Roland Kappler

Roland Kappler

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Roland Kappler

Roland Kappler

Publications by authors named "Roland Kappler"

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Vessel adherent growth represents a major challenge in the surgical resection of neuroblastoma and is associated with adverse outcome.

J Pediatr Surg 2019 Jul 23. Epub 2019 Jul 23.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2019.07.012DOI Listing
July 2019

Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.

Int J Oncol 2019 May 5;54(5):1853-1863. Epub 2019 Mar 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.

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http://dx.doi.org/10.3892/ijo.2019.4741DOI Listing
May 2019

Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants.

Anticancer Res 2019 May;39(5):2351-2360

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.21873/anticanres.13352DOI Listing
May 2019

Overexpression of promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma.

Clin Epigenetics 2018 2;10:27. Epub 2018 Mar 2.

1Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 2a, 80337 Munich, Germany.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0462-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833129PMC
February 2019

MiR-492 regulates metastatic properties of hepatoblastoma via CD44.

Liver Int 2018 07 25;38(7):1280-1291. Epub 2018 Jan 25.

Department of Pediatric Hematology and Oncology, Children's Research Center, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/liv.13687DOI Listing
July 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Expression of Truncated Neurokinin-1 Receptor in Childhood Neuroblastoma is Independent of Tumor Biology and Stage.

Anticancer Res 2017 11;37(11):6079-6085

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany

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http://dx.doi.org/10.21873/anticanres.12056DOI Listing
November 2017

Transcriptional activation of Hedgehog pathway components in aggressive haemangioma.

Exp Dermatol 2017 10 15;26(10):934-939. Epub 2017 Aug 15.

Department of Pediatric Surgery, Dr. von Hauner Childrens' Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/exd.13346DOI Listing
October 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Activation of the Wnt/β-catenin pathway is common in wilms tumor, but rarely through β-catenin mutation and APC promoter methylation.

Pediatr Surg Int 2016 Dec 27;32(12):1141-1146. Epub 2016 Sep 27.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Lindwurmstr. 4, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s00383-016-3970-6DOI Listing
December 2016

Connectivity map identifies HDAC inhibition as a treatment option of high-risk hepatoblastoma.

Cancer Biol Ther 2016 11 16;17(11):1168-1176. Epub 2016 Sep 16.

a Department of Pediatric Surgery, Dr. von Hauner Children's Hospital , Ludwig-Maximilians-University Munich , Munich , Germany.

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http://dx.doi.org/10.1080/15384047.2016.1235664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137489PMC
November 2016

Therapeutic Innovations for Targeting Hepatoblastoma.

Anticancer Res 2016 11;36(11):5577-5592

Department of Pediatric Surgery, Research Laboratories, Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany

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http://dx.doi.org/10.21873/anticanres.11143DOI Listing
November 2016

Association of expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker.

Oncol Lett 2016 Oct 5;12(4):2854-2859. Epub 2016 Aug 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, 80337 Bavaria, Germany.

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http://dx.doi.org/10.3892/ol.2016.4958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038485PMC
October 2016

Low expression of N-myc downstream-regulated gene 2 (NDRG2) correlates with poor prognosis in hepatoblastoma.

Hepatol Int 2016 Mar 8;10(2):370-6. Epub 2015 Dec 8.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 2a, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s12072-015-9686-1DOI Listing
March 2016

Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage.

Oncol Lett 2016 Jan 20;11(1):870-878. Epub 2015 Nov 20.

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig Maximilian University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/ol.2015.3951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726931PMC
January 2016

Platelet Derived Growth Factor Has a Role in Pressure Induced Bladder Smooth Muscle Cell Hyperplasia and Acts in a Paracrine Way.

J Urol 2015 Dec 6;194(6):1797-805. Epub 2015 Jun 6.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pediatric Surgery and Urology, Cnopf'sche Kinderklinik, Nuremberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.05.092DOI Listing
December 2015

Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma.

Mol Cancer Ther 2015 Dec 29;14(12):2712-21. Epub 2015 Oct 29.

Department of Pediatric Surgery, Research Laboratories, Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-15
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http://dx.doi.org/10.1158/1535-7163.MCT-15-0206DOI Listing
December 2015

Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells.

Int J Oncol 2015 Jul 21;47(1):151-60. Epub 2015 May 21.

Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.3892/ijo.2015.3016DOI Listing
July 2015

Reply to: "TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma".

J Hepatol 2015 Feb 5;62(2):498-9. Epub 2014 Nov 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.jhep.2014.10.043DOI Listing
February 2015

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.

J Hepatol 2014 Dec 15;61(6):1312-20. Epub 2014 Aug 15.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.08.009DOI Listing
December 2014

Intestinal expression of the anti-inflammatory interleukin-1 homologue IL-37 in pediatric inflammatory bowel disease.

J Pediatr Gastroenterol Nutr 2014 Aug;59(2):e18-26

*Department of Pediatrics †Department of Pediatric Surgery, Dr von Hauner Children's Hospital ‡Institute of Pathology, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1097/MPG.0000000000000387DOI Listing
August 2014

Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1.

Nutr Cancer 2013 15;65(8):1200-7. Epub 2013 Oct 15.

a Department of Pediatric Surgery, Dr. von Hauner Children's Hospital , Ludwig-Maximilians-University Munich , Munich , Germany.

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http://dx.doi.org/10.1080/01635581.2013.828085DOI Listing
June 2014

Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo.

J Hepatol 2014 May 8;60(5):985-94. Epub 2014 Jan 8.

Research Laboratory on Neuropeptides, Virgen del Rocío Children's Hospital, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.12.024DOI Listing
May 2014

Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma.

Int J Oncol 2014 May 27;44(5):1727-35. Epub 2014 Feb 27.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/ijo.2014.2312DOI Listing
May 2014

Frequent hypermethylation of a CTCF binding site influences Wilms tumor 1 expression in Wilms tumors.

Oncol Rep 2014 Apr 11;31(4):1871-6. Epub 2014 Feb 11.

Department of Pediatric Surgery, Research Laboratories, Ludwig-Maximilians University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/or.2014.3019DOI Listing
April 2014

β-Catenin mutations in 2 nested stromal epithelial tumors of the liver--a neoplasia with defective mesenchymal-epithelial transition.

Hum Pathol 2012 Nov 29;43(11):1815-27. Epub 2012 Jun 29.

Institut für Pathologie, Kinderchirurgische Klinik, Haunersches Kinderspital, Ludwig-Maximilians-Universität, 80337 München, Germany.

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http://dx.doi.org/10.1016/j.humpath.2012.03.018DOI Listing
November 2012

Genetics and epigenetics of hepatoblastoma.

Pediatr Blood Cancer 2012 Nov 13;59(5):785-92. Epub 2012 Jul 13.

Department of Pediatrics, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.

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http://dx.doi.org/10.1002/pbc.24213DOI Listing
November 2012

Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients.

Eur J Cancer 2012 Oct 28;48(15):2442-50. Epub 2012 Jan 28.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, D-80337 Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1016/j.ejca.2011.12.032DOI Listing
October 2012

Neutrophils express distinct RNA receptors in a non-canonical way.

J Biol Chem 2012 Jun 24;287(23):19409-17. Epub 2012 Apr 24.

Department of Pediatric Surgery, Research Center, Dr von Hauner Children's Hospital, Ludwig Maximilians University of Munich, 80539 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.353557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365979PMC
June 2012

In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis.

ScientificWorldJournal 2011 26;11:2480-90. Epub 2011 Dec 26.

Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, 80337 Munich, Germany.

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http://dx.doi.org/10.1100/2011/968479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253525PMC
April 2012

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors.

Mol Cancer 2012 Mar 8;11. Epub 2012 Mar 8.

Department of Pediatric Surgery, Dr, von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, 80337 Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1186/1476-4598-11-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349592PMC
March 2012

A better way forward: targeting hedgehog signaling in liver cancer.

Front Biosci (Schol Ed) 2012 Jan 1;4:277-86. Epub 2012 Jan 1.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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January 2012

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

Nucleic Acids Res 2011 Oct 10;39(19):8355-65. Epub 2011 Jul 10.

Department of Biochemistry III, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkr528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201865PMC
October 2011

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway.

Clin Cancer Res 2011 May 1;17(10):3204-18. Epub 2011 Apr 1.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-2451DOI Listing
May 2011

Altered expression of imprinted genes in Wilms tumors.

Oncol Rep 2011 Mar 20;25(3):817-23. Epub 2010 Dec 20.

Department of Pediatric Surgery, Research Laboratories, Ludwig-Maximilians-University of Munich, Lindwurmstrasse 2a, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/or.2010.1113DOI Listing
March 2011

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma.

Hepatology 2011 Mar 11;53(3):833-42. Epub 2011 Feb 11.

Children's Research Center, Division of Pediatric Hematology and Oncology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Germany.

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http://dx.doi.org/10.1002/hep.24125DOI Listing
March 2011

Hirschsprung-associated enterocolitis develops independently of NOD2 variants.

J Pediatr Surg 2010 Sep;45(9):1826-31

Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2010.02.039DOI Listing
September 2010

NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease.

J Pediatr Surg 2010 Aug;45(8):1591-7

Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2009.10.046DOI Listing
August 2010

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.

Acta Paediatr 2009 Nov 29;98(11):1835-40. Epub 2009 Jul 29.

Department of Paediatric Surgery, Research Laboratories, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/j.1651-2227.2009.01438.xDOI Listing
November 2009

Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

J Pediatr Gastroenterol Nutr 2009 Jul;49(1):147-50

Department of Pediatric Surgery, Dr von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Lindwurmstr, Munich, Germany.

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http://dx.doi.org/10.1097/MPG.0b013e31818de1a8DOI Listing
July 2009

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis.

Cancer Res 2009 Jul 7;69(14):5784-92. Epub 2009 Jul 7.

Departments of Medicine, University Hospital Innenstadt, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4428DOI Listing
July 2009

Blocking the hedgehog pathway inhibits hepatoblastoma growth.

Hepatology 2009 Feb;49(2):482-90

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1002/hep.22649DOI Listing
February 2009

Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors.

Int J Mol Med 2008 Dec;22(6):787-92

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, 80337 Munich, Germany.

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December 2008

Rare occurrence of PHOX2b mutations in sporadic neuroblastomas.

J Pediatr Hematol Oncol 2008 Oct;30(10):728-32

Department of Pediatric Surgery, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1097/MPH.0b013e3181772141DOI Listing
October 2008

Association of a CXCL9 polymorphism with pediatric Crohn's disease.

Biochem Biophys Res Commun 2007 Nov 18;363(3):701-7. Epub 2007 Sep 18.

Dr. von Haunersches Kinderspital, Pediatric Surgical Clinic, Research Laboratories, Ludwig-Maximilians-University of Munich, Lindwurmstr 4, D-80337 Munich, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2007.09.020DOI Listing
November 2007

Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice.

Int J Oncol 2007 Aug;31(2):405-12

Pediatric Surgical Clinic, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, D-80337 Munich, Germany.

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August 2007

Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma.

Oncogene 2004 Nov;23(54):8785-95

Institute of Human Genetics, University of Göttingen, Heinrich-Düker-Weg 12, Göttingen, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208133DOI Listing
November 2004

Analysis of the PTCH1 signaling pathway in ovarian dermoids.

Int J Mol Med 2004 Nov;14(5):793-9

Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.

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November 2004

Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma.

Int J Oncol 2004 Jul;25(1):113-20

Institute of Human Genetics, University of Göttingen, D-37073 Göttingen, Germany.

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July 2004

Analysis of the PTCH coding region in human rhabdomyosarcoma.

Hum Mutat 2002 Sep;20(3):233-4

Institute of Pathology, Technical University Munich, Munich Goettingen, Federal Republic of Germany.

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http://dx.doi.org/10.1002/humu.9056DOI Listing
September 2002

Reduced body growth and excessive incisor length in insertional mutants mapping to mouse Chromosome 13.

Mamm Genome 2002 Sep;13(9):504-9

Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Veterinärplatz 1, Austria.

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http://dx.doi.org/10.1007/s00335-002-3006-5DOI Listing
September 2002

Unbalanced overexpression of the mutant allele in murine Patched mutants.

Carcinogenesis 2002 May;23(5):727-33

Institute of Pathology, Technical University Munich, Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1093/carcin/23.5.727DOI Listing
May 2002