Roger R Reddel

Roger R Reddel

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Roger R Reddel

Publications by authors named "Roger R Reddel"

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Addressing the challenges of high-throughput cancer tissue proteomics for clinical application: ProCan.

Proteomics 2019 Jul 18:e1900109. Epub 2019 Jul 18.

ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.

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http://dx.doi.org/10.1002/pmic.201900109DOI Listing
July 2019

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT).

Nat Commun 2019 05 28;10(1):2252. Epub 2019 May 28.

Telomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, 2145, NSW, Australia.

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http://dx.doi.org/10.1038/s41467-019-10180-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538672PMC
May 2019

Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency.

J Cell Sci 2019 Mar 14;132(5). Epub 2019 Mar 14.

Cancer Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, Australia

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http://dx.doi.org/10.1242/jcs.222349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432714PMC
March 2019

BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.

EMBO J 2017 10 6;36(19):2907-2919. Epub 2017 Sep 6.

Telomere Length Regulation Unit, Children's Medical Research Institute, University of Sydney, Westmead, NSW, Australia

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http://dx.doi.org/10.15252/embj.201796889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623873PMC
October 2017

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 10 27;550(7677):548. Epub 2017 Sep 27.

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http://dx.doi.org/10.1038/nature24026DOI Listing
October 2017

Functional dissection of breast cancer risk-associated promoter variants.

Oncotarget 2017 Sep 26;8(40):67203-67217. Epub 2017 May 26.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

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http://dx.doi.org/10.18632/oncotarget.18226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620167PMC
September 2017

MatCol: a tool to measure fluorescence signal colocalisation in biological systems.

Sci Rep 2017 08 21;7(1):8879. Epub 2017 Aug 21.

Bioinformatics Unit, Children's Medical Research Institute, The University of Sydney, Westmead, NSW, Australia.

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http://dx.doi.org/10.1038/s41598-017-08786-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566543PMC
August 2017

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres.

Cell Rep 2017 06;19(12):2544-2556

Cancer Research Unit, Children's Medical Research Institute, University of Sydney, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.087DOI Listing
June 2017

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences.

Cell Death Dis 2017 04 20;8(4):e2755. Epub 2017 Apr 20.

DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305 8565, Japan.

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http://dx.doi.org/10.1038/cddis.2017.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477593PMC
April 2017

Whole-genome landscape of pancreatic neuroendocrine tumours.

Authors:
Aldo Scarpa David K Chang Katia Nones Vincenzo Corbo Ann-Marie Patch Peter Bailey Rita T Lawlor Amber L Johns David K Miller Andrea Mafficini Borislav Rusev Maria Scardoni Davide Antonello Stefano Barbi Katarzyna O Sikora Sara Cingarlini Caterina Vicentini Skye McKay Michael C J Quinn Timothy J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne McLean Craig Nourse Ehsan Nourbakhsh Peter J Wilson Matthew J Anderson J Lynn Fink Felicity Newell Nick Waddell Oliver Holmes Stephen H Kazakoff Conrad Leonard Scott Wood Qinying Xu Shivashankar Hiriyur Nagaraj Eliana Amato Irene Dalai Samantha Bersani Ivana Cataldo Angelo P Dei Tos Paola Capelli Maria Vittoria Davì Luca Landoni Anna Malpaga Marco Miotto Vicki L J Whitehall Barbara A Leggett Janelle L Harris Jonathan Harris Marc D Jones Jeremy Humphris Lorraine A Chantrill Venessa Chin Adnan M Nagrial Marina Pajic Christopher J Scarlett Andreia Pinho Ilse Rooman Christopher Toon Jianmin Wu Mark Pinese Mark Cowley Andrew Barbour Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Jessica A Lovell Nigel B Jamieson Fraser Duthie Marie-Claude Gingras William E Fisher Rebecca A Dagg Loretta M S Lau Michael Lee Hilda A Pickett Roger R Reddel Jaswinder S Samra James G Kench Neil D Merrett Krishna Epari Nam Q Nguyen Nikolajs Zeps Massimo Falconi Michele Simbolo Giovanni Butturini George Van Buren Stefano Partelli Matteo Fassan Kum Kum Khanna Anthony J Gill David A Wheeler Richard A Gibbs Elizabeth A Musgrove Claudio Bassi Giampaolo Tortora Paolo Pederzoli John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2017 03 15;543(7643):65-71. Epub 2017 Feb 15.

University of Melbourne Centre for Cancer Research, University of Melbourne, Melbourne, 3010, Victoria, Australia.

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http://dx.doi.org/10.1038/nature21063DOI Listing
March 2017

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency.

Mol Ther Nucleic Acids 2017 Mar 10;6:1-14. Epub 2016 Dec 10.

Gene Therapy Research Unit, Children's Medical Research Institute, The University of Sydney and The Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2016.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363493PMC
March 2017

Comparative analysis of whole genome sequencing-based telomere length measurement techniques.

Methods 2017 02 24;114:4-15. Epub 2016 Aug 24.

Telomere Length Regulation Group, Children's Medical Research Institute, The University of Sydney, Westmead, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.08.008DOI Listing
February 2017

The C-Circle Assay for alternative-lengthening-of-telomeres activity.

Methods 2017 02 3;114:74-84. Epub 2016 Sep 3.

Cancer Research Unit, Children's Medical Research Institute, University of Sydney, Westmead, NSW, Australia.

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http://dx.doi.org/10.1016/j.ymeth.2016.08.016DOI Listing
February 2017

DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta.

Mol Hum Reprod 2016 11 7;22(11):791-799. Epub 2016 Sep 7.

Murdoch Childrens Research Institute-Cancer and Disease Epigenetics, Royal Children's Hospital Flemington Road, Parkville, Melbourne, Victoria 3052, Australia

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http://dx.doi.org/10.1093/molehr/gaw053DOI Listing
November 2016

Is cell culture a risky business? Risk analysis based on scientist survey data.

Int J Cancer 2016 Feb 14;138(3):664-70. Epub 2015 Sep 14.

CellBank Australia, Children's Medical Research Institute, University of Sydney, Westmead, NSW, Australia.

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http://dx.doi.org/10.1002/ijc.29817DOI Listing
February 2016

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.

Nat Struct Mol Biol 2015 Nov 4;22(11):875-80. Epub 2015 Nov 4.

Cancer Research Unit, Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/nsmb.3106DOI Listing
November 2015

Telomere maintenance mechanisms in cancer: clinical implications.

Authors:
Roger R Reddel

Curr Pharm Des 2014 ;20(41):6361-74

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262939PMC
http://dx.doi.org/10.2174/1381612820666140630101047DOI Listing
June 2015

ATRX represses alternative lengthening of telomeres.

Oncotarget 2015 Jun;6(18):16543-58

Cancer Research Unit, Children's Medical Research Institute, The University of Sydney, Westmead, NSW, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599288PMC
http://dx.doi.org/10.18632/oncotarget.3846DOI Listing
June 2015

Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.

Clin Epigenetics 2015 1;7:52. Epub 2015 May 1.

Epigenetic Research Laboratory, Genomics and Epigenetic Division, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010 Australia ; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Level 5 deLacy Building, St Vincent's Hospital, Victoria Street, Darlinghurst, NSW 2010 Australia.

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http://dx.doi.org/10.1186/s13148-015-0086-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424562PMC
May 2015

STC1 expression is associated with tumor growth and metastasis in breast cancer.

Clin Exp Metastasis 2015 Jan 13;32(1):15-27. Epub 2014 Nov 13.

Cancer Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia.

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http://dx.doi.org/10.1007/s10585-014-9687-9DOI Listing
January 2015

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

Nat Struct Mol Biol 2014 Sep 24;21(9):760-70. Epub 2014 Aug 24.

1] Telomere Length Regulation Group, Children's Medical Research Institute, Westmead, New South Wales, Australia. [2] Sydney Medical School, University of Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/nsmb.2877DOI Listing
September 2014

Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein.

Exp Cell Res 2014 Apr 28;322(2):324-34. Epub 2014 Jan 28.

Cell Proliferation Research Group and DBT-AIST International Laboratory for Advanced Biomedicine, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144827140004
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http://dx.doi.org/10.1016/j.yexcr.2014.01.022DOI Listing
April 2014

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.

Nucleic Acids Res 2014 Feb 12;42(3):1733-46. Epub 2013 Nov 12.

Telomere Length Regulation Group, Children's Medical Research Institute, Westmead NSW 2145, Australia, Cancer Research Unit, Children's Medical Research Institute, Westmead NSW 2145, Australia, Terry Fox Laboratory, BC Cancer Agency, Vancouver V5Z 1L3, Canada, Sydney Medical School, University of Sydney, Sydney NSW 2006, Australia and Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead NSW 2145, Australia.

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http://dx.doi.org/10.1093/nar/gkt1117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919612PMC
February 2014

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Authors:
Stig E Bojesen Karen A Pooley Sharon E Johnatty Jonathan Beesley Kyriaki Michailidou Jonathan P Tyrer Stacey L Edwards Hilda A Pickett Howard C Shen Chanel E Smart Kristine M Hillman Phuong L Mai Kate Lawrenson Michael D Stutz Yi Lu Rod Karevan Nicholas Woods Rebecca L Johnston Juliet D French Xiaoqing Chen Maren Weischer Sune F Nielsen Melanie J Maranian Maya Ghoussaini Shahana Ahmed Caroline Baynes Manjeet K Bolla Qin Wang Joe Dennis Lesley McGuffog Daniel Barrowdale Andrew Lee Sue Healey Michael Lush Daniel C Tessier Daniel Vincent Françis Bacot Ignace Vergote Sandrina Lambrechts Evelyn Despierre Harvey A Risch Anna González-Neira Mary Anne Rossing Guillermo Pita Jennifer A Doherty Nuria Alvarez Melissa C Larson Brooke L Fridley Nils Schoof Jenny Chang-Claude Mine S Cicek Julian Peto Kimberly R Kalli Annegien Broeks Sebastian M Armasu Marjanka K Schmidt Linde M Braaf Boris Winterhoff Heli Nevanlinna Gottfried E Konecny Diether Lambrechts Lisa Rogmann Pascal Guénel Attila Teoman Roger L Milne Joaquin J Garcia Angela Cox Vijayalakshmi Shridhar Barbara Burwinkel Frederik Marme Rebecca Hein Elinor J Sawyer Christopher A Haiman Shan Wang-Gohrke Irene L Andrulis Kirsten B Moysich John L Hopper Kunle Odunsi Annika Lindblom Graham G Giles Hermann Brenner Jacques Simard Galina Lurie Peter A Fasching Michael E Carney Paolo Radice Lynne R Wilkens Anthony Swerdlow Marc T Goodman Hiltrud Brauch Montserrat Garcia-Closas Peter Hillemanns Robert Winqvist Matthias Dürst Peter Devilee Ingo Runnebaum Anna Jakubowska Jan Lubinski Arto Mannermaa Ralf Butzow Natalia V Bogdanova Thilo Dörk Liisa M Pelttari Wei Zheng Arto Leminen Hoda Anton-Culver Clareann H Bunker Vessela Kristensen Roberta B Ness Kenneth Muir Robert Edwards Alfons Meindl Florian Heitz Keitaro Matsuo Andreas du Bois Anna H Wu Philipp Harter Soo-Hwang Teo Ira Schwaab Xiao-Ou Shu William Blot Satoyo Hosono Daehee Kang Toru Nakanishi Mikael Hartman Yasushi Yatabe Ute Hamann Beth Y Karlan Suleeporn Sangrajrang Susanne Krüger Kjaer Valerie Gaborieau Allan Jensen Diana Eccles Estrid Høgdall Chen-Yang Shen Judith Brown Yin Ling Woo Mitul Shah Mat Adenan Noor Azmi Robert Luben Siti Zawiah Omar Kamila Czene Robert A Vierkant Børge G Nordestgaard Henrik Flyger Celine Vachon Janet E Olson Xianshu Wang Douglas A Levine Anja Rudolph Rachel Palmieri Weber Dieter Flesch-Janys Edwin Iversen Stefan Nickels Joellen M Schildkraut Isabel Dos Santos Silva Daniel W Cramer Lorna Gibson Kathryn L Terry Olivia Fletcher Allison F Vitonis C Ellen van der Schoot Elizabeth M Poole Frans B L Hogervorst Shelley S Tworoger Jianjun Liu Elisa V Bandera Jingmei Li Sara H Olson Keith Humphreys Irene Orlow Carl Blomqvist Lorna Rodriguez-Rodriguez Kristiina Aittomäki Helga B Salvesen Taru A Muranen Elisabeth Wik Barbara Brouwers Camilla Krakstad Els Wauters Mari K Halle Hans Wildiers Lambertus A Kiemeney Claire Mulot Katja K Aben Pierre Laurent-Puig Anne Mvan Altena Thérèse Truong Leon F A G Massuger Javier Benitez Tanja Pejovic Jose Ignacio Arias Perez Maureen Hoatlin M Pilar Zamora Linda S Cook Sabapathy P Balasubramanian Linda E Kelemen Andreas Schneeweiss Nhu D Le Christof Sohn Angela Brooks-Wilson Ian Tomlinson Michael J Kerin Nicola Miller Cezary Cybulski Brian E Henderson Janusz Menkiszak Fredrick Schumacher Nicolas Wentzensen Loic Le Marchand Hannah P Yang Anna Marie Mulligan Gord Glendon Svend Aage Engelholm Julia A Knight Claus K Høgdall Carmel Apicella Martin Gore Helen Tsimiklis Honglin Song Melissa C Southey Agnes Jager Ans M Wvan den Ouweland Robert Brown John W M Martens James M Flanagan Mieke Kriege James Paul Sara Margolin Nadeem Siddiqui Gianluca Severi Alice S Whittemore Laura Baglietto Valerie McGuire Christa Stegmaier Weiva Sieh Heiko Müller Volker Arndt France Labrèche Yu-Tang Gao Mark S Goldberg Gong Yang Martine Dumont John R McLaughlin Arndt Hartmann Arif B Ekici Matthias W Beckmann Catherine M Phelan Michael P Lux Jenny Permuth-Wey Bernard Peissel Thomas A Sellers Filomena Ficarazzi Monica Barile Argyrios Ziogas Alan Ashworth Aleksandra Gentry-Maharaj Michael Jones Susan J Ramus Nick Orr Usha Menon Celeste L Pearce Thomas Brüning Malcolm C Pike Yon-Dschun Ko Jolanta Lissowska Jonine Figueroa Jolanta Kupryjanczyk Stephen J Chanock Agnieszka Dansonka-Mieszkowska Arja Jukkola-Vuorinen Iwona K Rzepecka Katri Pylkäs Mariusz Bidzinski Saila Kauppila Antoinette Hollestelle Caroline Seynaeve Rob A E M Tollenaar Katarzyna Durda Katarzyna Jaworska Jaana M Hartikainen Veli-Matti Kosma Vesa Kataja Natalia N Antonenkova Jirong Long Martha Shrubsole Sandra Deming-Halverson Artitaya Lophatananon Pornthep Siriwanarangsan Sarah Stewart-Brown Nina Ditsch Peter Lichtner Rita K Schmutzler Hidemi Ito Hiroji Iwata Kazuo Tajima Chiu-Chen Tseng Daniel O Stram David van den Berg Cheng Har Yip M Kamran Ikram Yew-Ching Teh Hui Cai Wei Lu Lisa B Signorello Qiuyin Cai Dong-Young Noh Keun-Young Yoo Hui Miao Philip Tsau-Choong Iau Yik Ying Teo James McKay Charles Shapiro Foluso Ademuyiwa George Fountzilas Chia-Ni Hsiung Jyh-Cherng Yu Ming-Feng Hou Catherine S Healey Craig Luccarini Susan Peock Dominique Stoppa-Lyonnet Paolo Peterlongo Timothy R Rebbeck Marion Piedmonte Christian F Singer Eitan Friedman Mads Thomassen Kenneth Offit Thomas V O Hansen Susan L Neuhausen Csilla I Szabo Ignacio Blanco Judy Garber Steven A Narod Jeffrey N Weitzel Marco Montagna Edith Olah Andrew K Godwin Drakoulis Yannoukakos David E Goldgar Trinidad Caldes Evgeny N Imyanitov Laima Tihomirova Banu K Arun Ian Campbell Arjen R Mensenkamp Christi J van Asperen Kees E P van Roozendaal Hanne Meijers-Heijboer J Margriet Collée Jan C Oosterwijk Maartje J Hooning Matti A Rookus Rob B van der Luijt Theo A Mvan Os D Gareth Evans Debra Frost Elena Fineberg Julian Barwell Lisa Walker M John Kennedy Radka Platte Rosemarie Davidson Steve D Ellis Trevor Cole Brigitte Bressac-de Paillerets Bruno Buecher Francesca Damiola Laurence Faivre Marc Frenay Olga M Sinilnikova Olivier Caron Sophie Giraud Sylvie Mazoyer Valérie Bonadona Virginie Caux-Moncoutier Aleksandra Toloczko-Grabarek Jacek Gronwald Tomasz Byrski Amanda B Spurdle Bernardo Bonanni Daniela Zaffaroni Giuseppe Giannini Loris Bernard Riccardo Dolcetti Siranoush Manoukian Norbert Arnold Christoph Engel Helmut Deissler Kerstin Rhiem Dieter Niederacher Hansjoerg Plendl Christian Sutter Barbara Wappenschmidt Ake Borg Beatrice Melin Johanna Rantala Maria Soller Katherine L Nathanson Susan M Domchek Gustavo C Rodriguez Ritu Salani Daphne Gschwantler Kaulich Muy-Kheng Tea Shani Shimon Paluch Yael Laitman Anne-Bine Skytte Torben A Kruse Uffe Birk Jensen Mark Robson Anne-Marie Gerdes Bent Ejlertsen Lenka Foretova Sharon A Savage Jenny Lester Penny Soucy Karoline B Kuchenbaecker Curtis Olswold Julie M Cunningham Susan Slager Vernon S Pankratz Ed Dicks Sunil R Lakhani Fergus J Couch Per Hall Alvaro N A Monteiro Simon A Gayther Paul D P Pharoah Roger R Reddel Ellen L Goode Mark H Greene Douglas F Easton Andrew Berchuck Antonis C Antoniou Georgia Chenevix-Trench Alison M Dunning

Nat Genet 2013 Apr;45(4):371-84, 384e1-2

Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ng.2566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670748PMC
April 2013

Alternative lengthening of telomeres: remodeling the telomere architecture.

Front Oncol 2013 20;3:27. Epub 2013 Feb 20.

Cancer Research Unit, Children's Medical Research Institute Westmead, NSW, Australia ; Sydney Medical School, University of Sydney NSW, Australia.

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http://dx.doi.org/10.3389/fonc.2013.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576624PMC
February 2013

Detection of alternative lengthening of telomeres by telomere quantitative PCR.

Nucleic Acids Res 2013 Jan 25;41(2):e34. Epub 2012 Aug 25.

Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.

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http://dx.doi.org/10.1093/nar/gks781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553966PMC
January 2013

Alternative lengthening of telomeres in normal mammalian somatic cells.

Genes Dev 2013 Jan;27(1):18-23

Cancer Research Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1101/gad.205062.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553280PMC
January 2013

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

J Cell Biol 2012 Dec;199(6):893-906

Cancer Research Unit, Children's Medical Research Institute, Westmead NSW 2145, Australia.

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http://dx.doi.org/10.1083/jcb.201207189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518223PMC
December 2012

Enhanced isolation of fibroblasts from human skin explants.

Biotechniques 2012 Oct;53(4):239-44

Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.2144/0000113939DOI Listing
October 2012

Cancer. Cancer and telomeres--an ALTernative to telomerase.

Science 2012 Jun;336(6087):1388-90

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.1222394DOI Listing
June 2012

The role of telomere trimming in normal telomere length dynamics.

Cell Cycle 2012 Apr 1;11(7):1309-15. Epub 2012 Apr 1.

Children's Medical Research Institute and Sydney Medical School, University of Sydney, New South Wales, Australia.

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http://dx.doi.org/10.4161/cc.19632DOI Listing
April 2012

Normal mammalian cells negatively regulate telomere length by telomere trimming.

Hum Mol Genet 2011 Dec 8;20(23):4684-92. Epub 2011 Sep 8.

Children’s Medical Research Institute, Westmead, NSW 2145, Australia.

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http://dx.doi.org/10.1093/hmg/ddr402DOI Listing
December 2011

Five dysfunctional telomeres predict onset of senescence in human cells.

EMBO Rep 2011 Dec 23;13(1):52-9. Epub 2011 Dec 23.

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.227
Publisher Site
http://dx.doi.org/10.1038/embor.2011.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246253PMC
December 2011

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region.

Nucleic Acids Res 2011 Oct 30;39(18):8078-91. Epub 2011 Jun 30.

National Institute of Advanced Industrial Science & Technology, Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki - 305 8562, Japan.

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http://dx.doi.org/10.1093/nar/gkr492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185413PMC
October 2011

Telomerase activity in pleural malignant mesotheliomas.

Lung Cancer 2011 Sep 31;73(3):283-8. Epub 2011 Jan 31.

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1016/j.lungcan.2010.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135747PMC
September 2011

HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.

PLoS One 2011 Feb 15;6(2):e17036. Epub 2011 Feb 15.

Cancer Research Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017036PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039646PMC
February 2011

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.

FEBS Lett 2010 Sep 11;584(17):3800-11. Epub 2010 Jun 11.

Children's Medical Research Institute, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.febslet.2010.06.009DOI Listing
September 2010

Alternative lengthening of telomeres: models, mechanisms and implications.

Nat Rev Genet 2010 May 30;11(5):319-30. Epub 2010 Mar 30.

Cancer Research Unit, Childrens Medical Research Institute, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/nrg2763DOI Listing
May 2010

Senescence: an antiviral defense that is tumor suppressive?

Authors:
Roger R Reddel

Carcinogenesis 2010 Jan 3;31(1):19-26. Epub 2009 Nov 3.

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1093/carcin/bgp274DOI Listing
January 2010

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.

Nat Biotechnol 2009 Dec;27(12):1181-5

Children's Medical Research Institute, University of Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/nbt.1587DOI Listing
December 2009

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

Nat Struct Mol Biol 2009 Dec 22;16(12):1244-51. Epub 2009 Nov 22.

Cancer Research Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/nsmb.1725DOI Listing
December 2009

Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning.

Hum Mol Genet 2009 Aug 28;18(16):3098-109. Epub 2009 May 28.

Cancer Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1093/hmg/ddp251DOI Listing
August 2009

Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1).

J Cell Sci 2009 Aug 28;122(Pt 16):2989-95. Epub 2009 Jul 28.

Children's Medical Research Institute, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1242/jcs.044107DOI Listing
August 2009

Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.

J Cell Biol 2009 Jun 25;185(5):797-810. Epub 2009 May 25.

Cancer Research Unit, Children's Medical Research Institute, Westmead 2145, New South Wales, Australia.

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http://dx.doi.org/10.1083/jcb.200810084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711592PMC
June 2009

Control of telomere length by a trimming mechanism that involves generation of t-circles.

EMBO J 2009 Apr 12;28(7):799-809. Epub 2009 Feb 12.

Cancer Research Group, Children's Medical Research Institute, Westmead, NSW, Australia.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.42
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http://dx.doi.org/10.1038/emboj.2009.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670870PMC
April 2009

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres.

Hum Mol Genet 2009 Mar 18;18(6):1017-27. Epub 2008 Dec 18.

Cancer Research Unit, Children's Medical Research Institute, Sydney, NSW 2145, Australia.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddn436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649016PMC
March 2009

Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma.

Clin Cancer Res 2008 Jul;14(13):4134-40

Department of Experimental Oncology and Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0099DOI Listing
July 2008

PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma.

Cancer Res 2008 Jul;68(14):5724-32

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-0058DOI Listing
July 2008

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells.

Cancer Sci 2008 Jun;99(6):1092-9

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145 Australia, and University of Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00815.xDOI Listing
June 2008

The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.

Endocrinology 2008 May 7;149(5):2403-10. Epub 2008 Feb 7.

Cancer Research Unit, The Children's Hospital, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1210/en.2007-1219DOI Listing
May 2008

Telomere uncapping and alternative lengthening of telomeres.

Mech Ageing Dev 2008 Jan-Feb;129(1-2):99-108. Epub 2007 Dec 8.

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1016/j.mad.2007.11.006DOI Listing
April 2008

A sensitive direct human telomerase activity assay.

Nat Methods 2008 Apr;5(4):355-60

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia.

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http://www.nature.com/articles/nmeth.f.209
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http://dx.doi.org/10.1038/nmeth.f.209DOI Listing
April 2008

Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.

J Biol Chem 2007 Oct 9;282(40):29314-22. Epub 2007 Aug 9.

Cancer Research Unit, Children's Medical Research Institute, Westmead 2145, Sydney 2006, New South Wales, Australia.

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http://dx.doi.org/10.1074/jbc.M701413200DOI Listing
October 2007

DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA.

Cancer Res 2007 Aug 24;67(15):7072-7. Epub 2007 Jul 24.

Children's Medical Research Institute, Westmead, and University of Sydney, New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1556DOI Listing
August 2007

A SUMO ligase for ALT.

Authors:
Roger R Reddel

Nat Struct Mol Biol 2007 Jul;14(7):570-1

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http://dx.doi.org/10.1038/nsmb0707-570DOI Listing
July 2007

Protein composition of catalytically active human telomerase from immortal cells.

Science 2007 Mar;315(5820):1850-3

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead NSW 2145, Australia.

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http://dx.doi.org/10.1126/science.1138596DOI Listing
March 2007

Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.

Int J Cancer 2006 Jun;118(12):2973-80

Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1002/ijc.21773DOI Listing
June 2006

The murine stanniocalcin 1 gene is not essential for growth and development.

Mol Cell Biol 2005 Dec;25(23):10604-10

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.23.10604-10610.200
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http://dx.doi.org/10.1128/MCB.25.23.10604-10610.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291238PMC
December 2005

The first molecular details of ALT in human tumor cells.

Hum Mol Genet 2005 Oct;14 Spec No. 2:R191-6

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales 2145, Australia.

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http://hmg.oxfordjournals.org/content/14/suppl_2/R191.full.p
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddi266
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http://dx.doi.org/10.1093/hmg/ddi266DOI Listing
October 2005

Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

Hum Mol Genet 2005 Jul 11;14(13):1785-94. Epub 2005 May 11.

Department of Genetics, University of Leicester, UK.

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http://dx.doi.org/10.1093/hmg/ddi185DOI Listing
July 2005

Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies.

Cancer Res 2005 Apr;65(7):2722-9

Children's Medical Research Institute, Westmead, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2881DOI Listing
April 2005

hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere.

Nucleic Acids Res 2005 19;33(2):486-96. Epub 2005 Jan 19.

Department of Biochemistry and Molecular Biology, The University of Queensland QLD 4072, Australia.

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http://dx.doi.org/10.1093/nar/gki203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548348PMC
February 2005

Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.

Oncogene 2004 Apr;23(17):3116-21

Children's Medical Research Institute, 214 Hawkesbury Rd, Westmead, Sydney NSW 2145, Australia.

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http://dx.doi.org/10.1038/sj.onc.1207440DOI Listing
April 2004

Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

Cancer Res 2004 Apr;64(7):2324-7

Institut National de la Santé et de la Recherche Médicale, Paris, France.

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April 2004

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts.

Exp Cell Res 2003 May;286(1):96-101

National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

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http://dx.doi.org/10.1016/s0014-4827(03)00101-0DOI Listing
May 2003

Alternative lengthening of telomeres, telomerase, and cancer.

Authors:
Roger R Reddel

Cancer Lett 2003 May;194(2):155-62

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Sydney, Australia.

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http://dx.doi.org/10.1016/s0304-3835(02)00702-4DOI Listing
May 2003

Human POT1 facilitates telomere elongation by telomerase.

Curr Biol 2003 May;13(11):942-6

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia.

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http://dx.doi.org/10.1016/s0960-9822(03)00339-7DOI Listing
May 2003

Alternative lengthening of telomeres: dangerous road less travelled.

Lancet 2003 May;361(9372):1840-1

Cancer Research Unit, Children's Medical Research Institute, Westmead, New South Wales 2145, Sydney, Australia.

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http://dx.doi.org/10.1016/S0140-6736(03)13538-6DOI Listing
May 2003

Telomere maintenance and cancer -- look, no telomerase.

Nat Rev Cancer 2002 Nov;2(11):879-84

Cancer Research Unit, Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales 2145, Australia.

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http://dx.doi.org/10.1038/nrc929DOI Listing
November 2002

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.

J Biol Chem 2002 Oct 1;277(40):37765-70. Epub 2002 Aug 1.

Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

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http://dx.doi.org/10.1074/jbc.M204177200DOI Listing
October 2002

A major functional difference between the mouse and human ARF tumor suppressor proteins.

J Biol Chem 2002 Sep 26;277(39):36665-70. Epub 2002 Jul 26.

Gene Function Research Laboratory, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

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http://dx.doi.org/10.1074/jbc.M203222200DOI Listing
September 2002

Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo.

Cancer Res 2002 Aug;62(15):4434-8

Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki 305-8566, Japan.

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August 2002

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.

Exp Cell Res 2002 Apr;274(2):246-53

Chugai Research Institute for Medical Sciences, 153-2 Nagai, Niihari Mura, Ibaraki, 300-41, Japan.

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http://dx.doi.org/10.1006/excr.2002.5468DOI Listing
April 2002

Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.

Cancer Res 2002 Mar;62(5):1289-95

Cancer Functional Genomics Unit, Murdoch Children's Research Institute, 10 Floor Royal Children's Hospital, Parkville, Victoria 3052, Australia.

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March 2002

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells.

Nat Genet 2002 Mar 4;30(3):301-5. Epub 2002 Feb 4.

Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng834DOI Listing
March 2002

Alternative lengthening of telomeres in mammalian cells.

Oncogene 2002 Jan;21(4):598-610

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney 2145, Australia.

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http://dx.doi.org/10.1038/sj.onc.1205058DOI Listing
January 2002