Rolf Kaiser

Rolf Kaiser

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Rolf Kaiser

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Defining aggressive or early progressing nononcogene-addicted non-small-cell lung cancer: a separate disease entity?

Future Oncol 2019 Apr 13;15(12):1363-1383. Epub 2019 Feb 13.

Boehringer Ingelheim Pharma GmbH & Co, KG, Germany & Institute of Pharmacology, Johannes Gutenberg-University Mainz, Germany.

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http://dx.doi.org/10.2217/fon-2018-0948DOI Listing
April 2019

A pan-genotypic Hepatitis C Virus NS5A amplification method for reliable genotyping and resistance testing.

J Clin Virol 2019 04 30;113:8-13. Epub 2019 Jan 30.

Institute of Virology, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193002
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http://dx.doi.org/10.1016/j.jcv.2019.01.012DOI Listing
April 2019

State of the Art in HIV Drug Resistance: Surveillance and Regional Gaps.

AIDS Rev 2018 Jan-Mar;20(1):43-57

KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Leuven, Belgium.

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October 2018

State of the Art in HIV Drug Resistance: Science and Technology Knowledge Gap.

AIDS Rev 2018 Jan-Mar;20(1):27-42

KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Leuven, Belgium.

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October 2018

Performance Evaluation of a Genotypic Tropism Test Using HIV-1 CRF01_AE Isolates in Japan.

Jpn J Infect Dis 2018 Jul 27;71(4):264-266. Epub 2018 Apr 27.

Molecular Virology, Department Biomedicine - Petersplatz, University of Basel.

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http://dx.doi.org/10.7883/yoken.JJID.2017.482DOI Listing
July 2018

geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data.

Nucleic Acids Res 2018 07;46(W1):W271-W277

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gky349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031006PMC
July 2018

Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations.

J Chem Theory Comput 2018 Jul 21;14(7):3397-3408. Epub 2018 Jun 21.

Department for Computational Biology and Applied Algorithmics , Max Planck Institute for Informatics , D-66123 Saarbrücken , Germany.

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http://dx.doi.org/10.1021/acs.jctc.7b01109DOI Listing
July 2018

Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms.

Genes (Basel) 2018 Jul 6;9(7). Epub 2018 Jul 6.

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.3390/genes9070343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071292PMC
July 2018

A phase I study of nintedanib combined with cisplatin/gemcitabine as first-line therapy for advanced squamous non-small cell lung cancer (LUME-Lung 3).

Lung Cancer 2018 06 9;120:27-33. Epub 2018 Mar 9.

Department of Oncology, University College London Cancer Institute, London, UK; University College London Hospitals NHS Foundation Trust, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183029
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http://dx.doi.org/10.1016/j.lungcan.2018.03.007DOI Listing
June 2018

Using drug exposure for predicting drug resistance - A data-driven genotypic interpretation tool.

PLoS One 2017 10;12(4):e0174992. Epub 2017 Apr 10.

Department of Computational Biology and Applied Algorithmics, Max-Planck-Institut für Informatik, Saarbrücken, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174992PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386274PMC
August 2017

Results of the first international HIV-1 coreceptor proficiency panel test.

J Clin Virol 2017 08 10;93:53-56. Epub 2017 Jun 10.

Institute of Virology, University of Cologne, 50935 Cologne, Germany.

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http://dx.doi.org/10.1016/j.jcv.2017.06.002DOI Listing
August 2017

Efficacy and Safety of Nintedanib Plus Docetaxel in Patients with Advanced Lung Adenocarcinoma: Complementary and Exploratory Analyses of the Phase III LUME-Lung 1 Study.

Target Oncol 2017 08;12(4):475-485

Department of Thoracic Oncology, LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), 22927, Grosshansdorf, Germany.

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http://dx.doi.org/10.1007/s11523-017-0517-2DOI Listing
August 2017

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.

PLoS One 2016 19;11(5):e0155869. Epub 2016 May 19.

German Center for Infection Research (DZIF)-Saarbrücken Partner Site, Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123, Saarbrücken, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155869PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873220PMC
July 2017

A genotype independent, full-genome reverse-transcription protocol for HCV genotyping and resistance testing.

J Clin Virol 2017 06 10;91:42-48. Epub 2017 Apr 10.

Institute of Virology, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2017.04.008DOI Listing
June 2017

Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure.

Virol J 2017 06 8;14(1):106. Epub 2017 Jun 8.

Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/s12985-017-0779-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465446PMC
June 2017

Determination of Phenotypic Resistance Cutoffs From Routine Clinical Data.

J Acquir Immune Defic Syndr 2017 04;74(5):e129-e137

*Department of Computational Biology and Applied Algorithmics, Max-Planck-Institut für Informatik, Saarbrücken, Germany; †Medizinisches Infektiologiezentrum Berlin, Berlin, Germany; ‡Medizinisches Labor Stendal, Stendal, Germany; §Institute for Virology, University Clinic of Cologne, Germany; ‖Institute of Virology, University of Düsseldorf, Germany; and ¶Clinic of Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1097/QAI.0000000000001198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351752PMC
April 2017

HCV Resistance Profile Evolution in a GT1b, DAA-Naive Patient Before, On, and After Failing Triple DAA Therapy.

Clin Gastroenterol Hepatol 2017 02 23;15(2):307-309. Epub 2016 Sep 23.

German Center for Infection Research, partner site Köln-Bonn, Institute of Virology, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.09.139DOI Listing
February 2017

Development of a phenotypic susceptibility assay for HIV-1 integrase inhibitors.

J Virol Methods 2016 12 11;238:29-37. Epub 2016 Oct 11.

Institute of Virology, University of Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.10.002DOI Listing
December 2016

A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology 2016 Dec 20;13(1):85. Epub 2016 Dec 20.

Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, Campus E 1 4, 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1186/s12977-016-0320-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168878PMC
December 2016

Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

Antivir Ther 2015 5;20(8):779-87. Epub 2015 Jan 5.

Institute of Medical Virology, Justus Liebig University Giessen, National Reference Center for Hepatitis B and D Viruses, Biomedical Research Center Seltersberg, Giessen, Germany.

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http://dx.doi.org/10.3851/IMP2928DOI Listing
November 2016

Pharmacokinetic Properties of Nintedanib in Healthy Volunteers and Patients With Advanced Cancer.

J Clin Pharmacol 2016 11;56(11):1387-1394

Boehringer Ingelheim Pharma GmbH & Co KG, Translational Medicine and Clinical Pharmacology, Biberach an der Riß, Germany.

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http://dx.doi.org/10.1002/jcph.752DOI Listing
November 2016

New findings in HCV genotype distribution in selected West European, Russian and Israeli regions.

J Clin Virol 2016 08 24;81:82-9. Epub 2016 May 24.

Cologne-Bonn DZIF Partner Site, Institute of Virology, University of Cologne, 50935 Cologne, Germany.

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http://dx.doi.org/10.1016/j.jcv.2016.05.010DOI Listing
August 2016

Genotypic resistance testing of HCV - is there a clinical need?

GMS Infect Dis 2016 4;4:Doc05. Epub 2016 Aug 4.

Institute for Virology, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany.

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http://dx.doi.org/10.3205/id000023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301723PMC
August 2016

Proviral DNA as a Target for HIV-1 Resistance Analysis.

Intervirology 2015 27;58(3):184-9. Epub 2015 Jun 27.

Institute of Virology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000431093DOI Listing
June 2016

Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C.

Sci Rep 2016 04 29;6:24883. Epub 2016 Apr 29.

Department of Bioinformatics, Straubing Center of Science, University of Applied Sciences Weihenstephan-Triesdorf, Straubing, Germany.

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http://dx.doi.org/10.1038/srep24883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850382PMC
April 2016

Longitudinal comparison of HIV-1 plasma viral load and cellular proviral load.

J Int AIDS Soc 2014 2;17(4 Suppl 3):19669. Epub 2014 Nov 2.

Institute of Virology, University of Köln, Köln, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225422PMC
http://dx.doi.org/10.7448/IAS.17.4.19669DOI Listing
January 2016

Improved therapy-success prediction with GSS estimated from clinical HIV-1 sequences.

J Int AIDS Soc 2014 2;17(4 Suppl 3):19743. Epub 2014 Nov 2.

Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrücken, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225326PMC
http://dx.doi.org/10.7448/IAS.17.4.19743DOI Listing
January 2016

Time on drug analysis based on real life data.

J Int AIDS Soc 2014 2;17(4 Suppl 3):19790. Epub 2014 Nov 2.

Institute of Virology, University of Duisburg-Essen, Essen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225363PMC
http://dx.doi.org/10.7448/IAS.17.4.19790DOI Listing
January 2016

Phase I study of nintedanib in combination with pemetrexed as second-line treatment of Japanese patients with advanced non-small cell lung cancer.

Cancer Chemother Pharmacol 2015 Dec 11;76(6):1225-33. Epub 2015 Nov 11.

Department of Medical Oncology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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http://dx.doi.org/10.1007/s00280-015-2896-3DOI Listing
December 2015

Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis.

Future Oncol 2015 5;11(3):409-20. Epub 2014 Dec 5.

Department of Medicine (Lung), Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

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http://dx.doi.org/10.2217/fon.14.290DOI Listing
November 2015

Erratum to "Detection and characterization of enteroviruses and parechoviruses in healthy people living in the South of Côte d'Ivoire" [J. Clin. Virol. 71 (2015) 40-43].

J Clin Virol 2015 Nov 21;72:153. Epub 2015 Oct 21.

Centre Don Orione Pour Handicapés Physiques, Bonoua, Côte d'Ivoire; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1016/j.jcv.2015.10.005DOI Listing
November 2015

Acute epididymitis revisited: impact of molecular diagnostics on etiology and contemporary guideline recommendations.

Eur Urol 2015 Sep 24;68(3):428-35. Epub 2014 Dec 24.

Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1016/j.eururo.2014.12.005DOI Listing
September 2015

[Not Available].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2015 Sep;58(9):1025

Nationales Referenzzentrum für Retroviren, Universitätsklinikum Frankfurt, Frankfurt, Deutschland.

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http://dx.doi.org/10.1007/s00103-015-2214-6DOI Listing
September 2015

HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey.

Med Microbiol Immunol 2015 Aug 28;204(4):551-5. Epub 2015 Apr 28.

Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00430-015-0419-9DOI Listing
August 2015

CytoSorb, a novel therapeutic approach for patients with septic shock: a case report.

Int J Artif Organs 2015 Aug 31;38(8):461-4. Epub 2015 Aug 31.

Department of Internal Medicine and Intensive Care Medicine, KMG Clinic Güstrow, Güstrow - Germany.

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http://dx.doi.org/10.5301/ijao.5000429DOI Listing
August 2015

Determination of drug resistance and virus typology in HIV-1-positive pediatric patients in Istanbul, Turkey.

Intervirology 2014 28;57(5):297-9. Epub 2014 Jun 28.

Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.1159/000362335DOI Listing
April 2015

Hepatitis B virus drug resistance tools: one sequence, two predictions.

Intervirology 2014 15;57(3-4):232-6. Epub 2014 Jul 15.

Institute of Virology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000361076DOI Listing
April 2015

Effects of sequence alterations on results from genotypic tropism testing.

J Clin Virol 2015 Apr 10;65:68-73. Epub 2015 Feb 10.

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E 14, 66123 Saarbrücken,Germany.

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http://dx.doi.org/10.1016/j.jcv.2015.02.006DOI Listing
April 2015

Inferring short-range linkage information from sequencing chromatograms.

PLoS One 2013 20;8(12):e81687. Epub 2013 Dec 20.

Department of Computational Biology and Applied Algorithms, Max Planck Institute for Informatics, Saarbrücken, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081687PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869653PMC
March 2015

Tolerability of nintedanib (BIBF 1120) in combination with docetaxel: a phase 1 study in Japanese patients with previously treated non-small-cell lung cancer.

J Thorac Oncol 2015 Feb;10(2):346-52

*Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka, Japan; †Center for Clinical and Translational Research, Faculty of Medicine, Kyusyu University Hospital, Fukuoka, Japan; ‡Department of Internal Medicine, Suita Municipal Hospital, Osaka, Japan; §Department of Medical Oncology, Nara Hospital, Kinki University Faculty of Medicine, Nara, Japan; ║Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University Hospital, Fukuoka, Japan; ¶Department of Medical Oncology, Kishiwada Municipal Hospital, Osaka, Japan; #Department of Thoracic Oncology, Kansai Medical University, Hirakata Hospital, Osaka, Japan; **Department of Medical Oncology, National Kyushu Cancer Centre, Fukuoka, Japan; ††Department of Medical Oncology, National Kyushu Cancer Centre, Fukuoka, Japan; ‡‡Nippon Boehringer Ingelheim Co. Ltd., Medical Development Division, Hyogo, Japan; and §§Clinical Pharmacokinetics/Pharmacodynamics Department, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000395DOI Listing
February 2015

Nintedanib: from discovery to the clinic.

J Med Chem 2015 Feb 14;58(3):1053-63. Epub 2015 Jan 14.

Department of Medicinal Chemistry; §Department of Drug Metabolism and Pharmacokinetics; ‡Department of Non-Clinical Drug Safety; ∥Department of Translational Medicine and Clinical Pharmacology; ⊥Department of Respiratory Diseases Research; and #Corporate Division Medicine, TA Oncology, Boehringer Ingelheim Pharma GmbH & Co. KG , 88397 Biberach an der Riss, Germany.

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http://dx.doi.org/10.1021/jm501562aDOI Listing
February 2015

A diagnostic HIV-1 tropism system based on sequence relatedness.

J Clin Microbiol 2015 Feb 10;53(2):597-610. Epub 2014 Dec 10.

Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/JCM.02762-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298515PMC
February 2015

HIV in Turkey, a country bridging the Islamic world and Europe.

J Infect Public Health 2014 May-Jun;7(3):249-50. Epub 2014 Mar 2.

Institute of Virology, University of Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jiph.2013.09.009DOI Listing
December 2014

Randomized phase II study of nintedanib in metastatic castration-resistant prostate cancer postdocetaxel.

Anticancer Drugs 2014 Oct;25(9):1081-8

aDepartment of Medical Oncology, Centre Léon-Bérard, Claude Bernard Lyon-1 University, Lyon bMedical Oncology Department, Georges Pompidou European Hospital (HEGP), Paris cDepartment of Medical Oncology, Institut Claudius Regaud, Toulouse dBoehringer Ingelheim France S.A.S, Reims, France eBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

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http://dx.doi.org/10.1097/CAD.0000000000000131DOI Listing
October 2014

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

AIDS 2014 Sep;28(15):2319-22

aDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden bDivision of Public Health and Infection, St. John's Research Institute, Bangalore India cUnit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden dInstitute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany eDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA fIndian Institute of Science Education and Research, Pune, Maharashtra, India gInstitute of Virology, University of Cologne, Cologne, Germany hDepartment of Medicine, University of California, San Francisco, California, USA iDepartment of Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia jBioinformatics Institute kDepartment of Biological Sciences, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/QAD.0000000000000419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198440PMC
September 2014

Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis.

BMC Cancer 2014 Jul 11;14:510. Epub 2014 Jul 11.

Tumor Biology Center, Department of Medical Oncology, Breisacherstrasse 117, D-79106 Freiburg in Breisgau, Germany.

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http://dx.doi.org/10.1186/1471-2407-14-510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105047PMC
July 2014

Personalized HIV therapy to control drug resistance.

Drug Discov Today Technol 2014 Mar;11:57-64

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http://dx.doi.org/10.1016/j.ddtec.2014.02.004DOI Listing
March 2014

Analysis of physicochemical and structural properties determining HIV-1 coreceptor usage.

PLoS Comput Biol 2013 21;9(3):e1002977. Epub 2013 Mar 21.

Max Planck Institute for Computer Science, Saarbrucken, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1002977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605109PMC
November 2013

Molecular epidemiology of HIV in a cohort of men having sex with men from Istanbul.

Med Microbiol Immunol 2013 Jun 8;202(3):251-5. Epub 2013 Jan 8.

Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00430-012-0285-7DOI Listing
June 2013

HIV-2EU: supporting standardized HIV-2 drug resistance interpretation in Europe.

Clin Infect Dis 2013 Jun 19;56(11):1654-8. Epub 2013 Feb 19.

Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Bichat-Claude Bernard, HUPNVS, Université Paris Diderot, France.

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http://dx.doi.org/10.1093/cid/cit104DOI Listing
June 2013

High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.

J Med Virol 2013 May 13;85(5):775-9. Epub 2013 Feb 13.

Institute of Virology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/jmv.23530DOI Listing
May 2013

Genotyping hepatitis B virus dual infections using population-based sequence data.

J Gen Virol 2012 Sep 13;93(Pt 9):1899-1907. Epub 2012 Jun 13.

Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarbrücken, Germany.

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http://dx.doi.org/10.1099/vir.0.043042-0DOI Listing
September 2012

HIV co-receptor tropism: old target for new therapeutic strategies.

Curr Opin HIV AIDS 2012 Sep;7(5):429-31

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http://dx.doi.org/10.1097/COH.0b013e328356f909DOI Listing
September 2012

An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data.

Retrovirology 2012 Jul 25;9:60. Epub 2012 Jul 25.

Department of Computational Biology and Applied Algorithmics, Max Planck for Computer Sciences, Campus E1 4 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1186/1742-4690-9-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464718PMC
July 2012