Roger W Beuerman

Roger W Beuerman

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Roger W Beuerman

Publications by authors named "Roger W Beuerman"

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Surface Immobilization of Nano-Silver on Polymeric Medical Devices to Prevent Bacterial Biofilm Formation.

Pathogens 2019 Jun 28;8(3). Epub 2019 Jun 28.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 169856, Singapore.

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http://dx.doi.org/10.3390/pathogens8030093DOI Listing
June 2019

The penetration and distribution of topical atropine in animal ocular tissues.

Acta Ophthalmol 2019 Mar 26;97(2):e238-e247. Epub 2018 Sep 26.

Singapore Eye Research Institute, The Academia, Singapore city, Singapore.

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http://dx.doi.org/10.1111/aos.13889DOI Listing
March 2019

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays.

Invest Ophthalmol Vis Sci 2019 03;60(4):868-876

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.18-25761DOI Listing
March 2019

Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia.

J Transl Med 2019 Jan 23;17(1):38. Epub 2019 Jan 23.

Clinical Center for Molecular Medicine, Children's Hospital of Chongqing Medical University, 136 Zhongshan 2 Rd, Chongqing, 400014, China.

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http://dx.doi.org/10.1186/s12967-019-1783-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343345PMC
January 2019

Recent advances in the applications of metabolomics in eye research.

Anal Chim Acta 2018 Dec 7;1037:28-40. Epub 2018 Feb 7.

Singapore Eye Research Institute, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183016
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http://dx.doi.org/10.1016/j.aca.2018.01.060DOI Listing
December 2018

Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization.

Biochim Biophys Acta Biomembr 2018 11 18;1860(11):2281-2298. Epub 2018 May 18.

Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, 169856, Singapore; Duke-NUS Medical School, SRP Neuroscience and Behavioral Disorders, 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2018.05.006DOI Listing
November 2018

Design and synthesis of oligo-lipidated arginyl peptide (OLAP) dimers with enhanced physicochemical activity, peptide stability and their antimicrobial actions against MRSA infections.

Amino Acids 2018 Oct 31;50(10):1329-1345. Epub 2018 Jul 31.

Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s00726-018-2607-6DOI Listing
October 2018

Conformational Transitions of Melittin between Aqueous and Lipid Phases: Comparison of Simulations with Experiments.

J Phys Chem B 2018 Sep 10;122(37):8698-8705. Epub 2018 Sep 10.

Bioinformatics Institute (A*Star) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore.

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http://dx.doi.org/10.1021/acs.jpcb.8b06781DOI Listing
September 2018

Patient stratification in clinical glaucoma trials using the individual tear proteome.

Sci Rep 2018 Aug 13;8(1):12038. Epub 2018 Aug 13.

SILK, Department of Ophthalmology, Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-018-30369-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089987PMC
August 2018

Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics.

Sci Rep 2018 Jun 4;8(1):8537. Epub 2018 Jun 4.

Department of Medical Oncology, The Affiliated 6th People's Hospital of Shanghai Jiaotong University, Shanghai, 200233, China.

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http://dx.doi.org/10.1038/s41598-018-26761-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986741PMC
June 2018

Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity.

Invest Ophthalmol Vis Sci 2018 03;59(3):1332-1342

Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky, United States.

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http://dx.doi.org/10.1167/iovs.17-23127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846334PMC
March 2018

Molecular Insights into the Membrane Affinities of Model Hydrophobes.

ACS Omega 2018 Mar 1;3(3):2498-2507. Epub 2018 Mar 1.

Singapore Eye Research Institute, The Academia, 20 College Road, 169856, Singapore.

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http://dx.doi.org/10.1021/acsomega.7b01759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044992PMC
March 2018

Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance.

J Med Chem 2017 12 8;60(24):10135-10150. Epub 2017 Dec 8.

Singapore Eye Research Institute, The Academia , 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01348DOI Listing
December 2017

Discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis.

Ocul Surf 2017 10 27;15(4):770-783. Epub 2017 Jun 27.

Singapore Eye Research Institute, Singapore, 169856, Singapore; SRP Neuroscience and Behavioral Disorders, Duke-NUS, Singapore, 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2017.06.002DOI Listing
October 2017

Recent advances in synthetic lipopeptides as anti-microbial agents: designs and synthetic approaches.

Amino Acids 2017 10 19;49(10):1653-1677. Epub 2017 Aug 19.

Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s00726-017-2476-4DOI Listing
October 2017

Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity.

Biomaterials 2017 Sep 26;138:153-168. Epub 2017 May 26.

Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, 169856, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.05.043DOI Listing
September 2017

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA).

J Med Chem 2017 07 7;60(14):6152-6165. Epub 2017 Jul 7.

Singapore Eye Research Institute , The Academia, 20 College Road, Discovery Tower Level 6, 169856 Singapore, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00380DOI Listing
July 2017

Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study.

J Proteomics 2017 05 5;161:1-10. Epub 2017 Apr 5.

Shanghai University of Medicine & Health Sciences Shanghai Sixth People's Hospital East Campus, Shanghai 201306, PR China; Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.04.005DOI Listing
May 2017

The power of tears: how tear proteomics research could revolutionize the clinic.

Expert Rev Proteomics 2017 03 1;14(3):189-191. Epub 2017 Feb 1.

a Singapore Eye Research Institute , Singapore.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2017.1
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http://dx.doi.org/10.1080/14789450.2017.1285703DOI Listing
March 2017

Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity.

J Med Chem 2017 02 13;60(4):1362-1378. Epub 2017 Feb 13.

Singapore Eye Research Institute, The Academia , 20 College Road, Discovery Tower Level 6, 169856, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01403DOI Listing
February 2017

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design.

Front Neurosci 2017 14;11:73. Epub 2017 Feb 14.

Ocular Chemistry and Anti-Infectives, Singapore Eye Research InstituteSingapore, Singapore; Duke-NUS Graduate Medical School, SRP Neuroscience and BDSingapore, Singapore.

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http://dx.doi.org/10.3389/fnins.2017.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306396PMC
February 2017

type III secreted protein BipC: role in actin modulation and translocation activities required for the bacterial intracellular lifecycle.

PeerJ 2016 21;4:e2532. Epub 2016 Dec 21.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya , Kuala Lumpur , Malaysia.

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http://dx.doi.org/10.7717/peerj.2532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180589PMC
December 2016

Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties.

Eur J Med Chem 2016 Nov 30;123:684-703. Epub 2016 Jul 30.

Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, 169856, Singapore; Duke-NUS Medical School, SRP Neuroscience and Behavioural Disorders, 169857, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234163063
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http://dx.doi.org/10.1016/j.ejmech.2016.07.068DOI Listing
November 2016

Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering.

Biomaterials 2016 10 14;104:323-38. Epub 2016 Jul 14.

Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.07.007DOI Listing
October 2016

Ex Vivo Propagation of Human Corneal Stromal "Activated Keratocytes" for Tissue Engineering.

Cell Transplant 2015 6;24(9):1845-61. Epub 2014 Oct 6.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.3727/096368914X685069DOI Listing
June 2016

Insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced wound dressings.

Acta Biomater 2016 06 11;37:155-64. Epub 2016 Apr 11.

Anti-Infectives Research Group, Singapore Eye Research Institute, Singapore 169856, Singapore; SRP in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2016.04.015DOI Listing
June 2016

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Authors:
Qiao Fan Virginie J M Verhoeven Robert Wojciechowski Veluchamy A Barathi Pirro G Hysi Jeremy A Guggenheim René Höhn Veronique Vitart Anthony P Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W Hewitt Xiaobo Guo Johanna Mazur Jenifer E Huffman Katie M Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F Wilson Peter K Joshi George McMahon Beate St Pourcain David M Evans Claire L Simpson Tae-Hwi Schwantes-An Robert P Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppala Tanja Zeller Thomas Meitinger Janina S Ried Christian Gieger Laura Portas Elisabeth M van Leeuwen Najaf Amin André G Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E H Ho Wan'e Lim Roger W Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N Luben Paul J Foster Barbara E K Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L Young Mingguang He Olavi Pärssinen Cornelia M van Duijn Jie Jin Wang Cathy Williams Jost B Jonas Yik-Ying Teo David A Mackey Konrad Oexle Nagahisa Yoshimura Andrew D Paterson Norbert Pfeiffer Tien-Yin Wong Paul N Baird Dwight Stambolian Joan E Bailey Wilson Ching-Yu Cheng Christopher J Hammond Caroline C W Klaver Seang-Mei Saw Jugnoo S Rahi Jean-François Korobelnik John P Kemp Nicholas J Timpson George Davey Smith Jamie E Craig Kathryn P Burdon Rhys D Fogarty Sudha K Iyengar Emily Chew Sarayut Janmahasatian Nicholas G Martin Stuart MacGregor Liang Xu Maria Schache Vinay Nangia Songhomitra Panda-Jonas Alan F Wright Jeremy R Fondran Jonathan H Lass Sheng Feng Jing Hua Zhao Kay-Tee Khaw Nick J Wareham Taina Rantanen Jaakko Kaprio Chi Pui Pang Li Jia Chen Pancy O Tam Vishal Jhanji Alvin L Young Angela Döring Leslie J Raffel Mary-Frances Cotch Xiaohui Li Shea Ping Yip Maurice K H Yap Ginevra Biino Simona Vaccargiu Maurizio Fossarello Brian Fleck Seyhan Yazar Jan Willem L Tideman Milly Tedja Margaret M Deangelis Margaux Morrison Lindsay Farrer Xiangtian Zhou Wei Chen Nobuhisa Mizuki Akira Meguro Kari Matti Mäkelä

Nat Commun 2016 Mar 29;7:11008. Epub 2016 Mar 29.

Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms11008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820539PMC
March 2016

Biofilms of Pathogenic Nontuberculous Mycobacteria Targeted by New Therapeutic Approaches.

Antimicrob Agents Chemother 2016 01 12;60(1):24-35. Epub 2015 Oct 12.

Singapore Eye Research Institute, Singapore SRP Neuroscience and Behavioral Disorders, Duke-NUS, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://dx.doi.org/10.1128/AAC.01509-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704195PMC
January 2016

Nonpeptidic Amphiphilic Xanthone Derivatives: Structure-Activity Relationship and Membrane-Targeting Properties.

J Med Chem 2016 Jan 18;59(1):171-93. Epub 2015 Dec 18.

Singapore Eye Research Institute , The Academia, 20 College Road, Discovery Tower Level 6, 169856 Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01500DOI Listing
January 2016

Multifunctional Polyphenols- and Catecholamines-Based Self-Defensive Films for Health Care Applications.

ACS Appl Mater Interfaces 2016 Jan 8;8(2):1220-32. Epub 2016 Jan 8.

Anti-Infectives Research Group, Singapore Eye Research Institute , Singapore 168751.

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http://dx.doi.org/10.1021/acsami.5b09633DOI Listing
January 2016

Corneal Biofilms: From Planktonic to Microcolony Formation in an Experimental Keratitis Infection with Pseudomonas Aeruginosa.

Ocul Surf 2015 Oct 26;13(4):331-45. Epub 2015 Jul 26.

Singapore Eye Research Institute (SERI), Singapore; Duke-NUS SRP Neuroscience and Behavioural Disorders and Emerging Infectious Diseases, Singapore; Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2015.07.001DOI Listing
October 2015

A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression

eNeuro 2015 Jan-Feb;2(1). Epub 2015 Mar 14.

Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School , Singapore, 169857, Singapore.

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http://dx.doi.org/10.1523/ENEURO.0020-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586916PMC
October 2015

Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress.

J Proteome Res 2015 Sep 19;14(9):3982-95. Epub 2015 Aug 19.

Singapore Eye Research Institute , The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00443
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http://dx.doi.org/10.1021/acs.jproteome.5b00443DOI Listing
September 2015

N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization.

J Med Chem 2015 Aug 12;58(16):6533-48. Epub 2015 Aug 12.

Singapore Eye Research Institute, The Academia , 20 College Road, Discovery Tower Level 6, 169856, Singapore.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00628DOI Listing
August 2015

A novel fragment based strategy for membrane active antimicrobials against MRSA.

Biochim Biophys Acta 2015 Apr 10;1848(4):1023-31. Epub 2015 Jan 10.

Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, 168751, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074, Singapore; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore; Duke-NUS, SRP Neuroscience-Behavioural Disorders, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.01.001DOI Listing
April 2015

Regulation of Toll-like receptor expression in human conjunctival epithelial cells.

Mediators Inflamm 2014 25;2014:493596. Epub 2014 May 25.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China.

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http://dx.doi.org/10.1155/2014/493596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058181PMC
February 2015

Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry.

J Proteomics 2015 Feb 19;115:36-48. Epub 2014 Dec 19.

Singapore Eye Research Institute, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; SRP Neuroscience and Behavioral Disorder, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.12.002DOI Listing
February 2015

Biochemical properties and aggregation propensity of transforming growth factor-induced protein (TGFBIp) and the amyloid forming mutants.

Ocul Surf 2015 Jan 8;13(1):9-25. Epub 2014 Oct 8.

Singapore Eye Research Institute, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2014.04.003DOI Listing
January 2015

Involvement of GABA transporters in atropine-treated myopic retina as revealed by iTRAQ quantitative proteomics.

J Proteome Res 2014 Nov 1;13(11):4647-58. Epub 2014 Oct 1.

Singapore Eye Research Institute , 11 Third Hospital Avenue, Singapore 168751, Singapore.

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http://dx.doi.org/10.1021/pr500558yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227558PMC
November 2014

Synthetic multivalent antifungal peptides effective against fungi.

PLoS One 2014 3;9(2):e87730. Epub 2014 Feb 3.

Singapore Eye Research Institute, Singapore, Singapore ; Department of Neuroscience and Behavioural Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore ; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912015PMC
October 2014

Clinical and genetic aspects of the TGFBI-associated corneal dystrophies.

Ocul Surf 2014 Oct 18;12(4):234-51. Epub 2014 Jul 18.

Singapore Eye Research Institute, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore National Eye Centre, Singapore; Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2013.12.002DOI Listing
October 2014

Effectiveness of antimicrobial peptide immobilization for preventing perioperative cornea implant-associated bacterial infection.

Antimicrob Agents Chemother 2014 Sep 23;58(9):5229-38. Epub 2014 Jun 23.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore Antimicrobials Group, Singapore Eye Research Institute, Singapore Singapore National Eye Centre, Singapore Duke-NUS Graduate Medical School, Singapore

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http://dx.doi.org/10.1128/AAC.02859-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135834PMC
September 2014

Moesin expression in fibrosis in the mouse cornea after sterile mechanical trauma or infection.

Cornea 2014 Sep;33(9):973-80

*Singapore Eye Research Institute, Singapore, Singapore; and †SRP Neuroscience and Behavioral Disorders, Duke-NUS, Singapore, Singapore.

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http://dx.doi.org/10.1097/ICO.0000000000000179DOI Listing
September 2014

Comparative analysis of two femtosecond LASIK platforms using iTRAQ quantitative proteomics.

Invest Ophthalmol Vis Sci 2014 May 6;55(6):3396-402. Epub 2014 May 6.

Singapore Eye Research Institute, Singapore Singapore National Eye Centre, Singapore Office of Clinical, Academic, and Faculty Affairs, Duke-National University of Singapore Graduate Medical School, Singapore.

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http://dx.doi.org/10.1167/iovs.14-14113DOI Listing
May 2014

Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces.

Sci Rep 2013 Dec 13;3:3451. Epub 2013 Dec 13.

p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648.

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http://dx.doi.org/10.1038/srep03451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506440PMC
December 2013

Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.

Dis Model Mech 2013 Sep 2;6(5):1146-58. Epub 2013 May 2.

Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751 Singapore, Singapore.

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http://dx.doi.org/10.1242/dmm.010967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759334PMC
September 2013

Quantitative proteomic analysis of N-linked glycoproteins in human tear fluid.

Methods Mol Biol 2013 ;951:297-306

Singapore Eye Research Institute, Singapore, Singapore.

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http://dx.doi.org/10.1007/978-1-62703-146-2_20DOI Listing
June 2013

Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability.

Biochim Biophys Acta 2013 Mar 26;1828(3):1112-21. Epub 2012 Dec 26.

Singapore Eye Research Institute, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.bbamem.2012.12.015DOI Listing
March 2013

Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.

Biochim Biophys Acta 2013 Feb 13;1828(2):834-44. Epub 2012 Sep 13.

Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751, Singapore.

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http://dx.doi.org/10.1016/j.bbamem.2012.09.004DOI Listing
February 2013

Molecular dynamics simulations of a new branched antimicrobial peptide: a comparison of force fields.

J Chem Phys 2012 Dec;137(21):215101

Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751.

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http://dx.doi.org/10.1063/1.4768899DOI Listing
December 2012

Tear analysis in ocular surface diseases.

Prog Retin Eye Res 2012 Nov 23;31(6):527-50. Epub 2012 Jun 23.

Singapore Eye Research Institute, Singapore.

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http://ac.els-cdn.com/S1350946212000420/1-s2.0-S135094621200
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S135094621200042
Publisher Site
http://dx.doi.org/10.1016/j.preteyeres.2012.06.002DOI Listing
November 2012

Dual functionalization of titanium with vascular endothelial growth factor and β-defensin analog for potential application in keratoprosthesis.

J Biomed Mater Res B Appl Biomater 2012 Nov 23;100(8):2090-100. Epub 2012 Jul 23.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore 168751, Singapore.

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http://dx.doi.org/10.1002/jbm.b.32774DOI Listing
November 2012

In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt.

Br J Ophthalmol 2012 Sep 16;96(9):1252-8. Epub 2012 Jul 16.

Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1136/bjophthalmol-2012-301633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432489PMC
September 2012

Expression, purification and characterization of fourth FAS1 domain of TGFβIp-associated corneal dystrophic mutants.

Protein Expr Purif 2012 Jul 2;84(1):108-15. Epub 2012 May 2.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1016/j.pep.2012.04.018DOI Listing
July 2012

In-depth analysis of the human tear proteome.

J Proteomics 2012 Jul 23;75(13):3877-85. Epub 2012 May 23.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1016/j.jprot.2012.04.053DOI Listing
July 2012

In vivo evaluation of titanium oxide and hydroxyapatite as an artificial cornea skirt.

J Mater Sci Mater Med 2012 Apr 17;23(4):1063-72. Epub 2012 Mar 17.

Tissue Engineering and Stem Cell Research Group, Singapore Eye Research Institute, Singapore, Singapore.

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http://link.springer.com/content/pdf/10.1007/s10856-012-4578
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http://link.springer.com/10.1007/s10856-012-4578-6
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http://dx.doi.org/10.1007/s10856-012-4578-6DOI Listing
April 2012

S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue.

Mol Vis 2011 20;17:2263-71. Epub 2011 Aug 20.

Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164687PMC
January 2012

Characterization of the human tear metabolome by LC-MS/MS.

J Proteome Res 2011 Oct 30;10(10):4876-82. Epub 2011 Aug 30.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1021/pr2004874DOI Listing
October 2011

Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication.

Invest Ophthalmol Vis Sci 2011 Sep 22;52(10):7385-91. Epub 2011 Sep 22.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1167/iovs.10-6532DOI Listing
September 2011

Association of tear proteins with Meibomian gland disease and dry eye symptoms.

Br J Ophthalmol 2011 Jun 28;95(6):848-52. Epub 2010 Oct 28.

Singapore Eye Research Institute, Singapore, Singapore.

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http://bjo.bmj.com/content/early/2010/10/27/bjo.2010.185256.
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June 2011

Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview.

Transplantation 2011 Apr;91(8):811-9

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1097/TP.0b013e3182111f01DOI Listing
April 2011

A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability.

Nat Mater 2011 Feb 12;10(2):149-56. Epub 2010 Dec 12.

School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.

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http://dx.doi.org/10.1038/nmat2915DOI Listing
February 2011

The nuclear-factor kappaB pathway is activated in pterygium.

Invest Ophthalmol Vis Sci 2011 Jan 5;52(1):230-6. Epub 2011 Jan 5.

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.10-5735DOI Listing
January 2011

In vivo real-time intraocular pressure variations during LASIK flap creation.

Invest Ophthalmol Vis Sci 2010 Sep 14;51(9):4641-5. Epub 2010 Apr 14.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1167/iovs.10-5228DOI Listing
September 2010

Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore.

Invest Ophthalmol Vis Sci 2010 Jul 24;51(7):3449-54. Epub 2010 Feb 24.

Singapore National Eye Center, Singapore.

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http://dx.doi.org/10.1167/iovs.09-4445DOI Listing
July 2010

Expression of neural receptors in mouse meibomian gland.

Cornea 2010 Jul;29(7):794-801

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1097/ICO.0b013e3181ca3262DOI Listing
July 2010

Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction.

Biomaterials 2010 Jan 24;31(2):216-25. Epub 2009 Sep 24.

Singapore Eye Research Institute, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.biomaterials.2009.09.034DOI Listing
January 2010