Publications by authors named "Rolf Gebhardt"

100Publications

β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis.

Am J Pathol 2019 05 19;189(5):1091-1104. Epub 2019 Feb 19.

Department of Gynecology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, China; Pittsburgh Liver Research Center, Pittsburgh, Pennsylvania. Electronic address:

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May 2019

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells.

Lipids Health Dis 2017 Oct 3;16(1):191. Epub 2017 Oct 3.

Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstraße 21, 04103, Leipzig, Germany.

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October 2017

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD).

Arch Toxicol 2017 Apr 19;91(4):1545-1563. Epub 2016 Dec 19.

Faculty of Medicine, Institute of Biochemistry, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany.

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April 2017

Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system.

Arch Toxicol 2017 Feb 10;91(2):799-810. Epub 2016 Mar 10.

Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.

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February 2017

Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells.

J Anat 2016 06 19;228(6):996-1005. Epub 2016 Feb 19.

Laboratory of Histology and Embryology, Department of Microscopy, ICBAS - Institute of Biomedical Sciences Abel Salazar, U.Porto - University of Porto, Porto, Portugal.

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June 2016

Optimality in the zonation of ammonia detoxification in rodent liver.

Arch Toxicol 2015 Nov 5;89(11):2069-78. Epub 2015 Oct 5.

Department of Simulation and Optimal Processes, Ilmenau University of Technology, Helmholtzplatz 5, 98693, Ilmenau, Germany.

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November 2015

Liposomes as carriers: not as innocent as one would like.

Arch Toxicol 2015 Sep 6;89(9):1399-400. Epub 2015 Aug 6.

Faculty of Medicine, Institute of Biochemistry, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany,

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September 2015

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.

Mol Biosyst 2015 Aug;11(8):2190-7

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Beutenbergstr. 11a, 07745 Jena, Germany.

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August 2015

Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.

Sci Rep 2015 Mar 5;5:8777. Epub 2015 Mar 5.

Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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March 2015

FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells.

Biochem Biophys Res Commun 2015 Mar 3;458(2):334-40. Epub 2015 Feb 3.

Center for Pediatric Research Leipzig, University Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany.

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March 2015

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.

J Pharm Sci 2015 Jan 12;104(1):191-206. Epub 2014 Nov 12.

Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany; Institute of Applied Microbiology, RWTH Aachen, Aachen, Germany.

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January 2015

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.

Mol Cancer Res 2015 Feb 30;13(2):239-49. Epub 2014 Sep 30.

Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Paul Flechsig Institute of Brain Research, Leipzig, Germany.

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February 2015

The many faces of Hedgehog signalling in the liver: recent progress reveals striking cellular diversity and the importance of microenvironments.

J Hepatol 2014 Dec 23;61(6):1449-50. Epub 2014 Aug 23.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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December 2014

Liver zonation: Novel aspects of its regulation and its impact on homeostasis.

World J Gastroenterol 2014 Jul;20(26):8491-504

Rolf Gebhardt, Madlen Matz-Soja, Institute of Biochemistry, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.

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July 2014

Speeding up hepatocyte proliferation: how triiodothyronine and β-catenin join forces.

Authors:
Rolf Gebhardt

Hepatology 2014 Jun 29;59(6):2074-6. Epub 2014 Apr 29.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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June 2014

Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes.

PLoS One 2014 6;9(3):e91045. Epub 2014 Mar 6.

Center for Pediatric Research Leipzig, University Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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February 2015

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels.

Cell Commun Signal 2014 Feb 18;12:11. Epub 2014 Feb 18.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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February 2014

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.

Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.

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August 2013

Dual luciferase assay for secreted luciferases based on Gaussia and NanoLuc.

Assay Drug Dev Technol 2013 May;11(4):244-52

Institute of Biochemistry, Leipzig University Hospital, Faculty of Medicine, Leipzig University, Leipzig, Germany.

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May 2013

Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?

Cell Commun Signal 2013 Mar 26;11(1):21. Epub 2013 Mar 26.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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March 2013

Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation?

Med Hypotheses 2013 May 21;80(5):589-94. Epub 2013 Feb 21.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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May 2013

Dual origin, development, and fate of bovine pancreatic islets.

J Anat 2013 Mar 21;222(3):358-71. Epub 2012 Nov 21.

Institute of Anatomy, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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March 2013

Tissue proteomics by one-dimensional gel electrophoresis combined with label-free protein quantification.

J Proteome Res 2012 Jul 21;11(7):3680-9. Epub 2012 Jun 21.

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

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July 2012

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.

PLoS One 2012 24;7(4):e34787. Epub 2012 Apr 24.

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.

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August 2012

Hedgehog signaling in glioblastoma multiforme.

Cancer Biol Ther 2012 May 1;13(7):487-95. Epub 2012 May 1.

Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Leipzig AöR, Leipzig, Germany.

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May 2012

Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice.

Endocrinology 2011 Dec 4;152(12):4764-76. Epub 2011 Oct 4.

Endocrine Research Unit, Medizinische Klinik-Innenstadt, Ludwig-Maximilians University, D-80336 Munich, Germany.

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December 2011

"Artificial micro organs"--a microfluidic device for dielectrophoretic assembly of liver sinusoids.

Biomed Microdevices 2011 Jun;13(3):493-501

NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstrasse 55, Reutlingen, Germany.

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June 2011

Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approach.

Cancer Invest 2011 May 23;29(4):272-81. Epub 2011 Feb 23.

Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Leipzig AöR, 04103 Leipzig, Germany,1.

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May 2011

Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet.

Comp Hepatol 2010 Oct 13;9. Epub 2010 Oct 13.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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October 2010

A method for patterned in situ biofunctionalization in injection-molded microfluidic devices.

Lab Chip 2010 Oct 30;10(19):2551-8. Epub 2010 Jul 30.

Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstrasse 55, D-72770 Reutlingen, Germany.

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October 2010

Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes.

Planta Med 2011 Jan 22;77(1):32-9. Epub 2010 Jul 22.

Institute of Pharmaceutical Sciences - Pharmacognosy, Karl-Franzens University of Graz, Graz, Austria.

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January 2011

Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway.

Toxicol Appl Pharmacol 2010 Jul 6;246(1-2):100-6. Epub 2010 May 6.

Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

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July 2010

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model.

Mol Cancer 2010 Jan 6;9. Epub 2010 Jan 6.

Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany.

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January 2010

Carnosine inhibits ATP production in cells from malignant glioma.

Neurol Res 2010 Feb 11;32(1):101-5. Epub 2009 Nov 11.

Klinik und Poliklinik für Neurochirurgie, Medizinische Fakultät der Universität Leipzig, Leipzig, Germany.

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February 2010

Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells.

Life Sci 2010 Jan 3;86(3-4):79-86. Epub 2009 Nov 3.

Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.

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January 2010

Comparison of uptake and neuroprotective potential of seven zinc-salts.

Neurochem Int 2010 Jan 24;56(1):84-93. Epub 2009 Sep 24.

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Leipzig, Germany.

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January 2010

Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond.

Dev Dyn 2010 Jan;239(1):45-55

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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January 2010

From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age.

Planta Med 2009 Oct 28;75(13):1371-80. Epub 2009 Jul 28.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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October 2009

Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue.

J Anat 2009 Aug 14;215(2):176-83. Epub 2009 May 14.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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August 2009

Prevention of cadmium-induced toxicity in liver-derived cells by the combination preparation Hepeel(®).

Authors:
Rolf Gebhardt

Environ Toxicol Pharmacol 2009 May 31;27(3):402-9. Epub 2009 Jan 31.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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May 2009

Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

Toxicol In Vitro 2009 Jun 21;23(4):653-9. Epub 2009 Mar 21.

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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June 2009

Differential inhibition of matrix metalloproteinases-2, -9, and -13 activities by selected anthraquinones.

Planta Med 2009 Mar 16;75(4):327-9. Epub 2009 Jan 16.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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March 2009

Functional interactions of Cu-ATPase ATP7B with cisplatin and the role of ATP7B in the resistance of cells to the drug.

J Biol Chem 2009 Mar 13;284(12):7793-802. Epub 2009 Jan 13.

Department of Medicine II and Department of Biochemistry, University of Leipzig, 04103 Leipzig, Germany.

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March 2009

Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.

Mol Cancer 2008 Feb 18;7:21. Epub 2008 Feb 18.

Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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February 2008

E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells.

J Mol Histol 2007 Aug 29;38(4):359-68. Epub 2007 Jun 29.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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August 2007

Mathematical modelling of liver regeneration after intoxication with CCl(4).

Chem Biol Interact 2007 May 2;168(1):74-93. Epub 2007 Feb 2.

Interdisciplinary Centre for Bioinformatics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.

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May 2007

Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver.

Prog Histochem Cytochem 2007 8;41(4):201-66. Epub 2007 Feb 8.

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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May 2007

Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors.

Hepatology 2006 Oct;44(4):967-75

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Leipzig, Germany.

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October 2006

Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells.

Free Radic Res 2005 Dec;39(12):1377-90

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Liebigstr. 16, Leipzig, 04103, Germany.

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December 2005

Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.

Eur J Neurosci 2005 Jul;22(1):50-64

Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D-04109 Leipzig, Germany.

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July 2005

Synthesis and biological evaluation of new derivatives of emodin.

Bioorg Med Chem 2004 Nov;12(22):5961-71

Institut für Pharmazie, Fakultät für Biowissenschaften, Pharmazie und Psychologie, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany.

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November 2004

Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids.

Planta Med 2004 Oct;70(10):1006-8

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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October 2004

Flavonoid binding to a multi-drug-resistance transporter protein: an STD-NMR study.

Anal Bioanal Chem 2004 Aug 7;379(7-8):1045-9. Epub 2004 Jul 7.

Institute of Biochemistry, Medical Faculty, University of Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany.

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August 2004

Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy.

Biochim Biophys Acta 2004 May;1663(1-2):97-107

Junior Research Group "Solid-state NMR Studies of the Structure of Membrane-associated Proteins", Biotechnological-Biomedical Center of the University of Leipzig, Liebigstr. 27, D-04103 Leipzig, Germany.

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May 2004

Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination.

Authors:
Rolf Gebhardt

Arzneimittelforschung 2003 ;53(12):823-30

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany.

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February 2004

Heterogeneity of rat liver parenchyma in taurocholate uptake.

Hepatol Res 2003 Nov;27(3):238-247

Klinikum der Ludwig-Maximilians-Universität München, I. Frauenklinik Innenstadt, Maistr. 11, D-80337, Munich, Germany

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November 2003

A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids.

Mol Endocrinol 2004 Jan 16;18(1):63-9. Epub 2003 Oct 16.

Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany.

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January 2004