Publications by authors named "Roland H Wenger"

100Publications

Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor.

J Photochem Photobiol B 2020 Jul 27;210:111980. Epub 2020 Jul 27.

Institute of Physiology, University of Zurich, Zurich, & National Centre of Competence in Research 'Kidney.CH', Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111980DOI Listing
July 2020

Thin air - thick science.

Authors:
Roland H Wenger

Nat Rev Mol Cell Biol 2020 Aug 4. Epub 2020 Aug 4.

Institute of Physiology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41580-020-0277-1DOI Listing
August 2020

Simultaneous Three-Dimensional Vascular and Tubular Imaging of Whole Mouse Kidneys With X-ray μCT.

Microsc Microanal 2020 Aug;26(4):731-740

University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057Zurich, Switzerland.

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http://dx.doi.org/10.1017/S1431927620001725DOI Listing
August 2020

Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription.

Biochim Biophys Acta Gene Regul Mech 2020 Aug 25;1863(8):194568. Epub 2020 Apr 25.

Institute of Physiology, University of Zürich, CH-8057 Zürich, Switzerland; National Centre of Competence in Research "Kidney.CH", Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2020.194568DOI Listing
August 2020

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity.

FASEB J 2020 Feb 19;34(2):2344-2358. Epub 2019 Dec 19.

Institute of Physiology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1096/fj.201902240RDOI Listing
February 2020

Now a Nobel gas: oxygen.

Pflugers Arch 2019 12 22;471(11-12):1343-1358. Epub 2019 Nov 22.

Institute of Physiology and National Center of Competence in Research "Kidney.CH", University of Zürich, CH-8057, Zürich, Switzerland.

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http://dx.doi.org/10.1007/s00424-019-02334-8DOI Listing
December 2019

The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.

FASEB J 2019 11 30;33(11):12812-12824. Epub 2019 Aug 30.

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1096/fj.201901385RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902676PMC
November 2019

Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1.

Redox Biol 2019 09 2;26:101265. Epub 2019 Jul 2.

Institute of Physiology, University of Zurich, 8057, Zurich, Switzerland; National Centre of Competence in Research 'Kidney.CH', Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624438PMC
September 2019

Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men.

Pflugers Arch 2018 10 2;470(10):1569-1582. Epub 2018 Jul 2.

University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00424-018-2171-7DOI Listing
October 2018

Source and microenvironmental regulation of erythropoietin in the kidney.

Curr Opin Nephrol Hypertens 2018 07;27(4):277-282

Institute of Physiology, University of Zurich, Zurich, and National Center of Competence in Research 'Kidney.CH', Zurich, Switzerland.

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http://dx.doi.org/10.1097/MNH.0000000000000420DOI Listing
July 2018

The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road.

Exp Cell Res 2017 07 15;356(2):152-159. Epub 2017 Mar 15.

Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2017.03.027DOI Listing
July 2017

The Three "Musketairs" - Lasker Prize 2016 goes to the protagonists of hypoxia research.

Hypoxia (Auckl) 2016 25;4:161-162. Epub 2016 Nov 25.

Institute of Cardiovascular Physiology, Georg-August University Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.2147/HP.S126290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135071PMC
November 2016

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells.

Free Radic Biol Med 2016 12 5;101:129-142. Epub 2016 Oct 5.

Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.002DOI Listing
December 2016

Induction of long noncoding RNA MALAT1 in hypoxic mice.

Hypoxia (Auckl) 2015 8;3:45-52. Epub 2015 Oct 8.

Institute of Physiology and Zurich Center for Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland; National Center of Competence in Research "Kidney.CH", Zurich, Switzerland.

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http://dx.doi.org/10.2147/HP.S90555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045088PMC
October 2015

Frequently asked questions in hypoxia research.

Hypoxia (Auckl) 2015 18;3:35-43. Epub 2015 Sep 18.

Institute of Physiology and Zurich Center for Human Physiology (ZIHP), University of Zurich; National Center of Competence in Research "Kidney. CH", Zurich, Switzerland; Institute of Physiology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.2147/HP.S92198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045069PMC
September 2015

Hypoxia of the growing liver accelerates regeneration.

Surgery 2017 03 16;161(3):666-679. Epub 2016 Jul 16.

Institute of Physiology, Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland; Institute of Anesthesiology, University Hospital Zürich, Zürich, Switzerland; Department of Anesthesiology, University of Illinois Chicago, Chicago, IL.

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http://dx.doi.org/10.1016/j.surg.2016.05.018DOI Listing
March 2017

Erythropoietin production by PDGFR-β(+) cells.

Pflugers Arch 2016 08 25;468(8):1479-87. Epub 2016 May 25.

Institute of Physiology, University of Regensburg, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00424-016-1829-2DOI Listing
August 2016

Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells.

Oncotarget 2016 May;7(21):31153-65

Institute of Physiology and Zurich Centre for Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.8866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058746PMC
May 2016

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping.

Nucleic Acids Res 2015 Jul 24;43(12):5810-23. Epub 2015 May 24.

Institute of Physiology and Zürich Center for Integrative Human Physiology ZIHP, University of Zürich, CH-8057 Zürich, Switzerland National Center of Competence in Research "Kidney.CH", Switzerland Institute of Physiology, University of Duisburg-Essen, D-45122 Essen, Germany

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkv506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499134PMC
July 2015

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

Cell Rep 2014 Jun 15;7(5):1343-1352. Epub 2014 May 15.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140034
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http://dx.doi.org/10.1016/j.celrep.2014.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516227PMC
June 2014

Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer.

Hypoxia (Auckl) 2014 31;2:23-33. Epub 2014 Mar 31.

Institute of Physiology and Zurich Center for Human Physiology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.2147/HP.S54404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045054PMC
March 2014

PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.

Mol Neurobiol 2014 Oct 21;50(2):314-26. Epub 2014 Jan 21.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Plaza S. Ramón y Cajal, s/n, Madrid, 28040, Spain,

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http://link.springer.com/10.1007/s12035-013-8630-4
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http://dx.doi.org/10.1007/s12035-013-8630-4DOI Listing
October 2014

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Cancer Res 2013 Sep 8;73(18):5810-20. Epub 2013 Aug 8.

Authors' Affiliations: Division of Hematology, Oncology, and Transplantation, Department of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Center for Cancer Research, Department of Pathology and Laboratory Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee; and Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820501PMC
September 2013

Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36.

Atherosclerosis 2013 Jul 9;229(1):110-7. Epub 2013 May 9.

Cellular Oxygen Physiology, Institute of Physiology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.04.034DOI Listing
July 2013

Onconeuronal antigen Cdr2 correlates with HIF prolyl-4-hydroxylase PHD1 and worse prognosis in renal cell carcinoma.

Exp Mol Pathol 2013 Jun 24;94(3):453-7. Epub 2013 Mar 24.

Institute of Physiology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.yexmp.2013.03.005DOI Listing
June 2013

Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.

J Neurosci 2013 Jan;33(5):1915-26

Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1523/JNEUROSCI.3402-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619134PMC
January 2013

HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia.

Biol Chem 2013 Apr;394(4):519-28

Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1515/hsz-2012-0311DOI Listing
April 2013

Combined whole-body vibration, resistance exercise, and sustained vascular occlusion increases PGC-1α and VEGF mRNA abundances.

Eur J Appl Physiol 2013 Apr 20;113(4):1081-90. Epub 2012 Oct 20.

Exercise Physiology, Institute of Human Movement Sciences and Sport, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

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http://link.springer.com/content/pdf/10.1007/s00421-012-2524
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http://www.wellwave.net/resources/ETH/Item_2012_Occlusion_ae
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http://link.springer.com/10.1007/s00421-012-2524-4
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http://dx.doi.org/10.1007/s00421-012-2524-4DOI Listing
April 2013

The transcription factor encyclopedia.

Authors:
Dimas Yusuf Stefanie L Butland Magdalena I Swanson Eugene Bolotin Amy Ticoll Warren A Cheung Xiao Yu Cindy Zhang Christopher T D Dickman Debra L Fulton Jonathan S Lim Jake M Schnabl Oscar H P Ramos Mireille Vasseur-Cognet Charles N de Leeuw Elizabeth M Simpson Gerhart U Ryffel Eric W-F Lam Ralf Kist Miranda S C Wilson Raquel Marco-Ferreres Jan J Brosens Leonardo L Beccari Paola Bovolenta Bérénice A Benayoun Lara J Monteiro Helma D C Schwenen Lars Grontved Elizabeth Wederell Susanne Mandrup Reiner A Veitia Harini Chakravarthy Pamela A Hoodless M Michela Mancarelli Bruce E Torbett Alison H Banham Sekhar P Reddy Rebecca L Cullum Michaela Liedtke Mario P Tschan Michelle Vaz Angie Rizzino Mariastella Zannini Seth Frietze Peggy J Farnham Astrid Eijkelenboom Philip J Brown David Laperrière Dominique Leprince Tiziana de Cristofaro Kelly L Prince Marrit Putker Luis del Peso Gieri Camenisch Roland H Wenger Michal Mikula Marieke Rozendaal Sylvie Mader Jerzy Ostrowski Simon J Rhodes Capucine Van Rechem Gaylor Boulay Sam W Z Olechnowicz Mary B Breslin Michael S Lan Kyster K Nanan Michael Wegner Juan Hou Rachel D Mullen Stephanie C Colvin Peter John Noy Carol F Webb Matthew E Witek Scott Ferrell Juliet M Daniel Jason Park Scott A Waldman Daniel J Peet Michael Taggart Padma-Sheela Jayaraman Julien J Karrich Bianca Blom Farhad Vesuna Henriette O'Geen Yunfu Sun Richard M Gronostajski Mark W Woodcroft Margaret R Hough Edwin Chen G Nicholas Europe-Finner Magdalena Karolczak-Bayatti Jarrod Bailey Oliver Hankinson Venu Raman David P LeBrun Shyam Biswal Christopher J Harvey Jason P DeBruyne John B Hogenesch Robert F Hevner Christophe Héligon Xin M Luo Marissa Cathleen Blank Kathleen Joyce Millen David S Sharlin Douglas Forrest Karin Dahlman-Wright Chunyan Zhao Yuriko Mishima Satrajit Sinha Rumela Chakrabarti Elodie Portales-Casamar Frances M Sladek Philip H Bradley Wyeth W Wasserman

Genome Biol 2012 ;13(3):R24

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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http://digital.csic.es/bitstream/10261/53044/2/gb-2012-13-3-
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http://genomebiology.com/2012/13/3/R24
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http://dx.doi.org/10.1186/gb-2012-13-3-r24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439975PMC
September 2012

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.

Nucleic Acids Res 2012 Mar 10;40(5):1928-43. Epub 2011 Nov 10.

Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, 8057 Zürich, Switzerland.

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http://dx.doi.org/10.1093/nar/gkr978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300025PMC
March 2012

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1.

Anticancer Res 2011 Oct;31(10):3115-24

Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland.

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October 2011

Erythropoietin.

Compr Physiol 2011 Oct;1(4):1759-94

Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1002/cphy.c100075DOI Listing
October 2011

The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.

PLoS One 2011 13;6(7):e22107. Epub 2011 Jul 13.

Institute of Physiology and Zürich Center for Integrative Human Physiology ZIHP, University of Zürich UZH, Zürich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022107PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135610PMC
November 2011

Vitamin C is dispensable for oxygen sensing in vivo.

Blood 2011 May 23;117(20):5485-93. Epub 2011 Feb 23.

Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1182/blood-2010-09-307637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109719PMC
May 2011

A graphical simulation software for instruction in cardiovascular mechanics physiology.

Biomed Eng Online 2011 Jan 25;10. Epub 2011 Jan 25.

Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1186/1475-925X-10-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041719PMC
January 2011

Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells.

Am J Physiol Renal Physiol 2010 Jun 10;298(6):F1287-96. Epub 2010 Mar 10.

Institute of Physiology and Zürich Center for Integrative Human Physiology ZIHP, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00736.2009DOI Listing
June 2010

HIF prolyl-4-hydroxylase interacting proteins: consequences for drug targeting.

Curr Pharm Des 2009 ;15(33):3886-94

Institute of Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.2174/138161209789649411DOI Listing
January 2010

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events.

Proc Natl Acad Sci U S A 2009 Aug 31;106(33):14004-9. Epub 2009 Jul 31.

Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1073/pnas.0901194106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729010PMC
August 2009

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

J Biol Chem 2009 Aug 22;284(34):23046-58. Epub 2009 Jun 22.

Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1074/jbc.M109.032631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755711PMC
August 2009

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts.

Carcinogenesis 2008 Dec 8;29(12):2306-16. Epub 2008 Oct 8.

Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1093/carcin/bgn231DOI Listing
December 2008

Determination and modulation of prolyl-4-hydroxylase domain oxygen sensor activity.

Methods Enzymol 2007 ;435:43-60

Institute of Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/S0076-6879(07)35003-9DOI Listing
February 2008

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

Blood 2007 Nov 7;110(10):3610-7. Epub 2007 Aug 7.

Department of Heart and Circulatory Physiology, Center of Physiology and Pathophysiology, Georg-August University Göttingen, Göttingen, Germany.

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http://www.bloodjournal.org/content/110/10/3610.full.pdf
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http://www.bloodjournal.org/content/early/2007/08/07/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-09
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http://dx.doi.org/10.1182/blood-2007-06-094441DOI Listing
November 2007

Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.

Antioxid Redox Signal 2007 Sep;9(9):1329-38

Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1089/ars.2007.1683DOI Listing
September 2007

Time course of hypoxia-induced lung injury in rats.

Respir Physiol Neurobiol 2007 Oct 18;159(1):45-54. Epub 2007 May 18.

Carl-Ludwig-Institute of Physiology, University of Leipzig, Liebigstr. 27, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.resp.2007.05.008DOI Listing
October 2007

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.

Mol Cell Biol 2007 May 12;27(10):3758-68. Epub 2007 Mar 12.

Institute of Physiology and Center for Integrative Human Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01324-06
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http://dx.doi.org/10.1128/MCB.01324-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899990PMC
May 2007

Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.

Diabetes 2007 Jan;56(1):113-7

Institute of Physiology, University of Zürich, Zürich Center for Integrative Human Physiology, Switzerland.

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http://dx.doi.org/10.2337/db06-0798DOI Listing
January 2007

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.

J Biol Chem 2006 Aug 21;281(33):23482-91. Epub 2006 Jun 21.

Institute of Physiology and Center for Integrative Human Physiology, University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1074/jbc.M601719200DOI Listing
August 2006

TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.

FEBS Lett 2006 Jun 5;580(15):3731-8. Epub 2006 Jun 5.

Cell Physiology Group, Martin-Luther University of Halle, Magdeburger Strasse 2, D-06097 Halle, Germany.

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http://dx.doi.org/10.1016/j.febslet.2006.05.058DOI Listing
June 2006

Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors.

Cancer Res 2005 Dec;65(23):11094-100

Cell Physiology Group, Medical Faculty, Martin Luther University Halle, Halle, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1877DOI Listing
December 2005

Integration of oxygen signaling at the consensus HRE.

Sci STKE 2005 Oct 18;2005(306):re12. Epub 2005 Oct 18.

Institute of Physiology, Center for Integrative Human Physiology, University of Zürich, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1126/stke.3062005re12DOI Listing
October 2005

Mitochondria: oxygen sinks rather than sensors?

Authors:
Roland H Wenger

Med Hypotheses 2006 17;66(2):380-3. Epub 2005 Oct 17.

Institute of Physiology and Center for Integrative Human Physiology (CIHP), University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.mehy.2005.08.047DOI Listing
June 2006

The hypoxic testis and post-meiotic expression of PAS domain proteins.

Semin Cell Dev Biol 2005 Aug-Oct;16(4-5):547-53

Institute of Physiology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.semcdb.2005.03.008DOI Listing
July 2006

Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.

Cell Physiol Biochem 2004 ;14(4-6):351-60

Cell Physiology Group, Medical Faculty, Martin-Luther-University Halle, Germany.

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http://dx.doi.org/10.1159/000080345DOI Listing
February 2005

Cardiac remodeling in erythropoietin-transgenic mice.

Cell Physiol Biochem 2004 ;14(4-6):277-84

Carl-Ludwig-Institute of Physiology, University of Leipzig, Germany.

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http://dx.doi.org/10.1159/000080337DOI Listing
February 2005

Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect.

J Biol Chem 2004 Sep 20;279(39):40462-9. Epub 2004 Jul 20.

Unité Mixte de Recherche 5018 CNRS-Université Paul Sabatier, IFR31, Bât. L1, Complexe Hospitalier Universitaire Rangueil, 31059 Toulouse Cedex 9, France.

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http://dx.doi.org/10.1074/jbc.M407258200DOI Listing
September 2004

A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis.

Biol Reprod 2004 Jul 17;71(1):331-9. Epub 2004 Mar 17.

Institute of Physiology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1095/biolreprod.104.027797DOI Listing
July 2004

Norepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin.

Cardiovasc Res 2004 Jan;61(1):105-14

Carl-Ludwig-Institute of Physiology, Leipzig University, Liebigstrasse 27, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cardiores.2003.10.026DOI Listing
January 2004

Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.

J Biol Chem 2003 Nov 25;278(46):45651-60. Epub 2003 Aug 25.

Department of Dermatology and Venereology and Institute of Immunology and Proteome Center, University of Rostock, 18055 Rostock, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301373200
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November 2003

Iron chelation, angiogenesis and tumor therapy.

Int J Cancer 2003 Sep;106(3):458-9

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http://dx.doi.org/10.1002/ijc.11223DOI Listing
September 2003

Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channel.

J Biol Chem 2003 Aug 5;278(33):31444-55. Epub 2003 Jun 5.

Maternal and Child Health Sciences, Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M303051200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134977PMC
August 2003

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

Oncogene 2003 May;22(21):3213-20

Institute of Physiology, University of Lübeck, D-23538 Lübeck, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206385DOI Listing
May 2003

The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha.

Eur J Biochem 2003 May;270(10):2228-35

Institut für Physiologie der Universität Regensburg, Germany.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03590.xDOI Listing
May 2003

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.

FASEB J 2003 Apr 19;17(6):761-3. Epub 2003 Feb 19.

Institute of Physiology, Medical University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1096/fj.02-0586fjeDOI Listing
April 2003

Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy.

Comp Biochem Physiol C Toxicol Pharmacol 2002 Dec;133(4):475-81

Institute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

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http://dx.doi.org/10.1016/s1532-0456(02)00117-5DOI Listing
December 2002

Hypoxic up-regulation of erythroid 5-aminolevulinate synthase.

Blood 2003 Jan 29;101(1):348-50. Epub 2002 Aug 29.

Institute of Veterinary Physiology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1182/blood-2002-03-0773DOI Listing
January 2003

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression.

Authors:
Roland H Wenger

FASEB J 2002 Aug;16(10):1151-62

Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany.

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http://www.fasebj.org/doi/10.1096/fj.01-0944rev
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August 2002

DNA-binding activity of hypoxia-inducible factors (HIFs).

Methods Mol Biol 2002 ;196:117-29

Actelion Pharmaceuticals Ltd., Allschwil, Switzerland.

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http://dx.doi.org/10.1385/1-59259-274-0:117DOI Listing
February 2003

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

Cancer Res 2002 May;62(10):2962-70

Institute of Physiology, Section of Diagnostic Imaging, School of Veterinary Medicine, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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May 2002

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway.

FEBS Lett 2002 Feb;512(1-3):157-62

Institute of Physiology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany.

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http://dx.doi.org/10.1016/s0014-5793(02)02247-0DOI Listing
February 2002

Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis.

Mol Endocrinol 2002 Feb;16(2):234-43

Max-Planck-Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, D-61231 Bad Nauheim, Germany.

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http://dx.doi.org/10.1210/mend.16.2.0786DOI Listing
February 2002