Publications by authors named "Roman Fischer"

99Publications

Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas.

Biochem Biophys Res Commun 2020 Sep 27. Epub 2020 Sep 27.

Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2020.09.081DOI Listing
September 2020

Assessment of different screening methods for selecting palaeontological bone samples for peptide sequencing.

J Proteomics 2020 Sep 14;230:103986. Epub 2020 Sep 14.

Department of Mammalogy, American Museum of Natural History, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2020.103986DOI Listing
September 2020

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis.

Clin Proteomics 2020 17;17:31. Epub 2020 Aug 17.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12014-020-09294-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433176PMC
August 2020

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.

Neurobiol Dis 2020 Oct 13;144:105050. Epub 2020 Aug 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom; Lead Contact. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2020.105050DOI Listing
October 2020

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.

Cell Metab 2020 Sep 12;32(3):468-478.e7. Epub 2020 Aug 12.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2020.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422798PMC
September 2020

Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300.

Proc Natl Acad Sci U S A 2020 08 5;117(34):20753-20763. Epub 2020 Aug 5.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2004281117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456151PMC
August 2020

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach.

Front Cell Dev Biol 2020 26;8:401. Epub 2020 May 26.

Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2020.00401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264106PMC
May 2020

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development.

Oxid Med Cell Longev 2020 12;2020:7191080. Epub 2020 May 12.

Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7191080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240663PMC
May 2020

MaxQuant Software for Ion Mobility Enhanced Shotgun Proteomics.

Mol Cell Proteomics 2020 06 10;19(6):1058-1069. Epub 2020 Mar 10.

Computational Systems Biochemistry Research Group, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.TIR119.001720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261821PMC
June 2020

Characterization of exosomes in peritoneal fluid of endometriosis patients.

Fertil Steril 2020 02;113(2):364-373.e2

Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2019.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057257PMC
February 2020

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein.

Front Pharmacol 2019 18;10:1490. Epub 2019 Dec 18.

Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.01490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930692PMC
December 2019

BMP signaling inhibition in secondary cells remodels the seminal proteome and self and rival ejaculate functions.

Proc Natl Acad Sci U S A 2019 12 18;116(49):24719-24728. Epub 2019 Nov 18.

Edward Grey Institute, Department of Zoology, University of Oxford, OX1 3PS Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1914491116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900634PMC
December 2019

Mechanism of Signalling and Adaptation through the Cytoplasmic Chemoreceptor Cluster.

Int J Mol Sci 2019 Oct 14;20(20). Epub 2019 Oct 14.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20205095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829392PMC
October 2019

Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases.

Am J Physiol Gastrointest Liver Physiol 2019 11 23;317(5):G625-G639. Epub 2019 Sep 23.

Cancer Research United Kingdom/Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00014.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879896PMC
November 2019

Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis.

Exp Neurol 2020 01 6;323:113061. Epub 2019 Sep 6.

Department of Biology, Drexel University, Papadakis Integrated Science Building, Philadelphia, PA 19104, United States of America. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.113061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961843PMC
January 2020

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Front Immunol 2019 19;10:1495. Epub 2019 Jul 19.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659470PMC
October 2020

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

Nat Commun 2019 07 17;10(1):3142. Epub 2019 Jul 17.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford, OX3 7DQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-11095-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637133PMC
July 2019

Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain.

J Proteome Res 2019 04 25;18(4):1787-1795. Epub 2019 Feb 25.

Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Roosevelt Drive , Oxford , OX3 7FZ , U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.8b00981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456870PMC
April 2019

Detailed Assessment of Incontinence, Psychological Problems and Parental Stress in Children with Autism Spectrum Disorder.

J Autism Dev Disord 2019 May;49(5):1966-1975

Department of Child and Adolescent Psychiatry, Saarland University Hospital, 66421, Homburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10803-019-03885-6DOI Listing
May 2019

Tumor necrosis factor receptor 1 inhibition is therapeutic for neuropathic pain in males but not in females.

Pain 2019 Apr;160(4):922-931

Department of Biology, Drexel University, Philadelphia, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001470DOI Listing
April 2019

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Proteomics 2018 12 10;18(24):e1800257. Epub 2018 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pmic.201800257
Publisher Site
http://dx.doi.org/10.1002/pmic.201800257DOI Listing
December 2018

Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion.

Nat Commun 2018 11 8;9(1):4685. Epub 2018 Nov 8.

MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-07024-0
Publisher Site
http://dx.doi.org/10.1038/s41467-018-07024-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224562PMC
November 2018

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Cell Rep 2018 09;24(13):3404-3412

Cancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.08.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172692PMC
September 2018

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.

Sci Rep 2018 09 25;8(1):14310. Epub 2018 Sep 25.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-32481-4
Publisher Site
http://dx.doi.org/10.1038/s41598-018-32481-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156325PMC
September 2018

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Nat Commun 2018 09 18;9(1):3798. Epub 2018 Sep 18.

Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-06235-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143588PMC
September 2018

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Proc Natl Acad Sci U S A 2018 09 27;115(37):E8668-E8677. Epub 2018 Aug 27.

Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Headington, OX3 7DQ Oxford, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1810498115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140509PMC
September 2018

Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome.

Neurology 2018 08 25;91(8):e714-e723. Epub 2018 Jul 25.

From the Oxford Autoimmune Neurology Group (G.B., D.A.M., T.M., P.J.W., I.W., S.T., M.P., A.V., S.R.I., B.L.), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford; Target Discovery Institute (G.B., R.F., B.K.), NDM Research Building, University of Oxford, Old Road Campus, Oxford; Paediatric Neurosciences Research Group (S.Z.), School of Medicine, University of Glasgow; Division of Structural Biology (A.R.A.), Nuffield Department of Clinical Medicine, University of Oxford, UK; Clinical Neuroimmunology (R.C.D.), Institute for Neuroscience and Muscle Research, University of Sydney, Australia; Children's Neuroscience Centre (M.L.), Evelina London Children's Hospital at St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Science Centre, London; and Faculty of Medicine and Life Sciences (M.L.), King's College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107266PMC
August 2018

A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Nat Commun 2018 07 11;9(1):2685. Epub 2018 Jul 11.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, OX3 7DQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-04849-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041281PMC
July 2018

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Lancet Oncol 2018 07 13;19(7):930-939. Epub 2018 Jun 13.

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(18)30294-8DOI Listing
July 2018

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Diabetes 2018 06 2;67(6):1057-1067. Epub 2018 Apr 2.

Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Oxford, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-1195DOI Listing
June 2018

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

Biochem Pharmacol 2018 07 31;153:292-298. Epub 2018 Jan 31.

Center for Inflammation Research, VIB, Unit of Molecular Signal Transduction in Inflammation, Technologiepark 927, Zwijnaarde, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde, Ghent 9052, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2018.01.039DOI Listing
July 2018

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

EMBO Rep 2018 03 18;19(3). Epub 2018 Jan 18.

Department of Oncology, Cancer Research UK and Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK

View Article

Download full-text PDF

Source
http://embor.embopress.org/lookup/doi/10.15252/embr.20174479
Publisher Site
http://dx.doi.org/10.15252/embr.201744799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836097PMC
March 2018

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Ann Neurol 2018 02 9;83(2):258-268. Epub 2018 Feb 9.

Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25143DOI Listing
February 2018

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells.

Nucleic Acids Res 2017 Sep;45(17):10042-10055

CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, Oxford OX37DQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkx635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622344PMC
September 2017

Inflammatory Stroke Extracellular Vesicles Induce Macrophage Activation.

Stroke 2017 08 23;48(8):2292-2296. Epub 2017 May 23.

From the Acute Stroke Programme, Radcliffe Department of Medicine, John Radcliffe Hospital (Y.C., A.A.N., A.M.B.), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital (N.A.), Target Discovery Institute, Nuffield Department of Medicine (S.D., R.F.), and Centre for Prevention of Stroke and Dementia, John Radcliffe Hospital, Nuffield Department of Clinical Neurosciences (P.M.R., A.I.B.), University of Oxford, United Kingdom; and Turku Centre for Biotechnology, University of Turku, Biocity, Finland (A.M.D.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.117.017236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531255PMC
August 2017

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.

J Proteome Res 2017 03 22;16(3):1288-1299. Epub 2017 Feb 22.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.6b00915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363888PMC
March 2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Free Radic Biol Med 2017 03 17;104:214-225. Epub 2017 Jan 17.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338462PMC
March 2017

PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.

DNA Repair (Amst) 2017 02 31;50:22-35. Epub 2016 Dec 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264654PMC
February 2017

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Mol Cell 2016 11 27;64(4):704-719. Epub 2016 Oct 27.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128727PMC
November 2016

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.

Proc Natl Acad Sci U S A 2016 10 10;113(43):12304-12309. Epub 2016 Oct 10.

Department of Molecular Neurobiology, Groningen Institute of Evolutionary Life Sciences, Faculty of Mathematics and Natural Sciences, University of Groningen, NL-9700 CC Groningen, The Netherlands; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1605195113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087045PMC
October 2016

Plasma degradome affected by variable storage of human blood.

Clin Proteomics 2016 26;13:26. Epub 2016 Sep 26.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12014-016-9126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037888PMC
September 2016

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

Sci Rep 2016 Apr 15;6:24491. Epub 2016 Apr 15.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep24491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832251PMC
April 2016