Dr. Rolf, PhD - UT Southwestern Medical Center - Professor

Dr. Rolf

PhD

UT Southwestern Medical Center

Professor

Dallas, Texas | United States

ORCID logohttps://orcid.org/0000-0003-2704-2377

Dr. Rolf, PhD - UT Southwestern Medical Center - Professor

Dr. Rolf

PhD

Introduction

Primary Affiliation: UT Southwestern Medical Center - Dallas, Texas , United States

Education

Feb 1999
UT Southwestern
PhD
May 1991
Luther College
BA/ Biology

Publications

151Publications

3421Reads

3Profile Views

3069PubMed Central Citations

Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.

Mol Cancer Res 2019 02 17;17(2):348-355. Epub 2018 Oct 17.

Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-18-0427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359969PMC
February 2019
6 Reads
4.380 Impact Factor

Does Axl have potential as a therapeutic target in pancreatic cancer?

Expert Opin Ther Targets 2018 11 3;22(11):955-966. Epub 2018 Oct 3.

a Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas , TX , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14728222.2018.1527315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292430PMC
November 2018
2 Reads
1 Citation
5.140 Impact Factor

Sitravatinib potentiates immune checkpoint blockade in refractory cancer models.

JCI Insight 2018 11 2;3(21). Epub 2018 Nov 2.

Division of Surgical Oncology, Department of Surgery, and Hamon Center for Therapeutic Oncology Research, and.

View Article

Download full-text PDF

Source
https://insight.jci.org/articles/view/124184
Publisher Site
http://dx.doi.org/10.1172/jci.insight.124184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238734PMC
November 2018
2 Reads

Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma.

Mol Cancer Res 2018 10 4;16(10):1590-1600. Epub 2018 Jun 4.

Department of Surgery, Ajou University School of Medicine, Suwon, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-17-0710DOI Listing
October 2018
23 Reads
4.380 Impact Factor

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Mol Metab 2018 10 11;16:139-149. Epub 2018 Jun 11.

Division of Surgical Oncology, Department of Surgery and the Hamon Center for Therapeutic Oncology Research, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157474PMC
October 2018
27 Reads

Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2.

J Med Chem 2018 09 20;61(17):7977-7990. Epub 2018 Aug 20.

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b01045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287892PMC
September 2018
36 Reads
5.450 Impact Factor

Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-HO Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay.

Anal Chem 2018 05 17;90(9):5930-5937. Epub 2018 Apr 17.

Department of Chemistry and Biochemistry , University of Texas at El Paso , 500 West University Avenue , El Paso , Texas 79968 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177380PMC
May 2018
9 Reads
1 Citation
5.640 Impact Factor

Assessment of TANK-binding kinase 1 as a therapeutic target in cancer.

J Cell Commun Signal 2018 Mar 7;12(1):83-90. Epub 2017 Dec 7.

Cancer Biology Graduate Program, Hamon Center for Therapeutic Oncology Research and Department of Surgery, UT Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX, 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12079-017-0438-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842199PMC
March 2018
5 Reads
1 Citation

The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy.

Curr Drug Targets 2016 ;17(15):1747-1754

Department of Cancer Genetics and Medicine, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 142631, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673093PMC
http://dx.doi.org/10.2174/1389450117666151209123544DOI Listing
August 2017
26 Reads
3 Citations
3.021 Impact Factor

From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.

J Leukoc Biol 2017 08 29;102(2):277-286. Epub 2017 Mar 29.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.3MR1116-475RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505752PMC
August 2017
2 Reads
4.290 Impact Factor

Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

PLoS One 2016 27;11(7):e0158757. Epub 2016 Jul 27.

Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158757PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963039PMC
July 2017
25 Reads
5 Citations
3.234 Impact Factor

Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch.

J Bone Miner Res 2017 Jul 28;32(7):1442-1454. Epub 2017 Apr 28.

Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.3133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489363PMC
July 2017
25 Reads
5 Citations
6.832 Impact Factor

Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma.

BMC Cancer 2017 01 31;17(1):87. Epub 2017 Jan 31.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX, 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-017-3051-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286810PMC
January 2017
57 Reads
2 Citations
3.362 Impact Factor

Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts.

Ann Surg Oncol 2016 12 4;23(Suppl 5):583-591. Epub 2016 Feb 4.

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-016-5107-5DOI Listing
December 2016
7 Reads
4 Citations
3.930 Impact Factor

Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.

J Biol Chem 2016 Oct 16;291(42):22244-22252. Epub 2016 Aug 16.

From the Hamon Center for Therapeutic Oncology Research, Cancer Biology Graduate Program, Division of Surgical Oncology, Department of Surgery, and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.730945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064003PMC
October 2016
8 Reads
5 Citations
4.573 Impact Factor

Matrix control of pancreatic cancer: New insights into fibronectin signaling.

Cancer Lett 2016 10 29;381(1):252-8. Epub 2015 Dec 29.

Hamon Center for Therapeutic Oncology Research and the Division of Surgical Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Departments of Surgery and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927402PMC
October 2016
2 Reads
5 Citations
5.621 Impact Factor

Axl Receptor Axis: A New Therapeutic Target in Lung Cancer.

J Thorac Oncol 2016 08 26;11(8):1357-1362. Epub 2016 Apr 26.

Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961571PMC
August 2016
9 Reads
4 Citations
5.282 Impact Factor

Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.

Oncotarget 2016 08;7(32):51569-51580

Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239497PMC
August 2016
27 Reads
1 Citation
6.360 Impact Factor

Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma.

Cancer Immunol Res 2016 06 4;4(6):531-40. Epub 2016 Apr 4.

Hamon Center for Therapeutic Oncology Research, Departments of Surgery and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-15-0250DOI Listing
June 2016
47 Reads
6 Citations

Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer.

Mol Cell Oncol 2015 Jul-Sep;2(3):e975606. Epub 2014 Dec 1.

Division of Surgical Oncology; Department of Surgery and Hamon Center for Therapeutic Oncology Research; University of Texas Southwestern Medical Center ; Dallas, TX USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/23723556.2014.975606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905287PMC
June 2016
4 Reads
1 Citation

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

J Med Chem 2016 06 3;59(12):5911-6. Epub 2016 Jun 3.

State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue, Guangzhou 510530, China.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053573PMC
http://dx.doi.org/10.1021/acs.jmedchem.6b00140DOI Listing
June 2016
29 Reads
2 Citations
5.450 Impact Factor

Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.

Oncotarget 2016 May;7(21):30678-90

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.8929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058709PMC
May 2016
29 Reads
4 Citations
6.360 Impact Factor

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

Cell Rep 2016 Mar 25;14(9):2193-2208. Epub 2016 Feb 25.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791963PMC
March 2016
8 Reads
2 Citations
7.210 Impact Factor

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.

Cancer Res 2015 Dec 17;75(23):5058-69. Epub 2015 Nov 17.

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, Texas. Department of Surgery, UT Southwestern Medical Center, Dallas, Texas. Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668215PMC
December 2015
13 Reads
8 Citations
9.330 Impact Factor

Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells.

ACS Chem Biol 2015 Dec 28;10(12):2891-9. Epub 2015 Oct 28.

Advanced Imaging Research Center, ‡Simmons Comprehensive Cancer Center, §Hamon Center for Therapeutic Oncology Research, ∥Departments of Biochemistry, ⊥Pharmacology, #Internal Medicine, and ▽Surgery, University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd., Dallas, Texas 75390, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774050PMC
December 2015
27 Reads
5 Citations
5.331 Impact Factor

Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo.

Invest Ophthalmol Vis Sci 2015 Nov;56(12):7137-45

Department of Ophthalmology University of Texas Southwestern Medical Center, Dallas, Texas, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.15-17302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634629PMC
November 2015
15 Reads
1 Citation
3.404 Impact Factor

Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts.

Am J Nucl Med Mol Imaging 2015 12;5(5):493-503. Epub 2015 Oct 12.

Department of Radiology, University of Texas Southwestern Medical Center Dallas, Texas 75390-8852, USA ; Department of Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center Dallas, Texas 75390-8852, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620176PMC
November 2015
14 Reads
4 Citations

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.

Cancer Res 2015 Sep 23;75(18):3699-705. Epub 2015 Jul 23.

Division of Surgical Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-2887-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572915PMC
September 2015
14 Reads
17 Citations
9.330 Impact Factor

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Nat Chem Biol 2015 Jun 13;11(6):401-8. Epub 2015 Apr 13.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433765PMC
June 2015
27 Reads
13 Citations
13.000 Impact Factor

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer.

Cancer Lett 2015 Apr 29;359(2):335-43. Epub 2015 Jan 29.

Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China; Gastric Cancer Center of Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835150006
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2015.01.033DOI Listing
April 2015
54 Reads
19 Citations
5.621 Impact Factor

Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.

Cancer Lett 2015 Mar 16;358(1):59-66. Epub 2014 Dec 16.

Department of Surgery, Indiana University School of Medicine, South Bend, IN 46617; Division of Surgical Oncology, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75390; Indiana University Health Goshen Center for Cancer Care, Indiana University School of Medicine, South Bend, IN 46617.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2014.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450873PMC
March 2015
15 Reads
10 Citations
5.621 Impact Factor

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Proc Natl Acad Sci U S A 2014 Nov 31;111(45):15999-6004. Epub 2014 Oct 31.

Departments of Pharmacology and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1419057111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234555PMC
November 2014
32 Reads
11 Citations
9.810 Impact Factor

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma.

Oncotarget 2014 Oct;5(20):9811-22

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO. Department of Anatomy and Neurobiology , Washington University School of Medicine, St. Louis, MO.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259439PMC
http://dx.doi.org/10.18632/oncotarget.2443DOI Listing
October 2014
12 Reads
8 Citations
6.360 Impact Factor

Vascular channels formed by subpopulations of PECAM1+ melanoma cells.

Nat Commun 2014 Oct 22;5:5200. Epub 2014 Oct 22.

1] Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [3] McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261234PMC
October 2014
23 Reads
20 Citations
10.742 Impact Factor

Hypoxia Studies with Pimonidazole .

Bio Protoc 2014 Oct;4(19)

Department of Surgery, Hamon Center for Therapeutic Oncology Research, Dallas, USA; Department of Pharmacology, UT Southwestern Medical Center, Dallas, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956402PMC
http://dx.doi.org/10.21769/bioprotoc.1254DOI Listing
October 2014
2 Reads
1 Citation

Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis.

Cancer Res 2014 Sep 24;74(18):4996-5007. Epub 2014 Jul 24.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167492PMC
September 2014
20 Reads
17 Citations
9.330 Impact Factor

Vascular endothelial growth factor promotes fibrosis resolution and repair in mice.

Gastroenterology 2014 May 4;146(5):1339-50.e1. Epub 2014 Feb 4.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.01.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001704PMC
May 2014
73 Reads
49 Citations
16.720 Impact Factor

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature.

PLoS One 2013 2;8(9):e74686. Epub 2013 Sep 2.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759473PMC
April 2014
33 Reads
14 Citations
3.234 Impact Factor

Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.

Cancer Res 2014 Feb 17;74(4):1032-44. Epub 2013 Dec 17.

Authors' Affiliations: Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research; Departments of Pathology and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Neurological Surgery, University of California San Francisco, San Francisco, California; and Department of Surgery, Ajou University School of Medicine, Suwon, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-2800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944405PMC
February 2014
24 Reads
21 Citations
9.330 Impact Factor

Role of SPARC in bone remodeling and cancer-related bone metastasis.

J Cell Biochem 2014 Jan;115(1):17-26

INEB-Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal; Departamento de Engenharia Metalúrgica e de Materiais, Faculdade de Engenharia (FEUP), Universidade do Porto, Rua Roberto Frias, s/n, 4200-465, Porto, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.24649DOI Listing
January 2014
16 Reads
12 Citations
3.263 Impact Factor

Recruitment and retention: factors that affect pericyte migration.

Cell Mol Life Sci 2014 Jan 4;71(2):299-309. Epub 2013 Aug 4.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX, 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-013-1432-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880607PMC
January 2014
18 Reads
17 Citations
5.810 Impact Factor

Faulty ECM signaling facilitates autoimmune lymphomagenesis.

Authors:
Rolf A Brekken

Cancer Discov 2014 Jan;4(1):25-6

Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology and Departments of Surgery and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0912DOI Listing
January 2014
1 Read
15.930 Impact Factor

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.

Cell Rep 2013 Nov 7;5(3):637-45. Epub 2013 Nov 7.

Department of Pediatrics, Division of Pulmonary and Vascular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2013.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950897PMC
November 2013
50 Reads
60 Citations
7.210 Impact Factor

Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function.

Diabetes 2013 Aug 8;62(8):2870-8. Epub 2013 Jul 8.

Diabetes Center and the Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db12-1619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717875PMC
August 2013
40 Reads
8 Citations
8.100 Impact Factor

PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.

Mol Cancer Ther 2013 Jul 21;12(7):1190-201. Epub 2013 May 21.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/content/early/2013/06/05/1535-71
Web Search
http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-12
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-12-1123DOI Listing
July 2013
15 Reads
21 Citations
5.683 Impact Factor

BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer.

Mol Cancer Ther 2013 Jun 31;12(6):992-1001. Epub 2013 May 31.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-0995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681897PMC
June 2013
18 Reads
26 Citations
5.683 Impact Factor

RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas.

Cancer Discov 2013 Apr 28;3(4):444-57. Epub 2013 Jan 28.

Department of Internal Medicine, Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-12-0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625467PMC
April 2013
43 Reads
42 Citations
15.930 Impact Factor

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.

J Clin Invest 2013 Apr;123(4):1732-40

Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI65385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613914PMC
April 2013
61 Reads
45 Citations
13.215 Impact Factor

Loss of SPARC in bladder cancer enhances carcinogenesis and progression.

J Clin Invest 2013 Feb 16;123(2):751-66. Epub 2013 Jan 16.

Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI64782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561835PMC
February 2013
17 Reads
22 Citations
13.215 Impact Factor

Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.

Mol Cancer Ther 2012 Nov 28;11(11):2473-82. Epub 2012 Aug 28.

Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Mail Code 8852, Dallas, TX 75390-8852, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-0431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495993PMC
November 2012
16 Reads
12 Citations
5.683 Impact Factor

Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.

Clin Cancer Res 2012 Sep 24;18(18):5031-42. Epub 2012 Jul 24.

Division of Surgical Oncology, Department of Surgery, The Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-0453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777527PMC
September 2012
25 Reads
15 Citations
8.722 Impact Factor

TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression.

Cancer Res 2012 Sep 11;72(18):4840-5. Epub 2012 Jul 11.

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-0634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764481PMC
September 2012
30 Reads
24 Citations
9.330 Impact Factor

Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib.

Carcinogenesis 2012 Sep 7;33(9):1639-46. Epub 2012 Jun 7.

Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgs195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514897PMC
September 2012
24 Reads
4 Citations
5.334 Impact Factor

Lack of "immunological fitness" during fasting in metabolically challenged animals.

J Lipid Res 2012 Jul 13;53(7):1254-67. Epub 2012 Apr 13.

Touchstone Diabetes Center, Departments of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M021725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371237PMC
July 2012
5 Reads
15 Citations
4.421 Impact Factor

Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

PLoS One 2012 14;7(2):e31384. Epub 2012 Feb 14.

Division of Surgical Oncology, Department of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031384PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279359PMC
July 2012
6 Reads
18 Citations
3.234 Impact Factor

Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.

PLoS One 2011 12;6(12):e28947. Epub 2011 Dec 12.

Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236226PMC
April 2012
5 Reads
23 Citations
3.234 Impact Factor

Dichotomous effects of VEGF-A on adipose tissue dysfunction.

Proc Natl Acad Sci U S A 2012 Apr 26;109(15):5874-9. Epub 2012 Mar 26.

Department of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1200447109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326476PMC
April 2012
10 Reads
111 Citations
9.810 Impact Factor

Anti-VEGF therapy revived by c-Met inhibition, but is c-Met the answer?

Cancer Discov 2012 Mar;2(3):211-3

Department of Pharmacology, Division of Surgical Oncology, UT Southwestern Medical Center, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-12-0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512948PMC
March 2012
42 Reads
3 Citations
15.930 Impact Factor

SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/α2β1 integrin axis.

J Invest Dermatol 2011 Dec 18;131(12):2438-47. Epub 2011 Aug 18.

Laboratory of Molecular and Cellular Therapy, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jid.2011.239DOI Listing
December 2011
67 Reads
14 Citations
7.220 Impact Factor

Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.

Cancer Biol Ther 2011 Oct 1;12(7):617-28. Epub 2011 Oct 1.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218386PMC
http://dx.doi.org/10.4161/cbt.12.7.15955DOI Listing
October 2011
24 Reads
18 Citations
3.072 Impact Factor

The regulatory function of SPARC in vascular biology.

Cell Mol Life Sci 2011 Oct 6;68(19):3165-73. Epub 2011 Aug 6.

Department of Surgery and the Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Blvd., NB8.224, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-011-0781-8DOI Listing
October 2011
3 Reads
23 Citations
5.810 Impact Factor

SPARC regulates collagen interaction with cardiac fibroblast cell surfaces.

Am J Physiol Heart Circ Physiol 2011 Sep 10;301(3):H841-7. Epub 2011 Jun 10.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, and Ralph H. Johnson Department of Veteran's Affairs Health Center, Charleston, South Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.01247.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191098PMC
September 2011
4 Reads
21 Citations
3.840 Impact Factor

The VEGF family in cancer and antibody-based strategies for their inhibition.

MAbs 2010 Mar-Apr;2(2):165-75

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840235PMC
http://dx.doi.org/10.4161/mabs.2.2.11360DOI Listing
July 2011
35 Reads
32 Citations
4.560 Impact Factor

Molecular and clinical aspects of targeting the VEGF pathway in tumors.

J Oncol 2010 10;2010:652320. Epub 2010 Jun 10.

Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2010/652320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902148PMC
July 2011
5 Reads
4 Citations

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.

J Cell Biol 2011 Jun;193(7):1305-19

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201011143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216331PMC
June 2011
2 Reads
20 Citations
9.834 Impact Factor

Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer.

Anticancer Res 2011 Mar;31(3):843-7

Department of Oncology, Medical University, 12 Ogrodowa St., Bialystok, Poland.

View Article

Download full-text PDF

Source
March 2011
28 Reads
3 Citations
1.872 Impact Factor

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.

BMC Cancer 2011 Jan 12;11:15. Epub 2011 Jan 12.

Division of Surgical Oncology, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-11-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034706PMC
January 2011
5 Reads
11 Citations
3.362 Impact Factor

Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.

Clin Cancer Res 2011 Jan 11;17(2):275-85. Epub 2011 Jan 11.

Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-10-1983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806682PMC
January 2011
54 Reads
25 Citations
8.722 Impact Factor

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes.

Dis Model Mech 2010 Sep-Oct;3(9-10):567-80. Epub 2010 Jul 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.003210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931535PMC
December 2010
65 Reads
13 Citations
4.973 Impact Factor

Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood.

Circ Res 2010 Dec 14;107(12):1460-9. Epub 2010 Oct 14.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.110.223669DOI Listing
December 2010
40 Reads
7 Citations
11.020 Impact Factor

Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans.

Nephrol Dial Transplant 2010 Oct 15;25(10):3170-80. Epub 2010 Apr 15.

Division of Nephrology, Medical Clinic III, University of Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfq200DOI Listing
October 2010
46 Reads
10 Citations
3.580 Impact Factor

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting.

J Am Chem Soc 2010 Sep;132(37):12829-31

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja105563aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967214PMC
September 2010
7 Reads
20 Citations
12.113 Impact Factor

Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.

Dis Model Mech 2010 May-Jun;3(5-6):333-42. Epub 2010 Mar 2.

Hamon Center for Therapeutic Oncology Research, and Departments of Surgery and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.003707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860852PMC
September 2010
5 Reads
21 Citations
4.973 Impact Factor

Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice.

Cancer 2010 Aug;116(16):3862-74

Department of Surgery, University of Colorado at Denver, Denver Health Medical Center, Denver, Colorado 80204-0206, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.25140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400465PMC
August 2010
25 Reads
8 Citations
4.890 Impact Factor

r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction.

PLoS One 2010 Aug 6;5(8):e12031. Epub 2010 Aug 6.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012031PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917360PMC
August 2010
19 Reads
20 Citations
3.234 Impact Factor

VEGF and pleiotrophin modulate the immune profile of breast cancer.

Cancers (Basel) 2010 May 26;2(2):970-88. Epub 2010 May 26.

Division of Surgical Oncology, Department of Surgery; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers2020970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835113PMC
May 2010
47 Reads
7 Citations

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.

Cancer Res 2010 Apr 23;70(7):2852-61. Epub 2010 Mar 23.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848888PMC
April 2010
38 Reads
43 Citations
9.330 Impact Factor

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.

Dis Model Mech 2010 Jan-Feb;3(1-2):57-72. Epub 2009 Dec 9.

Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.003228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806901PMC
March 2010
24 Reads
35 Citations
4.973 Impact Factor

Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts.

Exp Biol Med (Maywood) 2010 Feb;235(2):263-70

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, the University of Texas Southwestern Medical School, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1258/ebm.2009.009215DOI Listing
February 2010
42 Reads
18 Citations

Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway.

Exp Biol Med (Maywood) 2010 Jan;235(1):3-9

Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1258/ebm.2009.009191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471161PMC
January 2010
22 Reads
11 Citations

SPARC: a matricellular regulator of tumorigenesis.

J Cell Commun Signal 2009 Dec 7;3(3-4):255-73. Epub 2009 Oct 7.

Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology and Departments of Surgery and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390-8593 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12079-009-0072-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778590PMC
December 2009
37 Reads
38 Citations

Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer.

PLoS One 2009 Nov 3;4(11):e7669. Epub 2009 Nov 3.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007669PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766251PMC
November 2009
6 Reads
46 Citations
3.234 Impact Factor

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

Mol Cell Biol 2009 Aug 22;29(16):4467-83. Epub 2009 Jun 22.

Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00192-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725728PMC
August 2009
7 Reads
218 Citations
4.780 Impact Factor

Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts.

Mol Cancer Ther 2009 Jul 30;8(7):1761-71. Epub 2009 Jun 30.

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-09-0280DOI Listing
July 2009
51 Reads
46 Citations
5.680 Impact Factor

K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.

Mol Cancer Res 2009 Jun 9;7(6):799-808. Epub 2009 Jun 9.

Department of Gastroenterology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-08-0577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267726PMC
June 2009
41 Reads
23 Citations
4.380 Impact Factor

The acellular fraction of stored platelets promotes tumor cell invasion.

J Surg Res 2009 May 7;153(1):132-7. Epub 2008 May 7.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2008.04.013DOI Listing
May 2009
37 Reads
7 Citations
1.940 Impact Factor

Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity.

Am J Obstet Gynecol 2009 Feb 6;200(2):180.e1-7. Epub 2008 Nov 6.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2008.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709016PMC
February 2009
65 Reads
8 Citations
4.700 Impact Factor

The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer.

BMC Cancer 2008 Nov 27;8:352. Epub 2008 Nov 27.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-8-352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627916PMC
November 2008
12 Reads
15 Citations
3.360 Impact Factor

The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues.

Bioorg Med Chem Lett 2008 Nov 10;18(22):5892-4. Epub 2008 Jul 10.

Department of Internal Medicine and Molecular Biology, Division of Translational Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9185, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593102PMC
November 2008
5 Reads
13 Citations
2.420 Impact Factor

Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.

Cancer Res 2008 Nov;68(21):9050-9

Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Universita degli Studi di Milano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-1327DOI Listing
November 2008
13 Reads
44 Citations
9.330 Impact Factor

Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.

Cancer Res 2008 Oct;68(20):8295-303

Departments of Internal Medicine, Hamon Center for Therapeutic Oncology Research-Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-6601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760388PMC
October 2008
19 Reads
27 Citations
9.330 Impact Factor

Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC.

Exp Biol Med (Maywood) 2008 Jul 29;233(7):860-73. Epub 2008 Apr 29.

Hamon Center for Therapeutic Oncology Research, UT-Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3181/0801-RM-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459223PMC
July 2008
5 Reads
23 Citations

Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice.

Cancer Res 2008 Jun;68(11):4340-6

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-6705DOI Listing
June 2008
46 Reads
67 Citations
9.330 Impact Factor

A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site.

Bioorg Med Chem 2008 Jun 9;16(12):6338-43. Epub 2008 May 9.

Department of Internal Medicine, Division of Translational Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9185, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2008.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2460570PMC
June 2008
7 Reads
6 Citations
2.790 Impact Factor

A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity.

J Am Chem Soc 2008 Apr 2;130(17):5744-52. Epub 2008 Apr 2.

Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9185, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja711193xDOI Listing
April 2008
5 Reads
72 Citations
12.110 Impact Factor

Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model.

Int J Cancer 2007 Nov;121(10):2181-91

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ijc.22937
Publisher Site
http://dx.doi.org/10.1002/ijc.22937DOI Listing
November 2007
8 Reads
35 Citations
5.080 Impact Factor

Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics.

Cancer Res 2007 Oct;67(20):9929-36

Dalton Cardiovascular Research Center, Veterinary Pathobiology, and Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-1103DOI Listing
October 2007
19 Reads
31 Citations
9.330 Impact Factor

Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.

Cancer Res 2007 Oct;67(19):9435-42

Department of Pediatrics, Neurology, University of California-San Francisco Medical School, San Francisco, California 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-1316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921769PMC
October 2007
38 Reads
22 Citations
9.330 Impact Factor

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

Circ Res 2007 Mar 1;100(4):e47-57. Epub 2007 Feb 1.

National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.RES.0000259564.92792.93DOI Listing
March 2007
41 Reads
77 Citations
11.020 Impact Factor

The effects of aging on tumor growth and angiogenesis are tumor-cell dependent.

Int J Cancer 2007 Feb;120(4):753-60

Department of Medicine, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.22351DOI Listing
February 2007
30 Reads
15 Citations
5.080 Impact Factor

Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.

Clin Cancer Res 2007 Jan;13(1):323-30

Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-06-1313DOI Listing
January 2007
4 Reads
75 Citations
8.720 Impact Factor

Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones.

Endocr Relat Cancer 2006 Sep;13(3):905-19

Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park Drive, Columbia, Missouri 65211, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/erc.1.01221DOI Listing
September 2006
10 Reads
34 Citations
4.800 Impact Factor

Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts.

Ann Surg Oncol 2006 Aug 21;13(8):1145-55. Epub 2006 Jun 21.

Department of Surgery, Division of Surgical Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/ASO.2006.05.049DOI Listing
August 2006
2 Reads
10 Citations
3.930 Impact Factor

Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain.

Neurosurgery 2006 Aug;59(2):374-82; discussion 374-82

Department of Neurosurgery, Stanford University, Stanford, California 94305-5327, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1227/01.NEU.0000222658.66878.CCDOI Listing
August 2006
6 Reads
16 Citations
3.620 Impact Factor

Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice.

Int J Cancer 2006 May;118(10):2639-43

Simmons Comprehensive Cancer Center and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21684DOI Listing
May 2006
5 Reads
22 Citations
5.080 Impact Factor

Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.

J Clin Invest 2006 Feb;116(2):422-9

Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40536-0284, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI26316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1359054PMC
February 2006
9 Reads
30 Citations
13.210 Impact Factor

Targeting vascular endothelium with avidin microbubbles.

Ultrasound Med Biol 2005 Sep;31(9):1279-83

Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultrasmedbio.2005.06.001DOI Listing
September 2005
17 Reads
20 Citations
2.210 Impact Factor

Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.

Mol Cancer Res 2005 Jul;3(7):413-23

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-04-0206DOI Listing
July 2005
5 Reads
52 Citations
4.380 Impact Factor

SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges.

J Histochem Cytochem 2005 May;53(5):571-81

Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Ave., Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1369/jhc.4A6425.2005DOI Listing
May 2005
81 Reads
13 Citations
1.960 Impact Factor

Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer.

J Am Coll Surg 2005 Mar;200(3):371-7

Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamcollsurg.2004.10.005DOI Listing
March 2005
4 Reads
22 Citations
5.120 Impact Factor

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer.

Clin Cancer Res 2004 Oct;10(20):6993-7000

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-04-0808DOI Listing
October 2004
22 Reads
22 Citations
8.720 Impact Factor

Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies.

J Histochem Cytochem 2004 Jun;52(6):723-33

Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1369/jhc.3A6153.2004DOI Listing
June 2004
18 Reads
11 Citations
1.960 Impact Factor

Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins.

J Histochem Cytochem 2004 Jun;52(6):735-48

Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104-2046, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1369/jhc.3A6245.2004DOI Listing
June 2004
2 Reads
18 Citations
1.960 Impact Factor

Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis.

Mol Cancer Res 2004 Apr;2(4):215-24

Department of Vascular Biology, Hope Heart Institute, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
April 2004
4 Reads
50 Citations
4.380 Impact Factor

SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells.

J Cell Biochem 2004 Apr;91(5):915-25

Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.20008DOI Listing
April 2004
4 Reads
30 Citations
3.260 Impact Factor

Functional imaging of angiogenesis in an orthotopic model of pancreatic cancer.

J Cell Biochem 2003 Oct;90(3):492-501

The Hamon Center for Therapeutic Oncology Research and the Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8593, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.10644DOI Listing
October 2003
22 Reads
7 Citations
3.260 Impact Factor

Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.

Cancer Res 2003 Sep;63(17):5376-80

Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis 68100, Greece.

View Article

Download full-text PDF

Source
September 2003
4 Reads
56 Citations
9.330 Impact Factor

Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.

J Clin Invest 2003 Feb;111(4):487-95

Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104-2046, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI16804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151926PMC
February 2003
6 Reads
55 Citations
13.210 Impact Factor

Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.

Oncogene 2002 Oct;21(46):7011-26

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1205679DOI Listing
October 2002
10 Reads
94 Citations
8.460 Impact Factor

Strategies for vascular targeting in tumors.

Int J Cancer 2002 Jul;100(2):123-30

Department of Vascular Biology, The Hope Heart Institute, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.10462DOI Listing
July 2002
101 Reads
7 Citations
5.080 Impact Factor

Top co-authors

Jason E Toombs
Jason E Toombs

Hamon Center for Therapeutic Oncology Research

16
Lee B Rivera
Lee B Rivera

Brain Tumor Research Center

9
Michael T Dellinger
Michael T Dellinger

University of Texas Southwestern Medical Center

8
John D Minna
John D Minna

Hamon Center for Therapeutic Oncology Research

7
Christina L Roland
Christina L Roland

The University of Texas MD Anderson Cancer Center

7
Sean P Dineen
Sean P Dineen

University of Texas Southwestern Medical School

7
Diego H Castrillon
Diego H Castrillon

UT Southwestern Medical Center

5
Katherine T Ostapoff
Katherine T Ostapoff

University of Texas Southwestern Medical Center

5
Amanda Kirane
Amanda Kirane

University of California

5