Publications by authors named "Roman Chrast"

68Publications

Metabolic Interaction Between Schwann Cells and Axons Under Physiological and Disease Conditions.

Front Cell Neurosci 2020 29;14:148. Epub 2020 May 29.

Department of Neuroscience, KarolinskaInstitutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2020.00148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274022PMC
May 2020

Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration.

Cell Rep 2019 06;27(11):3152-3166.e7

Department of Biology, University of Fribourg, Fribourg, Switzerland; Department of Biology, Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.05.060DOI Listing
June 2019

Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C.

Int J Mol Sci 2018 Dec 17;19(12). Epub 2018 Dec 17.

John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19124072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320960PMC
December 2018

Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.

J Physiol 2019 02 26;597(3):889-901. Epub 2018 Dec 26.

Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1113/JP276919
Publisher Site
http://dx.doi.org/10.1113/JP276919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355634PMC
February 2019

Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.

FASEB J 2019 01 20;33(1):652-667. Epub 2018 Jul 20.

Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201800361RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355067PMC
January 2019

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

Cell Death Dis 2018 02 28;9(3):333. Epub 2018 Feb 28.

Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-017-0125-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832431PMC
February 2018

Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.

Arterioscler Thromb Vasc Biol 2018 02 7;38(2):324-334. Epub 2017 Dec 7.

From the Department of Microbiology and Immunology (A.E.V., C.M.R.B., M.D.W.), Department of Pathology and Translational Pathobiology (J.M.G., B.H.P., A.W.O.), Department of Cell Biology and Anatomy (A.C.F.), Feist-Weiller Cancer Center (D.T.C.), and Pharmacology, Toxicology, and Neuroscience (R.L.K.), Louisiana State University Health Sciences Center, Shreveport; Department of Pharmacology, University of California San Diego, La Jolla (A.R.N.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (R.C.); and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO (B.N.F.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.117.310455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785462PMC
February 2018

Charcot-Marie-Tooth Disease type 4C: Novel mutations, clinical presentations, and diagnostic challenges.

Muscle Nerve 2018 05 24;57(5):749-755. Epub 2017 Oct 24.

Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive Iowa City, Iowa, 52242, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.25981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886823PMC
May 2018

Oligodendroglial myelination requires astrocyte-derived lipids.

PLoS Biol 2017 05 26;15(5):e1002605. Epub 2017 May 26.

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.1002605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446120PMC
May 2017

The Role of Peripheral Myelin Protein 2 in Remyelination.

Cell Mol Neurobiol 2018 Mar 26;38(2):487-496. Epub 2017 Apr 26.

Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10571-017-0494-0DOI Listing
March 2018

Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.

Sci Rep 2016 09 26;6:34117. Epub 2016 Sep 26.

Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036185PMC
http://dx.doi.org/10.1038/srep34117DOI Listing
September 2016

Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS.

J Neurosci 2016 Apr;36(16):4506-21

Neuroscience Institute and Departments of Neuroscience and Physiology and Neurology, New York University-Langone Medical Center, New York, New York 10016,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3521-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837684PMC
April 2016

Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.

Hum Mol Genet 2015 Oct 17;24(20):5677-86. Epub 2015 Jul 17.

Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain, CRG CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Catalonia 08003, Spain, Dexeus Women's Health, University Hospital Quiron-Dexeus, Barcelona, Catalonia 08028, Spain

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddv281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692992PMC
October 2015

Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.

J Physiol 2015 Oct 18;593(19):4373-86. Epub 2015 Aug 18.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/JP270701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594240PMC
October 2015

Reply: Is SIGMAR1 a confirmed FTD/MND gene?

Brain 2015 Nov 18;138(Pt 11):e394. Epub 2015 Jun 18.

4 Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden

View Article

Download full-text PDF

Source
https://academic.oup.com/brain/article-lookup/doi/10.1093/br
Publisher Site
http://dx.doi.org/10.1093/brain/awv174DOI Listing
November 2015

Loss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies.

Brain 2015 Aug 13;138(Pt 8):2161-72. Epub 2015 Jun 13.

2 Neurogenetics Group, VIB-Department of Molecular Genetics, University of Antwerp, Antwerpen 2610, Belgium 3 Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerpen 2610, Belgium 16 Department of Neurology, Antwerp University Hospital, Antwerpen 2610, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840952PMC
August 2015

In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath.

Mitochondrion 2015 Jul 29;23:32-41. Epub 2015 May 29.

INSERM U1051, Institut des Neurosciences de Montpellier, Université de Montpellier, Montpellier 34091, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2015.05.004DOI Listing
July 2015

Sox4 participates in the modulation of Schwann cell myelination.

Eur J Neurosci 2015 Jul 19;42(2):1788-96. Epub 2015 May 19.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.12929DOI Listing
July 2015

Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.

PLoS Genet 2015 Apr 10;11(4):e1005115. Epub 2015 Apr 10.

Program in Rare and Genetic Diseases and IBV/CSIC Associated Unit, Centro de Investigación Príncipe Felipe, Valencia, Spain; CIBER de Enfermedades Raras (CIBERER), ISCIII, Valencia and Madrid, Spain; University of Castilla-La Mancha School of Medicine at Ciudad Real, Ciudad Real, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393229PMC
April 2015

Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.

J Neurosci 2015 Mar;35(10):4151-6

Departments of Medical Genetics and Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3534-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605293PMC
March 2015

Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration.

Brain 2015 Apr 11;138(Pt 4):875-90. Epub 2015 Feb 11.

1 Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland 4 Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv008DOI Listing
April 2015

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells.

Glia 2014 Sep 21;62(9):1502-12. Epub 2014 May 21.

Department of Medical Genetics, University of Lausanne, Switzerland; Graduate Program in Neurosciences, University of Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.22696DOI Listing
September 2014

Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.

Front Cell Neurosci 2013 25;7:228. Epub 2013 Nov 25.

Department of Medical Genetics, University of Lausanne Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2013.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839048PMC
December 2013

Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.

Hepatology 2013 Dec 17;58(6):1953-63. Epub 2013 Oct 17.

Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835749PMC
December 2013

Novel pathogenic pathways in diabetic neuropathy.

Trends Neurosci 2013 Aug 29;36(8):439-49. Epub 2013 May 29.

Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2013.04.008DOI Listing
August 2013

Sh3tc2 deficiency affects neuregulin-1/ErbB signaling.

Glia 2013 Jul 2;61(7):1041-51. Epub 2013 Apr 2.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.22493DOI Listing
July 2013

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Proc Natl Acad Sci U S A 2013 Jan 24;110(2):642-7. Epub 2012 Dec 24.

Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1213493110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545773PMC
January 2013

Epineurial adipocytes are dispensable for Schwann cell myelination.

J Neurochem 2012 Dec 10;123(5):662-7. Epub 2012 Oct 10.

Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2012.07896.xDOI Listing
December 2012

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models.

J Lipid Res 2011 Mar 9;52(3):419-34. Epub 2010 Nov 9.

Department of Medical Genetics, University of Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.R009761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035679PMC
March 2011

PPARgamma in placental angiogenesis.

Endocrinology 2010 Oct 1;151(10):4969-81. Epub 2010 Sep 1.

Center for Integrative Genomics, Department of Medical Genetics and Electron Microscopy Platform, University of Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2010-0131DOI Listing
October 2010

Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.

Brain 2010 May;133(Pt 5):1460-9

Department of Cell Biology, University of Geneva, 30 quai Ernest-Ansermet, 1211 Genève 4, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awq082DOI Listing
May 2010

SCAP is required for timely and proper myelin membrane synthesis.

Proc Natl Acad Sci U S A 2009 Dec 30;106(50):21383-8. Epub 2009 Nov 30.

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0905633106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795508PMC
December 2009

Generation and phenotypic analysis of protein S-deficient mice.

Blood 2009 Sep 30;114(11):2307-14. Epub 2009 Jun 30.

Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-03-209031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745849PMC
September 2009

Complement factors in adult peripheral nerve: a potential role in energy metabolism.

Neurochem Int 2004 Jul-Aug;45(2-3):353-9

Molecular Neurobiology Laboratory, The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2003.09.011DOI Listing
July 2004

Local regulation of fat metabolism in peripheral nerves.

Genes Dev 2003 Oct;17(19):2450-64

Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1116203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218081PMC
October 2003

Refined localization of dominant intermediate Charcot-Marie-Tooth neuropathy and exclusion of seven known candidate genes in the region.

Neurogenetics 2003 Aug 22;4(4):179-83. Epub 2003 May 22.

Neurobiology Laboratory, ANZAC Research Institute, Concord Hospital, New South Wales, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10048-003-0147-yDOI Listing
August 2003