Publications by authors named "Roland Eils"

100Publications

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics.

Neuro Oncol 2020 Aug;22(8):1138-1149

Digital Health Center, Berlin Institute of Health and Charité, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/noaa091DOI Listing
August 2020

Automated 3D light-sheet screening with high spatiotemporal resolution reveals mitotic phenotypes.

J Cell Sci 2020 Jun 1;133(11). Epub 2020 Jun 1.

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.245043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286290PMC
June 2020

SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.

EMBO J 2020 05 14;39(10):e105114. Epub 2020 Apr 14.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.20105114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232010PMC
May 2020

Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer.

Clin Cancer Res 2020 Jul 11;26(14):3616-3628. Epub 2020 Mar 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-19-3997DOI Listing
July 2020

Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity.

Sci Adv 2020 02 5;6(6):eaay0187. Epub 2020 Feb 5.

Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aay0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002122PMC
February 2020

The landscape of viral associations in human cancers.

Nat Genet 2020 03 5;52(3):320-330. Epub 2020 Feb 5.

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0558-9DOI Listing
March 2020

Genetic Interactions and Tissue Specificity Modulate the Association of Mutations with Drug Response.

Mol Cancer Ther 2020 03 11;19(3):927-936. Epub 2019 Dec 11.

Oncology Bioinformatics, Merck KGaA, Darmstadt, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-19-0045DOI Listing
March 2020

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.

J Exp Med 2019 09 3;216(9):2113-2127. Epub 2019 Jul 3.

Department for Immunology, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20181454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719417PMC
September 2019

Impact of cancer mutational signatures on transcription factor motifs in the human genome.

BMC Med Genomics 2019 05 20;12(1):64. Epub 2019 May 20.

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12920-019-0525-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528224PMC
May 2019

Longitudinal trends of serum IgE and IL5RA expression throughout childhood are associated with asthma but not with persistent wheeze.

Allergy 2019 10 21;74(10):2002-2006. Epub 2019 May 21.

Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, associated partner of the German Center for Lung Research (DZL), Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13837DOI Listing
October 2019

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins.

Nucleic Acids Res 2019 07;47(13):e75

Synthetic Biology Group, Institute for Pharmacy and Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg 69120, Germany.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/advance-article/doi/10.1093/nar
Publisher Site
http://dx.doi.org/10.1093/nar/gkz271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648350PMC
July 2019

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 12;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444093PMC
December 2018

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9.

Nat Methods 2018 11 30;15(11):924-927. Epub 2018 Oct 30.

Synthetic Biology Group, Institute for Pharmacy and Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41592-018-0178-9
Publisher Site
http://dx.doi.org/10.1038/s41592-018-0178-9DOI Listing
November 2018

Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells.

Front Immunol 2018 8;9:1840. Epub 2018 Aug 8.

Department for Immunology, Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), Dortmund, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092488PMC
September 2019

Unraveling mitotic protein networks by 3D multiplexed epitope drug screening.

Mol Syst Biol 2018 08 13;14(8):e8238. Epub 2018 Aug 13.

Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), Heidelberg University, Heidelberg, Germany

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088390PMC
http://dx.doi.org/10.15252/msb.20188238DOI Listing
August 2018

Rigid and non-rigid registration of polarized light imaging data for 3D reconstruction of the temporal lobe of the human brain at micrometer resolution.

Neuroimage 2018 11 6;181:235-251. Epub 2018 Jul 6.

Dept. of Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, BIOQUANT, IPMB, University of Heidelberg, Germany; German Cancer Research Center (DKFZ), Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2018.06.084DOI Listing
November 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations.

BMC Genomics 2018 Apr 4;19(1):234. Epub 2018 Apr 4.

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-018-4625-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885322PMC
April 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Early-onset childhood atopic dermatitis is related to NLRP2 repression.

J Allergy Clin Immunol 2018 04 9;141(4):1482-1485.e16. Epub 2017 Dec 9.

Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.11.018DOI Listing
April 2018

Tagmentation-Based Library Preparation for Low DNA Input Whole Genome Bisulfite Sequencing.

Methods Mol Biol 2018 ;1708:105-122

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-7481-8_6
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-7481-8_6DOI Listing
July 2018

Transcription factors, coregulators, and epigenetic marks are linearly correlated and highly redundant.

PLoS One 2017 7;12(12):e0186324. Epub 2017 Dec 7.

Division of Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186324PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720766PMC
January 2018

The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells.

Nano Lett 2017 11 17;17(11):6941-6948. Epub 2017 Oct 17.

Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University , Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.7b03358DOI Listing
November 2017

Correlated receptor transport processes buffer single-cell heterogeneity.

PLoS Comput Biol 2017 Sep 25;13(9):e1005779. Epub 2017 Sep 25.

Cellnetworks Cluster and Institute of Physical Chemistry, BioQuant, Heidelberg University, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1005779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659801PMC
September 2017

Quantitative Single-Molecule Localization Microscopy (qSMLM) of Membrane Proteins Based on Kinetic Analysis of Fluorophore Blinking Cycles.

Methods Mol Biol 2017 ;1663:115-126

Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, 60438, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7265-4_10DOI Listing
May 2018

OTP: An automatized system for managing and processing NGS data.

J Biotechnol 2017 Nov 10;261:53-62. Epub 2017 Aug 10.

Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2017.08.006DOI Listing
November 2017

Workflows for microscopy image analysis and cellular phenotyping.

J Biotechnol 2017 Nov 27;261:70-75. Epub 2017 Jul 27.

High-Content Analysis of the Cell (HiCell) and ViroQuant-CellNetworks RNAi Screening Facility, BioQuant, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2017.07.019DOI Listing
November 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Diagnosis of CoPAN by whole exome sequencing: Waking up a sleeping tiger's eye.

Am J Med Genet A 2017 Jul 10;173(7):1878-1886. Epub 2017 May 10.

Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.38252DOI Listing
July 2017

Nucleosome repositioning during differentiation of a human myeloid leukemia cell line.

Nucleus 2017 03;8(2):188-204

d Department of Pharmaceutical Sciences , College of Pharmacy, University of New England , Portland , ME , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19491034.2017.1295201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403151PMC
March 2017

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications.

J Allergy Clin Immunol 2018 02 6;141(2):741-753. Epub 2017 Apr 6.

Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig-Halle, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.03.017DOI Listing
February 2018

The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke-associated atopic dermatitis.

J Allergy Clin Immunol 2017 08 6;140(2):603-605. Epub 2017 Mar 6.

Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.01.034DOI Listing
August 2017

Between-species differences in gene copy number are enriched among functions critical for adaptive evolution in Arabidopsis halleri.

BMC Genomics 2016 12 22;17(Suppl 13):1034. Epub 2016 Dec 22.

Department of Plant Physiology, Ruhr University Bochum, Universitätsstrasse 150, Bochum, 44801, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-016-3319-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259951PMC
December 2016

Identification of immunotherapeutic targets by genomic profiling of rectal NET metastases.

Oncoimmunology 2016 22;5(11):e1213931. Epub 2016 Jul 22.

Clinical Cooperation Unit "Applied Tumor Immunity", National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT) and University Hospital Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2016.1213931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139646PMC
July 2016

Role of the ESCRT Complexes in Telomere Biology.

mBio 2016 11 8;7(6). Epub 2016 Nov 8.

Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Tel Aviv, Israel

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01793-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101353PMC
November 2016

Pedigree based DNA sequencing pipeline for germline genomes of cancer families.

Hered Cancer Clin Pract 2016 9;14:16. Epub 2016 Aug 9.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13053-016-0058-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977614PMC
August 2016

Optogenetic Control of Nuclear Protein Import in Living Cells Using Light-Inducible Nuclear Localization Signals (LINuS).

Curr Protoc Chem Biol 2016 06 2;8(2):131-145. Epub 2016 Jun 2.

Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cpch.4
Publisher Site
http://dx.doi.org/10.1002/cpch.4DOI Listing
June 2016

Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism.

Cancer Res 2016 07 23;76(14):4058-67. Epub 2016 May 23.

Network Modeling, Leibniz Institute for Natural Products Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany. Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2350DOI Listing
July 2016

Complex heatmaps reveal patterns and correlations in multidimensional genomic data.

Bioinformatics 2016 09 20;32(18):2847-9. Epub 2016 May 20.

Division of Theoretical Bioinformatics.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btw313DOI Listing
September 2016

HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data.

Bioinformatics 2016 08 24;32(15):2372-4. Epub 2016 Mar 24.

Division of Theoretical Bioinformatics.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btw161DOI Listing
August 2016

gtrellis: an R/Bioconductor package for making genome-level Trellis graphics.

BMC Bioinformatics 2016 Apr 18;17:169. Epub 2016 Apr 18.

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-016-1051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835841PMC
April 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
Web Search
http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
Publisher Site
http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.

Nucleic Acids Res 2016 06 22;44(10):e93. Epub 2016 Feb 22.

Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Germany Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI) Jena, Beutenbergstrasse 11a, 07745 Jena, Germany Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkw111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889924PMC
June 2016

Optogenetic control of nuclear protein export.

Nat Commun 2016 Feb 8;7:10624. Epub 2016 Feb 8.

Department of Bioinformatics and Functional Genomics, Synthetic Biology Group, Institute for Pharmacy and Biotechnology (IPMB), University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748110PMC
February 2016

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

Nat Commun 2015 Dec 9;6:10001. Epub 2015 Dec 9.

CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682041PMC
December 2015

Automated Analysis of Single-Molecule Photobleaching Data by Statistical Modeling of Spot Populations.

Biophys J 2015 Dec;109(11):2352-62

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2015.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675885PMC
December 2015

Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network.

Exp Cell Res 2015 Nov 8;339(1):1-9. Epub 2015 Oct 8.

Department of Translational Inflammation Research, Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany; Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2015.10.005DOI Listing
November 2015