Rogier W Sanders

Rogier W Sanders

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Broadly neutralising antibodies in post-treatment control.

Lancet HIV 2019 May 15;6(5):e271-e272. Epub 2019 Apr 15.

Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23523018193007
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http://dx.doi.org/10.1016/S2352-3018(19)30075-XDOI Listing
May 2019

HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry.

J Biol Chem 2019 Apr 29;294(15):5736-5746. Epub 2019 Jan 29.

From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands,

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http://dx.doi.org/10.1074/jbc.RA119.007360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463712PMC
April 2019

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms.

Curr Opin HIV AIDS 2019 Apr 30. Epub 2019 Apr 30.

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/COH.0000000000000549DOI Listing
April 2019

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users.

Viruses 2019 Apr 25;11(4). Epub 2019 Apr 25.

Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/v11040384DOI Listing
April 2019

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Nat Commun 2019 02 15;10(1):763. Epub 2019 Feb 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-019-08738-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377653PMC
February 2019

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Immunity 2019 Jan 11;50(1):241-252.e6. Epub 2018 Dec 11.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183049
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http://dx.doi.org/10.1016/j.immuni.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335502PMC
January 2019

Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice.

AIDS Res Hum Retroviruses 2018 Sep 22;34(9):790-793. Epub 2018 Aug 22.

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/AID.2018.0114DOI Listing
September 2018

Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies.

Retrovirology 2018 09 12;15(1):63. Epub 2018 Sep 12.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12977-018-0445-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134781PMC
September 2018

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Cell Rep 2018 Aug;24(8):1958-1966.e5

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; Biological Sciences and the Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113929PMC
August 2018

Hitting HIV's Harpoon.

Immunity 2018 07;49(1):14-15

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.07.003DOI Listing
July 2018

Harnessing post-translational modifications for next-generation HIV immunogens.

Biochem Soc Trans 2018 06 21;46(3):691-698. Epub 2018 May 21.

Centre for Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K.

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http://dx.doi.org/10.1042/BST20170394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013407PMC
June 2018

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype.

AIDS Res Hum Retroviruses 2016 Oct/Nov;32(10-11):1135-1142. Epub 2016 Feb 24.

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/aid.2015.0324DOI Listing
December 2017

Opposites attract in bispecific antibody engineering.

J Biol Chem 2017 09;292(35):14718-14719

From the Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands and

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http://dx.doi.org/10.1074/jbc.H117.793497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582862PMC
September 2017

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Immunity 2017 06;46(6):1073-1088.e6

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483234PMC
June 2017

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.

Curr Opin HIV AIDS 2017 May;12(3):241-249

aDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands bDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, USA cSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK.

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http://dx.doi.org/10.1097/COH.0000000000000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389599PMC
May 2017

Native-like Env trimers as a platform for HIV-1 vaccine design.

Immunol Rev 2017 01;275(1):161-182

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299501PMC
January 2017

HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike.

J Virol 2016 Dec 14;90(23):10587-10599. Epub 2016 Nov 14.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

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http://dx.doi.org/10.1128/JVI.01616-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110188PMC
December 2016

HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies.

Expert Rev Vaccines 2016 8;15(3):349-65. Epub 2016 Jan 8.

a Department of Medical Microbiology, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1586/14760584.2016.1129905DOI Listing
November 2016

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Cell Rep 2016 11;17(9):2195-2209

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142765PMC
November 2016

HIV's Achilles' Heel.

Sci Am 2016 11;315(6):50-55

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http://dx.doi.org/10.1038/scientificamerican1216-50DOI Listing
November 2016

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Proc Natl Acad Sci U S A 2016 10 4;113(43):E6639-E6648. Epub 2016 Oct 4.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Chevy Chase, MD 20815

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http://dx.doi.org/10.1073/pnas.1606050113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086995PMC
October 2016

Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies.

AIDS 2016 09;30(14):2179-84

aDepartment of Medical Microbiology bDepartment of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam cJanssen Pharmaceuticals, Leiden, The Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York City, New York, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001177DOI Listing
September 2016

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

Cell Rep 2016 08 18;16(9):2327-38. Epub 2016 Aug 18.

Department of Immunology & Microbial Science, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007210PMC
August 2016

HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.

Trends Immunol 2016 Mar 9;37(3):221-232. Epub 2016 Feb 9.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454186PMC
March 2016

Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals.

PLoS One 2015 24;10(3):e0120648. Epub 2015 Mar 24.

Institut de Recerca de la SIDA-IrsiCaixa-HIVACAT, Badalona, Barcelona, Spain; Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain; Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona, Spain; Universitat de Vic-Central de Catalunya, UVIC-UCC, Vic, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372395PMC
February 2016

Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals.

PLoS One 2015 24;10(3):e0120648. Epub 2015 Mar 24.

Institut de Recerca de la SIDA-IrsiCaixa-HIVACAT, Badalona, Barcelona, Spain; Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain; Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona, Spain; Universitat de Vic-Central de Catalunya, UVIC-UCC, Vic, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372395PMC
February 2016

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

Virology 2015 Dec 1;486:116-20. Epub 2015 Oct 1.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712445PMC
December 2015

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Immunity 2015 Dec;43(6):1053-63

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00459-8.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500459
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http://dx.doi.org/10.1016/j.immuni.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692269PMC
December 2015

Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein.

AIDS Res Hum Retroviruses 2015 Nov 20;31(11):1160-5. Epub 2015 Jul 20.

1 Department of Microbiology and Immunology, Weill Cornell Medical College , Cornell University, New York, New York.

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http://dx.doi.org/10.1089/AID.2015.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651053PMC
November 2015

Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody.

J Immunol 2015 Oct 9;195(8):3759-68. Epub 2015 Sep 9.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Clinical Infection, Microbiology, and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, United Kingdom.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1402344
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1402344DOI Listing
October 2015

Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

Acta Crystallogr D Biol Crystallogr 2015 Oct 26;71(Pt 10):2099-108. Epub 2015 Sep 26.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1107/S1399004715013917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601371PMC
October 2015

Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.

Biomolecules 2015 Oct 23;5(4):2919-34. Epub 2015 Oct 23.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.

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http://dx.doi.org/10.3390/biom5042919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693263PMC
October 2015

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

PLoS Pathog 2015 Oct 30;11(10):e1005238. Epub 2015 Oct 30.

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627763PMC
October 2015

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.

Proc Natl Acad Sci U S A 2015 Sep 8;112(38):11947-52. Epub 2015 Sep 8.

Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative ( IAVI) Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1507793112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586835PMC
September 2015

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.

Retrovirology 2015 Sep 26;12:82. Epub 2015 Sep 26.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12977-015-0210-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583754PMC
September 2015

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.

PLoS Pathog 2015 Aug 12;11(8):e1005110. Epub 2015 Aug 12.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534392PMC
August 2015

Enhanced immunogenicity of HIV-1 envelope gp140 proteins fused to APRIL.

PLoS One 2014 23;9(9):e107683. Epub 2014 Sep 23.

Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107683PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172553PMC
June 2015

Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment.

AIDS 2015 Jun;29(9):1003-14

aLaboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam (CINIMA) bDepartment of Cell Biology and Histology, Center for Immunology Amsterdam (CIA) cDepartment of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000637DOI Listing
June 2015

What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?

J Virol 2015 Jun 25;89(11):5981-95. Epub 2015 Mar 25.

Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York, USA

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http://dx.doi.org/10.1128/JVI.00320-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442429PMC
June 2015

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers.

Cell Rep 2015 Jun 4;11(10):1604-13. Epub 2015 Jun 4.

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555872PMC
June 2015

Immunosilencing a highly immunogenic protein trimerization domain.

J Biol Chem 2015 Mar 29;290(12):7436-42. Epub 2015 Jan 29.

From the Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands and Weill Medical College of Cornell University, New York, New York 10065

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http://dx.doi.org/10.1074/jbc.M114.620534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367253PMC
March 2015

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.

PLoS Pathog 2015 Mar 25;11(3):e1004767. Epub 2015 Mar 25.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373910PMC
March 2015

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env.

Nat Commun 2015 Feb 5;6:6144. Epub 2015 Feb 5.

Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/ncomms7144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338595PMC
February 2015

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.

Proc Natl Acad Sci U S A 2014 Dec 24;111(49):17624-9. Epub 2014 Nov 24.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02142

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http://dx.doi.org/10.1073/pnas.1415789111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267403PMC
December 2014

In vivo protection by broadly neutralizing HIV antibodies.

Trends Microbiol 2014 Oct 26;22(10):550-1. Epub 2014 Aug 26.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2014.08.006DOI Listing
October 2014

HIV: A stamp on the envelope.

Nature 2014 Oct 8;514(7523):437-8. Epub 2014 Oct 8.

Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836556PMC
October 2014

CD4-induced activation in a soluble HIV-1 Env trimer.

Structure 2014 Jul 12;22(7):974-84. Epub 2014 Jun 12.

Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231881PMC
July 2014

ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer.

Biochim Biophys Acta 2014 May 3;1838(5):1296-305. Epub 2014 Jan 3.

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2013.12.022DOI Listing
May 2014

Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers.

AIDS 2014 May;28(8):1237-40

aDepartment of Experimental Immunology and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam bCrucell Holland BV, Leiden cDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York eRagon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000228DOI Listing
May 2014

Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens.

J Immunol 2014 May 11;192(10):4628-35. Epub 2014 Apr 11.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1303401DOI Listing
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May 2014

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Immunity 2014 May 24;40(5):657-68. Epub 2014 Apr 24.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070425PMC
May 2014

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.

Immunity 2014 May 24;40(5):669-80. Epub 2014 Apr 24.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://www.cell.com/cms/attachment/2014544846/2035942764/mmc
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May 2014

HIV-1 autologous antibody neutralization associates with mother to child transmission.

PLoS One 2013 17;8(7):e69274. Epub 2013 Jul 17.

Laboratory of Experimental Virology, Department of Medical Microbiology, Centre for Infection and Immunity Amsterdam (CINIMA), Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.

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https://www.burnet.edu.au/system/publication/file/2872/Baan_
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March 2014

Crystal structure of a soluble cleaved HIV-1 envelope trimer.

Science 2013 Dec 31;342(6165):1477-83. Epub 2013 Oct 31.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1245625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886632PMC
December 2013

Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.

Science 2013 Dec 31;342(6165):1484-90. Epub 2013 Oct 31.

National Resource for Automated Molecular Microscopy, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1245627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954647PMC
December 2013

HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.

Retrovirology 2013 Sep 23;10:102. Epub 2013 Sep 23.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/1742-4690-10-102DOI Listing
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September 2013

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

PLoS Pathog 2013 Sep 19;9(9):e1003618. Epub 2013 Sep 19.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1003618DOI Listing
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September 2013