Epub 2014 Jun 23.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic.

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December 2015

Continuous Therapy Versus Fixed Duration of Therapy in Patients With Newly Diagnosed Multiple Myeloma.

J Clin Oncol 2015 Oct 17;33(30):3459-66. Epub 2015 Aug 17.

Antonio Palumbo, Francesca Gay, Federica Cavallo, Alessandra Larocca, Francesca Donato, Chiara Cerrato, Luana Boccadifuoco, and Mario Boccadoro, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino; Giulia Benevolo, S.C. Ematologia A.O. Città della Salute e della Scienza di Torino; Tommasina Guglielmelli, University of Turin and San Luigi Hospital; Giovannino Ciccone, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino and CPO Piemonte, Torino; Francesco Di Raimondo, Ospedale Ferrarotto, Azienda Policlinico-OVE, University of Catania, Catania; Maria T. Petrucci, Sapienza University of Rome; Tommaso Caravita, Ematologia Ospedale S. Eugenio, Rome; Sara Pezzatti, Azienda Ospedaliera San Gerardo, Monza; Francesca Patriarca, DISM, University Hospital, Udine; Chiara Nozzoli, AOU Careggi, Florence; Donatella Vincelli, A.O "Bianchi-Melacrino-Morelli," Reggio Calabria; Pellegrino Musto, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Referral Cancer Center of Basilicata, Rionero in Vulture; Paolo Corradini, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Milano, Milano; Michele Cavo, Institute of Hematology and Medical Oncology "Seràgnoli," Bologna University School of Medicine S. Orsola's University Hospital, Bologna, Italy; Izhar Hardan, Meir Medical Center, Kfar-Saba; Arnon Nagler, Tel Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Roman Hajek, University Hospital Ostrava and University of Ostrava, Ostrava, Czech Republic; Michel Delforge, University Hospital Leuven, Leuven, Belgium; Zhinuan Yu and Christian Jacques, Celgene, Summit, NJ; and Meletios A. Dimopoulos, National and Kapodistrian University of Athens, School of Medicine, Alexandra Hospital, Athens, Greece.

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October 2015

MicroRNAs in urine are not biomarkers of multiple myeloma.

J Negat Results Biomed 2015 Sep 23;14:16. Epub 2015 Sep 23.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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September 2015

Plasma cell leukemia: from biology to treatment.

Eur J Haematol 2015 Jul 16;95(1):16-26. Epub 2015 Mar 16.

University Hospital Ostrava, Department of Haematooncology, Ostrava, Czech Republic.

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July 2015

Flow cytometry in immunoglobulin light chain amyloidosis: Short review.

Leuk Res 2015 Jul 13. Epub 2015 Jul 13.

Department of Haematooncology, University Hospital Ostrava and Faculty of Medicine OU, Ostrava, Czech Republic. Electronic address:

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July 2015

The miR-29 family in hematological malignancies.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Jun 4;159(2):184-91. Epub 2014 Jul 4.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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June 2015

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Jun 16;159(2):288-93. Epub 2015 Apr 16.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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June 2015

Analysis of B-cell subpopulations in monoclonal gammopathies.

Clin Lymphoma Myeloma Leuk 2015 Apr 12;15(4):e61-71. Epub 2014 Dec 12.

Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic; Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic.

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April 2015

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia.

Am J Hematol 2015 Mar 16;90(3):E51-2. Epub 2015 Jan 16.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic.

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March 2015

Shared structural features of the 9aaTAD family in complex with CBP.

Mol Biosyst 2015 Mar 7;11(3):844-51. Epub 2015 Jan 7.

Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic.

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March 2015

European perspective on multiple myeloma treatment strategies in 2014.

Oncologist 2014 Aug 25;19(8):829-44. Epub 2014 Jul 25.

Department of Oncology, Hematology and Palliative Care, Wilhelminenspital, Vienna, Austria; Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands; Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom; Department of Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain; Divisione di Ematologia dell'Università di Torino, Azienda Ospedaliera S. Giovanni Battista, Ospedale Molinette, Turin, Italy; Institute of Hematology and Medical Oncology, Seragnoli, Bologna, Italy; Haemato-Oncology Unit, Royal Marsden Hospital, Surrey, United Kingdom; Hematology Service, University Hospital La Fe, Valencia, Spain; Department of Hematology, University Hospital, Leuven, Belgium; Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece; Universitätsklinik Würzburg, Medizinische Klinik und Poliklinik II, Würzburg, Germany; Service d'Hématologie, Centre Hospitalier Universitaire, Lille, France; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany; University Hospital, Nantes, France; Karolinska Institute, Stockholm, Sweden; Department of Hematology, Center Lillebaelt, University of Southern Denmark, Odense, Denmark; Clinica Universidad de Navarra, Centro Investigaciones Medicas Aplicada, Pamplona, Spain; Department of Hemato-oncology, University of Ostrava, Ostrava, Czech Republic; University of Giessen, Giessen, Germany.

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August 2014

Flow cytometry-based enumeration and functional characterization of CD8 T regulatory cells in patients with multiple myeloma before and after lenalidomide plus dexamethasone treatment.

Cytometry B Clin Cytom 2014 Jul 6;86(4):220-8. Epub 2013 Aug 6.

Department of Pathological Physiology, Babak Myeloma Group, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

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July 2014

Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma.

J Cell Mol Med 2014 Jun 8;18(6):947-61. Epub 2014 Apr 8.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic.

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June 2014

Nestin expression throughout multistep pathogenesis of multiple myeloma.

Br J Haematol 2014 Mar 16;164(5):701-9. Epub 2013 Dec 16.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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March 2014

High-risk multiple myeloma: different definitions, different outcomes?

Clin Lymphoma Myeloma Leuk 2014 Feb 28;14(1):24-30. Epub 2013 Sep 28.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Clinical Hematology, University Hospital Brno, Czech Republic. Electronic address:

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February 2014

International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation.

J Clin Oncol 2014 Feb 13;32(6):587-600. Epub 2014 Jan 13.

Antonio Palumbo and Alessandra Larocca, University of Torino, Torino; Michele Cavo, Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy; S. Vincent Rajkumar, Mayo Clinic, Rochester, MN; Jesus F. San Miguel, University Hospital of Salamanca, Salamanca, Spain; Ruben Niesvizky, Weill Cornell Medical College, New York, NY; Gareth Morgan, Royal Marsden Hospital, London, United Kingdom; Ola Landgren, National Cancer Institute, Bethesda, MD; Roman Hajek, University of Ostrava School of Medicine and University Hospital Ostrava, Ostrava, Czech Republic; Hermann Einsele, University of Wurzburg, Wurzburg, Germany; Kenneth C. Anderson and Paul G. Richardson, Dana-Farber Cancer Institute, Boston, MA; Meletios A. Dimopoulos, University of Athens School of Medicine, Athens, Greece; Andrew Spencer, Alfred Hospital, Melbourne, Victoria, Australia; A. Keith Stewart, Mayo Clinic, Scottsdale, AZ; Kazuyuki Shimizu, Aichi Gakuin Hospital, Nagoya, Japan; Sagar Lonial, Emory University, Atlanta, GA; Pieter Sonneveld, Erasmus Medical Centre, Rotterdam, the Netherlands; Brian G.M. Durie, Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA; Philippe Moreau, University Hospital, Nantes, France; and Robert Z. Orlowski, MD Anderson Cancer Center, Houston, TX.

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February 2014

The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma.

Leuk Lymphoma 2014 Jan 12;55(1):11-8. Epub 2013 Jun 12.

Faculty of Medicine, University of Ostrava and University Hospital Ostrava, Ostrava, Czech Republic.

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January 2014

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma.

Br J Haematol 2013 Dec 20;163(5):551-64. Epub 2013 Sep 20.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Haemato-oncology, University Hospital Ostrava, Ostrava, Czech Republic; Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.

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December 2013

Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia.

Genomics 2013 Oct 3;102(4):243-9. Epub 2013 Jul 3.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address:

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October 2013

Contribution of regulatory T cells to immunosuppression and disease progression in multiple myeloma patients.

Oncoimmunology 2013 Sep 9;2(9):e25619. Epub 2013 Jul 9.

Babak Myeloma Group; Department of Pathological Physiology; Faculty of Medicine; Masaryk University; Brno, Czech Republic.

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September 2013

Flow cytometry based enumeration and functional characterization of CD8 T regulatory cells in patients with multiple myeloma before and after lenalidomide plus dexamethasone treatment.

Cytometry B Clin Cytom 2013 Jul 3. Epub 2013 Jul 3.

Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

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July 2013