Publications Authored by Roland Kappler

Vessel adherent growth represents a major challenge in the surgical resection of neuroblastoma and is associated with adverse outcome.

Authors:

Jakob Mühling Corinna Eberherr Josef Müller Höcker Veit Grote Dietrich von Schweinitz Roland Kappler Alexandra Fröba-Pohl

J Pediatr Surg 2019 Jul 23. Epub 2019 Jul 23.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2019.07.012	DOI Listing

July 2019

Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.

Authors:

Corinna Eberherr Alexander Beck Christian Vokuhl Kristina Becker Beate Häberle Dietrich Von Schweinitz Roland Kappler

Int J Oncol 2019 May 5;54(5):1853-1863. Epub 2019 Mar 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, D‑80337 Munich, Germany.

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http://dx.doi.org/10.3892/ijo.2019.4741	DOI Listing

May 2019

Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants.

Authors:

Danielle Wendling-Keim Christian Vokuhl Christoph Walz Lynn Rieder Rainer Grantzow Dietrich VON Schweinitz Roland Kappler Michael Berger

Anticancer Res 2019 May;39(5):2351-2360

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.21873/anticanres.13352	DOI Listing

May 2019

Overexpression of promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma.

Authors:

Alexander Beck Franziska Trippel Alexandra Wagner Saskia Joppien Max Felle Christian Vokuhl Thomas Schwarzmayr Tim M Strom Dietrich von Schweinitz Gernot Längst Roland Kappler

Clin Epigenetics 2018 2;10:27. Epub 2018 Mar 2.

1Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 2a, 80337 Munich, Germany.

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https://clinicalepigeneticsjournal.biomedcentral.com/article	Publisher Site
http://dx.doi.org/10.1186/s13148-018-0462-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833129	PMC

February 2019

MiR-492 regulates metastatic properties of hepatoblastoma via CD44.

Authors:

Julia von Frowein Stefanie M Hauck Roland Kappler Philipp Pagel Katrin K Fleischmann Thomas Magg Stefano Cairo Adelbert Roscher Dietrich von Schweinitz Irene Schmid

Liver Int 2018 07 25;38(7):1280-1291. Epub 2018 Jan 25.

Department of Pediatric Hematology and Oncology, Children's Research Center, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/liv.13687	DOI Listing

July 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Authors:

Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2	DOI Listing

July 2018

The landscape of genomic alterations across childhood cancers.

Authors:

Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480	DOI Listing

March 2018

Expression of Truncated Neurokinin-1 Receptor in Childhood Neuroblastoma is Independent of Tumor Biology and Stage.

Authors:

Alexandra Pohl Roland Kappler Jakob Mühling Dietrich VON Schweinitz Michael Berger

Anticancer Res 2017 11;37(11):6079-6085

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany

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http://dx.doi.org/10.21873/anticanres.12056	DOI Listing

November 2017

Transcriptional activation of Hedgehog pathway components in aggressive haemangioma.

Authors:

Danielle S Wendling-Keim Lynn Wanie Dietrich von Schweinitz Rainer Grantzow Roland Kappler

Exp Dermatol 2017 10 15;26(10):934-939. Epub 2017 Aug 15.

Department of Pediatric Surgery, Dr. von Hauner Childrens' Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/exd.13346	DOI Listing

October 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Authors:

Tim Ripperger Stefan S Bielack Arndt Borkhardt Ines B Brecht Birgit Burkhardt Gabriele Calaminus Klaus-Michael Debatin Hedwig Deubzer Uta Dirksen Cornelia Eckert Angelika Eggert Miriam Erlacher Gudrun Fleischhack Michael C Frühwald Astrid Gnekow Gudrun Goehring Norbert Graf Helmut Hanenberg Julia Hauer Barbara Hero Simone Hettmer Katja von Hoff Martin Horstmann Juliane Hoyer Thomas Illig Peter Kaatsch Roland Kappler Kornelius Kerl Thomas Klingebiel Udo Kontny Uwe Kordes Dieter Körholz Ewa Koscielniak Christof M Kramm Michaela Kuhlen Andreas E Kulozik Britta Lamottke Ivo Leuschner Dietmar R Lohmann Andrea Meinhardt Markus Metzler Lüder H Meyer Olga Moser Michaela Nathrath Charlotte M Niemeyer Rainer Nustede Kristian W Pajtler Claudia Paret Mareike Rasche Dirk Reinhardt Olaf Rieß Alexandra Russo Stefan Rutkowski Brigitte Schlegelberger Dominik Schneider Reinhard Schneppenheim Martin Schrappe Christopher Schroeder Dietrich von Schweinitz Thorsten Simon Monika Sparber-Sauer Claudia Spix Martin Stanulla Doris Steinemann Brigitte Strahm Petra Temming Kathrin Thomay Andre O von Bueren Peter Vorwerk Olaf Witt Marcin Wlodarski Willy Wössmann Martin Zenker Stefanie Zimmermann Stefan M Pfister Christian P Kratz

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142	DOI Listing

April 2017

Activation of the Wnt/β-catenin pathway is common in wilms tumor, but rarely through β-catenin mutation and APC promoter methylation.

Authors:

Amei Schweigert Carmen Fischer Doris Mayr Dietrich von Schweinitz Roland Kappler Jochen Hubertus

Pediatr Surg Int 2016 Dec 27;32(12):1141-1146. Epub 2016 Sep 27.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Lindwurmstr. 4, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s00383-016-3970-6	DOI Listing

December 2016

Connectivity map identifies HDAC inhibition as a treatment option of high-risk hepatoblastoma.

Authors:

Alexander Beck Corinna Eberherr Michaela Hagemann Stefano Cairo Beate Häberle Christian Vokuhl Dietrich von Schweinitz Roland Kappler

Cancer Biol Ther 2016 11 16;17(11):1168-1176. Epub 2016 Sep 16.

a Department of Pediatric Surgery, Dr. von Hauner Children's Hospital , Ludwig-Maximilians-University Munich , Munich , Germany.

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http://dx.doi.org/10.1080/15384047.2016.1235664	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137489	PMC

November 2016

Therapeutic Innovations for Targeting Hepatoblastoma.

Authors:

Agnès Garnier Matthias Ilmer Roland Kappler Michael Berger

Anticancer Res 2016 11;36(11):5577-5592

Department of Pediatric Surgery, Research Laboratories, Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany

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http://dx.doi.org/10.21873/anticanres.11143	DOI Listing

November 2016

Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management.

Hepatology 2016 10 16;64(4):1121-35. Epub 2016 Jun 16.

XenTech, 4 rue Pierre Fontaine, Evry, France.

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http://dx.doi.org/10.1002/hep.28621	DOI Listing

October 2016

Association of expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker.

Authors:

Nadja Apelt Jochen Hubertus Doris Mayr Norbert Graf Rhoikos Furtwängler Dietrich Von Schweinitz Roland Kappler

Oncol Lett 2016 Oct 5;12(4):2854-2859. Epub 2016 Aug 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, 80337 Bavaria, Germany.

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http://dx.doi.org/10.3892/ol.2016.4958	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038485	PMC

October 2016

γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets.

Authors:

Carmen Dorneburg Annika V Goß Matthias Fischer Frederik Roels Thomas F E Barth Frank Berthold Roland Kappler Franz Oswald Jens T Siveke Jan J Molenaar Klaus-Michael Debatin Christian Beltinger

Oncotarget 2016 09;7(39):62799-62813

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.18632/oncotarget.11715	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325329	PMC

September 2016

Low expression of N-myc downstream-regulated gene 2 (NDRG2) correlates with poor prognosis in hepatoblastoma.

Authors:

Jan Gödeke Elke Luxenburger Franziska Trippel Kristina Becker Beate Häberle Josef Müller-Höcker Dietrich von Schweinitz Roland Kappler

Hepatol Int 2016 Mar 8;10(2):370-6. Epub 2015 Dec 8.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstr. 2a, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s12072-015-9686-1	DOI Listing

March 2016

Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage.

Authors:

Agnès Garnier Matthias Ilmer Kristina Becker Beate Häberle Dietrich VON Schweinitz Roland Kappler Michael Berger

Oncol Lett 2016 Jan 20;11(1):870-878. Epub 2015 Nov 20.

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig Maximilian University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/ol.2015.3951	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726931	PMC

January 2016

Platelet Derived Growth Factor Has a Role in Pressure Induced Bladder Smooth Muscle Cell Hyperplasia and Acts in a Paracrine Way.

Authors:

Laura Preis Annika Herlemann Rosalyn M Adam Hans-Georg Dietz Roland Kappler Maximilian Stehr

J Urol 2015 Dec 6;194(6):1797-805. Epub 2015 Jun 6.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pediatric Surgery and Urology, Cnopf'sche Kinderklinik, Nuremberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.05.092	DOI Listing

December 2015

Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma.

Authors:

Matthias Ilmer Agnès Garnier Jody Vykoukal Eckhard Alt Dietrich von Schweinitz Roland Kappler Michael Berger

Mol Cancer Ther 2015 Dec 29;14(12):2712-21. Epub 2015 Oct 29.

Department of Pediatric Surgery, Research Laboratories, Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-15	Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-15-0206	DOI Listing

December 2015

Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells.

Authors:

Agnès Garnier Jody Vykoukal Jochen Hubertus Eckhard Alt Dietrich von Schweinitz Roland Kappler Michael Berger Matthias Ilmer

Int J Oncol 2015 Jul 21;47(1):151-60. Epub 2015 May 21.

Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.3892/ijo.2015.3016	DOI Listing

July 2015

Reply to: "TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma".

Authors:

Roland Kappler Ivo Leuschner Dietrich von Schweinitz

J Hepatol 2015 Feb 5;62(2):498-9. Epub 2014 Nov 5.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.jhep.2014.10.043	DOI Listing

February 2015

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.

Authors:

Melanie Eichenmüller Franziska Trippel Michaela Kreuder Alexander Beck Thomas Schwarzmayr Beate Häberle Stefano Cairo Ivo Leuschner Dietrich von Schweinitz Tim M Strom Roland Kappler

J Hepatol 2014 Dec 15;61(6):1312-20. Epub 2014 Aug 15.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.08.009	DOI Listing

December 2014

Intestinal expression of the anti-inflammatory interleukin-1 homologue IL-37 in pediatric inflammatory bowel disease.

Authors:

Simon Weidlich Ana-Maria Bulau Tobias Schwerd Johanna Althans Roland Kappler Sibylle Koletzko Doris Mayr Philip Bufler

J Pediatr Gastroenterol Nutr 2014 Aug;59(2):e18-26

*Department of Pediatrics †Department of Pediatric Surgery, Dr von Hauner Children's Hospital ‡Institute of Pathology, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1097/MPG.0000000000000387	DOI Listing

August 2014

Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1.

Authors:

Jan Gödeke Sarah Maier Melanie Eichenmüller Josef Müller-Höcker Dietrich von Schweinitz Roland Kappler

Nutr Cancer 2013 15;65(8):1200-7. Epub 2013 Oct 15.

a Department of Pediatric Surgery, Dr. von Hauner Children's Hospital , Ludwig-Maximilians-University Munich , Munich , Germany.

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http://dx.doi.org/10.1080/01635581.2013.828085	DOI Listing

June 2014

Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo.

Authors:

Michael Berger Olaf Neth Matthias Ilmer Agnès Garnier Manuel Vicente Salinas-Martín Juan Carlos de Agustín Asencio Dietrich von Schweinitz Roland Kappler Miguel Muñoz

J Hepatol 2014 May 8;60(5):985-94. Epub 2014 Jan 8.

Research Laboratory on Neuropeptides, Virgen del Rocío Children's Hospital, Seville, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.12.024	DOI Listing

May 2014

Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma.

Authors:

Sebastian Wolf Beate Hagl Roland Kappler

Int J Oncol 2014 May 27;44(5):1727-35. Epub 2014 Feb 27.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/ijo.2014.2312	DOI Listing

May 2014

Molecular profiling of chordoma.

Authors:

Stefanie Scheil-Bertram Roland Kappler Alexandra von Baer Erich Hartwig Michael Sarkar Massimo Serra Silke Brüderlein Bettina Westhoff Ingo Melzner Birgit Bassaly Jochen Herms Heinz-Hermann Hugo Michael Schulte Peter Möller

Int J Oncol 2014 Apr 21;44(4):1041-55. Epub 2014 Jan 21.

Institute of Pathology, University Hospitals of Ulm, Germany.

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http://dx.doi.org/10.3892/ijo.2014.2268	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977807	PMC

April 2014

Frequent hypermethylation of a CTCF binding site influences Wilms tumor 1 expression in Wilms tumors.

Authors:

Ferdinand Zitzmann Doris Mayr Michael Berger Maximilian Stehr Dietrich von Schweinitz Roland Kappler Jochen Hubertus

Oncol Rep 2014 Apr 11;31(4):1871-6. Epub 2014 Feb 11.

Department of Pediatric Surgery, Research Laboratories, Ludwig-Maximilians University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/or.2014.3019	DOI Listing

April 2014

Selective methylation of CpGs at regulatory binding sites controls NNAT expression in Wilms tumors.

Authors:

Jochen Hubertus Ferdinand Zitzmann Franziska Trippel Josef Müller-Höcker Maximilian Stehr Dietrich von Schweinitz Roland Kappler

PLoS One 2013 25;8(6):e67605. Epub 2013 Jun 25.

Department of Pediatric Surgery, Research Laboratories, Ludwig-Maximilians-University, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067605	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692448	PMC

February 2014

β-Catenin mutations in 2 nested stromal epithelial tumors of the liver--a neoplasia with defective mesenchymal-epithelial transition.

Authors:

Gerald Assmann Roland Kappler Evelyn Zeindl-Eberhart Irene Schmid Beate Häberle Christian Graeb Andreas Jung Josef Müller-Höcker

Hum Pathol 2012 Nov 29;43(11):1815-27. Epub 2012 Jun 29.

Institut für Pathologie, Kinderchirurgische Klinik, Haunersches Kinderspital, Ludwig-Maximilians-Universität, 80337 München, Germany.

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http://dx.doi.org/10.1016/j.humpath.2012.03.018	DOI Listing

November 2012

Genetics and epigenetics of hepatoblastoma.

Authors:

Gail E Tomlinson Roland Kappler

Pediatr Blood Cancer 2012 Nov 13;59(5):785-92. Epub 2012 Jul 13.

Department of Pediatrics, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.

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http://dx.doi.org/10.1002/pbc.24213	DOI Listing

November 2012

Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients.

Authors:

Ferdinand Wagner Bente Henningsen Christine Lederer Melanie Eichenmüller Jan Gödeke Josef Müller-Höcker Dietrich von Schweinitz Roland Kappler

Eur J Cancer 2012 Oct 28;48(15):2442-50. Epub 2012 Jan 28.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, D-80337 Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1016/j.ejca.2011.12.032	DOI Listing

October 2012

Neutrophils express distinct RNA receptors in a non-canonical way.

Authors:

Michael Berger Chin-Yuan Hsieh Martina Bakele Veronica Marcos Nikolaus Rieber Michael Kormann Lauren Mays Laura Hofer Olaf Neth Ljubomir Vitkov Wolf Dietrich Krautgartner Dietrich von Schweinitz Roland Kappler Andreas Hector Alexander Weber Dominik Hartl

J Biol Chem 2012 Jun 24;287(23):19409-17. Epub 2012 Apr 24.

Department of Pediatric Surgery, Research Center, Dr von Hauner Children's Hospital, Ludwig Maximilians University of Munich, 80539 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.353557	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365979	PMC

June 2012

In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis.

Authors:

Ana-Maria Bulau Michaela Fink Christof Maucksch Roland Kappler Doris Mayr Kai Wagner Philip Bufler

ScientificWorldJournal 2011 26;11:2480-90. Epub 2011 Dec 26.

Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, 80337 Munich, Germany.

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http://dx.doi.org/10.1100/2011/968479	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253525	PMC

April 2012

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors.

Authors:

Ivonne Regel Melanie Eichenmüller Saskia Joppien Johanna Liebl Beate Häberle Josef Müller-Höcker Angelika Vollmar Dietrich von Schweinitz Roland Kappler

Mol Cancer 2012 Mar 8;11. Epub 2012 Mar 8.

Department of Pediatric Surgery, Dr, von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, 80337 Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1186/1476-4598-11-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349592	PMC

March 2012

A better way forward: targeting hedgehog signaling in liver cancer.

Authors:

Roland Kappler Dietrich von Schweinitz

Front Biosci (Schol Ed) 2012 Jan 1;4:277-86. Epub 2012 Jan 1.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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January 2012

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

Authors:

Max Felle Saskia Joppien Attila Németh Sarah Diermeier Verena Thalhammer Thomas Dobner Elisabeth Kremmer Roland Kappler Gernot Längst

Nucleic Acids Res 2011 Oct 10;39(19):8355-65. Epub 2011 Jul 10.

Department of Biochemistry III, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkr528	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201865	PMC

October 2011

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway.

Authors:

Ivonne Naumann Roland Kappler Dietrich von Schweinitz Klaus-Michael Debatin Simone Fulda

Clin Cancer Res 2011 May 1;17(10):3204-18. Epub 2011 Apr 1.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0	Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-10-2451	DOI Listing

May 2011

Altered expression of imprinted genes in Wilms tumors.

Authors:

Jochen Hubertus Martin Lacher Marietta Rottenkolber Josef Müller-Höcker Michael Berger Maximilian Stehr Dietrich von Schweinitz Roland Kappler

Oncol Rep 2011 Mar 20;25(3):817-23. Epub 2010 Dec 20.

Department of Pediatric Surgery, Research Laboratories, Ludwig-Maximilians-University of Munich, Lindwurmstrasse 2a, D-80337 Munich, Germany.

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http://dx.doi.org/10.3892/or.2010.1113	DOI Listing

March 2011

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma.

Authors:

Julia von Frowein Philipp Pagel Roland Kappler Dietrich von Schweinitz Adelbert Roscher Irene Schmid

Hepatology 2011 Mar 11;53(3):833-42. Epub 2011 Feb 11.

Children's Research Center, Division of Pediatric Hematology and Oncology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Germany.

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http://dx.doi.org/10.1002/hep.24125	DOI Listing

March 2011

Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease.

Authors:

Sebastian Schroepf Roland Kappler Stephan Brand Christine Prell Peter Lohse Jürgen Glas Eva Hoster Johanna Helmbrecht Antje Ballauff Michael Berger Dietrich von Schweinitz Sibylle Koletzko Martin Lacher

Inflamm Bowel Dis 2010 Nov;16(11):1882-90

Department of Pediatric Surgery, Research Laboratories, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/ibd.21312	DOI Listing

November 2010

Hirschsprung-associated enterocolitis develops independently of NOD2 variants.

Authors:

Martin Lacher Guido Fitze Johanna Helmbrecht Sebastian Schroepf Michael Berger Peter Lohse Sibylle Koletzko Antje Ballauff Veit Grote Jan Goedeke Dietrich von Schweinitz Roland Kappler

J Pediatr Surg 2010 Sep;45(9):1826-31

Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2010.02.039	DOI Listing

September 2010

NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease.

Authors:

Martin Lacher Johanna Helmbrecht Sebastian Schroepf Sibylle Koletzko Antje Ballauff Martin Classen Holm Uhlig Jochen Hubertus Dominik Hartl Peter Lohse Dietrich von Schweinitz Roland Kappler

J Pediatr Surg 2010 Aug;45(8):1591-7

Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany.

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http://dx.doi.org/10.1016/j.jpedsurg.2009.10.046	DOI Listing

August 2010

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.

Authors:

Martin Lacher Sebastian Schroepf Antje Ballauff Peter Lohse Dietrich von Schweinitz Roland Kappler Sibylle Koletzko

Acta Paediatr 2009 Nov 29;98(11):1835-40. Epub 2009 Jul 29.

Department of Paediatric Surgery, Research Laboratories, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/j.1651-2227.2009.01438.x	DOI Listing

November 2009

Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

Authors:

Martin Lacher Roland Kappler Sebastian Schroepf Stefan Berkholz Antje Ballauff Philip Bufler Hansjoerg Baurecht Dietrich von Schweinitz Sibylle Koletzko

J Pediatr Gastroenterol Nutr 2009 Jul;49(1):147-50

Department of Pediatric Surgery, Dr von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Lindwurmstr, Munich, Germany.

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http://dx.doi.org/10.1097/MPG.0b013e31818de1a8	DOI Listing

July 2009

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis.

Authors:

Inga K Johnsen Roland Kappler Christoph J Auernhammer Felix Beuschlein

Cancer Res 2009 Jul 7;69(14):5784-92. Epub 2009 Jul 7.

Departments of Medicine, University Hospital Innenstadt, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4428	DOI Listing

July 2009

Blocking the hedgehog pathway inhibits hepatoblastoma growth.

Authors:

Melanie Eichenmüller Ivonne Gruner Beate Hagl Beate Häberle Josef Müller-Höcker Dietrich von Schweinitz Roland Kappler

Hepatology 2009 Feb;49(2):482-90

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1002/hep.22649	DOI Listing

February 2009

Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors.

Authors:

Danielle S Wendling Clemens Lück Dietrich von Schweinitz Roland Kappler

Int J Mol Med 2008 Dec;22(6):787-92

Department of Pediatric Surgery, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, 80337 Munich, Germany.

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December 2008

Rare occurrence of PHOX2b mutations in sporadic neuroblastomas.

Authors:

Alexandre Serra Beate Häberle Inke R König Roland Kappler Meinolf Suttorp Hans K Schackert Dietmar Roesner Guido Fitze

J Pediatr Hematol Oncol 2008 Oct;30(10):728-32

Department of Pediatric Surgery, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1097/MPH.0b013e3181772141	DOI Listing

October 2008

Association of a CXCL9 polymorphism with pediatric Crohn's disease.

Authors:

Martin Lacher Roland Kappler Stefan Berkholz Hansjoerg Baurecht Dietrich von Schweinitz Sibylle Koletzko

Biochem Biophys Res Commun 2007 Nov 18;363(3):701-7. Epub 2007 Sep 18.

Dr. von Haunersches Kinderspital, Pediatric Surgical Clinic, Research Laboratories, Ludwig-Maximilians-University of Munich, Lindwurmstr 4, D-80337 Munich, Germany.

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