Roland Rad

Roland Rad

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Roland Rad

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Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.

Neoplasia 2019 10 20;21(10):974-988. Epub 2019 Aug 20.

Institute of Pathology, Ludwig-Maximilians University (LMU), Thalkirchnerstraße 36, 80337 Munich, Germany; Research group "Signaling pathways in colorectal cancer"; German Cancer Consortium (DKTK), and German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710297PMC
October 2019

PiggyBac Transposon-Based Insertional Mutagenesis in Mice.

Methods Mol Biol 2019 ;1907:171-183

Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-8967-6_14DOI Listing
July 2019

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Cell Rep 2019 02;26(7):1854-1868.e5

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389594PMC
February 2019

Engineering CRISPR mouse models of cancer.

Curr Opin Genet Dev 2019 02 9;54:88-96. Epub 2019 May 9.

Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München, Germany; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Technische Universität München, Germany; Department of Medicine II, TUM School of Medicine, Technische Universität München, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.04.001DOI Listing
February 2019

Editorial overview: Functionalizing cancer genomes in the era of big data.

Curr Opin Genet Dev 2019 02 20;54:iii-vi. Epub 2019 Jul 20.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.06.011DOI Listing
February 2019

Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype.

Cell Stem Cell 2018 12 15;23(6):794-805.e4. Epub 2018 Nov 15.

Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Rhine Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.011DOI Listing
December 2018

Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG-DFO[Zr] for Tumor-Specific PET/CT Imaging.

Cancer Res 2018 11 18;78(21):6268-6281. Epub 2018 Sep 18.

Radiation Immuno Oncology Group, Center for Translational Cancer Research (TranslaTUM), Campus Klinikum rechts der Isar, Technische Universität München (TUM), Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0707DOI Listing
November 2018

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.

Nature 2017 12 15;552(7683):121-125. Epub 2017 Nov 15.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany.

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http://dx.doi.org/10.1038/nature24649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821214PMC
December 2017

Disentangling -cooperating tumor suppressor gene networks in cancer.

Mol Cell Oncol 2017 4;4(4):e1325550. Epub 2017 May 4.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1080/23723556.2017.1325550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540202PMC
May 2017

Tissue-specific tumorigenesis: context matters.

Nat Rev Cancer 2017 04 3;17(4):239-253. Epub 2017 Mar 3.

University Hospital Klinikum rechts der Isar, Technische Universität München, School of Medicine, Ismaningerstr. 22, 81675 München, Germany; and at the Division of Translational Cancer Research, DKFZ and DKTK, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrc.2017.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823237PMC
April 2017

siRNA-coupled nanoparticles for improved therapeutic targeting of pancreatic cancer.

Gut 2016 11 19;65(11):1780-1781. Epub 2016 Jul 19.

Department of Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1136/gutjnl-2016-312092DOI Listing
November 2016

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

Blood 2016 07 27;128(1):e1-9. Epub 2016 Apr 27.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Department of Haematology, Haemato-oncology Diagnostic Service, Cambridge University Hospitals National Health Service Trust, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-11-683334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937362PMC
July 2016

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.

Cancer Cell 2016 07;30(1):75-91

III. Medical Department for Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.002DOI Listing
July 2016

Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide.

PLoS One 2014 28;9(8):e105344. Epub 2014 Aug 28.

Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Clinical Cooperation Group (CCG) ''Innate Immunity in Tumor Biology'', Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148261PMC
October 2015

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.

Cell Rep 2015 Mar 26;10(8):1239-45. Epub 2015 Feb 26.

Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542313PMC
March 2015

Clonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen.

PLoS One 2013 5;8(8):e72338. Epub 2013 Aug 5.

Department of Neuroscience, Department of Developmental and Regenerative Biology, Department of Neurosurgery, Icahn School of Medicine at Mount, Sinai, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733837PMC
April 2014

A new mouse model for studying EGFR-dependent gastric polyps.

Biochim Biophys Acta 2012 Aug 8;1822(8):1293-9. Epub 2012 May 8.

Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09254439120010
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http://dx.doi.org/10.1016/j.bbadis.2012.05.002DOI Listing
August 2012

Messenger RNA and microRNA profiling during early mouse EB formation.

Gene Expr Patterns 2011 Jun-Jul;11(5-6):334-44. Epub 2011 Apr 1.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1016/j.gep.2011.03.004DOI Listing
September 2011

Genetic screens using the piggyBac transposon.

Methods 2011 Apr 23;53(4):366-71. Epub 2010 Dec 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1016/j.ymeth.2010.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650578PMC
April 2011

The use of DNA transposons for cancer gene discovery in mice.

Methods Enzymol 2010 ;477:91-106

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(10)77006-3DOI Listing
December 2010

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13438-43. Epub 2010 Jul 12.

Second Department of Internal Medicine and Institute of Pathology, Technical University of Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1002423107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922150PMC
July 2010

Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer.

Cytokine 2009 May 28;46(2):182-6. Epub 2009 Feb 28.

Technische Universität of München, II. Medizinische Klinik, Klinikum rechts der Isar, Ismaninger Str. 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.cyto.2009.01.005DOI Listing
May 2009

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.

Nat Methods 2009 May 31;6(5):363-9. Epub 2009 Mar 31.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677165PMC
May 2009

Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival.

Neuroendocrinology 2009 18;89(1):66-78. Epub 2008 Aug 18.

II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1159/000151482DOI Listing
March 2009

Gastric cancer in Japan.

Authors:
Roland Rad

N Engl J Med 2008 Nov;359(22):2394; author reply 2394-5

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November 2008

Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2.

Eur J Immunol 2007 Aug;37(8):2174-84

Institute of Medical Microbiology, Immunology and Hygiene, 2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany.

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http://doi.wiley.com/10.1002/eji.200737063
Publisher Site
http://dx.doi.org/10.1002/eji.200737063DOI Listing
August 2007

Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori.

Gastroenterology 2007 Jul 3;133(1):150-163.e3. Epub 2007 May 3.

2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2007.04.071DOI Listing
July 2007

Fox-P3-positive regulatory T cells are present in the skin of generalized atopic eczema patients and are not particularly affected by medium-dose UVA1 therapy.

Photodermatol Photoimmunol Photomed 2007 Apr-Jun;23(2-3):81-5

Department of Dermatology and Allergy, Biederstein, Technical University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/j.1600-0781.2007.00284.xDOI Listing
June 2007

Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase.

Gastroenterology 2007 May 21;132(5):1820-33. Epub 2007 Feb 21.

Department of Medicine II, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2007.02.031DOI Listing
May 2007

Conjugative transfer of chromosomally encoded antibiotic resistance from Helicobacter pylori to Campylobacter jejuni.

J Clin Microbiol 2007 Feb 29;45(2):402-8. Epub 2006 Nov 29.

Department of Poultry Science, Auburn University, Auburn, Alabama 36849, USA.

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http://dx.doi.org/10.1128/JCM.01456-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829062PMC
February 2007

Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms.

J Infect Dis 2006 Nov 10;194(10):1346-55. Epub 2006 Oct 10.

Second Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/5084
Publisher Site
http://dx.doi.org/10.1086/508426DOI Listing
November 2006

VacA-associated inhibition of T-cell function: reviewed and reconsidered.

Helicobacter 2006 Jun;11(3):144-6

II. Medical Department, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/j.1523-5378.2006.00393.xDOI Listing
June 2006

Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries.

FEMS Immunol Med Microbiol 2005 May;44(2):151-6

Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden.

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http://dx.doi.org/10.1016/j.femsim.2004.10.010DOI Listing
May 2005

Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa.

J Infect Dis 2003 Jul 3;188(2):272-81. Epub 2003 Jul 3.

Department of Internal Medicine II and Gastroenterology, Bogenhausen Academic Teaching Hospital, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1086/376458DOI Listing
July 2003

Pathogenesis of Helicobacter pylori infection.

Helicobacter 2002 ;7 Suppl 1:17-23

Laboratory of Molecular Gastroenterology, Department of Medicine II, Technical University of Munich, Germany.

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http://dx.doi.org/10.1046/j.1523-5378.7.s1.3.xDOI Listing
November 2002

The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response.

J Immunol 2002 Mar;168(6):3033-41

Departments of Medicine II and Gastroenterology, Microbiology, and Pathology, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.168.6.3033DOI Listing
March 2002