Roger L Williams

Roger L Williams

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Roger L Williams

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Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time.

Authors:
Madhanagopal Anandapadamanaban Roger L Williams

Structure 2019 Dec;27(12):1739-1741

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.11.009DOI Listing
December 2019

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.

Authors:
Heather P Harding Adriana Ordonez Felicity Allen Leopold Parts Alison J Inglis Roger L Williams David Ron

Elife 2019 Nov 21;8. Epub 2019 Nov 21.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.50149DOI Listing
November 2019

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Authors:
Madhanagopal Anandapadamanaban Glenn R Masson Olga Perisic Alex Berndt Jonathan Kaufman Chris M Johnson Balaji Santhanam Kacper B Rogala David M Sabatini Roger L Williams

Science 2019 10;366(6462):203-210

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aax3939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795536PMC
October 2019

Structural Mechanisms of PTEN Regulation.

Authors:
Glenn R Masson Roger L Williams

Cold Spring Harb Perspect Med 2019 Oct 21. Epub 2019 Oct 21.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a036152DOI Listing
October 2019

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

Authors:
Andrew J Takeda Timothy J Maher Yu Zhang Stephen M Lanahan Molly L Bucklin Susan R Compton Paul M Tyler William A Comrie Makoto Matsuda Kenneth N Olivier Stefania Pittaluga Joshua J McElwee Debra A Long Priel Douglas B Kuhns Roger L Williams Peter J Mustillo Matthias P Wymann V Koneti Rao Carrie L Lucas

Nat Commun 2019 Sep 25;10(1):4364. Epub 2019 Sep 25.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41467-019-12311-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761123PMC
September 2019

A class of highly selective inhibitors bind to an active state of PI3Kγ.

Authors:
Gangadhara Gangadhara Göran Dahl Thomas Bohnacker Rebecca Rae Jenny Gunnarsson Stefan Blaho Linda Öster Helena Lindmark Kostas Karabelas Nils Pemberton Christian Tyrchan Mickael Mogemark Matthias P Wymann Roger L Williams Matthew W D Perry Tineke Papavoine Jens Petersen

Nat Chem Biol 2019 04 4;15(4):348-357. Epub 2019 Feb 4.

Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

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http://www.nature.com/articles/s41589-018-0215-0
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http://dx.doi.org/10.1038/s41589-018-0215-0DOI Listing
April 2019

Activation of GCN2 by the ribosomal P-stalk.

Authors:
Alison J Inglis Glenn R Masson Sichen Shao Olga Perisic Stephen H McLaughlin Ramanujan S Hegde Roger L Williams

Proc Natl Acad Sci U S A 2019 03 25;116(11):4946-4954. Epub 2019 Feb 25.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://dx.doi.org/10.1073/pnas.1813352116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421407PMC
March 2019

VPS34 complexes from a structural perspective.

Authors:
Yohei Ohashi Shirley Tremel Roger L Williams

J Lipid Res 2019 02 5;60(2):229-241. Epub 2018 Nov 5.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://www.jlr.org/lookup/doi/10.1194/jlr.R089490
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http://dx.doi.org/10.1194/jlr.R089490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358306PMC
February 2019

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Authors:
Tom D Bunney Alison J Inglis Domenico Sanfelice Brendan Farrell Christopher J Kerr Gary S Thompson Glenn R Masson Nethaji Thiyagarajan Dmitri I Svergun Roger L Williams Alexander L Breeze Matilda Katan

Structure 2018 03 22;26(3):446-458.e8. Epub 2018 Feb 22.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846801PMC
March 2018

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.

Authors:
Roger L Williams Madhanagopal Anandapadamanaban

Biochemistry 2017 12 29;56(49):6411-6412. Epub 2017 Nov 29.

MRC Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, U.K.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b01120
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http://dx.doi.org/10.1021/acs.biochem.7b01120DOI Listing
December 2017

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP Signaling.

Authors:
Thomas C Buckles Brian P Ziemba Glenn R Masson Roger L Williams Joseph J Falke

Biophys J 2017 Dec;113(11):2396-2405

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738497PMC
December 2017

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

Authors:
Florent Beaufils Natasa Cmiljanovic Vladimir Cmiljanovic Thomas Bohnacker Anna Melone Romina Marone Eileen Jackson Xuxiao Zhang Alexander Sele Chiara Borsari Jürgen Mestan Paul Hebeisen Petra Hillmann Bernd Giese Marketa Zvelebil Doriano Fabbro Roger L Williams Denise Rageot Matthias P Wymann

J Med Chem 2017 09 1;60(17):7524-7538. Epub 2017 Sep 1.

Department of Biomedicine, University of Basel , Mattenstrasse 28, 4058 Basel, Switzerland.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00930
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http://dx.doi.org/10.1021/acs.jmedchem.7b00930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656176PMC
September 2017

Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.

Authors:
Glenn R Masson Sarah L Maslen Roger L Williams

Biochem J 2017 05 16;474(11):1867-1877. Epub 2017 May 16.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BCJ20170127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544108PMC
May 2017

Structures of closed and open conformations of dimeric human ATM.

Authors:
Domagoj Baretić Hannah K Pollard David I Fisher Christopher M Johnson Balaji Santhanam Caroline M Truman Tomas Kouba Alan R Fersht Christopher Phillips Roger L Williams

Sci Adv 2017 May 10;3(5):e1700933. Epub 2017 May 10.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/sciadv.1700933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425235PMC
May 2017

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Authors:
Thomas Bohnacker Andrea E Prota Florent Beaufils John E Burke Anna Melone Alison J Inglis Denise Rageot Alexander M Sele Vladimir Cmiljanovic Natasa Cmiljanovic Katja Bargsten Amol Aher Anna Akhmanova J Fernando Díaz Doriano Fabbro Marketa Zvelebil Roger L Williams Michel O Steinmetz Matthias P Wymann

Nat Commun 2017 03 9;8:14683. Epub 2017 Mar 9.

Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncomms14683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347140PMC
March 2017

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

Authors:
Glenn R Masson John E Burke Roger L Williams

Methods Mol Biol 2016 ;1388:215-30

Laboratory of Molecular Biology, Medical Research Council (MRC), Francis Crick Avenue, Cambridge Biomedical campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_14DOI Listing
December 2016

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.

Authors:
Yohei Ohashi Nicolas Soler Miguel García Ortegón Lufei Zhang Marie L Kirsten Olga Perisic Glenn R Masson John E Burke Arjen J Jakobi Apostolos A Apostolakis Christopher M Johnson Maki Ohashi Nicholas T Ktistakis Carsten Sachse Roger L Williams

Autophagy 2016 11 14;12(11):2129-2144. Epub 2016 Sep 14.

a MRC Laboratory of Molecular Biology , Cambridge , United Kingdom.

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https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1
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http://dx.doi.org/10.1080/15548627.2016.1226736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103362PMC
November 2016

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Authors:
Brian P Ziemba G Hayden Swisher Glenn Masson John E Burke Roger L Williams Joseph J Falke

Biochemistry 2016 Nov 10;55(46):6395-6405. Epub 2016 Nov 10.

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado , Boulder, Colorado 80309-0215, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632315PMC
November 2016

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

Authors:
Antonio Galindo Nicolas Soler Stephen H McLaughlin Minmin Yu Roger L Williams Sean Munro

Cell Rep 2016 07 30;16(3):839-50. Epub 2016 Jun 30.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956616PMC
July 2016

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11.

Authors:
Melissa L Fowler Jacob A McPhail Meredith L Jenkins Glenn R Masson Florentine U Rutaganira Kevan M Shokat Roger L Williams John E Burke

Protein Sci 2016 Apr 1;25(4):826-39. Epub 2016 Feb 1.

Department of Biochemistry and Microbiology, University of Victoria, British Columbia, V8P 5C2, Canada.

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http://dx.doi.org/10.1002/pro.2879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832280PMC
April 2016

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

Authors:
Domagoj Baretić Alex Berndt Yohei Ohashi Christopher M Johnson Roger L Williams

Nat Commun 2016 Apr 13;7:11016. Epub 2016 Apr 13.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/ncomms11016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833857PMC
April 2016

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Authors:
Brian P Ziemba John E Burke Glenn Masson Roger L Williams Joseph J Falke

Biophys J 2016 04;110(8):1811-1825

Molecular Biophysics Program, University of Colorado, Boulder, Colorado; Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850241PMC
April 2016

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

Authors:
Glenn R Masson Olga Perisic John E Burke Roger L Williams

Biochem J 2016 Jan 2;473(2):135-44. Epub 2015 Nov 2.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BJ20150931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700475PMC
January 2016

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.

Authors:
Ksenia Rostislavleva Nicolas Soler Yohei Ohashi Lufei Zhang Els Pardon John E Burke Glenn R Masson Chris Johnson Jan Steyaert Nicholas T Ktistakis Roger L Williams

Science 2015 Oct;350(6257):aac7365

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aac7365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601532PMC
October 2015

PTEN regulates cilia through Dishevelled.

Authors:
Iryna Shnitsar Mikhail Bashkurov Glenn R Masson Abiodun A Ogunjimi Sherly Mosessian Eduardo Aguiar Cabeza Calley L Hirsch Daniel Trcka Gerald Gish Jing Jiao Hong Wu Rudolf Winklbauer Roger L Williams Laurence Pelletier Jeffrey L Wrana Miriam Barrios-Rodiles

Nat Commun 2015 Sep 24;6:8388. Epub 2015 Sep 24.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms9388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598566PMC
September 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Authors:
Aliaksei Shymanets Prajwal Oscar Vadas Cornelia Czupalla Jaclyn LoPiccolo Michael Brenowitz Alessandra Ghigo Emilio Hirsch Eberhard Krause Reinhard Wetzker Roger L Williams Christian Harteneck Bernd Nürnberg

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
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http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

Authors:
Jonathan H Clarke Maria-Luisa Giudici John E Burke Roger L Williams David J Maloney Juan Marugan Robin F Irvine

Biochem J 2015 Mar;466(2):359-67

*Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, U.K.

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https://www.repository.cam.ac.uk/bitstream/handle/1810/24686
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http://biochemj.org/lookup/doi/10.1042/BJ20141333
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http://dx.doi.org/10.1042/BJ20141333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687057PMC
March 2015

Synergy in activating class I PI3Ks.

Authors:
John E Burke Roger L Williams

Trends Biochem Sci 2015 Feb 5;40(2):88-100. Epub 2015 Jan 5.

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tibs.2014.12.003DOI Listing
February 2015

The structural basis for mTOR function.

Authors:
Domagoj Baretić Roger L Williams

Semin Cell Dev Biol 2014 Dec 5;36:91-101. Epub 2014 Oct 5.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.09.024DOI Listing
December 2014

PIKKs--the solenoid nest where partners and kinases meet.

Authors:
Domagoj Baretić Roger L Williams

Curr Opin Struct Biol 2014 Dec 3;29:134-42. Epub 2014 Dec 3.

Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2014.11.003DOI Listing
December 2014

Progressively reducing regulatory burden.

Authors:
Vinod P Shah Todd L Cecil Srini V Srinivasan Roger L Williams

AAPS J 2014 Jul 17;16(4):621-4. Epub 2014 Apr 17.

, N Potomac, Maryland, 20878, USA,

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http://dx.doi.org/10.1208/s12248-014-9601-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070254PMC
July 2014

Role of public standards in the safety and efficacy of biologic medicines.

Authors:
Roger L Williams Adrian F Bristow Walter W Hauck V Srini Srinivasan Tina Morris Fouad Atouf Michael Ambrose Koduru V Surendranath Ranjan Chakrabarty Krishna Menon

AAPS J 2014 May 2;16(3):516-21. Epub 2014 Apr 2.

United States Pharmacopeial Convention, 12601 Twinbrook Parkway, Rockville, Maryland, 20852, USA.

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http://dx.doi.org/10.1208/s12248-014-9586-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012053PMC
May 2014

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.

Authors:
John E Burke Alison J Inglis Olga Perisic Glenn R Masson Stephen H McLaughlin Florentine Rutaganira Kevan M Shokat Roger L Williams

Science 2014 May;344(6187):1035-8

Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1253397
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http://dx.doi.org/10.1126/science.1253397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046302PMC
May 2014

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

Authors:
Romy Walser John E Burke Elena Gogvadze Thomas Bohnacker Xuxiao Zhang Daniel Hess Peter Küenzi Michael Leitges Emilio Hirsch Roger L Williams Muriel Laffargue Matthias P Wymann

PLoS Biol 2013 25;11(6):e1001587. Epub 2013 Jun 25.

Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.1001587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692425PMC
January 2014

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α.

Authors:
Karuna Ganesh Febe van Maldegem Stephanie B Telerman Paul Simpson Christopher M Johnson Roger L Williams Michael S Neuberger Cristina Rada

FEBS Lett 2014 Jan 20;588(1):21-7. Epub 2013 Nov 20.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2013.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885797PMC
January 2014

Weight-loss study in African-American Women: lessons learned from project take HEED and future, technologically enhanced directions.

Authors:
Pamala J Murphy Roger L Williams

Perm J 2013 ;17(2):55-9

Kaiser Permanente Ohio Center of Research and an Internist at the Bedford Medical Center in Ohio, USA.

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http://dx.doi.org/10.7812/TPP/12-094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662279PMC
December 2013

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:
Ivan Angulo Oscar Vadas Fabien Garçon Edward Banham-Hall Vincent Plagnol Timothy R Leahy Helen Baxendale Tanya Coulter James Curtis Changxin Wu Katherine Blake-Palmer Olga Perisic Deborah Smyth Mailis Maes Christine Fiddler Jatinder Juss Deirdre Cilliers Gašper Markelj Anita Chandra George Farmer Anna Kielkowska Jonathan Clark Sven Kracker Marianne Debré Capucine Picard Isabelle Pellier Nada Jabado James A Morris Gabriela Barcenas-Morales Alain Fischer Len Stephens Phillip Hawkins Jeffrey C Barrett Mario Abinun Menna Clatworthy Anne Durandy Rainer Doffinger Edwin R Chilvers Andrew J Cant Dinakantha Kumararatne Klaus Okkenhaug Roger L Williams Alison Condliffe Sergey Nejentsev

Science 2013 Nov 17;342(6160):866-71. Epub 2013 Oct 17.

Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1126/science.1243292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930011PMC
November 2013

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Authors:
Oscar Vadas Hashem A Dbouk Aliaksei Shymanets Olga Perisic John E Burke Widian F Abi Saab Bassem D Khalil Christian Harteneck Anne R Bresnick Bernd Nürnberg Jonathan M Backer Roger L Williams

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18862-7. Epub 2013 Nov 4.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1304801110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839701PMC
November 2013

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.

Authors:
Giovanni D'Angelo Takefumi Uemura Chia-Chen Chuang Elena Polishchuk Michele Santoro Henna Ohvo-Rekilä Takashi Sato Giuseppe Di Tullio Antonio Varriale Sabato D'Auria Tiziana Daniele Fabrizio Capuani Ludger Johannes Peter Mattjus Maria Monti Piero Pucci Roger L Williams John E Burke Frances M Platt Akihiro Harada Maria Antonietta De Matteis

Nature 2013 Sep 4;501(7465):116-20. Epub 2013 Aug 4.

Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy.

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http://dx.doi.org/10.1038/nature12423DOI Listing
September 2013

Connecting with an old partner in a new way.

Authors:
John E Burke Roger L Williams

Cancer Cell 2013 May;23(5):559-61

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.ccr.2013.04.023DOI Listing
May 2013

Allosteric activation of PI3Kα by oncogenic mutations.

Authors:
John E Burke Olga Perisic Roger L Williams

Oncotarget 2013 Feb;4(2):180-1

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712563PMC
http://dx.doi.org/10.18632/oncotarget.913DOI Listing
February 2013

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

Authors:
John E Burke Roger L Williams

Adv Biol Regul 2013 Jan 13;53(1):97-110. Epub 2012 Sep 13.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.jbior.2012.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613897PMC
January 2013

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Authors:
Hashem A Dbouk Oscar Vadas Aliaksei Shymanets John E Burke Rachel S Salamon Bassem D Khalil Mathew O Barrett Gary L Waldo Chinmay Surve Christine Hsueh Olga Perisic Christian Harteneck Peter R Shepherd T Kendall Harden Alan V Smrcka Ronald Taussig Anne R Bresnick Bernd Nürnberg Roger L Williams Jonathan M Backer

Sci Signal 2012 Dec 4;5(253):ra89. Epub 2012 Dec 4.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1126/scisignal.2003264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979326PMC
December 2012

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Authors:
Hashem A Dbouk Oscar Vadas Roger L Williams Jonathan M Backer

Oncotarget 2012 Dec;3(12):1485-6

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681480PMC
http://dx.doi.org/10.18632/oncotarget.787DOI Listing
December 2012

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.

Authors:
Michael A Hadders Monica Agromayor Takayuki Obita Olga Perisic Anna Caballe Magdalena Kloc Meindert H Lamers Roger L Williams Juan Martin-Serrano

Proc Natl Acad Sci U S A 2012 Oct 8;109(43):17424-9. Epub 2012 Oct 8.

Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491508PMC
October 2012

Toward global standards for comparator pharmaceutical products: case studies of amoxicillin, metronidazole, and zidovudine in the Americas.

Authors:
Raimar Löbenberg Nadia B Chacra Erika S Stippler Vinod P Shah Anthony J DeStefano Walter W Hauck Roger L Williams

AAPS J 2012 Sep 19;14(3):462-72. Epub 2012 Apr 19.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385829PMC
September 2012

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Authors:
John E Burke Olga Perisic Glenn R Masson Oscar Vadas Roger L Williams

Proc Natl Acad Sci U S A 2012 Sep 4;109(38):15259-64. Epub 2012 Sep 4.

Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom.

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September 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Authors:
Monica Agromayor Nicolas Soler Anna Caballe Tonya Kueck Stefan M Freund Mark D Allen Mark Bycroft Olga Perisic Yu Ye Bethan McDonald Hartmut Scheel Kay Hofmann Stuart J D Neil Juan Martin-Serrano Roger L Williams

Structure 2012 Mar;20(3):414-28

Department of Infectious Diseases, King's College London School of Medicine, London SE1 9RT, UK.

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March 2012

Membrane trafficking: Arls squeeze the fat out.

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Roger L Williams

Nat Chem Biol 2011 Nov 15;7(12):863-4. Epub 2011 Nov 15.

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November 2011

Dietary supplements and regulation.

Authors:
Roger L Williams

JAMA 2011 Oct;306(15):1657; author reply 1657-8

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http://dx.doi.org/10.1001/jama.2011.1494DOI Listing
October 2011

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Authors:
Oscar Vadas John E Burke Xuxiao Zhang Alex Berndt Roger L Williams

Sci Signal 2011 Oct 18;4(195):re2. Epub 2011 Oct 18.

Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB20QH, UK.

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October 2011

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Authors:
John E Burke Oscar Vadas Alex Berndt Tara Finegan Olga Perisic Roger L Williams

Structure 2011 Aug;19(8):1127-37

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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August 2011

Ensuring global access to quality medicines: role of the US Pharmacopeia.

Authors:
Matthew L Heyman Roger L Williams

J Pharm Sci 2011 Apr 24;100(4):1280-7. Epub 2010 Nov 24.

For membership see Appendix 1.

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April 2011

Establishing new acceptance limits for dissolution performance verification of USPC apparatus 1 and 2 using USPC prednisone tablets reference standard.

Authors:
Anthony J DeStefano Walter W Hauck Erika S Stippler William E Brown Chensheng Li Gloria G Huang Barbara J Jones Kevin O'Hool William F Koch Roger L Williams

Pharm Res 2011 Mar 16;28(3):505-16. Epub 2010 Oct 16.

US Pharmacopeial Convention, Rockville, Maryland 20852, USA.

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March 2011

Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Authors:
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Mol Cell 2011 Mar;41(5):567-78

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670040PMC
March 2011

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.

Authors:
Rachel Y Samson Takayuki Obita Ben Hodgson Michael K Shaw Parkson Lee-Gau Chong Roger L Williams Stephen D Bell

Mol Cell 2011 Jan;41(2):186-96

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/j.molcel.2010.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763469PMC
January 2011

Kinases charging to the membrane.

Authors:
Michael A Hadders Roger L Williams

Cell 2010 Dec;143(6):865-7

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1016/j.cell.2010.11.044DOI Listing
December 2010

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.

Authors:
Simon Miller Arkadiusz Oleksy Olga Perisic Roger L Williams

Autophagy 2010 Aug 3;6(6):805-7. Epub 2010 Aug 3.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1126/science.1184429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321845PMC
August 2010

Measurement science for food and drug monographs: toward a global system.

Authors:
William F Koch Walter W Hauck Susan S de Mars Roger L Williams

Pharm Res 2010 Jul 6;27(7):1203-7. Epub 2010 Apr 6.

US Pharmacopeial Convention, Rockville, Maryland, USA.

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http://dx.doi.org/10.1007/s11095-010-0118-6DOI Listing
July 2010

Metal impurities in food and drugs.

Authors:
Darrell R Abernethy Anthony J Destefano Todd L Cecil Kahkashan Zaidi Roger L Williams

Pharm Res 2010 May 9;27(5):750-5. Epub 2010 Mar 9.

Documentary Standards Division, US Pharmacopeia, Rockville, Maryland 20852-1790, USA.

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http://dx.doi.org/10.1007/s11095-010-0080-3DOI Listing
May 2010

The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Authors:
Alex Berndt Simon Miller Olusegun Williams Daniel D Le Benjamin T Houseman Joseph I Pacold Fabrice Gorrec Wai-Ching Hon Yi Liu Christian Rommel Pascale Gaillard Thomas Rückle Matthias K Schwarz Kevan M Shokat Jeffrey P Shaw Roger L Williams

Nat Chem Biol 2010 Mar;6(3):244

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http://dx.doi.org/10.1038/nchembio0310-244bDOI Listing
March 2010

Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.

Authors:
Simon Miller Brandon Tavshanjian Arkadiusz Oleksy Olga Perisic Benjamin T Houseman Kevan M Shokat Roger L Williams

Science 2010 Mar;327(5973):1638-42

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.1184429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860105PMC
March 2010

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Authors:
Alex Berndt Simon Miller Olusegun Williams Daniel D Le Benjamin T Houseman Joseph I Pacold Fabrice Gorrec Wai-Ching Hon Yi Liu Christian Rommel Pascale Gaillard Thomas Rückle Matthias K Schwarz Kevan M Shokat Jeffrey P Shaw Roger L Williams

Nat Chem Biol 2010 Feb;6(2):117-24

Medical Research Council-Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/nchembio.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880452PMC
February 2010

Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities.

Authors:
Lisa D DiMartino Lesley H Curtis Roger L Williams Darrell R Abernethy Kevin A Schulman

Food Drug Law J 2008 ;63(4):891-900

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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July 2009

FDA's dietary supplement CGMPs: standards without standardization.

Authors:
Ruth K Miller Carlos Celestino Gabriel I Giancaspro Roger L Williams

Food Drug Law J 2008 ;63(4):929-42

United States Pharmacopeial Convention, Rockville, MD, USA.

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July 2009

Change in criteria for USP dissolution performance verification tests.

Authors:
Walter W Hauck Anthony J DeStefano William E Brown Erika S Stippler Darrell R Abernethy William F Koch Roger L Williams

AAPS PharmSciTech 2009 9;10(1):21-6. Epub 2009 Jan 9.

US Pharmacopeial Convention, 12601 Twinbrook Parkway, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1208/s12249-008-9169-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663662PMC
June 2009

Evolution and assembly of ESCRTs.

Authors:
Sara Ghazi-Tabatabai Takayuki Obita Ajaybabu V Pobbati Olga Perisic Rachel Y Samson Stephen D Bell Roger L Williams

Biochem Soc Trans 2009 Feb;37(Pt 1):151-5

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1042/BST0370151DOI Listing
February 2009

A role for the ESCRT system in cell division in archaea.

Authors:
Rachel Y Samson Takayuki Obita Stefan M Freund Roger L Williams Stephen D Bell

Science 2008 Dec 13;322(5908):1710-3. Epub 2008 Nov 13.

Medical Research Council (MRC) Cancer Cell Unit, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1126/science.1165322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121953PMC
December 2008

[Roles of ESCRT complexes in the MVB pathway].

Authors:
Takayuki Obita Olga Perisic Roger L Williams

Tanpakushitsu Kakusan Koso 2008 Dec;53(16 Suppl):2089-93

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December 2008

Metrologic approaches to setting acceptance criteria: unacceptable and unusual characteristics.

Authors:
Walter W Hauck Darrell R Abernethy Roger L Williams

J Pharm Biomed Anal 2008 Nov 9;48(3):1042-5. Epub 2008 Aug 9.

US Pharmacopeia, Documentary Standards Development, 12601 Twinbrook Parkway, Rockville, MD 20852-1790, United States.

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http://dx.doi.org/10.1016/j.jpba.2008.07.027DOI Listing
November 2008

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

Authors:
Beth Apsel Jimmy A Blair Beatriz Gonzalez Tamim M Nazif Morri E Feldman Brian Aizenstein Randy Hoffman Roger L Williams Kevan M Shokat Zachary A Knight

Nat Chem Biol 2008 Nov 12;4(11):691-9. Epub 2008 Oct 12.

Program in Chemistry and Chemical Biology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nchembio.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880455PMC
November 2008

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

Authors:
Sara Ghazi-Tabatabai Suraj Saksena Judith M Short Ajaybabu V Pobbati Dmitry B Veprintsev R Anthony Crowther Scott D Emr Edward H Egelman Roger L Williams

Structure 2008 Sep;16(9):1345-56

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.str.2008.06.010DOI Listing
September 2008

The USP Performance Verification Test, Part I: USP Lot P Prednisone Tablets: quality attributes and experimental variables contributing to dissolution variance.

Authors:
Gang Deng Alyssa J Ashley William E Brown Joseph W Eaton Walter W Hauck Loice C Kikwai Mark R Liddell Ronald G Manning Jimmy M Munoz Pallavi Nithyanandan Maria J Glasgow Erika Stippler Samir Z Wahab Roger L Williams

Pharm Res 2008 May 3;25(5):1100-9. Epub 2008 Jan 3.

United States Pharmacopeia, Rockville, MD 20852, USA.

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May 2008

The USP Performance Verification Test, Part II: collaborative study of USP's Lot P Prednisone Tablets.

Authors:
Maria Glasgow Shawn Dressman William Brown Thomas Foster Stefan Schuber Ronald G Manning Samir Z Wahab Roger L Williams Walter W Hauck

Pharm Res 2008 May 3;25(5):1110-5. Epub 2008 Jan 3.

United States Pharmacopeia, Rockville, MD 20852, USA.

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May 2008

The barrier to enantiomerization of N-Boc-2-lithiopyrrolidine: the effect of chiral and achiral diamines.

Authors:
Taher I Yousaf Roger L Williams Iain Coldham Robert E Gawley

Chem Commun (Camb) 2008 Jan(1):97-8

Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA.

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http://dx.doi.org/10.1039/b714302hDOI Listing
January 2008

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

Authors:
Takayuki Obita Suraj Saksena Sara Ghazi-Tabatabai David J Gill Olga Perisic Scott D Emr Roger L Williams

Nature 2007 Oct;449(7163):735-9

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge CB2 0QH, UK.

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October 2007

Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity.

Authors:
Robert V Stahelin Dimitrios Karathanassis Diana Murray Roger L Williams Wonhwa Cho

J Biol Chem 2007 Aug 20;282(35):25737-47. Epub 2007 Jun 20.

Department of Chemistry, University of Illinois, Chicago, Illinois 60607-7061, USA.

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August 2007

The structural basis of novel endosome anchoring activity of KIF16B kinesin.

Authors:
Nichole R Blatner Michael I Wilson Cai Lei Wanjin Hong Diana Murray Roger L Williams Wonhwa Cho

EMBO J 2007 Aug 19;26(15):3709-19. Epub 2007 Jul 19.

Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949010PMC
August 2007

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

Authors:
David J Gill Hsiangling Teo Ji Sun Olga Perisic Dmitry B Veprintsev Yvonne Vallis Scott D Emr Roger L Williams

Biochem Soc Symp 2007 (74):47-57

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, CB2 2QH, UK.

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http://dx.doi.org/10.1042/BSS0740047DOI Listing
July 2007

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.

Authors:
Tomoyuki Tanaka Roger L Williams Terence H Rabbitts

EMBO J 2007 Jul 14;26(13):3250-9. Epub 2007 Jun 14.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914092PMC
July 2007

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Authors:
Nabil Miled Ying Yan Wai-Ching Hon Olga Perisic Marketa Zvelebil Yuval Inbar Dina Schneidman-Duhovny Haim J Wolfson Jonathan M Backer Roger L Williams

Science 2007 Jul;317(5835):239-42

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1135394
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July 2007

The emerging shape of the ESCRT machinery.

Authors:
Roger L Williams Sylvie Urbé

Nat Rev Mol Cell Biol 2007 May;8(5):355-68

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://www.nature.com/articles/nrm2162
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May 2007

US Pharmacopeia Council of Experts 2005-2010: work plans, new revision approaches, and other enhancements.

Authors:
Roger L Williams

AAPS J 2006 ;8(4):E661-4

US Pharmacopeia, Rockville, MD 20852-1790, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751362PMC
http://dx.doi.org/10.1208/aapsj080475DOI Listing
March 2007

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.

Authors:
David J Gill Hsiangling Teo Ji Sun Olga Perisic Dmitry B Veprintsev Scott D Emr Roger L Williams

EMBO J 2007 Jan 11;26(2):600-12. Epub 2007 Jan 11.

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783442PMC
January 2007

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Authors:
Robert V Stahelin Dimitrios Karathanassis Karol S Bruzik Michael D Waterfield Jerónimo Bravo Roger L Williams Wonhwa Cho

J Biol Chem 2006 Dec 12;281(51):39396-406. Epub 2006 Oct 12.

Departments of Chemistry and Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60607, USA.

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http://dx.doi.org/10.1074/jbc.M607079200DOI Listing
December 2006

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

Authors:
Sam Li Alan M Sandercock Paul Conduit Carol V Robinson Roger L Williams John V Kilmartin

J Cell Biol 2006 Jun;173(6):867-77

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK.

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http://dx.doi.org/10.1083/jcb.200603153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063913PMC
June 2006

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

Authors:
Zachary A Knight Beatriz Gonzalez Morri E Feldman Eli R Zunder David D Goldenberg Olusegun Williams Robbie Loewith David Stokoe Andras Balla Balazs Toth Tamas Balla William A Weiss Roger L Williams Kevan M Shokat

Cell 2006 May 27;125(4):733-47. Epub 2006 Apr 27.

Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2006.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946820PMC
May 2006

ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.

Authors:
Hsiangling Teo David J Gill Ji Sun Olga Perisic Dmitry B Veprintsev Yvonne Vallis Scott D Emr Roger L Williams

Cell 2006 Apr;125(1):99-111

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/j.cell.2006.01.047DOI Listing
April 2006

Balancing efficacy and safety in the use of oral sedation in dental outpatients.

Authors:
Raymond A Dionne John A Yagiela Charles J Coté Mark Donaldson Michael Edwards David J Greenblatt Daniel Haas Shobha Malviya Peter Milgrom Paul A Moore Guy Shampaine Michael Silverman Roger L Williams Stephen Wilson

J Am Dent Assoc 2006 Apr;137(4):502-13

Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, USA.

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http://dx.doi.org/10.14219/jada.archive.2006.0223DOI Listing
April 2006

Official USP Reference Standards: metrology concepts, overview, and scientific issues and opportunities.

Authors:
Roger L Williams

J Pharm Biomed Anal 2006 Jan 21;40(1):3-15. Epub 2005 Nov 21.

United States Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD 20852-1790, USA.

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http://dx.doi.org/10.1016/j.jpba.2005.07.017DOI Listing
January 2006

Improving the safety of neuromuscular blocking agents: a statement from the USP Safe Medication Use Expert Committee.

Authors:
Marjorie Shaw Phillips Roger L Williams

Am J Health Syst Pharm 2006 Jan;63(2):139-42

College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.2146/ajhp050169DOI Listing
January 2006

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Authors:
Olga Perisic Michael I Wilson Dimitrios Karathanassis Jerónimo Bravo Michael E Pacold Chris D Ellson Phillip T Hawkins Len Stephens Roger L Williams

Adv Enzyme Regul 2004 ;44:279-98

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2003.11.003DOI Listing
March 2005

A segment of cold shock protein directs the folding of a combinatorial protein.

Authors:
Stephanie de Bono Lutz Riechmann Eric Girard Roger L Williams Greg Winter

Proc Natl Acad Sci U S A 2005 Feb 25;102(5):1396-401. Epub 2005 Jan 25.

Centre for Protein Engineering and Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0407298102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547839PMC
February 2005

Oral dosage form performance tests: new dissolution approaches.

Authors:
Walter W Hauck Thomas Foster Eric Sheinin Todd Cecil William Brown Margareth Marques Roger L Williams

Pharm Res 2005 Feb;22(2):182-7

Biostatistics Section, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://link.springer.com/content/pdf/10.1007/s11095-004-1184
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http://dx.doi.org/10.1007/s11095-004-1184-4DOI Listing
February 2005

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

Authors:
Hsiangling Teo Olga Perisic Beatriz González Roger L Williams

Dev Cell 2004 Oct;7(4):559-69

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/j.devcel.2004.09.003DOI Listing
October 2004

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

Authors:
Beatriz González Michael J Schell Andrew J Letcher Dmitry B Veprintsev Robin F Irvine Roger L Williams

Mol Cell 2004 Sep;15(5):689-701

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/j.molcel.2004.08.004DOI Listing
September 2004

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

Authors:
Hsiangling Teo Dmitry B Veprintsev Roger L Williams

J Biol Chem 2004 Jul 24;279(27):28689-96. Epub 2004 Mar 24.

Medical Research Council Laboratory of Molecular Biology and Centre for Protein Engineering, Medical Research Council Centre, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M400023200DOI Listing
July 2004

Selected medication-error data from USP's MEDMARX program for 2002.

Authors:
Rodney W Hicks Diane D Cousins Roger L Williams

Am J Health Syst Pharm 2004 May;61(10):993-1000

Center for the Advancement of Patient Safety, United States Pharmacopeia, Rockville, MD, USA.

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http://dx.doi.org/10.1093/ajhp/61.10.993DOI Listing
May 2004

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

Authors:
Bojana Panic Olga Perisic Dmitry B Veprintsev Roger L Williams Sean Munro

Mol Cell 2003 Oct;12(4):863-74

MRC Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(03)00356-3DOI Listing
October 2003