Rogier Hintzen

Rogier Hintzen

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Rogier Hintzen

Publications by authors named "Rogier Hintzen"

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Pediatric autoimmune encephalitis: Recognition and diagnosis.

Neurol Neuroimmunol Neuroinflamm 2020 May 11;7(3). Epub 2020 Feb 11.

From the Department of Neurology (M.A.A.M.d.B., A.L.B., A.E.M.B., A.v.S., P.A.E.S.S., M.J.T.), Department of Immunology (M.W.J.S.), and Department of Pediatric Neurology (R.F.N.), Erasmus MC University Medical Center, Rotterdam; Haga Hospital (A.v.S.), The Hague; and Sophia Children's Hospital (R.F.N.), Rotterdam, the Netherlands. A.v.S. is currently working at Medisch Centrum Haaglanden, The Hague.

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http://dx.doi.org/10.1212/NXI.0000000000000682DOI Listing
May 2020

Relationship between conservation biology and ecology shown through machine reading of 32,000 articles.

Conserv Biol 2019 Nov 8. Epub 2019 Nov 8.

Department of Life Sciences, Imperial College London, Silwood Park campus, Buckhurst Road, Ascot, Berkshire, SL5 7PY, U.K.

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http://dx.doi.org/10.1111/cobi.13435DOI Listing
November 2019

Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes.

Neurology 2019 09 5;93(10):e968-e974. Epub 2019 Aug 5.

From the Department of Neurology, MS Centre ErasMS (Y.Y.M.W., A.L.B., D.v.P., R.Q.H.), Department of Immunology (M.-J.M., A.F.W., R.Q.H.), and Department of Pediatric Neurology (R.F.N.), Erasmus MC, Rotterdam, the Netherlands; and Neurologic Clinic and Policlinic (C.B., Z.M., J.K.), University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008057DOI Listing
September 2019

Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family.

Mult Scler 2019 06 6;25(7):909-917. Epub 2018 Jun 6.

Department of Neurology, MS Center ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458518777202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545620PMC
June 2019

Time Is Brain and Spine-Reply.

JAMA Neurol 2019 05;76(5):623-624

Department of Neurology, MS Center ErasMS, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamaneurol.2019.0149DOI Listing
May 2019

Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Neurology 2019 05 1;92(22):e2538-e2549. Epub 2019 May 1.

From the UCSF MS Center (E.W.), San Francisco, CA; The Children's Hospital of Philadelphia (B.B.), Perelman School of Medicine, University of Pennsylvania; Birmingham Children's Hospital (E.W.), UK; Department of Health Sciences (M.-P. S.), University of Genova and Ospedale Policlinico San Martino IRCCS; Department NEUROFARBA (M.-P.A.), University of Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi (M.-P.A.), Florence, Italy; Department of Neurology (R.H.), Erasmus MC, Rotterdam, the Netherlands; MS Comprehensive Care Center at NYU Langone (L.K.), New York, NY; Division of Paediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Datteln, Germany; Pediatric MS Center (S.T.), Department of Neurology, National Pediatric Hospital Dr. Garrahan, Buenos Aires, Argentina; and Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000007572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556085PMC
May 2019

Real-world validation of the 2017 McDonald criteria for pediatric MS.

Neurol Neuroimmunol Neuroinflamm 2019 03 14;6(2):e528. Epub 2018 Dec 14.

Department of Neurology (Y.Y.M.W., C.L.d.M., R.M.v.d.V.d.V., E.D.v.P., I.A.K., R.Q.H.), MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands; and Department of Pediatric Neurology (C.E.C.-B., R.F.N.), Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1212/NXI.0000000000000528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340337PMC
March 2019

Smoking at time of CIS increases the risk of clinically definite multiple sclerosis.

J Neurol 2018 May 20;265(5):1010-1015. Epub 2018 Feb 20.

Department of Neurology, MS Centre ErasMS, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00415-018-8780-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937895PMC
May 2018

Paediatric multiple sclerosis: early diagnosis as a first step.

Authors:
Rogier Q Hintzen

Lancet Child Adolesc Health 2018 03 1;2(3):161-162. Epub 2018 Feb 1.

MS Centre ErasMS, Dept of Neurology, Erasmus MC, 3000 CA Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(18)30028-2DOI Listing
March 2018

Specific myelopathy diagnoses using advancing diagnostics: Idiopathic no more.

Neurology 2018 01 15;90(2):51-52. Epub 2017 Dec 15.

From the Department of Pediatrics (Neurology) (E.A.Y.), SickKids Research Institute, Division of Neurosciences and Mental Health, Hospital for Sick Children, University of Toronto, Canada; and Departments of Neurology and Immunology (R.Q.H.), Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000004812DOI Listing
January 2018

Decreased Neuro-Axonal Proteins in CSF at First Attack of Suspected Multiple Sclerosis.

Proteomics Clin Appl 2017 Dec 23;11(11-12). Epub 2017 Oct 23.

Departments of Neurology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1002/prca.201700005DOI Listing
December 2017

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS.

J Neuroinflammation 2017 Dec 4;14(1):235. Epub 2017 Dec 4.

Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1186/s12974-017-1006-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716023PMC
December 2017

Genetic susceptibility to multiple sclerosis: Brain structure and cognitive function in the general population.

Mult Scler 2017 Nov 21;23(13):1697-1706. Epub 2016 Dec 21.

Department of Epidemiology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands/Department of Radiology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458516682104DOI Listing
November 2017

Elevated EBNA-1 IgG in MS is associated with genetic MS risk variants.

Neurol Neuroimmunol Neuroinflamm 2017 Nov 12;4(6):e406. Epub 2017 Oct 12.

Department of Neurology (K.L.K., G.P.V.N., M.J., R.Q.H.), MS Center ErasMS (K.L.K., M.J., R.Q.H.), Department of Viroscience (G.P.V.N., S.M.J.S., G.M.G.M.V.), and Department of Immunology (M.J., R.Q.H.), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1212/NXI.0000000000000406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778394PMC
November 2017

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.

Acta Neuropathol 2017 Sep 17;134(3):383-401. Epub 2017 Jun 17.

Department of Viroscience, Erasmus MC, University Medical Center, Room Ee1720a, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-017-1744-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563341PMC
September 2017

Axonal transport deficits in multiple sclerosis: spiraling into the abyss.

Acta Neuropathol 2017 07 18;134(1):1-14. Epub 2017 Mar 18.

Department Of Neurology, Erasmus MC Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-017-1697-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486629PMC
July 2017

A single demyelinating attack is enough to limit brain growth in children.

Neurology 2017 05 5;88(18):1691-1692. Epub 2017 Apr 5.

From the Department of Paediatric Neurology (Y.H.), Great Ormond Street Hospital for Children; Department of Neuroinflammation (Y.H.), Queen Square MS Centre, UCL Institute of Neurology, London, UK; Department of Neurology and Neurological Sciences (C.B.P.), Stanford University School of Medicine, Palo Alto, CA; and MS Centre ErasMS, Department of Neurology (R.H.), Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000003894DOI Listing
May 2017

Evolution of MRI abnormalities in paediatric acute disseminated encephalomyelitis.

Eur J Paediatr Neurol 2017 Mar 6;21(2):300-304. Epub 2016 Sep 6.

Department of Neurology, MS Centre ErasMS, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Paediatric Neurology, Erasmus MC-Sophia, PO Box 2060, 3000 CB Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2016.08.014DOI Listing
March 2017

Soluble CD27 Levels in Cerebrospinal Fluid as a Prognostic Biomarker in Clinically Isolated Syndrome.

JAMA Neurol 2017 03;74(3):286-292

Department of Neurology, MS Center ErasMS, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamaneurol.2016.4997DOI Listing
March 2017

Female sexual dysfunction in multiple sclerosis: Results of a survey among Dutch urologists and patients.

Neurourol Urodyn 2017 01 23;36(1):116-120. Epub 2015 Oct 23.

Department of Urology and Pediatric Urology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/nau.22884DOI Listing
January 2017

Clinical trials for pediatric MS should be prioritized to test only one or two of the most promising agents - Commentary.

Authors:
Rogier Hintzen

Mult Scler 2016 11 29;22(13):1653-1654. Epub 2016 Jul 29.

Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands

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http://dx.doi.org/10.1177/1352458516661240DOI Listing
November 2016

Neurogenic lower urinary tract dysfunction in the early disease phase of paediatric multiple sclerosis.

Mult Scler 2016 10 20;22(11):1490-1494. Epub 2015 Nov 20.

Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands/Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands

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http://dx.doi.org/10.1177/1352458515618541DOI Listing
October 2016

International Pediatric MS Study Group Global Members Symposium report.

Neurology 2016 Aug;87(9 Suppl 2):S110-6

From the Department of Neurology (E. Wassmer), Birmingham Children's Hospital, UK; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; Department NEUROFARBA (M.P.A.), Section Neurosciences, University of Florence, Italy; Division of Neurology (A.W.), Perelman School of Medicine (B.B.), The Children's Hospital of Philadelphia, University of Pennsylvania; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (R.Q.H.), MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands; Lourie Center for Pediatric MS (L.B.K.), Stony Brook Children's, Stony Brook University, NY; Departments of Pediatrics and Neurology (N.M.), Yale University School of Medicine, New Haven, CT; Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany; National Reference Center for Inflammatory Diseases of the Brain (M.T.), Hôpitaux Universitaires Paris-Sud, University Paris-Sud, France; Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Pediatric MS Center (E. Waubant), UCSF Benioff Children's Hospital, and Neurology Department, UCSF, San Francisco, CA; and the Department of Neurology (A.J.K.), Royal Children's Hospital, Parkville, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000002880DOI Listing
August 2016

Immunopathophysiology of pediatric CNS inflammatory demyelinating diseases.

Neurology 2016 Aug;87(9 Suppl 2):S12-9

From the Neuroimmunology Unit and Experimental Therapeutics Program (A.B.-O.), Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; Department of Neurology (R.Q.H.), MS Centre ErasMS, Neurology, Erasmus MC, Rotterdam, the Netherlands; Neuroimmunology Group (R.C.D.), Institute for Neuroscience and Muscle Research, the Children's Hospital at Westmead, University of Sydney, Australia; Department of Pediatric Neurology (K.R.), Witten/Herdecke University, Children's Hospital Datteln, Datteln, Germany; Department of Neuropathology (W.B.), University Medical Center Göttingen, Georg-August-University, Göttingen, Germany; and Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000002821DOI Listing
August 2016

Environmental and genetic factors in pediatric inflammatory demyelinating diseases.

Neurology 2016 Aug;87(9 Suppl 2):S20-7

From the Pediatric MS Center (E.W.), UCSF Benioff Children's Hospital; Neurology Department (E.W.), UCSF, San Francisco, CA; Murdoch Children's Research Institute (A.-L.P.), Royal Children's Hospital, University of Melbourne, Australia; Department of Biomedical and Specialty Surgical Sciences (M.P.), University of Ferrara, Italy; Neurosciences and Mental Health (H.H.), The Hospital for Sick Children, Toronto, Canada; Department of Neurology (E.M.M.), Johns Hopkins, Baltimore, MD; and MS Center ErasMS, Department of Neurology (R.Q.H.), Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000003029DOI Listing
August 2016

Pediatric acquired CNS demyelinating syndromes: Features associated with multiple sclerosis.

Neurology 2016 Aug;87(9 Suppl 2):S67-73

From the Departments of Neurology (R.Q.H., R.F.N.) and Immunology (R.Q.H.), MS Centre ErasMS, Neurology, Erasmus MC, Rotterdam, the Netherlands; Institute for Neuroscience and Muscle Research (R.C.D.), The Kids Research Institute at the Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Australia; Departments of Pediatric and Developmental Neurology (S.M.), Washington University School of Medicine, St. Louis, MO; and Division of Neurology (B.B.), The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania.

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http://dx.doi.org/10.1212/WNL.0000000000002881DOI Listing
August 2016

Burden of genetic risk variants in multiple sclerosis families in the Netherlands.

Mult Scler J Exp Transl Clin 2016 Jan-Dec;2:2055217316648721. Epub 2016 May 6.

Department of Neurology, Erasmus Medical Centre, the Netherlands.

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http://dx.doi.org/10.1177/2055217316648721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433503PMC
May 2016

Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins.

Mult Scler 2016 Mar 3;22(3):279-91. Epub 2015 Jun 3.

Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands/Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany

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http://dx.doi.org/10.1177/1352458515588581DOI Listing
March 2016

Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis.

J Neurosci Methods 2016 Mar 16;262:66-76. Epub 2016 Jan 16.

Cell Biology, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2016.01.013DOI Listing
March 2016

Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million.

Mult Scler J Exp Transl Clin 2016 Jan-Dec;2:2055217315625652. Epub 2016 Jan 26.

Department of Neurology, MS Centre Erasmus, the Netherlands.

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http://dx.doi.org/10.1177/2055217315625652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433331PMC
January 2016

Genome-wide significant association with seven novel multiple sclerosis risk loci.

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2015-103442DOI Listing
December 2015

Anti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort.

Mult Scler 2015 Oct 6;21(12):1513-20. Epub 2015 Feb 6.

Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands

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http://dx.doi.org/10.1177/1352458514566666DOI Listing
October 2015

Gray matter-related proteins are associated with childhood-onset multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2015 Oct 24;2(5):e155. Epub 2015 Sep 24.

MS Centre ErasMS, Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/NXI.0000000000000155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582906PMC
October 2015

Update on biomarkers in neuromyelitis optica.

Neurol Neuroimmunol Neuroinflamm 2015 Aug 23;2(4):e134. Epub 2015 Jul 23.

Stanford University (E.M., M.H.H.), Stanford, CA; Johns Hopkins University (M.L.), Baltimore, MD; University of Oxford (P.J.W.), UK; Tohoku University (D.K.S.), Sendai, Japan; University of São Paulo (D.K.S.), Brazil; University of Colorado (J.L.B.), Denver; Mt. Sinai University (G.R.J.), New York, NY; Thomas Jefferson University (D.C.H.), Philadelphia, PA; IDIBAPS (A.S.), Barcelona, Spain; Montreal Neurological Institute and Hospital (A.B.-O.), McGill University, Montreal, Quebec, Canada; Research Institute and Hospital of National Cancer Center (H.J.K.), Goyang, Korea; KS Hegde Medical Academy (L.P.), Nitte University, Mangalore, India; Oxford University Hospital (M.I.L.), Oxford, UK; University of Southern Denmark (N.A.), Odense; Vejle Hospital (N.A.), Denmark; University Hospital (N.K.), Marrakech, Morocco; MS Center (R.H.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Service de Neurologie A (R.M.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France; Molecular Neuroimmunology (S.J.), Department of Neurology, University Hospital Heidelberg, Germany; Tandem Labs (J.M.), San Diego, CA; University of Michigan Medical School (T.J.S.), Ann Arbor, MI; and David Geffen School of Medicine (M.R.Y.), University of California, Los Angeles.

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http://dx.doi.org/10.1212/NXI.0000000000000134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516398PMC
August 2015

Fatigue at time of CIS is an independent predictor of a subsequent diagnosis of multiple sclerosis.

J Neurol Neurosurg Psychiatry 2015 May 21;86(5):543-6. Epub 2014 Jul 21.

Department of Neurology, MS Center ErasMS, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://jnnp.bmj.com/content/86/5/543.full.pdf
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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2014-308374
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http://dx.doi.org/10.1136/jnnp-2014-308374DOI Listing
May 2015

Proteomics urine analysis of pregnant women suffering from multiple sclerosis.

J Proteome Res 2015 May 30;14(5):2065-73. Epub 2015 Mar 30.

Department of Neurology, Erasmus University Medical Center, Dr. Molewaterplein 50, Rotterdam 3015 GE, The Netherlands.

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http://dx.doi.org/10.1021/pr501162wDOI Listing
May 2015

Cerebrospinal fluid biomarker candidates associated with human WNV neuroinvasive disease.

PLoS One 2014 2;9(4):e93637. Epub 2014 Apr 2.

Aix Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France; Unité de Recherche en Biologie et Epidémiologie Parasitaires (URBEP), Institut de Recherche Biomédicale des Armées (IRBA), Marseille, France.

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http://repub.eur.nl/pub/58486/journal.pone.0093637.pdf
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http://dx.plos.org/10.1371/journal.pone.0093637
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973578PMC
February 2015

MODISTools - downloading and processing MODIS remotely sensed data in R.

Ecol Evol 2014 Dec 2;4(24):4658-68. Epub 2014 Dec 2.

Department of Life Sciences, Natural History Museum Cromwell Road, London, SW7 5BD, U.K.

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http://dx.doi.org/10.1002/ece3.1273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278818PMC
December 2014

No evidence for an association of osteopontin plasma levels with disease activity in multiple sclerosis.

Mult Scler 2014 Oct 31;20(12):1670-1. Epub 2014 Mar 31.

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458514528765DOI Listing
October 2014

Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands.

J Neurovirol 2014 Aug 27;20(4):412-8. Epub 2014 Mar 27.

Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s13365-014-0248-4DOI Listing
August 2014

Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination.

Neurology 2013 Dec 6;81(23):1996-2001. Epub 2013 Nov 6.

From the Departments of Neurology (E.D.v.P., J.Y.M., I.A.K., R.F.N., C.E.C.-B., R.Q.H.) and Epidemiology (S.K., L.B., C.J., C.M.v.D.), Erasmus MC, Rotterdam, the Netherlands; the Departments of Pediatrics and Neurology (N.M.), Yale School of Medicine, New Haven, CT; the Department of Epidemiology (C.J.), Emory University, Atlanta, GA; the Department of Neurology (B.B.), Children's Hospital of Philadelphia, PA; the Division of Neurology (B.B.), Hospital for Sick Children and University of Toronto; and Montreal Neurological Institute (A.B.-O.), McGill University, Canada.

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http://www.neurology.org/content/81/23/1996.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000436934.4
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http://dx.doi.org/10.1212/01.wnl.0000436934.40034ebDOI Listing
December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

PLoS Genet 2013 Nov 21;9(11):e1003926. Epub 2013 Nov 21.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts, United States of America ; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836799PMC
November 2013

Multiple sclerosis: Month of birth effect in MS--fact or artefact?

Authors:
Rogier Hintzen

Nat Rev Neurol 2013 Sep 13;9(9):489-90. Epub 2013 Aug 13.

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http://dx.doi.org/10.1038/nrneurol.2013.156DOI Listing
September 2013

Paediatric MS is the same disease as adult MS: yes.

Mult Scler 2013 Sep;19(10):1257-8

Department of Neurology, Erasmus MC, Rotterdam, Netherlands.

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http://dx.doi.org/10.1177/1352458513490548DOI Listing
September 2013

Effects of natalizumab treatment on the cerebrospinal fluid proteome of multiple sclerosis patients.

J Proteome Res 2013 Mar 4;12(3):1101-7. Epub 2013 Feb 4.

Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1021/pr3012107DOI Listing
March 2013

Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation.

J Neuroinflammation 2012 Dec 11;9:266. Epub 2012 Dec 11.

Department of Immunology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1742-2094-9-266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538711PMC
December 2012

Proteomics technologies for biomarker discovery in multiple sclerosis.

J Neuroimmunol 2012 Jul 29;248(1-2):40-7. Epub 2011 Nov 29.

Laboratories of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2011.11.004DOI Listing
July 2012

Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis.

Neurology 2012 Jul 13;79(3):261-6. Epub 2012 Jun 13.

Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0b013e31825fdec7DOI Listing
July 2012

Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis.

J Proteome Res 2012 Apr 23;11(4):2048-60. Epub 2012 Feb 23.

Department of Analytical Biochemistry, Centre for Pharmacy, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1021/pr201244tDOI Listing
April 2012

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

J Immunol 2012 Feb 18;188(4):1874-83. Epub 2012 Jan 18.

Department of Neurology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1102559DOI Listing
February 2012

Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients.

Mult Scler 2011 Dec 9;17(12):1527-30. Epub 2011 Aug 9.

Department of Neurology, MS Centre ErasMS, Erasmus University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/1352458511412995DOI Listing
December 2011

The association between cigarette smoking and multiple sclerosis.

J Neurol Sci 2011 Dec 4;311(1-2):78-85. Epub 2011 Oct 4.

Department of Neurology, ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jns.2011.09.008DOI Listing
December 2011

Breast-feeding, postpartum and prepregnancy disease activity in multiple sclerosis.

Neurology 2011 Apr;76(17):1532; author reply 1532-3

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http://dx.doi.org/10.1212/WNL.0b013e318210e908DOI Listing
April 2011

Role of CD8 regulatory T-cells in multiple sclerosis.

Ann Neurol 2011 Mar 11;69(3):593; author reply 593-4. Epub 2011 Mar 11.

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http://dx.doi.org/10.1002/ana.22288DOI Listing
March 2011

Genetics of multiple sclerosis.

Biochim Biophys Acta 2011 Feb 7;1812(2):194-201. Epub 2010 Oct 7.

Department of Neurology, MS Center ErasMS, Erasmus, Rotterdam, The Netherland.

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http://dx.doi.org/10.1016/j.bbadis.2010.09.017DOI Listing
February 2011

Evidence for acute neurotoxicity after chemotherapy.

Ann Neurol 2010 Dec;68(6):806-15

Department of Neuroimmunology, UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://doi.wiley.com/10.1002/ana.22169
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December 2010

Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis.

Mult Scler 2010 Nov 24;16(11):1303-7. Epub 2010 Aug 24.

Department of Neurology, ErasMS Centre, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/1352458510376778
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November 2010

Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry.

J Neurol 2010 Oct 12;257(10):1654-60. Epub 2010 May 12.

Department of Neurology, MS Centre ErasMS, Erasmus MC, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00415-010-5589-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951505PMC
October 2010

Pregnancy-induced fluctuations in functional T-cell subsets in multiple sclerosis patients.

Mult Scler 2010 Sep 7;16(9):1073-8. Epub 2010 Jul 7.

Department of Neurology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458510373939DOI Listing
September 2010

No evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosis.

J Clin Virol 2010 Sep 17;49(1):26-31. Epub 2010 Jul 17.

Department of Neurology, MS center ErasMS, Erasmus MC, Dr. Molewaterplein 50-60, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jcv.2010.06.007DOI Listing
September 2010

Fatigue and depression in children with multiple sclerosis and monophasic variants.

Eur J Paediatr Neurol 2010 Jul 12;14(4):320-5. Epub 2009 Oct 12.

Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.ejpn.2009.09.004DOI Listing
July 2010

Acute disseminating encephalomyelitis following legionnaires disease.

Arch Neurol 2010 May;67(5):623-6

Department of Neurology, Erasmus Medical Center, 3000 CA Rotterdam, the Netherlands.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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May 2010

Neurofilament ELISA validation.

J Immunol Methods 2010 Jan 24;352(1-2):23-31. Epub 2009 Oct 24.

Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.

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http://dx.doi.org/10.1016/j.jim.2009.09.014DOI Listing
January 2010

Barkhof magnetic resonance imaging criteria predict early relapse in pediatric multiple sclerosis.

Pediatr Neurol 2010 Jan;42(1):53-5

Department of Neurology, Erasmus Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.pediatrneurol.2009.07.013DOI Listing
January 2010

First trimester interleukin 8 levels are associated with postpartum relapse in multiple sclerosis.

Mult Scler 2009 Nov 29;15(11):1356-8. Epub 2009 Sep 29.

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458509107009DOI Listing
November 2009

Cigarette smoking and risk of MS in multiplex families.

Mult Scler 2009 Nov 13;15(11):1363-7. Epub 2009 Oct 13.

Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458509345907DOI Listing
November 2009

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.

J Hum Genet 2009 Nov 16;54(11):676-80. Epub 2009 Oct 16.

Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands.

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http://www.nature.com/articles/jhg200996
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November 2009