Rohan de Silva

Rohan de Silva

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Rohan de Silva

Publications by authors named "Rohan de Silva"

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Monoaminergic neuropathology in Alzheimer's disease.

Prog Neurobiol 2017 04 12;151:101-138. Epub 2016 Apr 12.

Fishberg Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061605PMC
http://dx.doi.org/10.1016/j.pneurobio.2016.04.001DOI Listing
April 2017

The role of tau in the pathological process and clinical expression of Huntington's disease.

Brain 2015 Jul 6;138(Pt 7):1907-18. Epub 2015 May 6.

1 John van Geest Cambridge Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.1093/brain/awv107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572485PMC
July 2015

A cognitive chameleon: lessons from a novel MAPT mutation case.

Neurocase 2014 2;20(6):684-94. Epub 2013 Sep 2.

a Dementia Research Centre, Department of Neurodegenerative Diseases , UCL Institute of Neurology , London WC1N 3BG , UK.

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http://dx.doi.org/10.1080/13554794.2013.826697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151790PMC
March 2015

Analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism.

Neurobiol Aging 2015 Feb 27;36(2):1221.e1-6. Epub 2014 Aug 27.

Department of Molecular Neuroscience, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK; Neurogenetics Laboratory, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK; The MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321829PMC
February 2015

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.

Alzheimers Res Ther 2014 1;6(5-8):77. Epub 2014 Dec 1.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1186/s13195-014-0077-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248436PMC
December 2014

Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies.

Brain Pathol 2014 Jul 28;24(4):334-43. Epub 2014 Mar 28.

Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/bpa.12130DOI Listing
July 2014

Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy.

Neurobiol Aging 2014 Jun 30;35(6):1491-8. Epub 2013 Dec 30.

MRC Centre for Neuromuscular Disease, UCL Institute of Neurology, London, UK; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988933PMC
June 2014

Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.

Neurobiol Aging 2014 Jun 13;35(6):1514.e1-12. Epub 2014 Jan 13.

Reta Lila Weston Institute, UCL Institute of Neurology, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104112PMC
June 2014

Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies.

Acta Neuropathol 2011 Oct 21;122(4):415-28. Epub 2011 Jul 21.

Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK.

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http://dx.doi.org/10.1007/s00401-011-0857-4DOI Listing
October 2011

Tau-positive grains are constant in centenarians' hippocampus.

Neurobiol Aging 2011 Jul 19;32(7):1296-303. Epub 2009 Aug 19.

Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Pitié-Salpétrière, 47-83 boulevard de l'Hôpital, Paris Cedex 13, France.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.009DOI Listing
July 2011

Novel L284R MAPT mutation in a family with an autosomal dominant progressive supranuclear palsy syndrome.

Neurodegener Dis 2011 14;8(3):149-52. Epub 2010 Sep 14.

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1159/000319454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078284PMC
July 2011

Genetics of progressive supranuclear palsy.

Handb Clin Neurol 2008 ;89:475-85

Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S007297520701244
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http://dx.doi.org/10.1016/S0072-9752(07)01244-4DOI Listing
December 2010

Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.

J Neurochem 2010 Jul 3;114(1):160-70. Epub 2010 Apr 3.

Department of Pharmacology, Ajou University School of Medicine, Suwon 442-749, Korea.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06732.xDOI Listing
July 2010

Rational therapeutic approaches to progressive supranuclear palsy.

Brain 2010 Jun 14;133(Pt 6):1578-90. Epub 2010 May 14.

Department of Neurology, Philipps University, Rudolf-Bultmann Str. 8, D-35033 Marburg, Germany.

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http://dx.doi.org/10.1093/brain/awq115DOI Listing
June 2010

Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?

Neurosci Lett 2009 Dec 14;467(3):208-11. Epub 2009 Oct 14.

Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/j.neulet.2009.10.036DOI Listing
December 2009

Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease.

Neurobiol Aging 2009 Sep 26;30(9):1477-82. Epub 2007 Dec 26.

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.11.019DOI Listing
September 2009

Adapting the Sniffin' Sticks to diagnose Parkinson's disease in Sri Lanka.

Mov Disord 2009 Jun;24(8):1229-33

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.22545DOI Listing
June 2009

Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies.

J Neurosci Methods 2009 May 5;180(1):34-42. Epub 2009 Mar 5.

Reta Lila Weston Institute of Neurological Studies and Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London WC1N1PJ, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2009.02.015DOI Listing
May 2009

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy.

Am J Pathol 2009 Jan 12;174(1):228-38. Epub 2008 Dec 12.

Department of Molecular Pharmacology and Physiology, Johnnie B. Byrd Sr. Alzheimer's Institute, University of South Florida, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.2353/ajpath.2009.080764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631335PMC
January 2009

MAPT S305I mutation: implications for argyrophilic grain disease.

Acta Neuropathol 2008 Jul 8;116(1):103-18. Epub 2007 Dec 8.

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-007-0322-6DOI Listing
July 2008

Differential incorporation of tau isoforms in Alzheimer's disease.

J Alzheimers Dis 2008 May;14(1):1-16

Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 526, Bronx, NY 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882247PMC
May 2008

DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders.

Neurobiol Dis 2007 Oct 18;28(1):122-32. Epub 2007 Jul 18.

Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, 1, Wakefield Street, WC1N 1PJ, UK.

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http://dx.doi.org/10.1016/j.nbd.2007.07.012DOI Listing
October 2007

Genetic variation at the tau locus and clinical syndromes associated with progressive supranuclear palsy.

Mov Disord 2007 Apr;22(6):895-7

The Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.21393DOI Listing
April 2007

Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus.

Hippocampus 2007 ;17(2):98-102

Department of Neuroanatomy, Paul-Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1002/hipo.20255DOI Listing
March 2007

Untangling the tau gene association with neurodegenerative disorders.

Hum Mol Genet 2006 Oct;15 Spec No 2:R188-95

Reta Lila Weston Institute of Neurological Studies, University College London, 1, Wakefield Street, London WC1N 1PJ, UK.

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http://dx.doi.org/10.1093/hmg/ddl190DOI Listing
October 2006

Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia.

Neurosci Lett 2006 Sep 21;405(1-2):29-33. Epub 2006 Jul 21.

Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, Tokyo 136-0075, Japan.

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http://dx.doi.org/10.1016/j.neulet.2006.06.036DOI Listing
September 2006

Tangle diseases and the tau haplotypes.

Alzheimer Dis Assoc Disord 2006 Jan-Mar;20(1):60-2

Laboratory of Neurogenetics, National Institutes on Aging and of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1097/01.wad.0000201853.54493.d8DOI Listing
July 2006

Sporadic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease.

Acta Neuropathol 2005 Dec 22;110(6):600-9. Epub 2005 Nov 22.

Department of Pathology, Brain Research Institute, University of Niigata, 1-757 Asahimachi, 951-8585, Niigata, Japan.

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http://link.springer.com/10.1007/s00401-005-1086-5
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http://dx.doi.org/10.1007/s00401-005-1086-5DOI Listing
December 2005

Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein.

Neurosci Lett 2005 Aug 25;383(3):225-30. Epub 2005 Apr 25.

Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, The Windeyer Building, 46, Cleveland Street, London W1T 4JF, UK.

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http://dx.doi.org/10.1016/j.neulet.2005.04.024DOI Listing
August 2005

The architecture of the tau haplotype block in different ethnicities.

Neurosci Lett 2005 Mar 22;377(2):81-4. Epub 2004 Dec 22.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Building 35, Room 1A1008, MSC 3707, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.11.072DOI Listing
March 2005

The tau H2 haplotype is almost exclusively Caucasian in origin.

Neurosci Lett 2004 Oct;369(3):183-5

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.05.119DOI Listing
October 2004

Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions.

Acta Neuropathol 2004 Jun 16;107(6):504-8. Epub 2004 Mar 16.

Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, 156-8585 Tokyo, Japan.

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http://dx.doi.org/10.1007/s00401-004-0842-2DOI Listing
June 2004

The structure of the tau haplotype in controls and in progressive supranuclear palsy.

Hum Mol Genet 2004 Jun 28;13(12):1267-74. Epub 2004 Apr 28.

Reta Lila Weston Institute of Neurological Studies, University College London, UK.

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http://dx.doi.org/10.1093/hmg/ddh138DOI Listing
June 2004

Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans.

Neurosci Lett 2004 Apr;359(1-2):94-8

Reta Lila Weston Institute of Neurological Studies, University College London, 46 Cleveland Street, London, W1T 4JF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400400137
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http://dx.doi.org/10.1016/j.neulet.2003.12.127DOI Listing
April 2004

Detecting tau isoforms in archival cases.

Acta Neuropathol 2004 Feb 2;107(2):181-2. Epub 2003 Dec 2.

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http://link.springer.com/10.1007/s00401-003-0795-x
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http://dx.doi.org/10.1007/s00401-003-0795-xDOI Listing
February 2004

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy.

Acta Neuropathol 2003 Sep 11;106(3):251-60. Epub 2003 Jun 11.

Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004 Yokohama, Japan.

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http://dx.doi.org/10.1007/s00401-003-0728-8DOI Listing
September 2003

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

J Neurochem 2003 Aug;86(3):582-90

Departments of Neuroscience and Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01879.xDOI Listing
August 2003

Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression.

J Neurochem 2003 Jul;86(2):394-404

Reta Lila Weston Institute of Neurological Studies, University College, London, UK.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01844.xDOI Listing
July 2003

Dementia with Lewy bodies from the perspective of tauopathy.

Acta Neuropathol 2003 Mar 22;105(3):265-70. Epub 2002 Nov 22.

Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Japan.

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http://link.springer.de/link/service/journals/00401/contents
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http://dx.doi.org/10.1007/s00401-002-0644-3DOI Listing
March 2003

The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease.

Neurosci Lett 2002 Sep;330(2):201-3

Reta Lila Weston Institute of Neurological Studies, Royal Free & University College Medical School, London, UK

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http://dx.doi.org/10.1016/s0304-3940(02)00742-5DOI Listing
September 2002

The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.

J Neurosci 2002 Aug;22(15):6394-400

Department of Neuroscience, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom.

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http://dx.doi.org/20026670DOI Listing
August 2002

Tau neurotoxicity without the lesions: a fly challenges a tangled web.

Trends Neurosci 2002 Jul;25(7):327-9

Reta Lila Weston Institute of Neurological Studies, Royal Free & University College Medical School, Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK.

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http://dx.doi.org/10.1016/s0166-2236(02)02170-7DOI Listing
July 2002

Argyrophilic grain disease is a sporadic 4-repeat tauopathy.

J Neuropathol Exp Neurol 2002 Jun;61(6):547-56

Department of Pathology, Mayo Clinic, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1093/jnen/61.6.547DOI Listing
June 2002

Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE.

Neurology 2000 Dec;55(12):1918-20

Neurogenetics Section, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1212/wnl.55.12.1918DOI Listing
December 2000

Preparation and purification of antisera against different regions or isoforms of beta-amyloid precursor protein.

Brain Res Brain Res Protoc 1997 Dec;2(1):23-30

MRC Laboratory, Imperial College School of Medicine, Charing Cross Hospital, London, UK.

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December 1997

Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes.

Brain Res Mol Brain Res 1997 Jul;47(1-2):147-56

Department of Biochemistry, Charing Cross and Westminster Medical School, London, UK.

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http://dx.doi.org/10.1016/s0169-328x(97)00045-4DOI Listing
July 1997

Presenilins and early-onset familial Alzheimer's disease.

Neuroreport 1997 May;8(8):i-xii

Department of Biochemistry, Charing Cross & Westminster Medical School, London, UK.

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May 1997

beta-Amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration.

Neuroreport 1996 Aug;7(12):2026-30

Department of Biochemistry, Charing Cross and Westminster Medical School, London, UK.

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http://dx.doi.org/10.1097/00001756-199608120-00035DOI Listing
August 1996

Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization.

Genomics 1996 Mar;32(2):272-6

Department of Medical Oncology & Therapeutics Research, City of Hope Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1006/geno.1996.0115DOI Listing
March 1996