Roland Beckmann

Roland Beckmann

UNVERIFIED PROFILE

Are you Roland Beckmann?   Register this Author

Register author
Roland Beckmann

Roland Beckmann

Publications by authors named "Roland Beckmann"

Are you Roland Beckmann?   Register this Author

100Publications

1633Reads

34Profile Views

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.

EMBO J 2020 Feb 20;39(3):e103365. Epub 2019 Dec 20.

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.2019103365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996574PMC
February 2020

Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins.

Nat Struct Mol Biol 2020 Feb 27;27(2):142-149. Epub 2020 Jan 27.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-019-0364-1DOI Listing
February 2020

Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex.

EMBO J 2020 Feb 17:e103788. Epub 2020 Feb 17.

Department of Biochemistry, Gene Center, Ludwig-Maximilians University Munich, München, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.2019103788DOI Listing
February 2020

Partially inserted nascent chain unzips the lateral gate of the Sec translocon.

EMBO Rep 2019 10 5;20(10):e48191. Epub 2019 Aug 5.

Gene Center Munich, Ludwig-Maximilian-University, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201948191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776908PMC
October 2019

Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.

Mol Cell 2019 09 1;75(6):1256-1269.e7. Epub 2019 Aug 1.

Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2019.06.032DOI Listing
September 2019

Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Nature 2019 Jul;571(7764):E4

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1360-7DOI Listing
July 2019

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Nature 2019 06 12;570(7762):538-542. Epub 2019 Jun 12.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1307-zDOI Listing
June 2019

Structural and mutational analysis of the ribosome-arresting human XBP1u.

Elife 2019 06 27;8. Epub 2019 Jun 27.

Gene Center, Department of Biochemistry, Center for integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.46267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624018PMC
June 2019

Structure of the 80S ribosome-Xrn1 nuclease complex.

Nat Struct Mol Biol 2019 04 25;26(4):275-280. Epub 2019 Mar 25.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41594-019-0202-5
Publisher Site
http://dx.doi.org/10.1038/s41594-019-0202-5DOI Listing
April 2019

Reconstitution of Isotopically Labeled Ribosomal Protein L29 in the 50S Large Ribosomal Subunit for Solution-State and Solid-State NMR.

Methods Mol Biol 2018 ;1764:87-100

Munich Center for Integrated Protein Science (CIPS-M) at Department Chemie, Technische Universität München (TUM), Garching, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7759-8_6DOI Listing
February 2019

Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.

Nat Struct Mol Biol 2019 01 17;26(1):35-39. Epub 2018 Dec 17.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41594-018-0165-yDOI Listing
January 2019

Folding pathway of an Ig domain is conserved on and off the ribosome.

Proc Natl Acad Sci U S A 2018 11 9;115(48):E11284-E11293. Epub 2018 Nov 9.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1810523115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275497PMC
November 2018

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Cell Rep 2018 11;25(9):2354-2368.e5

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183169
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.10.087DOI Listing
November 2018

Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.

Nat Microbiol 2018 10 3;3(10):1115-1121. Epub 2018 Sep 3.

Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41564-018-0237-0
Publisher Site
http://dx.doi.org/10.1038/s41564-018-0237-0DOI Listing
October 2018

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Chem Commun (Camb) 2018 Aug 16;54(62):8591-8593. Epub 2018 Jul 16.

Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc03980aDOI Listing
August 2018

Visualizing late states of human 40S ribosomal subunit maturation.

Nature 2018 06 6;558(7709):249-253. Epub 2018 Jun 6.

Gene Center Munich and Center of Integrated Protein Science-Munich (CiPS-M), Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-018-0193-0DOI Listing
June 2018

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.

Science 2018 04 8;360(6385):215-219. Epub 2018 Mar 8.

Department of Biochemistry, Gene Center and Center for Integrated Protein Science Munich, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aar7899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319373PMC
April 2018

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.

Nat Struct Mol Biol 2017 Dec 30;24(12):1107-1115. Epub 2017 Oct 30.

Biochemistry Centre, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3495DOI Listing
December 2017

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Cell 2017 Dec;171(7):1599-1610.e14

Gene Center Munich and Center of Integrated Protein Science-Munich (CiPS-M), Department of Biochemistry, Feodor-Lynen-Str. 25, University of Munich, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745149PMC
December 2017

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.

Nat Commun 2017 12 20;8(1):2213. Epub 2017 Dec 20.

Biochemistry Centre, University of Heidelberg, Heidelberg, 69221, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-02199-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738357PMC
December 2017

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.

Nat Struct Mol Biol 2017 Nov 2;24(11):954-964. Epub 2017 Oct 2.

Gene Center Munich and Center of Integrated Protein Science-Munich (CiPS-M), Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3476DOI Listing
November 2017

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.

Mol Cell 2017 Nov;68(3):515-527.e6

Gene Center, Department for Biochemistry and Center for integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynenstr. 25, 81377 Munich, Germany; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.10.014DOI Listing
November 2017

Cryo-EM structure of a late pre-40S ribosomal subunit from .

Elife 2017 11 20;6. Epub 2017 Nov 20.

Gene Center Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.30189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695908PMC
November 2017

Structure of the hibernating 100S ribosome reveals the basis for 70S dimerization.

EMBO J 2017 07 3;36(14):2061-2072. Epub 2017 May 3.

Gene Center, Department for Biochemistry and Center for integrated Protein Science Munich (CiPSM), University of Munich, Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201696189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509997PMC
July 2017

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.

Nat Struct Mol Biol 2017 May 3;24(5):453-460. Epub 2017 Apr 3.

Institute of Biochemistry, Biocenter, Goethe University, Frankfurt/Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3396DOI Listing
May 2017

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.

FEBS Lett 2017 05 10;591(9):1266-1277. Epub 2017 Apr 10.

Gene Center, Department of Biochemistry and Center for integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/1873-3468.12634
Publisher Site
http://dx.doi.org/10.1002/1873-3468.12634DOI Listing
May 2017

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Elife 2017 05 30;6. Epub 2017 May 30.

Gene Center, Department of Biochemistry and Center for integrated Protein Science Munich, Ludwig Maximilian University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.25642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449182PMC
May 2017

Cotranslational folding of spectrin domains via partially structured states.

Nat Struct Mol Biol 2017 03 23;24(3):221-225. Epub 2017 Jan 23.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3355DOI Listing
March 2017

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.

Nature 2017 01 1;541(7638):546-549. Epub 2016 Dec 1.

Gene Center, Department of Biochemistry and Center for integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature20821DOI Listing
January 2017

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.

Nat Struct Mol Biol 2016 Dec 24;23(12):1074-1082. Epub 2016 Oct 24.

Biochemistry Centre, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3312DOI Listing
December 2016

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.

Cell Rep 2016 12;17(11):2943-2954

Gene Center Munich, Department of Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, Munich 81377, Germany; Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-University, Butenandtstrasse 5-13, Munich 81377, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186731PMC
December 2016

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.

Science 2016 12;354(6318):1431-1433

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaf7520DOI Listing
December 2016

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.

Nat Commun 2016 11 8;7:13248. Epub 2016 Nov 8.

Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt a.M., Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms13248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105147PMC
November 2016

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Nucleic Acids Res 2016 07 25;44(13):6471-81. Epub 2016 May 25.

Gene Center and Department for Biochemistry, University of Munich, Munich 81377, Germany Center for integrated Protein Science Munich (CiPSM), University of Munich, Munich 81377, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkw470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291266PMC
July 2016

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.

Nat Commun 2016 07 6;7:12026. Epub 2016 Jul 6.

Gene Center and Department for Biochemistry, University of Munich, Feodor-Lynenstrasse 25, Munich 81377, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms12026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935803PMC
July 2016

Translation regulation via nascent polypeptide-mediated ribosome stalling.

Curr Opin Struct Biol 2016 Apr 7;37:123-33. Epub 2016 Feb 7.

Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2016.01.008DOI Listing
April 2016

Small protein domains fold inside the ribosome exit tunnel.

FEBS Lett 2016 Mar 25;590(5):655-60. Epub 2016 Feb 25.

Gene Center and Center for Integrated Protein Science Munich, CiPS-M, University of Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.12098DOI Listing
March 2016

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.

Nucleic Acids Res 2016 Feb 28;44(4):1944-51. Epub 2015 Dec 28.

Gene Center, Department of Biochemistry and Center for integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv1517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770232PMC
February 2016

Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.

Nat Struct Mol Biol 2016 Jan 30;23(1):37-44. Epub 2015 Nov 30.

Heidelberg University Biochemistry Center, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3132DOI Listing
January 2016

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.

Nat Commun 2014 ;5:3072

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4072DOI Listing
November 2015

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.

Nat Struct Mol Biol 2015 Oct 7;22(10):767-73. Epub 2015 Sep 7.

Gene Center, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3086DOI Listing
October 2015

Structure of a human translation termination complex.

Nucleic Acids Res 2015 Oct 17;43(18):8615-26. Epub 2015 Sep 17.

Gene Center and Center for integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Str. 25, University of Munich, 81377 Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605324PMC
October 2015

Cotranslational Protein Folding inside the Ribosome Exit Tunnel.

Cell Rep 2015 Sep 28;12(10):1533-40. Epub 2015 Aug 28.

Department of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm University, 106 91 Stockholm, Sweden; Science for Life Laboratory, Stockholm University, Box 1031, 171 21 Solna, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.07.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571824PMC
September 2015

Structure of the native Sec61 protein-conducting channel.

Nat Commun 2015 Sep 28;6:8403. Epub 2015 Sep 28.

Department of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms9403
Publisher Site
http://dx.doi.org/10.1038/ncomms9403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598622PMC
September 2015

Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.

J Biol Chem 2015 Jul 28;290(28):17250-61. Epub 2015 May 28.

From the Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, Nijenborgh 7, 9747 AG Groningen, The Netherlands,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.650309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498064PMC
July 2015

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.

Genome Biol Evol 2015 Apr 9;7(5):1235-51. Epub 2015 Apr 9.

Gene Center and Center for integrated Protein Science Munich (CiPSM), Department of Biochemistry, University of Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/gbe/evv061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453056PMC
April 2015

Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution.

Proc Natl Acad Sci U S A 2015 Apr 13;112(17):5401-6. Epub 2015 Apr 13.

Gene Center and Department for Biochemistry, University of Munich, 81377 Munich, Germany; and Center for integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1501775112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418892PMC
April 2015

Structural biology. Mitoribosome oddities.

Science 2015 Apr 16;348(6232):288-9. Epub 2015 Apr 16.

Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aab1054DOI Listing
April 2015

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.

Nat Commun 2015 Apr 23;6:6941. Epub 2015 Apr 23.

1] Gene Center and Department for Biochemistry, University of Munich, Feodor-Lynen-Street 25, Munich 81377, Germany [2] Center for integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynen-Street 25, Munich 81377, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms7941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423224PMC
April 2015

Drug sensing by the ribosome induces translational arrest via active site perturbation.

Mol Cell 2014 Nov 8;56(3):446-52. Epub 2014 Oct 8.

Gene Center and Department for Biochemistry, University of Munich, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2014.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252717PMC
November 2014

Molecular basis for the ribosome functioning as an L-tryptophan sensor.

Cell Rep 2014 Oct 9;9(2):469-75. Epub 2014 Oct 9.

Gene Center and Center for integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.09.011DOI Listing
October 2014

Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1.

Cell Rep 2014 Jul 4;8(1):59-65. Epub 2014 Jul 4.

Gene Center Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany; Center for Integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.04.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813808PMC
July 2014

A structural model of the active ribosome-bound membrane protein insertase YidC.

Elife 2014 Jul 10;3:e03035. Epub 2014 Jul 10.

Gene Center Munich, Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany Center for Integrated Protein Science Munich, Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.03035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124156PMC
July 2014

Visualization of a polytopic membrane protein during SecY-mediated membrane insertion.

Nat Commun 2014 Jun 10;5:4103. Epub 2014 Jun 10.

Department of Biochemistry, Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms5103DOI Listing
June 2014

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.

Nat Commun 2014 Mar 24;5:3491. Epub 2014 Mar 24.

Gene Center and Center of Integrated Protein Science Munich (CiPS-M), Department of Chemistry and Biochemistry, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4491DOI Listing
March 2014

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.

Nat Commun 2014 Mar 24;5:3501. Epub 2014 Mar 24.

1] Gene Center, Department for Biochemistry, University of Munich, Feodor-Lynen Strasse 25, 81377 Munich, Germany [2] Center for integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynen Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133097PMC
March 2014

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.

Nature 2014 Feb;506(7486):107-10

Gene Center and Center for integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12950DOI Listing
February 2014

The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli.

Mol Microbiol 2014 Jan 12;91(2):408-21. Epub 2013 Dec 12.

Institute of Microbiology and Molecular Biology, University of Hohenheim, 70599, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/mmi.12465DOI Listing
January 2014

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

Cell 2013 Sep;154(6):1207-19

Department of Biochemistry, Ludwig-Maximilian University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilian University, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2013.08.016DOI Listing
September 2013

Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs.

J Struct Biol 2013 May 21;182(2):59-66. Epub 2013 Feb 21.

Department of Statistics, Ludwig-Maximilians University München, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2013.02.008DOI Listing
May 2013

Structures of the human and Drosophila 80S ribosome.

Nature 2013 May;497(7447):80-5

Gene Center, Department of Biochemistry and Center for integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12104DOI Listing
May 2013

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.

Nat Struct Mol Biol 2013 Jan 2;20(1):23-8. Epub 2012 Dec 2.

Gene Center and Center of Integrated Protein Science Munich-CiPS-M, Department of Chemistry and Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2447DOI Listing
January 2013

Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue.

Curr Opin Struct Biol 2012 Dec 29;22(6):786-96. Epub 2012 Sep 29.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Feodor-Lynen-Straße 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2012.08.002DOI Listing
December 2012

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.

Nat Struct Mol Biol 2012 Dec 11;19(12):1234-41. Epub 2012 Nov 11.

Biochemistry Center, Universität Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678077PMC
December 2012

Structural basis for TetM-mediated tetracycline resistance.

Proc Natl Acad Sci U S A 2012 Oct 1;109(42):16900-5. Epub 2012 Oct 1.

Gene Center and Department for Biochemistry, University of Munich, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1208037109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479509PMC
October 2012

Mechanisms of SecM-mediated stalling in the ribosome.

Biophys J 2012 Jul 17;103(2):331-41. Epub 2012 Jul 17.

Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2012.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400775PMC
July 2012

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.

Nature 2012 Feb 22;482(7386):501-6. Epub 2012 Feb 22.

Gene Center and Center for integrated Protein Science Munich, Department of Biochemistry, University of Munich, Feodor-Lynen-Straße 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature10829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878762PMC
February 2012

The DARC site: a database of aligned ribosomal complexes.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D495-500. Epub 2011 Oct 18.

Gene Center and Department for Biochemistry and Center for integrated Protein Science Munich, University of Munich, Feodor-Lynenstr 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkr824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245104PMC
January 2012

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.

Nat Struct Mol Biol 2011 Jun 29;18(6):715-20. Epub 2011 May 29.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2057DOI Listing
June 2011

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling.

Curr Opin Struct Biol 2011 Apr;21(2):274-82

Gene Center and Department of Biochemistry, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2011.01.007DOI Listing
April 2011

Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins.

J Mol Biol 2011 Feb 4;405(5):1215-32. Epub 2010 Dec 4.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität, Feodor Lynen Str. 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2010.11.055DOI Listing
February 2011

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.

Mol Cell 2010 Oct;40(1):138-46

Gene Center and Department of Biochemistry and Center for integrated Protein Science Munich, University of Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S109727651000711
Publisher Site
http://dx.doi.org/10.1016/j.molcel.2010.09.009DOI Listing
October 2010

Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome.

J Biol Chem 2010 Jun 21;285(25):19679-87. Epub 2010 Apr 21.

Department of Biochemistry, Ludwig-Maximilians-Universität München, Gene Center Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.092536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885246PMC
June 2010

Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.

J Biol Chem 2010 May 31;285(20):14848-51. Epub 2010 Mar 31.

Department of Biochemistry, Gene Center and Center for Integrated Protein Science (CiPS), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C109.096057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865328PMC
May 2010

alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.

Nat Struct Mol Biol 2010 Mar 7;17(3):313-7. Epub 2010 Feb 7.

Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nsmb.1756
Publisher Site
http://dx.doi.org/10.1038/nsmb.1756DOI Listing
March 2010

Coupled chaperone action in folding and assembly of hexadecameric Rubisco.

Nature 2010 Jan;463(7278):197-202

Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature08651
Publisher Site
http://dx.doi.org/10.1038/nature08651DOI Listing
January 2010

Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome.

Science 2009 Dec 29;326(5958):1369-73. Epub 2009 Oct 29.

Gene Center Munich and Center for Integrated Protein Science, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1178535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920595PMC
December 2009

Structural insight into nascent polypeptide chain-mediated translational stalling.

Science 2009 Dec 29;326(5958):1412-5. Epub 2009 Oct 29.

Gene Center and Center for Integrated Protein Science Munich (CIPSM), Department for Chemistry and Biochemistry, University of Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1177662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920484PMC
December 2009

Structure of an archaeal RNA polymerase.

J Mol Biol 2008 Feb 5;376(2):303-7. Epub 2007 Sep 5.

Gene Center Munich and Center for integrated Protein Science CiPS(M), Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2007.08.066DOI Listing
February 2008

Functional architecture of RNA polymerase I.

Cell 2007 Dec;131(7):1260-72

Gene Center Munich and Center for Integrated Protein Science CIPSM, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2007.10.051DOI Listing
December 2007