Rohit N Kulkarni

Rohit N Kulkarni

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Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.

Stem Cells 2020 Apr 22;38(4):542-555. Epub 2020 Jan 22.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/stem.3135DOI Listing
April 2020

Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells.

J Am Chem Soc 2020 Apr 16;142(14):6477-6482. Epub 2020 Mar 16.

Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/jacs.0c00099DOI Listing
April 2020

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.

Diabetologia 2020 Mar 3;63(3):577-587. Epub 2020 Jan 3.

Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

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http://dx.doi.org/10.1007/s00125-019-05071-wDOI Listing
March 2020

RADAR: differential analysis of MeRIP-seq data with a random effect model.

Genome Biol 2019 12 23;20(1):294. Epub 2019 Dec 23.

Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1186/s13059-019-1915-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927177PMC
December 2019

"Omics" and "epi-omics" underlying the β-cell adaptation to insulin resistance.

Mol Metab 2019 09;27S:S42-S48

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Harvard Stem Cell Institute, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768500PMC
September 2019

mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes.

Nat Metab 2019 Aug 29;1(8):765-774. Epub 2019 Jul 29.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/s42255-019-0089-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924515PMC
August 2019

β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity.

Diabetes 2019 06;68(6):1121-1129

U.O.C. Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italia

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http://dx.doi.org/10.2337/db18-0856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905483PMC
June 2019

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.

iScience 2019 Jun 27;16:192-205. Epub 2019 May 27.

Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562146PMC
June 2019

How, When, and Where Do Human β-Cells Regenerate?

Curr Diab Rep 2019 06 27;19(8):48. Epub 2019 Jun 27.

Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1007/s11892-019-1176-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986204PMC
June 2019

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.

Mol Metab 2018 12 19;18:153-163. Epub 2018 Sep 19.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183069
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http://dx.doi.org/10.1016/j.molmet.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308035PMC
December 2018

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.

EMBO J 2018 12 16;37(24). Epub 2018 Nov 16.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

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http://dx.doi.org/10.15252/embj.2018100409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293338PMC
December 2018

Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells.

Mol Cells 2018 Oct 31;41(10):909-916. Epub 2018 Aug 31.

Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.

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http://dx.doi.org/10.14348/molcells.2018.0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199568PMC
October 2018

Fluorescent probes for G-protein-coupled receptor drug discovery.

Expert Opin Drug Discov 2018 10 24;13(10):933-947. Epub 2018 Sep 24.

a Center for Drug Discovery and Department of Pharmaceutical Sciences , Northeastern University , Boston , Massachusetts , USA.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2018.1
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http://dx.doi.org/10.1080/17460441.2018.1518975DOI Listing
October 2018

Sex differences underlying pancreatic islet biology and its dysfunction.

Mol Metab 2018 09 30;15:82-91. Epub 2018 May 30.

Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center School of Medicine, New Orleans, USA; Southeast Louisiana Veterans Healthcare System Medical Center, New Orleans, LA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066785PMC
September 2018

Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.

J Cell Mol Med 2018 04 12;22(4):2337-2345. Epub 2018 Feb 12.

Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.

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http://dx.doi.org/10.1111/jcmm.13523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867156PMC
April 2018

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.

Pancreatology 2018 Jan 5;18(1):12-19. Epub 2017 Dec 5.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway; Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2017.12.001DOI Listing
January 2018

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.

Mol Cell Endocrinol 2017 10 22;454:146-157. Epub 2017 Jun 22.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Norway; Department of Biomedicine, University of Bergen, Bergen, Norway; Department of Biomedical Laboratory Sciences and Chemical Engineering, Western Norway University of Applied Sciences, Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.06.020DOI Listing
October 2017

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

J Biol Chem 2017 10 31;292(43):17598-17608. Epub 2017 Aug 31.

From the Department of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts 02215,

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http://dx.doi.org/10.1074/jbc.M117.804328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663865PMC
October 2017

Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene.

Diabetologia 2017 Sep 31;60(9):1751-1760. Epub 2017 May 31.

Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.

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http://dx.doi.org/10.1007/s00125-017-4307-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709176PMC
September 2017

GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

Diabetologia 2017 08 20;60(8):1442-1453. Epub 2017 May 20.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Room 410, One Joslin Place, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00125-017-4303-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508991PMC
August 2017

Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.

Cell Metab 2017 Apr 9;25(4):868-882.e5. Epub 2017 Mar 9.

Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131173009
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http://dx.doi.org/10.1016/j.cmet.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382039PMC
April 2017

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Cell Metab 2017 02 5;25(2):448-462. Epub 2017 Jan 5.

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304432PMC
February 2017

Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.

J Biol Chem 2016 Oct 17;291(41):21485-21495. Epub 2016 Aug 17.

From the Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02215 and

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http://dx.doi.org/10.1074/jbc.M116.735738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076820PMC
October 2016

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

Diabetes 2016 08 13;65(8):2201-13. Epub 2016 May 13.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db16-0212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955980PMC
August 2016

Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?

Curr Diab Rep 2016 08;16(8):70

Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11892-016-0764-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877461PMC
August 2016

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Sci Rep 2016 07 5;6:28177. Epub 2016 Jul 5.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep28177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932502PMC
July 2016

The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice.

Diabetes 2016 06 7;65(6):1672-8. Epub 2016 Mar 7.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Harvard Stem Cell Institute, Boston, MA.

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http://dx.doi.org/10.2337/db15-1475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878426PMC
June 2016

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.

Diabetes 2016 05 2;65(5):1208-18. Epub 2016 Mar 2.

Diabetes Center, University of California, San Francisco, San Francisco, CA

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http://dx.doi.org/10.2337/db15-1331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839200PMC
May 2016

ERRγ-A New Player in β Cell Maturation.

Cell Metab 2016 05;23(5):765-7

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.026DOI Listing
May 2016

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation.

Cell Rep 2016 Apr 7;15(3):460-470. Epub 2016 Apr 7.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838491PMC
April 2016

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.

Stem Cell Reports 2016 Mar 11;6(3):357-67. Epub 2016 Feb 11.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788763PMC
March 2016

β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans.

J Clin Endocrinol Metab 2016 Feb 9;101(2):470-5. Epub 2015 Dec 9.

Endo-Metabolic Diseases Unit (T.M., G.P.S., C.C., V.A.S., C.M.A.C., S.M., A.P., A. G.), Università Cattolica del Sacro Cuore, Rome, Italy; Islet Cell & Regenerative Biology (T.M., R.H.K.), Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215; Institute of Neuroscience (A.M.), National Research Council, Padua, Italy.

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http://dx.doi.org/10.1210/jc.2015-2802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880124PMC
February 2016

Harnessing immune cells to enhance β-cell mass in type 1 diabetes.

J Investig Med 2016 Jan;64(1):14-20

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/jim-d-15-00196DOI Listing
January 2016

Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.

Endocrinology 2015 Nov 21;156(11):4047-58. Epub 2015 Aug 21.

Department of Medicine (Y.-J.L., C.L., M.L., G.K.S., K.I., A.S.B., P.L., G.-P.S.), Brigham and Women's Hospital and Harvard Medical School, Department of Genetics and Complex Diseases (K.I.), School of Public Health, Harvard University, and Department of Cell Biology (J.S., R.N.K.), Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02115; Department of Cardiology (C.L.), Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China; Institute of Cardiology (M.L.), Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430072, People's Republic of China; and NutriOmique team (M.A., S.A., K.C.), Institute of Cardiometabolism and Nutrition, INSERM, Unité Mixte de Recherche en Santé Unité 1166, and NutriOmique team (M.A., S.A., K.C.), Université Pierre et Marie Curie-Paris 6, Paris F-75013 France.

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http://dx.doi.org/10.1210/en.2015-1184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606759PMC
November 2015

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts.

Stem Cells Transl Med 2015 Oct 7;4(10):1101-8. Epub 2015 Aug 7.

Sections of Islet Cell and Regenerative Biology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;

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http://dx.doi.org/10.5966/sctm.2014-0217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572895PMC
October 2015

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools.

Mol Metab 2015 Sep 20;4(9):593-604. Epub 2015 Jun 20.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molmet.2015.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563028PMC
September 2015

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance.

Diabetes 2015 Aug 13;64(8):2780-90. Epub 2015 May 13.

Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH Department of Physiology and Pharmacology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH

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http://dx.doi.org/10.2337/db14-1772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512217PMC
August 2015

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.

J Proteome Res 2015 Aug 30;14(8):3111-3122. Epub 2015 Jul 30.

Islet Cell & Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1021/acs.jproteome.5b00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615688PMC
August 2015

Human β-cell proliferation and intracellular signaling: part 3.

Diabetes 2015 Jun;64(6):1872-85

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db14-1843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439562PMC
June 2015

High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.

Stem Cell Res 2015 May 18;14(3):307-22. Epub 2015 Feb 18.

Howard Hughes Medical Institute, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Joslin Diabetes Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061150002
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http://dx.doi.org/10.1016/j.scr.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439311PMC
May 2015

Cellular stress drives pancreatic plasticity.

Sci Transl Med 2015 Feb;7(273):273ps2

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010577DOI Listing
February 2015

Epigenetic modifiers of islet function and mass.

Trends Endocrinol Metab 2014 Dec 19;25(12):628-36. Epub 2014 Sep 19.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.08.006DOI Listing
December 2014

Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research.

Diabetes 2014 Dec;63(12):3979-81

Diabetes, Obesity and Metabolism Institute, Mount Sinai School of Medicine, New York, NY

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http://dx.doi.org/10.2337/db14-1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238004PMC
December 2014

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.

Am J Physiol Endocrinol Metab 2014 Nov 23;307(10):E906-18. Epub 2014 Sep 23.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1152/ajpendo.00210.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233258PMC
November 2014

The Polycomb protein, Bmi1, regulates insulin sensitivity.

Mol Metab 2014 Nov 27;3(8):794-802. Epub 2014 Aug 27.

Institute for Diabetes, Obesity and Metabolism and the Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molmet.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216405PMC
November 2014

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.

PLoS One 2014 3;9(2):e87941. Epub 2014 Feb 3.

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America ; Department of Medicine, Division of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087941PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912162PMC
October 2014

Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway.

Diabetes 2014 Oct 16;63(10):3404-15. Epub 2014 May 16.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN Department of Medicine, Indiana University School of Medicine, Indianapolis, IN Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN

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http://dx.doi.org/10.2337/db14-0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171659PMC
October 2014

Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function.

Endocrinology 2014 Sep 23;155(9):3329-38. Epub 2014 Jun 23.

Nutrition Department (S.L., Y.X., A.B., K.M., I.M., F.G.H.), University of California Davis, Davis, California 95616; Joslin Diabetes Center (R.N.K.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215; and Division of Endocrinology, Diabetes and Metabolism (F.G.H.), Department of Internal Medicine, and Comprehensive Cancer Center, University of California Davis, Sacramento, California 95817.

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http://dx.doi.org/10.1210/en.2013-2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138572PMC
September 2014

The regulation of pre- and post-maturational plasticity of mammalian islet cell mass.

Diabetologia 2014 Jul 14;57(7):1291-303. Epub 2014 May 14.

Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, 1 Joslin Place, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s00125-014-3251-7DOI Listing
July 2014

Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum.

Stem Cell Reports 2014 Jul 12;3(1):5-14. Epub 2014 Jun 12.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center; Department of Medicine, Brigham and Women's Hospital; and Harvard Medical School, Boston, MA 02215, USA.

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0014
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400148
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http://dx.doi.org/10.1016/j.stemcr.2014.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110751PMC
July 2014

Insulin resistance alters islet morphology in nondiabetic humans.

Diabetes 2014 Mar 11;63(3):994-1007. Epub 2013 Nov 11.

Islet Cell Biology & Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://diabetes.diabetesjournals.org/content/early/2013/11/1
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https://dash.harvard.edu/bitstream/handle/1/14351359/3931397
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-10
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http://dx.doi.org/10.2337/db13-1013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931397PMC
March 2014

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.

Diabetes 2014 Mar;63(3):819-31

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, and U.S. Department of Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI.

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http://dx.doi.org/10.2337/db13-1146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931400PMC
March 2014

GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation.

Mol Cell Endocrinol 2014 Jan 31;382(1):55-65. Epub 2013 Aug 31.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; Department of Biomedicine, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1016/j.mce.2013.08.020DOI Listing
January 2014

Soluble factors secreted by T cells promote β-cell proliferation.

Diabetes 2014 Jan 2;63(1):188-202. Epub 2013 Oct 2.

Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db13-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868047PMC
January 2014

p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.

Proc Natl Acad Sci U S A 2014 Jan 6;111(3):1192-7. Epub 2014 Jan 6.

Section on Integrative Physiology and Metabolism and Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215.

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http://dx.doi.org/10.1073/pnas.1322564111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903202PMC
January 2014

New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism.

Cell Metab 2013 Dec 12;18(6):775-91. Epub 2013 Sep 12.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858409PMC
December 2013

X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function.

Diabetes 2013 Jul 14;62(7):2439-49. Epub 2013 Mar 14.

Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-1747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712068PMC
July 2013

Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young.

J Biol Chem 2013 Feb 10;288(8):5353-6. Epub 2013 Jan 10.

Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.C112.428979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581399PMC
February 2013

Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets.

Endocrinology 2012 Oct 17;153(10):4593-9. Epub 2012 Jul 17.

Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, United Kingdom.

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http://dx.doi.org/10.1210/en.2012-1243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512010PMC
October 2012

Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.

EMBO J 2012 Oct 14;31(20):3956-7. Epub 2012 Sep 14.

Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/emboj.2012.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474931PMC
October 2012

Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.

Diabetes 2012 Sep 29;61(9):2205-13. Epub 2012 Jun 29.

Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425429PMC
September 2012

Identifying biomarkers of subclinical diabetes.

Authors:
Rohit N Kulkarni

Diabetes 2012 Aug;61(8):1925-6

Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-0599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402306PMC
August 2012

Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling.

Mol Endocrinol 2012 Jun 3;26(6):967-76. Epub 2012 Apr 3.

Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1210/me.2011-1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355538PMC
June 2012

RNA-binding protein HuD controls insulin translation.

Mol Cell 2012 Mar 1;45(6):826-35. Epub 2012 Mar 1.

Laboratory of Molecular Biology and Immunology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319250PMC
March 2012

Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.

Sci Signal 2012 Mar 20;5(216):ra23. Epub 2012 Mar 20.

National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1126/scisignal.2002519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524575PMC
March 2012

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2376-81. Epub 2012 Jan 30.

Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, QC, Canada H3T 1J4.

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http://www.poitoutlab.ca/Publications/Published%20article-MK
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http://www.pnas.org/cgi/doi/10.1073/pnas.1114350109
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http://dx.doi.org/10.1073/pnas.1114350109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289358PMC
February 2012

Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion.

Gastroenterology 2011 Dec 16;141(6):2166-2175.e7. Epub 2011 Sep 16.

Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2011.09.014DOI Listing
December 2011

Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids.

J Clin Endocrinol Metab 2011 Dec 28;96(12):3811-21. Epub 2011 Sep 28.

Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1210/jc.2011-0627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232618PMC
December 2011