Rolf Bodmer

Rolf Bodmer

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Rolf Bodmer

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Model System Identification of Novel Congenital Heart Disease Gene Candidates: focus on RPL13.

Hum Mol Genet 2019 Oct 18. Epub 2019 Oct 18.

Development, Aging and Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1093/hmg/ddz213DOI Listing
October 2019

As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Biochim Biophys Acta Mol Basis Dis 2019 Jul 27;1865(7):1831-1844. Epub 2018 Nov 27.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183046
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http://dx.doi.org/10.1016/j.bbadis.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527462PMC
July 2019

Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila.

Nat Commun 2019 01 14;10(1):193. Epub 2019 Jan 14.

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-018-08128-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331650PMC
January 2019

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.

Cell Rep 2018 03;22(10):2702-2715

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242704PMC
March 2018

TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan.

FEBS Lett 2017 11 10;591(21):3447-3458. Epub 2017 Oct 10.

Department of Biology, Molecular Biology and Heart Institutes, San Diego State University, CA, USA.

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http://dx.doi.org/10.1002/1873-3468.12860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683924PMC
November 2017

Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.

Matrix Biol 2017 10 25;62:15-27. Epub 2016 Oct 25.

Biomedical Sciences Program, UC, San Diego; La Jolla, CA 92093, USA; Department of Bioengineering, UC, San Diego; La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405015PMC
October 2017

Reduced Cardiac Expression Mimics Long-Term Hypoxia-Induced Heart Defects in .

Circ Cardiovasc Genet 2017 10;10(5)

From the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669044PMC
October 2017

High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster.

J Vis Exp 2017 09 13(127). Epub 2017 Sep 13.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute.

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http://dx.doi.org/10.3791/56029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752231PMC
September 2017

Expression patterns of cardiac aging in Drosophila.

Aging Cell 2017 Feb;16(1):82-92

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/acel.12559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242310PMC
February 2017

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.

Biochim Biophys Acta 2016 Jul 4;1863(7 Pt B):1717-27. Epub 2016 Mar 4.

Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA 92093-0412, USA; Sanford-Burnham-Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, CA 92037, USA; Stanford Cardiovascular Institute, 265 Campus Dr., Stanford, CA 94305-5454, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885786PMC
July 2016

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.

PLoS One 2015 24;10(8):e0134620. Epub 2015 Aug 24.

Department of Life and Environmental Science, University of Bournemouth, Talbot Campus, Poole, Dorset BH12 5BB, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547745PMC
May 2016

Genetic manipulation of cardiac ageing.

J Physiol 2016 Apr 14;594(8):2075-83. Epub 2015 Jul 14.

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1113/JP270563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933115PMC
April 2016

SPARC-Dependent Cardiomyopathy in Drosophila.

Circ Cardiovasc Genet 2016 Apr 2;9(2):119-29. Epub 2016 Feb 2.

From the Department of Life and Environmental Science, University of Bournemouth, Dorset, United Kingdom (P.S.H.); and Proteomics Facility (K.M.) and Development, Aging, and Regeneration Program (R.B., K.O.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838489PMC
April 2016

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

Rare Dis 2014 3;2(1):e968003. Epub 2014 Nov 3.

Department of Biology; Molecular Biology and Heart Institutes; San Diego State University; San Diego, CA USA; Development and Aging Program; Sanford-Burnham Institute for Medical Research; La Jolla, CA USA.

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http://dx.doi.org/10.4161/2167549X.2014.968003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755237PMC
March 2016

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Am J Physiol Regul Integr Comp Physiol 2015 Dec 16;309(11):R1347-57. Epub 2015 Sep 16.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California;

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http://dx.doi.org/10.1152/ajpregu.00164.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698404PMC
December 2015

Gaining Insights into Diabetic Cardiomyopathy from Drosophila.

Trends Endocrinol Metab 2015 Nov 16;26(11):618-627. Epub 2015 Oct 16.

Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Dicovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638170PMC
November 2015

Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster.

Am J Physiol Regul Integr Comp Physiol 2015 Sep 1;309(6):R658-67. Epub 2015 Jul 1.

School of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada;

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http://dx.doi.org/10.1152/ajpregu.00160.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591367PMC
September 2015

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

Hum Mol Genet 2015 Jul 19;24(13):3608-22. Epub 2015 Mar 19.

Departamento de Bioquímica, Facultad de Medicina, Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), c/ Arzobispo Morcillo s/n,Universidad Autónoma de Madrid, Madrid 28029, Spain, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid 28041, Spain

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http://dx.doi.org/10.1093/hmg/ddv106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459388PMC
July 2015

Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.

Dis Model Mech 2015 Jun 20;8(6):577-89. Epub 2015 Apr 20.

Department of Biochemistry and Molecular Biology, 4301 Jones Bridge Road, Uniformed Services University, Bethesda, MD 20814, USA

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.019208
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http://dx.doi.org/10.1242/dmm.019208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457034PMC
June 2015

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Sci Transl Med 2015 Jun;7(292):292ra99

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa5843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507505PMC
June 2015

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Cell Rep 2015 Mar 5;10(9):1572-1584. Epub 2015 Mar 5.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560688PMC
March 2015

Cellular Mechanisms of Drosophila Heart Morphogenesis.

J Cardiovasc Dev Dis 2015 Mar;2(1):2-16

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.3390/jcdd2010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520698PMC
March 2015

Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis.

J Cell Biol 2014 Sep;206(7):909-22

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1083/jcb.201405075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178965PMC
September 2014

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

PLoS Genet 2013 19;9(12):e1004024. Epub 2013 Dec 19.

Development and Aging Program, Sanford-Burnham Institute for Medical Research, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868535PMC
August 2014

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Aging Cell 2014 Jun 9;13(3):431-40. Epub 2014 Jan 9.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://doi.wiley.com/10.1111/acel.12193
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http://dx.doi.org/10.1111/acel.12193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032615PMC
June 2014

Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.

Genetics 2014 Jun 25;197(2):781-93. Epub 2014 Mar 25.

School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332.

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http://dx.doi.org/10.1534/genetics.114.163857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063932PMC
June 2014

Methods to assess Drosophila heart development, function and aging.

Methods 2014 Jun 12;68(1):265-72. Epub 2014 Apr 12.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058868PMC
June 2014

ROS regulate cardiac function via a distinct paracrine mechanism.

Cell Rep 2014 Apr 20;7(1):35-44. Epub 2014 Mar 20.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164050PMC
April 2014

Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.

Mol Metab 2014 Feb 23;3(1):42-54. Epub 2013 Oct 23.

Department of Pediatrics (Division of Respiratory Medicine), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123, USA.

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http://dx.doi.org/10.1016/j.molmet.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929909PMC
February 2014

Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

Exp Gerontol 2014 Jan 12;49:26-34. Epub 2013 Nov 12.

Development and Aging Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Rd, Building 7 Room 7125, La Jolla, CA 92037, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S05315565130031
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http://dx.doi.org/10.1016/j.exger.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340692PMC
January 2014

The role of pygopus in the differentiation of intracardiac valves in Drosophila.

Genesis 2014 Jan 21;52(1):19-28. Epub 2013 Nov 21.

The Center for Heart Development, Key Laboratory of MOE for Developmental Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China; Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037.

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http://dx.doi.org/10.1002/dvg.22724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142678PMC
January 2014

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

PLoS One 2013 29;8(4):e62909. Epub 2013 Apr 29.

Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639251PMC
November 2013

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Circ Cardiovasc Genet 2013 Oct 17;6(5):472-80. Epub 2013 Sep 17.

Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871875PMC
October 2013

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Aging Cell 2013 Aug 16;12(4):554-62. Epub 2013 May 16.

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1111/acel.12078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714369PMC
August 2013

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.

PLoS Genet 2013 Jun 27;9(6):e1003597. Epub 2013 Jun 27.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1371/journal.pgen.1003597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694841PMC
June 2013

A Drosophila model of high sugar diet-induced cardiomyopathy.

PLoS Genet 2013 10;9(1):e1003175. Epub 2013 Jan 10.

Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1003175
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http://dx.doi.org/10.1371/journal.pgen.1003175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542070PMC
May 2013

Regulation of parkin and PINK1 by neddylation.

Hum Mol Genet 2012 Jun 2;21(11):2514-23. Epub 2012 Mar 2.

Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/hmg/dds070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349425PMC
June 2012

Probing the polygenic basis of cardiomyopathies in Drosophila.

Authors:
Li Qian Rolf Bodmer

J Cell Mol Med 2012 May;16(5):972-7

Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2012.01529.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337951PMC
May 2012

Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction.

J Cell Mol Med 2012 May;16(5):966-71

Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2012.01522.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454526PMC
May 2012

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model.

PLoS One 2011 25;6(7):e22579. Epub 2011 Jul 25.

Department of Biology, Molecular Biology Institute and Heart Institute, San Diego State University, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022579PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143160PMC
December 2011

Phospholipid homeostasis and lipotoxic cardiomyopathy: a matter of balance.

Fly (Austin) 2011 Jul-Sep;5(3):234-6. Epub 2011 Jul 1.

Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225766PMC
http://dx.doi.org/10.4161/fly.5.3.15708DOI Listing
November 2011

Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

PLoS Genet 2011 Nov 3;7(11):e1002344. Epub 2011 Nov 3.

Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207880PMC
November 2011

Lipotoxicity and cardiac dysfunction in mammals and Drosophila.

Crit Rev Biochem Mol Biol 2011 Oct 19;46(5):376-85. Epub 2011 Aug 19.

Development and Aging Program, Sanford-Burnham Medical Research Institute , La Jolla, CA , USA.

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http://www.tandfonline.com/doi/full/10.3109/10409238.2011.59
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http://dx.doi.org/10.3109/10409238.2011.599830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386717PMC
October 2011

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):12024-9. Epub 2011 Jun 30.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67 084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1073/pnas.1108926108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141999PMC
July 2011

Drosophila as a model to study cardiac aging.

Exp Gerontol 2011 May 3;46(5):326-30. Epub 2010 Dec 3.

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.exger.2010.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079765PMC
May 2011

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.

Genes Dev 2011 Jan;25(2):189-200

Development and Aging Program, NASCR (Neuroscience, Aging, and Stem Cell Research) Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.1992411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022264PMC
January 2011

Sestrins at the crossroad between stress and aging.

Aging (Albany NY) 2010 Jun;2(6):369-74

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.

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http://www.aging-us.com/article/100157
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http://dx.doi.org/10.18632/aging.100157DOI Listing
June 2010

SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

BMB Rep 2010 May;43(5):355-61

The Center for Heart Development, Hunan Normal University, Changsha, Hunan, Peoples' Republic of China.

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May 2010

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

Science 2010 Mar;327(5970):1223-8

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1182228
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866632PMC
March 2010

KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

BMB Rep 2010 Jan;43(1):17-22

The Center For Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, Peoples' Republic of China.

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January 2010

Fluorescent labeling of Drosophila heart structures.

J Vis Exp 2009 Oct 13(32). Epub 2009 Oct 13.

Biology Department, San Diego State University, San Diego, CA, USA.

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http://dx.doi.org/10.3791/1423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164059PMC
October 2009

Partial loss of GATA factor Pannier impairs adult heart function in Drosophila.

Authors:
Li Qian Rolf Bodmer

Hum Mol Genet 2009 Sep 3;18(17):3153-63. Epub 2009 Jun 3.

NASCR Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/hmg/ddp254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722980PMC
September 2009

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.

Aging Cell 2009 Sep 9;8(5):542-52. Epub 2009 Jul 9.

Department of Internal Medicine/Institute of Gerontology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00504.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832479PMC
September 2009

Semi-automated Optical Heartbeat Analysis of small hearts.

J Vis Exp 2009 Sep 16(31). Epub 2009 Sep 16.

Development and Aging Program, The Burnham Institute for Medical Research, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150057PMC
September 2009

Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies.

Dev Biol 2009 Apr 20;328(2):483-92. Epub 2009 Feb 20.

Development and Aging Program, NASCR Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060900128
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http://dx.doi.org/10.1016/j.ydbio.2009.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829972PMC
April 2009

The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.

Development 2009 Jan 15;136(2):317-26. Epub 2008 Dec 15.

Institute for Biochemistry and Molecular Biology, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

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http://dx.doi.org/10.1242/dev.022533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685972PMC
January 2009

Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.

Proc Natl Acad Sci U S A 2008 Dec 11;105(50):19833-8. Epub 2008 Dec 11.

Development and Aging Program, Del E. Webb Neuroscience, Aging and Stem Cell Research Center (NASCR), Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0808705105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605007PMC
December 2008

A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE.

Mol Cells 2008 Nov;26(5):443-53

The Center for Heart Development, Key Lab of Ministry of Education for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, Peoples' Republic of China.

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November 2008

ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway.

Mol Cell Biochem 2008 Mar 15;310(1-2):141-51. Epub 2007 Dec 15.

The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Hunan, Changsha 410081, PR China.

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http://dx.doi.org/10.1007/s11010-007-9674-4DOI Listing
March 2008

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.

Aging Cell 2008 Mar 23;7(2):237-49. Epub 2008 Jan 23.

Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, Building 7, Room 7125, La Jolla, Ca 92037, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2008.00367.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840698PMC
March 2008

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons.

Mol Neurodegener 2008 Feb 8;3. Epub 2008 Feb 8.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276501PMC
February 2008

Drosophila aging 2006/2007.

Exp Gerontol 2008 Jan 3;43(1):5-10. Epub 2007 Dec 3.

Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.exger.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223272PMC
January 2008

Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites.

Dev Biol 2008 Jan 25;313(2):876-86. Epub 2007 Oct 25.

Development and Aging Program, Center for Neuroscienes, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245897PMC
January 2008

The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.

J Exp Biol 2008 Jan;211(Pt 1):15-23

Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://jeb.biologists.org/cgi/doi/10.1242/jeb.012435
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January 2008

Genetic control of heart function and aging in Drosophila.

Trends Cardiovasc Med 2007 Jul;17(5):177-82

Burnham Institute for Medical Research, Program for Systems and Developmental Biology, Center for Neuroscienes and Aging, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.tcm.2007.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950717PMC
July 2007

Genetic variation for cardiac dysfunction in Drosophila.

PLoS One 2007 Jul 11;2(7):e601. Epub 2007 Jul 11.

Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913553PMC
July 2007

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.

Proc Natl Acad Sci U S A 2007 Mar 28;104(10):3943-8. Epub 2007 Feb 28.

Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0609278104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820688PMC
March 2007

Cardiac aging.

Semin Cell Dev Biol 2007 Feb 27;18(1):111-6. Epub 2006 Dec 27.

Department of Internal Medicine, University of Michigan, 3013 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, United States.

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February 2007

Age-related cardiac disease model of Drosophila.

Mech Ageing Dev 2007 Jan 27;128(1):112-6. Epub 2006 Nov 27.

The Burnham Institute for Medical Research, Center for Neuroscience and Aging, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

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http://dx.doi.org/10.1016/j.mad.2006.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850850PMC
January 2007

Age-related cardiac deterioration: insights from Drosophila.

Front Biosci 2007 Jan 1;12:39-48. Epub 2007 Jan 1.

The Burnham Institute of Medical Research, Center for Neuroscience and Aging, 10901 North Torrey Pines Read, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.2741/2047DOI Listing
January 2007

Drosophila aging 2005/06.

Exp Gerontol 2006 Dec 28;41(12):1213-6. Epub 2006 Nov 28.

Centre for Neuroscience and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.exger.2006.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855203PMC
December 2006

Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.

Dev Genes Evol 2006 Nov 7;216(11):683-93. Epub 2006 Sep 7.

Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://link.springer.com/10.1007/s00427-006-0096-1
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November 2006

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.

Development 2006 Oct 20;133(20):4073-83. Epub 2006 Sep 20.

Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02586
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October 2006

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.

Proc Natl Acad Sci U S A 2006 Sep 24;103(36):13520-5. Epub 2006 Aug 24.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0604661103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569195PMC
September 2006

The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman.

Proc Natl Acad Sci U S A 2006 Aug 1;103(32):11999-2004. Epub 2006 Aug 1.

Del E. Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0603098103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567687PMC
August 2006

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

Cell Metab 2006 Aug;4(2):133-42

The Burnham Institute for Medical Research, Cancer Research Center, Neuroscience and Aging Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.cmet.2006.05.013DOI Listing
August 2006

Images in cardiovascular medicine: in vivo imaging of the adult Drosophila melanogaster heart with real-time optical coherence tomography.

Circulation 2006 Jul;114(2):e35-6

Department of Biomedical Engineering, Duke University, 136 Hudson Hall, PO Box 90281, Durham, NC 27708-0281, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.593541DOI Listing
July 2006