Roger S McIntyre

Roger S McIntyre

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Roger S McIntyre

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Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Dec 25;95:109720. Epub 2019 Jul 25.

Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network (UHN), Toronto, ON, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2019.109720DOI Listing
December 2019

Antidepressants Reduced Risk of Mortality in Patients With Diabetes Mellitus: A Population-Based Cohort Study in Taiwan.

J Clin Endocrinol Metab 2019 Oct;104(10):4619-4625

Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

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http://dx.doi.org/10.1210/jc.2018-02362DOI Listing
October 2019

Cariprazine for the treatment of bipolar mania with mixed features: A post hoc pooled analysis of 3 trials.

J Affect Disord 2019 Oct 5;257:600-606. Epub 2019 Jul 5.

Allergan plc, Madison, NJ, United States.

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http://dx.doi.org/10.1016/j.jad.2019.07.020DOI Listing
October 2019

Effort-based decision-making is affected by overweight/obesity in major depressive disorder.

J Affect Disord 2019 Sep 4;256:221-227. Epub 2019 Jun 4.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada; Research Group in Molecular and Behavioral Neurosciences of Mood Disorders, Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, SP, 04038-000, Brazil; Brain and Cognition Discovery Foundation, Mississauga, ON L5C 4E, Canada.

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http://dx.doi.org/10.1016/j.jad.2019.06.002DOI Listing
September 2019

Are early increases in physical activity a behavioral marker for successful antidepressant treatment?

J Affect Disord 2019 Sep 3;260:287-291. Epub 2019 Sep 3.

School of Kinesiology, University of British Columbia, Room 337, Lower Mall Research Station, 2259 Lower Mall, Vancouver, BC Canada V6T 1Z4. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.09.002DOI Listing
September 2019

Changes in sleep predict changes in depressive symptoms in depressed subjects receiving vortioxetine: An open-label clinical trial.

J Psychopharmacol 2019 Sep 18:269881119874485. Epub 2019 Sep 18.

Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/0269881119874485DOI Listing
September 2019

Keeping up with the clinical advances: depression.

CNS Spectr 2019 Aug;24(S1):25-37

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1017/S1092852919001159DOI Listing
August 2019

Aberrant brain structural-functional connectivity coupling in euthymic bipolar disorder.

Hum Brain Mapp 2019 Aug 24;40(12):3452-3463. Epub 2019 Apr 24.

Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.

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http://dx.doi.org/10.1002/hbm.24608DOI Listing
August 2019

Brexpiprazole as an augmentation agent to antidepressants in treatment resistant major depressive disorder.

Expert Rev Neurother 2019 Aug 14:1-7. Epub 2019 Aug 14.

a Mood Disorders Psychopharmacology Unit, University Health Network , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/14737175.2019.1653759DOI Listing
August 2019

Parsing metabolic heterogeneity in mood disorders: A hypothesis-driven cluster analysis of glucose and insulin abnormalities.

Bipolar Disord 2019 Aug 29. Epub 2019 Aug 29.

Mood Disorders Psychopharmacology Unit, University Health Network.

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http://dx.doi.org/10.1111/bdi.12826DOI Listing
August 2019

Thirty-year cardiovascular risk score in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives.

Aust N Z J Psychiatry 2019 Jul 5;53(7):651-662. Epub 2018 Dec 5.

1 The Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1177/0004867418815987DOI Listing
July 2019

Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2019 07 20;93:182-188. Epub 2019 Mar 20.

Research Group in Molecular and Behavioral Neuroscience of Bipolar Disorder, Federal University of São Paulo, São Paulo, Brazil; Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network (UHN), Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183090
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http://dx.doi.org/10.1016/j.pnpbp.2019.03.010DOI Listing
July 2019

The neural systems of emotion regulation and abnormalities in major depressive disorder.

Behav Brain Res 2019 Jul 2;367:181-188. Epub 2019 Apr 2.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01664328193014
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http://dx.doi.org/10.1016/j.bbr.2019.04.002DOI Listing
July 2019

Stress, epigenetics and depression: A systematic review.

Neurosci Biobehav Rev 2019 Jul 18;102:139-152. Epub 2019 Apr 18.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01497634183095
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http://dx.doi.org/10.1016/j.neubiorev.2019.04.010DOI Listing
July 2019

Letter to the Editor: Clinical versus statistical significance of pharmacogenomic-guided antidepressant therapy: What's really being measured and marketed?

J Psychiatr Res 2019 Jul 5;114:208-209. Epub 2019 Apr 5.

University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.

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http://dx.doi.org/10.1016/j.jpsychires.2019.04.002DOI Listing
July 2019

Association between cognitive function and performance on effort based decision making in patients with major depressive disorder treated with Vortioxetine.

Compr Psychiatry 2019 Jul 24;94:152113. Epub 2019 Jul 24.

Mood Disorders Psychopharmacology Unit, University Health Network, Canada; Brain and Cognition Discovery Foundation, Canada; University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.comppsych.2019.07.006DOI Listing
July 2019

Evaluating the role of orexins in the pathophysiology and treatment of depression: A comprehensive review.

Prog Neuropsychopharmacol Biol Psychiatry 2019 06 18;92:1-7. Epub 2018 Dec 18.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Pharmacology, University of Toronto, Toronto, ON M5S 1A1, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, ON M5T 2S8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2018.12.008DOI Listing
June 2019

Pharmacological interventions targeting anhedonia in patients with major depressive disorder: A systematic review.

Prog Neuropsychopharmacol Biol Psychiatry 2019 06 3;92:109-117. Epub 2019 Jan 3.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, China; Brain and Cognition Discovery Foundation, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.002DOI Listing
June 2019

The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2019 06 6;92:387-404. Epub 2019 Feb 6.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.001DOI Listing
June 2019

Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study.

Am J Psychiatry 2019 Jun 8;176(6):439-448. Epub 2019 Mar 8.

Allergan, Madison, N.J. (Earley, Burgess, Rekeda, Dickinson); Gedeon Richter, Budapest, Hungary (Szatmári, Németh); the Mood Disorders Psychopharmacology Unit, University Health Network, Toronto (McIntyre); the Department of Psychiatry, Harvard Medical School, and the Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston (Sachs); and the Department of Psychiatry, University of British Columbia, Vancouver (Yatham).

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http://dx.doi.org/10.1176/appi.ajp.2018.18070824DOI Listing
June 2019

A clinical model for identifying an inflammatory phenotype in mood disorders.

J Psychiatr Res 2019 Jun 10;113:148-158. Epub 2019 Feb 10.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.005DOI Listing
June 2019

Early improvement in HAMD-17 and HAMD-7 scores predict response and remission in depressed patients treated with fluoxetine or electroconvulsive therapy.

J Affect Disord 2019 Jun 22;253:154-161. Epub 2019 Apr 22.

Department of Psychiatry, University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.04.082DOI Listing
June 2019

Metabolic profiling for water-soluble metabolites in patients with schizophrenia and healthy controls in a Chinese population: A case-control study.

World J Biol Psychiatry 2019 Jun 4:1-11. Epub 2019 Jun 4.

a Department of Laboratorial Science and Technology, School of Public Health , Peking University , Beijing , P. R. China.

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http://dx.doi.org/10.1080/15622975.2019.1615639DOI Listing
June 2019

The Current Research Landscape on the Artificial Intelligence Application in the Management of Depressive Disorders: A Bibliometric Analysis.

Int J Environ Res Public Health 2019 06 18;16(12). Epub 2019 Jun 18.

Center of Excellence in Evidence-based Medicine, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam.

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http://dx.doi.org/10.3390/ijerph16122150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617113PMC
June 2019

Indices of Change, Expectations, and Popularity of Biological Treatments for Major Depressive Disorder between 1988 and 2017: A Scientometric Analysis.

Int J Environ Res Public Health 2019 06 26;16(13). Epub 2019 Jun 26.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijerph16132255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651662PMC
June 2019

Characterizing, Assessing, and Treating Cognitive Dysfunction in Major Depressive Disorder.

Harv Rev Psychiatry 2018 Sep/Oct;26(5):241-249

From the Mood Disorders Psychopharmacology Unit, University Health Network, Canada; Institute of Medical Science (Drs. McIntyre and Rosenblat, Ms. Lee, and Mr. Pan), Department of Psychiatry (Drs. McIntyre, Rosenblat, and Mansur), and Department of Pharmacology (Dr. McIntyre), University of Toronto; Paik Institute for Clinical Research, Inje University (Republic of Korea) (Dr. J Lee); Department of Psychiatry, Samsung Seoul Hospital, Sungkyunkwan University, School of Medicine (Republic of Korea) (Dr. J-G Lee); Department of Psychiatry, College of Medicine, Imam University (Saudi Arabia) (Dr. Alageel).

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http://dx.doi.org/10.1097/HRP.0000000000000171DOI Listing
May 2019

New use for old drugs: The protective effect of atypical antipsychotics on hepatocellular carcinoma.

Int J Cancer 2019 05 24;144(10):2428-2439. Epub 2018 Dec 24.

Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.

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http://doi.wiley.com/10.1002/ijc.31980
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http://dx.doi.org/10.1002/ijc.31980DOI Listing
May 2019

Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression.

Exp Neurol 2019 May 26;315:1-8. Epub 2019 Jan 26.

Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144886183063
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http://dx.doi.org/10.1016/j.expneurol.2019.01.016DOI Listing
May 2019

Consumer Warning for Genetic Tests Claiming to Predict Response to Medications: Implications for Psychiatry.

Am J Psychiatry 2019 May;176(5):412-413

Mood Disorder Psychopharmacology Unit, University Health Network, Department of Psychiatry and Department of Pharmacology and Toxicology, University of Toronto, Toronto (Rosenblat, McIntyre); Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Goldberg).

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http://dx.doi.org/10.1176/appi.ajp.2019.18121359DOI Listing
May 2019

Depressive symptom severity mediates the association between sleep disturbance and obesity in US adults: Results from the NHANES.

Ann Clin Psychiatry 2019 May;31(2):111-122

Mood Disorders, Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. E-MAIL:

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May 2019

Differential Diagnosis of Major Depressive Disorder Versus Bipolar Disorder: Current Status and Best Clinical Practices.

J Clin Psychiatry 2019 May 14;80(3). Epub 2019 May 14.

Department of Psychiatry, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.4088/JCP.ot18043ah2DOI Listing
May 2019

Risk of Dementia Among Individuals With Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan.

J Clin Psychiatry 2019 05 14;80(3). Epub 2019 May 14.

Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, No 6, Sec. West, Jiapu Rd, Puzih-City, Chiayi County, Taiwan.

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http://dx.doi.org/10.4088/JCP.18m12462DOI Listing
May 2019

Neurococognitive and neuroimaging correlates of obesity and components of metabolic syndrome in bipolar disorder: a systematic review.

Psychol Med 2019 Apr 17;49(5):738-749. Epub 2018 Oct 17.

Department of Psychiatry,Dokuz Eylul University School of Medicine,Izmir,Turkey.

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http://dx.doi.org/10.1017/S0033291718003008DOI Listing
April 2019

Cariprazine for the treatment of bipolar depression: a review.

Expert Rev Neurother 2019 Apr 20;19(4):317-323. Epub 2019 Feb 20.

a Mood Disorders Psychopharmacology Unit , University Health Network , Toronto , Canada.

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http://dx.doi.org/10.1080/14737175.2019.1580571DOI Listing
April 2019

Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives.

Int J Bipolar Disord 2019 Apr 2;7(1). Epub 2019 Apr 2.

Copenhagen Affective Disorders Research Centre (CADIC), Psychiatric Center Copenhagen, Department O, 6243, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s40345-019-0142-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443746PMC
April 2019

Does obesity and diabetes mellitus metastasize to the brain? "Metaboptosis" and implications for drug discovery and development.

CNS Spectr 2019 Apr 3:1-3. Epub 2019 Apr 3.

Mood Disorders Psychopharmacology Unit (MDPU),University Health Network, University of Toronto,Toronto, ON,Canada.

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http://dx.doi.org/10.1017/S1092852918001670DOI Listing
April 2019

The effect of caloric restriction on working memory in healthy non-obese adults.

CNS Spectr 2019 Apr 10:1-7. Epub 2019 Apr 10.

Mood Disorders Psychopharmacology Unit (MDPU),University Health Network, University of Toronto,Toronto, Ontario,Canada.

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http://dx.doi.org/10.1017/S1092852918001566DOI Listing
April 2019

Oral Ketamine for Depression: A Systematic Review.

J Clin Psychiatry 2019 Apr 16;80(3). Epub 2019 Apr 16.

Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4088/JCP.18r12475DOI Listing
April 2019

Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis.

Int J Environ Res Public Health 2019 04 26;16(9). Epub 2019 Apr 26.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijerph16091479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539366PMC
April 2019

Activating and Sedating Properties of Medications Used for the Treatment of Major Depressive Disorder and Their Effect on Patient Functioning.

J Clin Psychiatry 2019 Apr 30;80(3). Epub 2019 Apr 30.

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4088/JCP.lu18052ah1DOI Listing
April 2019

Serum metabolic profiling using small molecular water-soluble metabolites in individuals with schizophrenia: A longitudinal study using a pre-post-treatment design.

Psychiatry Clin Neurosci 2019 Mar 8;73(3):100-108. Epub 2018 Oct 8.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.

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http://dx.doi.org/10.1111/pcn.12779DOI Listing
March 2019

Hypersomnia and Bipolar Disorder: A systematic review and meta-analysis of proportion.

J Affect Disord 2019 03 18;246:659-666. Epub 2018 Dec 18.

Department of Psychiatry, Federal University of São Paulo, SP, Brazil; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jad.2018.12.030DOI Listing
March 2019

The long-term effect of bariatric surgery on depression and anxiety.

J Affect Disord 2019 03 28;246:886-894. Epub 2018 Dec 28.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.12.113DOI Listing
March 2019

Getting to Remission: Differentiating Residual Symptoms From Treatment Side Effects in Major Depressive Disorder.

Authors:
Roger S McIntyre

J Clin Psychiatry 2019 Jan/Feb;80(1)

University of Toronto, Canada; Depression and Bipolar Support Alliance, Chicago, Illinois, USA; and Guangzhou Medical University, China.

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http://dx.doi.org/10.4088/JCP.TK18036BR1CJDOI Listing
March 2019

Peripheral interleukin-6 levels and working memory in non-obese adults: A post-hoc analysis from the CALERIE study.

Nutrition 2019 02 12;58:18-22. Epub 2018 Jul 12.

Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada; The University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nut.2018.06.010DOI Listing
February 2019

Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme.

J Affect Disord 2019 02 6;244:67-70. Epub 2018 Oct 6.

Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua 3 de maio 100, Ed. INFAR, 3rd floor, CEP 04044-020 São Paulo, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183023
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http://dx.doi.org/10.1016/j.jad.2018.10.001DOI Listing
February 2019

Cognition in psychiatry: population health, clinical, and research implications.

Authors:
Roger S McIntyre

CNS Spectr 2019 Feb 6;24(1):2-3. Epub 2018 Nov 6.

Brain and Cognition Discovery,Mood Disorders Psychopharmacology Unit,University Health Network,University of Toronto,Toronto,Ontario,Canada.

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http://dx.doi.org/10.1017/S1092852918001153DOI Listing
February 2019

Validation of the University of California San Diego Performance-based Skills Assessment (UPSA) in major depressive disorder: Replication and extension of initial findings.

J Affect Disord 2019 02 5;245:508-516. Epub 2018 Nov 5.

Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, 399 Bathurst Street, Toronto M5T 2S8, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.11.034DOI Listing
February 2019

Cognitive impairment in major depressive disorder.

CNS Spectr 2019 Feb 23;24(1):22-29. Epub 2018 Nov 23.

1Mood Disorders Psychopharmacology Unit (MDPU),Toronto Western Hospital,University Health Network,Toronto,Ontario,Canada.

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http://dx.doi.org/10.1017/S1092852918001207DOI Listing
February 2019

A pilot case-control study on the association between N-acetyl derivatives in serum and first-episode schizophrenia.

Psychiatry Res 2019 02 6;272:36-41. Epub 2018 Dec 6.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China; Peking University Medical and Health Analysis Center, Peking University, Beijing 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2018.11.064DOI Listing
February 2019

Rapastinel - an investigational NMDA-R modulator for major depressive disorder: evidence to date.

Expert Opin Investig Drugs 2019 Feb 26;28(2):113-119. Epub 2018 Dec 26.

a Mood Disorders Psychopharmacology Unit , University Health Network , Toronto , Canada.

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https://www.tandfonline.com/doi/full/10.1080/13543784.2019.1
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http://dx.doi.org/10.1080/13543784.2019.1559295DOI Listing
February 2019

28 How is Postpartum Depression Currently Diagnosed and Managed? Insights from a Virtual Patient Simulation.

CNS Spectr 2019 Feb;24(1):189-190

3Professor of Psychiatry and Pharmacology,University of Toronto;Head,Mood Disorders Psychopharmacology Unit,University Health Network;Program Clinical Director,Mental Health and Addictions,The Royal Victoria Regional Health Centre,Toronto,Canada.

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http://dx.doi.org/10.1017/S1092852919000221DOI Listing
February 2019

Parental characteristics and the risk of schizophrenia in a Chinese population: a case-control study.

Nord J Psychiatry 2019 Feb 22;73(2):90-95. Epub 2019 Mar 22.

a Department of Laboratorial Science and Technology, School of Public Health , Peking University , Beijing , China.

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http://dx.doi.org/10.1080/08039488.2018.1529196DOI Listing
February 2019

Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease.

Behav Brain Res 2019 01 9;356:271-278. Epub 2018 Aug 9.

Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2018.08.006DOI Listing
January 2019

Treatment effectiveness and tolerability outcomes that are most important to individuals with bipolar and unipolar depression.

J Affect Disord 2019 01 12;243:116-120. Epub 2018 Sep 12.

Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada; Depression and Bipolar Support Alliance (DBSA), Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.09.027DOI Listing
January 2019

Comparison of serum essential trace metals between patients with schizophrenia and healthy controls.

J Trace Elem Med Biol 2019 Jan 5;51:79-85. Epub 2018 Oct 5.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, 100191, PR China; Vaccine Research Center, School of Public Health, Peking University, Beijing, 100191, PR China; Peking University Medical and Health Analysis Center, Peking University, Beijing, 100191, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jtemb.2018.10.009DOI Listing
January 2019

Characterizing acyl-carnitine biosignatures for schizophrenia: a longitudinal pre- and post-treatment study.

Transl Psychiatry 2019 01 17;9(1):19. Epub 2019 Jan 17.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, 100191, P. R. China.

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http://dx.doi.org/10.1038/s41398-018-0353-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336814PMC
January 2019

The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder.

Front Psychiatry 2019 31;10:17. Epub 2019 Jan 31.

Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00017
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http://dx.doi.org/10.3389/fpsyt.2019.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365446PMC
January 2019

The effect of pharmacogenomic testing on response and remission rates in the acute treatment of major depressive disorder: A meta-analysis.

J Affect Disord 2018 12 14;241:484-491. Epub 2018 Aug 14.

Head, Mood Disorder Psychopharmacology Unit, University Health Network, Professor of Psychiatry and Pharmacology, University of Toronto, 399 Bathurst Street, MP 9-325, Toronto, Ontario M5T 2S8, Canada,. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.08.056DOI Listing
December 2018

Applications of machine learning algorithms to predict therapeutic outcomes in depression: A meta-analysis and systematic review.

J Affect Disord 2018 12 14;241:519-532. Epub 2018 Aug 14.

Institute of Medical Science, University of Toronto, Toronto, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology, University of Toronto, Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183048
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http://dx.doi.org/10.1016/j.jad.2018.08.073DOI Listing
December 2018

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats.

Pharmacol Rep 2018 Dec 21;70(6):1173-1179. Epub 2018 Jul 21.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.pharep.2018.07.003DOI Listing
December 2018

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes.

J Psychiatr Res 2018 12 27;107:128-135. Epub 2018 Oct 27.

Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Canada; University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jpsychires.2018.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278951PMC
December 2018

Letter to the editor: Inadequate evidence to support improved patient outcomes with combinatorial pharmacogenomics.

J Psychiatr Res 2018 12 29;107:136-137. Epub 2018 Oct 29.

Mood Disorder Psychopharmacology Unit, University Health Network, Professor of Psychiatry and Pharmacology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183099
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http://dx.doi.org/10.1016/j.jpsychires.2018.10.017DOI Listing
December 2018

Is obesity changing the phenotype of bipolar disorder from predominately euphoric toward mixed presentations?

Authors:
Roger S McIntyre

Bipolar Disord 2018 12 28;20(8):685-686. Epub 2018 Nov 28.

University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1111/bdi.12717
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December 2018

Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression.

Ther Adv Psychopharmacol 2018 Dec 19;8(12):337-348. Epub 2018 Nov 19.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Brain and Cognition Discovery Foundation, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/2045125318791944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278744PMC
December 2018

Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: post hoc analyses of three placebo-controlled studies.

Neuropsychiatr Dis Treat 2019 20;15:37-45. Epub 2018 Dec 20.

Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada.

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https://www.dovepress.com/adjunctive-brexpiprazole-in-patien
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http://dx.doi.org/10.2147/NDT.S185815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305164PMC
December 2018

Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments.

Neurosci Biobehav Rev 2018 11 31;94:11-16. Epub 2018 Jul 31.

Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, Canada.

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http://dx.doi.org/10.1016/j.neubiorev.2018.07.020DOI Listing
November 2018

Effects of olanzapine and haloperidol on mTORC1 signaling, dendritic outgrowth, and synaptic proteins in rat primary hippocampal neurons under toxic conditions.

Neurosci Lett 2018 11 24;686:59-66. Epub 2018 Aug 24.

Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea; Department of Health Science and Technology, Graduate School, Inje University, Busan, Republic of Korea; Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2018.08.031DOI Listing
November 2018

Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis.

Neurosci Lett 2018 11 29;686:10-16. Epub 2018 Aug 29.

Department of Occupational and Environmental Health Sciences, Peking University, Beijing, 100191, China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2018.08.038DOI Listing
November 2018

Frequency of use and perceived helpfulness of wellness strategies for bipolar and unipolar depression.

Ann Clin Psychiatry 2018 11;30(4):296-304

Mood Disorders Psychopharmacology Unit, University Health Network,Toronto, ON M5T 2S8 Canada;E-mail:

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November 2018

Factors That Impact Treatment Decisions: Results From an Online Survey of Individuals With Bipolar and Unipolar Depression.

Prim Care Companion CNS Disord 2018 Nov 1;20(6). Epub 2018 Nov 1.

Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, 399 Bathurst St, MP 9-325, Toronto, ON M5T 2S8, Canada.

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http://www.psychiatrist.com/PCC/article/Pages/2018/v20n06/18
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http://dx.doi.org/10.4088/PCC.18m02340DOI Listing
November 2018

Brain structural networks and connectomes: the brain-obesity interface and its impact on mental health.

Neuropsychiatr Dis Treat 2018 26;14:3199-3208. Epub 2018 Nov 26.

Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan,

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http://dx.doi.org/10.2147/NDT.S180569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263220PMC
November 2018

Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus.

Life Sci 2018 Oct 4;210:177-184. Epub 2018 Sep 4.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183053
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http://dx.doi.org/10.1016/j.lfs.2018.09.003DOI Listing
October 2018

Coronary calcium score as an expression of multisystemic progression of bipolar disorder.

Braz J Psychiatry 2018 Oct-Dec;40(4):459-460

Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network (UHN), Toronto, ON, Canada.

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http://dx.doi.org/10.1590/1516-4446-2018-0125DOI Listing
September 2018

Prevalence of Depression among Migrants: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2018 09 12;15(9). Epub 2018 Sep 12.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijerph15091986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163821PMC
September 2018

Factors Associated with the Risk of Developing Coronary Artery Disease in Medicated Patients with Major Depressive Disorder.

Int J Environ Res Public Health 2018 09 21;15(10). Epub 2018 Sep 21.

Department of Psychological Medicine, National University Health System, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijerph15102073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210477PMC
September 2018

Association Between Sleep Duration, Quality and Body Mass Index in the Korean Population.

J Clin Sleep Med 2018 08 15;14(8):1353-1360. Epub 2018 Aug 15.

Korea University Research and Business Foundation, Seoul, Korea.

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http://dx.doi.org/10.5664/jcsm.7272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086945PMC
August 2018

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis.

Sci Rep 2018 Aug 13;8(1):12050. Epub 2018 Aug 13.

Department of Internal Medicine, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-018-30487-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089986PMC
August 2018

The Effect of Methylphenidate and Atomoxetine on Heart Rate and Systolic Blood Pressure in Young People and Adults with Attention-Deficit Hyperactivity Disorder (ADHD): Systematic Review, Meta-Analysis, and Meta-Regression.

Int J Environ Res Public Health 2018 08 20;15(8). Epub 2018 Aug 20.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

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http://dx.doi.org/10.3390/ijerph15081789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121294PMC
August 2018

Arabic Translation, Validation and Cultural Adaptation of the 7-Item Hamilton Depression Rating Scale in Two Community Samples.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e167-e172. Epub 2018 Sep 9.

Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18295/squmj.2018.18.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132530PMC
May 2018