Roger M Lyons

Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method.

Authors:

Adam Cuker Jenny M Despotovic Rachael F Grace Caroline Kruse Michele P Lambert Howard A Liebman Roger M Lyons Keith R McCrae Vinod Pullarkat Jeffrey S Wasser David Beenhouwer Sarah N Gibbs Irina Yermilov Michael S Broder

Res Pract Thromb Haemost 2021 Jan 8;5(1):69-80. Epub 2020 Dec 8.

Partnership for Health Analytic Research (PHAR), LLC Beverly Hills CA USA.

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January 2021

Efficacy and safety of ofatumumab and bendamustine followed by ofatumumab maintenance in patients with relapsed indolent non-Hodgkin lymphoma after prior rituximab.

Authors:

Roger M Lyons Mikhail Shtivelband Edwin Kingsley Mehdi Moezi Donald Richards Jeff Sharman Xiaoshu Feng Megan Cannan Rafik Fellague-Chebra Thomas E Boyd

Leuk Lymphoma 2021 Jan 15:1-8. Epub 2021 Jan 15.

Yakima Valley Memorial Hospital, Yakima, WI, USA.

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January 2021

A phase II study of addition of pracinostat to a hypomethylating agent in patients with myelodysplastic syndromes who have not responded to previous hypomethylating agent therapy.

Authors:

Fevzi F Yalniz Jesus G Berdeja Michael B Maris Roger M Lyons James A Reeves James H Essell Prapti Patel Mikkael Sekeres Amanda Hughes Silvia Mappa Guillermo Garcia-Manero

Br J Haematol 2020 02 29;188(3):404-412. Epub 2019 Aug 29.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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February 2020

Oprozomib, pomalidomide, and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma.

Authors:

Jatin Shah Saad Usmani Edward A Stadtmauer Robert M Rifkin James R Berenson Jesus G Berdeja Roger M Lyons Zandra Klippel Yu-Lin Chang Ruben Niesvizky

Clin Lymphoma Myeloma Leuk 2019 09 29;19(9):570-578.e1. Epub 2019 May 29.

Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY.

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September 2019

Role of Proteasome Inhibitors in Relapsed and/or Refractory Multiple Myeloma.

Authors:

Xavier Leleu Thomas G Martin Hermann Einsele Roger M Lyons Brian G M Durie Karim S Iskander Sikander Ailawadhi

Clin Lymphoma Myeloma Leuk 2019 01 5;19(1):9-22. Epub 2018 Sep 5.

Department of Hematology, Mayo Clinic, Jacksonville, FL.

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January 2019

Azacitidine in Lower-Risk Myelodysplastic Syndromes: A Meta-Analysis of Data from Prospective Studies.

Authors:

Rami Komrokji Arlene S Swern David Grinblatt Roger M Lyons Magnus Tobiasson Lewis R Silverman Hamid Sayar Ravi Vij Albert Fliss Nora Tu Mary M Sugrue

Oncologist 2018 02 8;23(2):159-170. Epub 2017 Nov 8.

Medical Affairs, Celgene Corporation, Summit, New Jersey, USA.

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February 2018

Romiplostim monotherapy in thrombocytopenic patients with myelodysplastic syndromes: long-term safety and efficacy.

Authors:

Pierre Fenaux Petra Muus Hagop Kantarjian Roger M Lyons Richard A Larson Mikkael A Sekeres Pamela S Becker Amelia Orejudos Janet Franklin

Br J Haematol 2017 09 14;178(6):906-913. Epub 2017 Jun 14.

Amgen Inc., Thousand Oaks, CA, USA.

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September 2017

Relation between chelation and clinical outcomes in lower-risk patients with myelodysplastic syndromes: Registry analysis at 5 years.

Authors:

Roger M Lyons Billie J Marek Carole Paley Jason Esposito Katie McNamara Paul D Richards Nicholas DiBella Guillermo Garcia-Manero

Leuk Res 2017 05 31;56:88-95. Epub 2017 Jan 31.

The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, United States. Electronic address:

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May 2017

Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial.

J Hematol Oncol 2017 02 22;10(1):55. Epub 2017 Feb 22.

Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 418, Houston, TX, 77030, USA.

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February 2017

Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes.

Cancer 2017 May 17;123(6):994-1002. Epub 2017 Jan 17.

Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical.

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May 2017

Edoxaban for venous thromboembolism in patients with cancer: results from a non-inferiority subgroup analysis of the Hokusai-VTE randomised, double-blind, double-dummy trial.

Authors:

Gary E Raskob Nick van Es Annelise Segers Pantep Angchaisuksiri Doyeun Oh Zoltan Boda Roger M Lyons Karina Meijer Ivan Gudz Jeffrey I Weitz George Zhang Hans Lanz Michele F Mercuri Harry R Büller

Lancet Haematol 2016 Aug 1;3(8):e379-87. Epub 2016 Jul 1.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.

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August 2016

CHAMPION-1: a phase 1/2 study of once-weekly carfilzomib and dexamethasone for relapsed or refractory multiple myeloma.

Authors:

James R Berenson Alan Cartmell Alberto Bessudo Roger M Lyons Wael Harb Dimitrios Tzachanis Richy Agajanian Ralph Boccia Morton Coleman Robert A Moss Robert M Rifkin Priti Patel Sandra Dixon Ying Ou Janet Anderl Sanjay Aggarwal Jesus G Berdeja

Blood 2016 06 12;127(26):3360-8. Epub 2016 May 12.

Sarah Cannon Research Institute, Nashville, TN.

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June 2016

Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG.

Authors:

Behyar Zoghi Paul Shaughnessy Roger M Lyons Richard Helmer Carlos Bachier C Frederick LeMaistre

Case Rep Hematol 2015 2;2015:809313. Epub 2015 Apr 2.

Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA.

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April 2015

Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I.

Haematologica 2015 Apr 23;100(4):479-88. Epub 2015 Jan 23.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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April 2015

Oral rivaroxaban versus enoxaparin with vitamin K antagonist for the treatment of symptomatic venous thromboembolism in patients with cancer (EINSTEIN-DVT and EINSTEIN-PE): a pooled subgroup analysis of two randomised controlled trials.

Authors:

Martin H Prins Anthonie W A Lensing Tim A Brighton Roger M Lyons Jeffrey Rehm Mila Trajanovic Bruce L Davidson Jan Beyer-Westendorf Ákos F Pap Scott D Berkowitz Alexander T Cohen Michael J Kovacs Philip S Wells Paolo Prandoni

Lancet Haematol 2014 Oct 28;1(1):e37-46. Epub 2014 Sep 28.

University of Padua, Padua, Italy.

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October 2014

Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin.

Authors:

Bruce L Davidson Sara Verheijen Anthonie W A Lensing Martin Gebel Timothy A Brighton Roger M Lyons Jeffrey Rehm Martin H Prins

JAMA Intern Med 2014 Jun;174(6):947-53

Maastricht University Medical Centre, Maastricht, the Netherlands.

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June 2014

Comparison of 24-month outcomes in chelated and non-chelated lower-risk patients with myelodysplastic syndromes in a prospective registry.

Authors:

Roger M Lyons Billie J Marek Carole Paley Jason Esposito Lawrence Garbo Nicholas DiBella Guillermo Garcia-Manero

Leuk Res 2014 Feb 13;38(2):149-54. Epub 2013 Nov 13.

University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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February 2014

Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts.

J Hematol Oncol 2013 Oct 29;6(1):81. Epub 2013 Oct 29.

University of Michigan, Comprehensive Cancer Center, 1500 E Medical Center Dr, Ann Arbor MI 48109, USA.

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October 2013

Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I.

Haematologica 2013 Dec 13;98(12):1865-71. Epub 2013 Sep 13.

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December 2013

Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies.

Haematologica 2014 Feb 2;99(2):292-8. Epub 2013 Aug 2.

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February 2014

The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis.

Br J Haematol 2013 May 11;161(4):508-16. Epub 2013 Mar 11.

The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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May 2013

Long-term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy.

Authors:

David J Kuter James B Bussel Adrian Newland Ross I Baker Roger M Lyons Jeffrey Wasser Jean-Francois Viallard Gail Macik Mathias Rummel Kun Nie Susie Jun

Br J Haematol 2013 May 22;161(3):411-23. Epub 2013 Feb 22.

Massachusetts General Hospital, Boston, MA 02114, USA.

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May 2013

A randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide.

Authors:

Eunice S Wang Roger M Lyons Richard A Larson Sunil Gandhi Delong Liu Carmen Matei Bart Scott Kuolung Hu Allen S Yang

J Hematol Oncol 2012 Nov 29;5:71. Epub 2012 Nov 29.

Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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November 2012

Myelodysplastic syndromes: therapy and outlook.

Authors:

Roger M Lyons

Am J Med 2012 Jul;125(7 Suppl):S18-23

Myelodysplasia Foundation Center of Excellence, Cancer Care Centers of South Texas/US Oncology, San Antonio, Texas 78229, USA.

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July 2012

Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS).

Authors:

Azra Raza Naomi Galili Deborah Mulford Scott E Smith Gail L Brown David P Steensma Roger M Lyons Ralph Boccia Mikkael A Sekeres Guillermo Garcia-Manero Ruben A Mesa

J Hematol Oncol 2012 Apr 30;5:18. Epub 2012 Apr 30.

Columbia University Medical Center, New York, NY, USA.

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April 2012

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis.

N Engl J Med 2012 Mar;366(9):799-807

Leukemia Department, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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March 2012

Oral ezatiostat HCl (Telintra®, TLK199) and idiopathic chronic neutropenia (ICN): a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat, a glutathione S-transferase P1-1 (GSTP1-1) inhibitor.

Authors:

Roger M Lyons Sharon T Wilks Shelby Young Gail L Brown

J Hematol Oncol 2011 Nov 2;4:43. Epub 2011 Nov 2.

Cancer Care Centers of South Texas, US Oncology, San Antonio, TX 78229, USA.

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November 2011

A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia.

Authors:

Craig Reynolds Nicholas Di Bella Roger M Lyons William Hyman Donald A Richards Gerald J Robbins Mark Vellek Kristi A Boehm Feng Zhan Lina Asmar

Invest New Drugs 2012 Jun 16;30(3):1232-40. Epub 2011 Sep 16.

US Oncology Research, LLC., The Woodlands, TX, USA.

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June 2012

Outpatient consolidation treatment with clofarabine in a phase 2 study of older adult patients with previously untreated acute myelogenous leukemia.

Authors:

David Claxton Harry P Erba Stefan Faderl Martha Arellano Roger M Lyons Tibor Kovacsovics Janice Gabrilove Dirk Huebner Pritesh J Gandhi Hagop Kantarjian

Leuk Lymphoma 2012 Mar 24;53(3):435-40. Epub 2011 Oct 24.

Division of Hematology/Oncology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

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March 2012

Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors.

Authors:

Hagop M Kantarjian Harry P Erba David Claxton Martha Arellano Roger M Lyons Tibor Kovascovics Janice Gabrilove Michael Craig Dan Douer Michael Maris Stephen Petersdorf Paul J Shami Andrew M Yeager Stephen Eckert Rekha Abichandani Stefan Faderl

J Clin Oncol 2010 Feb 21;28(4):549-55. Epub 2009 Dec 21.

University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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February 2010

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