Roger Sandhoff

Roger Sandhoff

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Roger Sandhoff

Roger Sandhoff

Publications by authors named "Roger Sandhoff"

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Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury.

Kidney Int 2019 Aug 28;96(2):327-341. Epub 2019 Feb 28.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany; Institute of Pharmacology, University of Marburg, Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.02.010DOI Listing
August 2019

Ganglioside Metabolism in Health and Disease.

Prog Mol Biol Transl Sci 2018 28;156:1-62. Epub 2018 Mar 28.

Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2018.01.002DOI Listing
February 2019

Emerging concepts of ganglioside metabolism.

FEBS Lett 2018 12 16;592(23):3835-3864. Epub 2018 Jun 16.

LIMES Institute, University of Bonn, Germany.

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http://dx.doi.org/10.1002/1873-3468.13114DOI Listing
December 2018

Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.

Oncotarget 2017 Dec 24;8(65):109201-109216. Epub 2017 Nov 24.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.22648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752514PMC
December 2017

Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells.

Front Immunol 2017 21;8:848. Epub 2017 Jul 21.

Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519558PMC
July 2017

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.

Hum Mol Genet 2017 05;26(10):1787-1800

Unité Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056 Inserm - Université de Toulouse, Place du Dr Baylac, Hôpital Purpan, TSA 40031, F-31059 Toulouse, Cedex 9, France.

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http://dx.doi.org/10.1093/hmg/ddx079DOI Listing
May 2017

The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes.

Angew Chem Int Ed Engl 2017 01 16;56(4):1146-1151. Epub 2016 Dec 16.

Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163, Mannheim, Germany.

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http://dx.doi.org/10.1002/anie.201610292DOI Listing
January 2017

Rat kidney lipid composition addressed by mass spectrometry imaging.

Kidney Int 2016 11;90(5):1129-1130

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany; Center for Applied Sciences at Technical Universities (ZAFH)-Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.07.033DOI Listing
November 2016

Molecular imaging of brain localization of liposomes in mice using MALDI mass spectrometry.

Sci Rep 2016 09 21;6:33791. Epub 2016 Sep 21.

Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS). Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.

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http://dx.doi.org/10.1038/srep33791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030664PMC
September 2016

Identification of the Key Enzyme of Roseoflavin Biosynthesis.

Angew Chem Int Ed Engl 2016 05 9;55(20):6103-6. Epub 2016 Apr 9.

Fakultät für Biotechnologie, Institut für Technische Mikrobiologie, Hochschule Mannheim, Paul-Wittsack-Strasse 10, 68163, Mannheim, Germany.

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http://dx.doi.org/10.1002/anie.201600581DOI Listing
May 2016

Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors.

Hum Mol Genet 2015 Sep 4;24(17):4792-808. Epub 2015 Jun 4.

Lipid Pathobiochemistry Group, Department of Cellular and Molecular Pathology, Department of Cellular and Molecular Pathology , Center for Applied Research "Applied Biomedical Mass Spectrometry" (ABIMAS), Mannheim 68163, Germany, Instrumental Analytics and Bioanalytics, Technical University of Applied Sciences Mannheim, Mannheim 69120, Germany

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv204DOI Listing
September 2015

Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism.

EMBO Rep 2015 Mar 2;16(3):321-31. Epub 2015 Feb 2.

Department of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ), Heidelberg, Germany Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

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http://dx.doi.org/10.15252/embr.201439333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364871PMC
March 2015

Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction.

J Lipid Res 2014 Nov 29;55(11):2354-69. Epub 2014 Sep 29.

Center for Applied Research "Applied Biomedical Mass Spectrometry" (ABIMAS), Mannheim, Germany Lipid Pathobiochemistry Group within Department of Cellular and Molecular Pathology German Cancer Research Center (DKFZ), Heidelberg, Germany Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Mannheim, Germany.

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http://dx.doi.org/10.1194/jlr.M051839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617137PMC
November 2014

Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods.

J Lipid Res 2014 Nov 1;55(11):2343-53. Epub 2014 Oct 1.

Center for Applied Research "Applied Biomedical Mass Spectrometry" (ABIMAS), Mannheim, Germany Lipid Pathobiochemistry Group within German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ), Heidelberg, Germany Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Mannheim, Germany.

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http://dx.doi.org/10.1194/jlr.M051821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617136PMC
November 2014

Ceramide synthesis in the epidermis.

Biochim Biophys Acta 2014 Mar 27;1841(3):422-34. Epub 2013 Aug 27.

Lipid Pathobiochemistry Group within Department of Cellular & Molecular Pathology, German Cancer Research Center (dkfz.), Heidelberg, Germany; Instrumental Analytics & Bioanalytics, Technical University of Applied Sciences, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.08.011DOI Listing
March 2014

1-O-acylceramides are natural components of human and mouse epidermis.

J Lipid Res 2013 Dec 27;54(12):3312-21. Epub 2013 Sep 27.

Lipid Pathobiochemistry Group within, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1194/jlr.M040097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826679PMC
December 2013

4-Phenyl-α-cyanocinnamic acid amide: screening for a negative ion matrix for MALDI-MS imaging of multiple lipid classes.

Anal Chem 2013 Oct 17;85(19):9156-63. Epub 2013 Sep 17.

Applied Research Center in Biomedical Mass Spectrometry (ABIMAS), ‡Instrumental Analysis and Bioanalysis, Mannheim University of Applied Sciences , Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.

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http://dx.doi.org/10.1021/ac4018154DOI Listing
October 2013

Quantitative characterization of tissue globotetraosylceramides in a rat model of polycystic kidney disease by PrimaDrop sample preparation and indirect high-performance thin layer chromatography-matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry with automated data acquisition.

Anal Chem 2013 Jul 11;85(13):6233-40. Epub 2013 Jun 11.

Instrumental Analysis and Bioanalysis, Department of Biotechnology, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany.

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http://dx.doi.org/10.1021/ac400931uDOI Listing
July 2013

A new, robust, and nonradioactive approach for exploring N-myristoylation.

J Lipid Res 2012 Nov 24;53(11):2459-68. Epub 2012 Jul 24.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1194/jlr.D026997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466015PMC
November 2012

Glycosphingolipids are essential for intestinal endocytic function.

J Biol Chem 2012 Sep 31;287(39):32598-616. Epub 2012 Jul 31.

Department of Cellular and Molecular Pathology, German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M112.371005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463339PMC
September 2012

Loss of ceramide synthase 3 causes lethal skin barrier disruption.

Hum Mol Genet 2012 Feb 28;21(3):586-608. Epub 2011 Oct 28.

Cellular & Molecular Pathology, German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddr494DOI Listing
February 2012

Imaging of complex sulfatides SM3 and SB1a in mouse kidney using MALDI-TOF/TOF mass spectrometry.

Anal Bioanal Chem 2011 Jul 27;401(1):53-64. Epub 2011 Feb 27.

Instrumental Analysis and Bioanalysis, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00216-011-4802-0DOI Listing
July 2011

Very long chain sphingolipids: tissue expression, function and synthesis.

Authors:
Roger Sandhoff

FEBS Lett 2010 May 24;584(9):1907-13. Epub 2009 Dec 24.

Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.febslet.2009.12.032DOI Listing
May 2010

Hepatic glycosphingolipid deficiency and liver function in mice.

Hepatology 2010 May;51(5):1799-809

Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hep.23545DOI Listing
May 2010

GD3-7-aldehyde is an apoptosis inducer and interacts with adenine nucleotide translocase.

Biochem Biophys Res Commun 2010 Jan 11;391(1):248-53. Epub 2009 Nov 11.

University of Versailles-SQY, PRES UniverSud Paris, CNRS UMR8159, 45 Avenue des Etats-Unis, 78035 Versailles, France.

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http://dx.doi.org/10.1016/j.bbrc.2009.11.044DOI Listing
January 2010

Disruption of blood-testis barrier dynamics in ether-lipid-deficient mice.

Cell Tissue Res 2009 Aug 4;337(2):281-99. Epub 2009 Jun 4.

Department of Anatomy and Medical Cell Biology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00441-009-0809-7DOI Listing
August 2009

Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.

Hum Mol Genet 2008 Aug 17;17(15):2257-64. Epub 2008 Apr 17.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1821, USA.

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http://dx.doi.org/10.1093/hmg/ddn126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2548282PMC
August 2008

Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.

J Biol Chem 2007 Nov 11;282(45):32655-64. Epub 2007 Sep 11.

Departments of Biochemistry and Pharmacology, University of Oxford, Mansfield Road, Oxford, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M702387200DOI Listing
November 2007

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

J Biol Chem 2007 Feb 4;282(5):3083-94. Epub 2006 Dec 4.

Department of Cellular und Molecular Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M610304200DOI Listing
February 2007

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice.

Int J Biol Sci 2007 Feb 6;3(2):120-8. Epub 2007 Feb 6.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796950PMC
http://dx.doi.org/10.7150/ijbs.3.120DOI Listing
February 2007

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.

Proc Natl Acad Sci U S A 2005 Aug 18;102(35):12459-64. Epub 2005 Aug 18.

Abteilungen Zelluläre und Molekulare Pathologie, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0500893102
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http://dx.doi.org/10.1073/pnas.0500893102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1194904PMC
August 2005

Novel class of glycosphingolipids involved in male fertility.

J Biol Chem 2005 Jul 25;280(29):27310-8. Epub 2005 May 25.

Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M502775200DOI Listing
July 2005

Chemokines bind to sulfatides as revealed by surface plasmon resonance.

Biochim Biophys Acta 2005 Feb;1687(1-3):52-63

German Cancer Research Center, Department of Cellular and Molecular Pathology, INF 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbalip.2004.11.011DOI Listing
February 2005

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.

Proc Natl Acad Sci U S A 2005 Feb 14;102(8):2725-30. Epub 2005 Feb 14.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0407785102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549464PMC
February 2005

Interaction of the GM2 activator protein with sulfated and sialylated glycosphingolipids.

Methods Enzymol 2003 ;363:207-22

Kekulé-Institute für Organische Chemie and Biochemie, Universitat Bonn, Gerhard Domagk Strasse 1, Bonn 53121, Germany.

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http://dx.doi.org/10.1016/S0076-6879(03)01053-XDOI Listing
December 2003

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

Proc Natl Acad Sci U S A 2003 Mar 10;100(6):3445-9. Epub 2003 Mar 10.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0635898100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152312PMC
March 2003

Kidney sulfatides in mouse models of inherited glycosphingolipid disorders: determination by nano-electrospray ionization tandem mass spectrometry.

J Biol Chem 2002 Jun 27;277(23):20386-98. Epub 2002 Mar 27.

Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Zelluläre und Molekulare Pathologie, INF 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M110641200DOI Listing
June 2002

Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage.

J Clin Invest 2002 May;109(9):1215-21

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI14530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150961PMC
May 2002

Physiological substrates for human lysosomal beta -hexosaminidase S.

J Biol Chem 2002 Jan 13;277(4):2562-72. Epub 2001 Nov 13.

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1074/jbc.M105457200DOI Listing
January 2002