Roland E Dolle

Roland E Dolle

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Roland E Dolle

Roland E Dolle

Publications by authors named "Roland E Dolle"

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The discovery and development of the N-substituted trans-3,4-dimethyl-4-(3'-hydroxyphenyl)piperidine class of pure opioid receptor antagonists.

ChemMedChem 2014 Aug 30;9(8):1638-54. Epub 2014 Jun 30.

Research Triangle Institute, Center for Organic and Medicinal Chemistry, 3040 Cornwallis Road, Research Triangle Park, NC 27709 (USA).

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http://dx.doi.org/10.1002/cmdc.201402142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588862PMC
August 2014

Historical overview of chemical library design.

Authors:
Roland E Dolle

Methods Mol Biol 2011 ;685:3-25

Department of Chemistry, Adolor Corporation, Exton, PA, USA.

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http://dx.doi.org/10.1007/978-1-60761-931-4_1DOI Listing
February 2011

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

J Comb Chem 2010 Nov 5;12(6):765-806. Epub 2010 Oct 5.

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://pubs.acs.org/doi/abs/10.1021/cc100128w
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http://dx.doi.org/10.1021/cc100128wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140011PMC
November 2010

Simultaneous optimization of potency, selectivity and physicochemical properties for cannabinoid CB(2) ligands.

Curr Pharm Des 2009 ;15(29):3345-66

Department of Chemistry, Adolor Corporation, Exton, PA 19341, USA.

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http://dx.doi.org/10.2174/138161209789105027DOI Listing
January 2010

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008.

J Comb Chem 2009 Sep-Oct;11(5):739-90

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc9000828DOI Listing
December 2009

High-performance liquid chromatographic enantioseparation of methanobenzazocines.

J Chromatogr A 2009 Nov 18;1216(45):7708-14. Epub 2009 Aug 18.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.chroma.2009.08.033DOI Listing
November 2009

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.

Bioorg Med Chem Lett 2009 Oct 21;19(20):5931-5. Epub 2009 Aug 21.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.08.063DOI Listing
October 2009

Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.

Bioorg Med Chem Lett 2009 Jul 3;19(13):3647-50. Epub 2009 May 3.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.105DOI Listing
July 2009

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

J Comb Chem 2008 Nov-Dec;10(6):753-802

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc800119zDOI Listing
December 2008

Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.

Bioorg Med Chem Lett 2008 May 7;18(9):2830-5. Epub 2008 Apr 7.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.006DOI Listing
May 2008

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

J Comb Chem 2007 Nov-Dec;9(6):855-902. Epub 2007 Sep 19.

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc700111eDOI Listing
February 2008

Discovery of a series of aminopiperidines as novel iNOS inhibitors.

Bioorg Med Chem Lett 2008 Jan 25;18(1):336-43. Epub 2007 Oct 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.10.073DOI Listing
January 2008

Mu opioid receptor antagonists: recent developments.

ChemMedChem 2007 Nov;2(11):1552-70

Department of Medicinal Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1002/cmdc.200700143DOI Listing
November 2007

Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.

Bioorg Med Chem Lett 2007 Jul 25;17(13):3652-6. Epub 2007 Apr 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.04.059DOI Listing
July 2007

Further studies of tyrosine surrogates in opioid receptor peptide ligands.

Bioorg Med Chem Lett 2007 May 2;17(9):2656-60. Epub 2007 Feb 2.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.01.092DOI Listing
May 2007

Novel malonamide derivatives as potent kappa opioid receptor agonists.

Bioorg Med Chem Lett 2007 Apr 25;17(7):1951-5. Epub 2007 Jan 25.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.01.053DOI Listing
April 2007

Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.

J Med Chem 2006 Dec;49(25):7290-306

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/jm0604878DOI Listing
December 2006

Comprehensive survey of combinatorial library synthesis: 2005.

J Comb Chem 2006 Sep-Oct;8(5):597-635

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc060095mDOI Listing
November 2006

Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.

Eur J Pain 2006 Aug 24;10(6):505-12. Epub 2005 Aug 24.

Department of Pharmacology, Adolor Corporation, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.ejpain.2005.07.004DOI Listing
August 2006

Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.

Bioorg Med Chem Lett 2006 Feb 2;16(3):645-8. Epub 2005 Nov 2.

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.034DOI Listing
February 2006

Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin.

J Comb Chem 2006 Jan-Feb;8(1):132-40

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc050106wDOI Listing
February 2006

Comprehensive survey of combinatorial library synthesis: 2003.

Authors:
Roland E Dolle

J Comb Chem 2004 Sep-Oct;6(5):623-79

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc0499082DOI Listing
January 2006

Comprehensive survey of combinatorial library synthesis: 2004.

Authors:
Roland E Dolle

J Comb Chem 2005 Nov-Dec;7(6):739-98

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1021/cc050082tDOI Listing
January 2006

Solid/solution-phase annulation reagents: single-step synthesis of cyclic amine derivatives.

Angew Chem Int Ed Engl 2005 Sep;44(36):5830-3

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1002/anie.200501665DOI Listing
September 2005

Azepinone as a conformational constraint in the design of kappa-opioid receptor agonists.

Bioorg Med Chem Lett 2004 Nov;14(22):5693-7

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.08.041DOI Listing
November 2004

(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands.

Bioorg Med Chem Lett 2004 Jul;14(13):3545-8

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.04.039DOI Listing
July 2004

10-hydroxy-10,9-boroxarophenanthrenes: versatile synthetic intermediates to 3,4-benzocoumarins and triaryls.

J Org Chem 2004 Jul;69(15):5147-9

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341-1127, USA.

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http://dx.doi.org/10.1021/jo049343wDOI Listing
July 2004

The solid-phase synthesis and use of N-monosubstituted piperazines in chemical library synthesis.

J Comb Chem 2003 May-Jun;5(3):260-6

Combinatorial Chemistry Department, Adolor Corporation, 371 Phoenixville Pike, Malvern, Pennsylvania 19355, USA.

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http://dx.doi.org/10.1021/cc020060wDOI Listing
February 2004

The development and application of tetrafluorophenol-activated resins for rapid amine derivatization.

Methods Enzymol 2003 ;369:151-63

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19345, USA.

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http://dx.doi.org/10.1016/S0076-6879(03)69008-7DOI Listing
February 2004

Comprehensive survey of combinatorial library synthesis: 2002.

Authors:
Roland E Dolle

J Comb Chem 2003 Nov-Dec;5(6):693-753

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1021/cc0340224DOI Listing
January 2004

trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists.

Bioorg Med Chem Lett 2003 Dec;13(24):4459-62

Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.

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http://dx.doi.org/10.1016/j.bmcl.2003.09.012DOI Listing
December 2003

Comprehensive survey of combinatorial library synthesis: 2001.

Authors:
Roland E Dolle

J Comb Chem 2002 Sep-Oct;4(5):369-418

Department of Chemistry, Adolor Corporation, 371 Phoenixville Pike, Malvern, PA 19355, USA.

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http://dx.doi.org/10.1021/cc020039vDOI Listing
October 2002