Roger Williams

Roger Williams

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Roger Williams

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Antimicrobial resistance in chronic liver disease.

Hepatol Int 2019 Dec 3. Epub 2019 Dec 3.

The Institute of Hepatology London and Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.

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http://dx.doi.org/10.1007/s12072-019-10004-1DOI Listing
December 2019

Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time.

Structure 2019 Dec;27(12):1739-1741

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.11.009DOI Listing
December 2019

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.

Elife 2019 Nov 21;8. Epub 2019 Nov 21.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.50149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919976PMC
November 2019

Identifying Key Challenges Facing Healthcare Systems In Africa And Potential Solutions.

Int J Gen Med 2019 6;12:395-403. Epub 2019 Nov 6.

Liver Unit, Department of Surgery and Cancer, St Mary's Campus, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.2147/IJGM.S223882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844097PMC
November 2019

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.

Prog Biophys Mol Biol 2019 10 27;147:4-16. Epub 2019 Jun 27.

Structure Biophysics and FBLG, Discovery Sciences, Biopharmaceuticals R&D, Cambridge, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.06.003DOI Listing
October 2019

Structural Mechanisms of PTEN Regulation.

Cold Spring Harb Perspect Med 2019 Oct 21. Epub 2019 Oct 21.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a036152DOI Listing
October 2019

Establishing a successful rat model of duodenal- jejunal bypass: A detailed guide.

Lab Anim 2019 Aug 18;53(4):362-371. Epub 2018 Sep 18.

1 Division of Diabetes and Nutritional Sciences, King's College London, UK.

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http://journals.sagepub.com/doi/10.1177/0023677218797370
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http://dx.doi.org/10.1177/0023677218797370DOI Listing
August 2019

Hepatology through the crystal ball.

Authors:
Roger Williams

Hepatol Int 2019 Jul 4;13(4):403-406. Epub 2019 Jul 4.

The Institute of Hepatology London, Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.

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http://dx.doi.org/10.1007/s12072-019-09959-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661024PMC
July 2019

Alcohol policy in the UK: where next?

Lancet 2019 Jun 11;393(10189):2377-2378. Epub 2019 Jun 11.

Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(19)31396-0DOI Listing
June 2019

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.

Mol Cell 2019 04 7;74(2):320-329.e6. Epub 2019 Mar 7.

Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK; Addenbrooke's Hospital, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.01.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477152PMC
April 2019

Dynamin-1-Like Protein Inhibition Drives Megamitochondria Formation as an Adaptive Response in Alcohol-Induced Hepatotoxicity.

Am J Pathol 2019 03 14;189(3):580-589. Epub 2018 Dec 14.

The Institute of Hepatology London, Foundation for Liver Research, London, United Kingdom; Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436109PMC
March 2019

Activation of GCN2 by the ribosomal P-stalk.

Proc Natl Acad Sci U S A 2019 03 25;116(11):4946-4954. Epub 2019 Feb 25.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://dx.doi.org/10.1073/pnas.1813352116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421407PMC
March 2019

VPS34 complexes from a structural perspective.

J Lipid Res 2019 02 5;60(2):229-241. Epub 2018 Nov 5.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://www.jlr.org/lookup/doi/10.1194/jlr.R089490
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http://dx.doi.org/10.1194/jlr.R089490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358306PMC
February 2019

Alcohol drinking patterns and risk of liver disease in women.

Lancet Public Health 2019 Jan 22;4(1):e6-e7. Epub 2018 Nov 22.

The Institute of Hepatology London and Foundation for Liver Research, London SE5 9NT, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2468-2667(18)30241-XDOI Listing
January 2019

Tackling alcohol harm would make huge savings.

Authors:
Roger Williams

BMJ 2018 11 1;363:k4519. Epub 2018 Nov 1.

Institute of Hepatology, King's College London, London SE5 9NT, UK.

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http://dx.doi.org/10.1136/bmj.k4519DOI Listing
November 2018

Synthesis of Biocompatible Titanate Nanofibers for Effective Delivery of Neuroprotective Agents.

Methods Mol Biol 2018 ;1727:433-442

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

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http://link.springer.com/10.1007/978-1-4939-7571-6_35
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http://dx.doi.org/10.1007/978-1-4939-7571-6_35DOI Listing
July 2018

Beyond KCH selection and options in acute liver failure.

Hepatol Int 2018 May 1;12(3):204-213. Epub 2018 Jun 1.

The Institute of Hepatology London and Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.

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http://dx.doi.org/10.1007/s12072-018-9869-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999149PMC
May 2018

Common founder effects of hereditary hemochromatosis, Wilson´s disease, the long QT syndrome and autosomal recessive deafness caused by two novel mutations in the and genes.

Hereditas 2017 19;154:16. Epub 2017 Dec 19.

Institute of Hepatology London, Foundation for Liver Research, London,SE5 9NT and Faculty of Life Sciences & Medicine, King´s College London, London, UK.

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http://dx.doi.org/10.1186/s41065-017-0052-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735936PMC
April 2018

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Structure 2018 03 22;26(3):446-458.e8. Epub 2018 Feb 22.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846801PMC
March 2018

Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells.

Am J Med Sci 2018 02 23;355(2):183-190. Epub 2017 Aug 23.

Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK; Faculty of Life Sciences & Medicine, King's College London, London, UK; Section of Gastroenterology, Ralph H Johnson VAMC, Charleston, South Carolina; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2017.08.012DOI Listing
February 2018

Clinical News.

Br J Hosp Med (Lond) 2018 Jan;79(1):8-11

Institut d'Investigacions Biomédiques August Pi i Sunyer-Fundació Privada Clínic de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.12968/hmed.2018.79.1.8DOI Listing
January 2018

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.

Biochemistry 2017 12 29;56(49):6411-6412. Epub 2017 Nov 29.

MRC Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, U.K.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b01120
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http://dx.doi.org/10.1021/acs.biochem.7b01120DOI Listing
December 2017

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP Signaling.

Biophys J 2017 Dec;113(11):2396-2405

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738497PMC
December 2017

Coil embolization for intrahepatic haemorrhage following liver biopsy in a patient with hepatitis C virus infection and hepatic microaneurysms.

Oxf Med Case Reports 2017 Dec 5;2017(12):omx073. Epub 2017 Dec 5.

Institute of Hepatology, Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1093/omcr/omx073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717710PMC
December 2017

Reply.

Hepatology 2017 10 26;66(4):1355-1356. Epub 2017 Aug 26.

George Mason University, Manassas, VA.

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http://dx.doi.org/10.1002/hep.29368DOI Listing
October 2017

Extracorporeal devices for treatment of refractory pruritus in cholestatic liver disease.

Authors:
Roger Williams

Hepatol Int 2017 Jul 6;11(4):371-373. Epub 2017 Jun 6.

The Institute of Hepatology London and Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT, UK.

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http://dx.doi.org/10.1007/s12072-017-9802-5DOI Listing
July 2017

Azithromycin-induced cholestatic hepatitis.

Oxf Med Case Reports 2017 Jun 1;2017(6):omx027. Epub 2017 Jun 1.

Institute of Hepatology, Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1093/omcr/omx027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451892PMC
June 2017

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2017 Jun 15;7(2):83-92. Epub 2017 Mar 15.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.1016/j.jceh.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478965PMC
June 2017

Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.

Biochem J 2017 05 16;474(11):1867-1877. Epub 2017 May 16.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BCJ20170127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544108PMC
May 2017

EASL Recognition Award Recipient 2017: Prof. Giorgina Mieli-Vergani.

Authors:
Roger Williams

J Hepatol 2017 05;66(5):878-881

The Institute of Hepatology London and Foundation for Liver Research, 111 Coldharbour Lane, London, SE5 9NT and Faculty of Life Sciences & Medicine, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.12.013DOI Listing
May 2017

Urinary metabolic profiling by H NMR spectroscopy in patients with cirrhosis may discriminate overt but not covert hepatic encephalopathy.

Metab Brain Dis 2017 04 17;32(2):331-341. Epub 2016 Sep 17.

Liver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, London, W2 1NY, UK.

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http://dx.doi.org/10.1007/s11011-016-9904-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346407PMC
April 2017

Widespread Use of Prescription Nonsteroidal Anti-Inflammatory Drugs Among U.S. Army Active Duty Soldiers.

Mil Med 2017 03;182(3):e1709-e1712

Team Unissant (SRA International), Pharmacy Analytics Support Section, Defense Health Agency Pharmacy Operations Division, 7800 IH-10 West, San Antonio, TX 78230.

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http://dx.doi.org/10.7205/MILMED-D-16-00183DOI Listing
March 2017

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

Methods Mol Biol 2016 ;1388:215-30

Laboratory of Molecular Biology, Medical Research Council (MRC), Francis Crick Avenue, Cambridge Biomedical campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_14DOI Listing
December 2016

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Biochemistry 2016 Nov 10;55(46):6395-6405. Epub 2016 Nov 10.

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado , Boulder, Colorado 80309-0215, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632315PMC
November 2016

Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

J Clin Exp Hepatol 2016 Sep 20;6(3):186-194. Epub 2016 Apr 20.

Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.1016/j.jceh.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052404PMC
September 2016

(90)Y Radioembolization: Multimodality Imaging Pattern Approach with Angiographic Correlation for Optimized Target Therapy Delivery.

Radiographics 2015 Sep-Oct;35(5):1602-18. Epub 2015 Jul 31.

From the Division of Interventional Radiology and Image-guided Medicine (J.C.C., N.K., K.Y., D.D.K., R.S.W.) and Division of Nuclear Medicine and Molecular Imaging (V.M., J.R.G., D.M.S.), Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322; Department of Radiology, Kaiser Permanente, Atlanta, Ga (H.E.R.); and Division of Interventional Radiology, Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pa (H.S.K.).

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http://pubs.rsna.org/doi/10.1148/rg.2015140314
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http://dx.doi.org/10.1148/rg.2015140314DOI Listing
July 2016

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

Cell Rep 2016 07 30;16(3):839-50. Epub 2016 Jun 30.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956616PMC
July 2016

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

Nat Commun 2016 Apr 13;7:11016. Epub 2016 Apr 13.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/ncomms11016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833857PMC
April 2016

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Biophys J 2016 04;110(8):1811-1825

Molecular Biophysics Program, University of Colorado, Boulder, Colorado; Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850241PMC
April 2016

Cryoablation of Osteoid Osteoma in the Pediatric and Adolescent Population.

J Vasc Interv Radiol 2016 Feb 9;27(2):232-7; quiz 238. Epub 2015 Dec 9.

Department of Radiology and Imaging Sciences, Divisions of Interventional Radiology and Image-guided Medicine Emory University School of Medicine, 1364 Clifton Road NE, Suite D112, Atlanta, GA 30322.

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http://dx.doi.org/10.1016/j.jvir.2015.10.005DOI Listing
February 2016

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

Biochem J 2016 Jan 2;473(2):135-44. Epub 2015 Nov 2.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BJ20150931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700475PMC
January 2016

Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.

Biochim Biophys Acta 2016 01 31;1862(1):135-44. Epub 2015 Oct 31.

Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK; Division of Transplantation Immunology and Mucosal Biology, King's College London, UK; Department of Surgery, Loyola University, Chicago, USA; Liver Unit, Barts Health NHS Trust, London, UK; Department of Physiology, University of the Basque Country, Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756594PMC
January 2016

PTEN regulates cilia through Dishevelled.

Nat Commun 2015 Sep 24;6:8388. Epub 2015 Sep 24.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms9388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598566PMC
September 2015

Liver disease in the UK: Startling findings & urgent need for action.

Authors:
Roger Williams

J Hepatol 2015 Aug 1;63(2):297-9. Epub 2015 May 1.

Institute of Hepatology, London & Foundation for Liver Research, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.04.022DOI Listing
August 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
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http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015

Percutaneous CT-guided cryoablation for the treatment of refractory pudendal neuralgia.

Skeletal Radiol 2015 May 17;44(5):709-14. Epub 2014 Dec 17.

Department of Radiology and Imaging Sciences Division of Interventional Radiology and Image-Guided Medicine, Emory University Hospital, 1364 Clifton Road, NE Suite D112, Atlanta, GA, 30322, USA,

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http://dx.doi.org/10.1007/s00256-014-2075-3DOI Listing
May 2015

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis.

FASEB J 2015 May 19;29(5):1676-87. Epub 2014 Dec 19.

*Foundation for Liver Research, Institute of Hepatology, London, United Kingdom; University College London (UCL)--Institute for Liver & Digestive Health, UCL Medical School, London, United Kingdom, Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; and Physiology and Experimental Medicine Research Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1096/fj.14-262717DOI Listing
May 2015

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

J Proteome Res 2015 May 20;14(5):2036-45. Epub 2015 Apr 20.

‡Institute of Hepatology, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom.

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http://dx.doi.org/10.1021/pr501039kDOI Listing
May 2015

Acute liver failure: A curable disease by 2024?

J Hepatol 2015 Apr;62(1 Suppl):S112-20

Institute of Hepatology London, Foundation for Liver Research, 69-75 Chenies Mews, London WC1 6HX, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278140093
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http://dx.doi.org/10.1016/j.jhep.2014.12.016DOI Listing
April 2015

Alcohol-related deaths: is misinformation hindering care improvement?

Lancet 2015 Apr;385(9978):1619-20

Institute of Hepatology and Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(15)60790-5DOI Listing
April 2015

Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production.

Gastroenterology 2015 Feb 8;148(2):403-14.e7. Epub 2014 Oct 8.

Novartis Pharma AG, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.10.004DOI Listing
February 2015

Synergy in activating class I PI3Ks.

Trends Biochem Sci 2015 Feb 5;40(2):88-100. Epub 2015 Jan 5.

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tibs.2014.12.003DOI Listing
February 2015

The structural basis for mTOR function.

Semin Cell Dev Biol 2014 Dec 5;36:91-101. Epub 2014 Oct 5.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.09.024DOI Listing
December 2014

PIKKs--the solenoid nest where partners and kinases meet.

Curr Opin Struct Biol 2014 Dec 3;29:134-42. Epub 2014 Dec 3.

Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2014.11.003DOI Listing
December 2014

Macrophages from patients with cirrhotic ascites showed function alteration of host defense receptor.

J Clin Exp Hepatol 2014 Dec 16;4(4):279-86. Epub 2014 Sep 16.

Institute of Hepatology, The Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1016/j.jceh.2014.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298631PMC
December 2014

Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection.

Hepatology 2014 Aug 19;60(2):487-96. Epub 2014 May 19.

Institute of Hepatology, Foundation for Liver Research, London, UK.

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http://dx.doi.org/10.1002/hep.27139DOI Listing
August 2014

Progressively reducing regulatory burden.

AAPS J 2014 Jul 17;16(4):621-4. Epub 2014 Apr 17.

, N Potomac, Maryland, 20878, USA,

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http://dx.doi.org/10.1208/s12248-014-9601-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070254PMC
July 2014

Identification of serum cytokine profiles associated with HBeAg seroconversion following antiviral treatment interruption.

Viral Immunol 2014 Jun 5;27(5):235-44. Epub 2014 May 5.

1 Institute of Hepatology , Foundation for Liver Research, London, United Kingdom .

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http://dx.doi.org/10.1089/vim.2014.0022DOI Listing
June 2014