Roger L Williams

Roger L Williams

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Roger L Williams

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Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time.

Structure 2019 Dec;27(12):1739-1741

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.11.009DOI Listing
December 2019

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.

Elife 2019 Nov 21;8. Epub 2019 Nov 21.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.50149DOI Listing
November 2019

Structural Mechanisms of PTEN Regulation.

Cold Spring Harb Perspect Med 2019 Oct 21. Epub 2019 Oct 21.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a036152DOI Listing
October 2019

Activation of GCN2 by the ribosomal P-stalk.

Proc Natl Acad Sci U S A 2019 03 25;116(11):4946-4954. Epub 2019 Feb 25.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://dx.doi.org/10.1073/pnas.1813352116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421407PMC
March 2019

VPS34 complexes from a structural perspective.

J Lipid Res 2019 02 5;60(2):229-241. Epub 2018 Nov 5.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://www.jlr.org/lookup/doi/10.1194/jlr.R089490
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http://dx.doi.org/10.1194/jlr.R089490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358306PMC
February 2019

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Structure 2018 03 22;26(3):446-458.e8. Epub 2018 Feb 22.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846801PMC
March 2018

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.

Biochemistry 2017 12 29;56(49):6411-6412. Epub 2017 Nov 29.

MRC Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, U.K.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b01120
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http://dx.doi.org/10.1021/acs.biochem.7b01120DOI Listing
December 2017

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP Signaling.

Biophys J 2017 Dec;113(11):2396-2405

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738497PMC
December 2017

Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.

Biochem J 2017 05 16;474(11):1867-1877. Epub 2017 May 16.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BCJ20170127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544108PMC
May 2017

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.

Methods Mol Biol 2016 ;1388:215-30

Laboratory of Molecular Biology, Medical Research Council (MRC), Francis Crick Avenue, Cambridge Biomedical campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1007/978-1-4939-3299-3_14DOI Listing
December 2016

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Biochemistry 2016 Nov 10;55(46):6395-6405. Epub 2016 Nov 10.

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado , Boulder, Colorado 80309-0215, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632315PMC
November 2016

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.

Cell Rep 2016 07 30;16(3):839-50. Epub 2016 Jun 30.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956616PMC
July 2016

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

Nat Commun 2016 Apr 13;7:11016. Epub 2016 Apr 13.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/ncomms11016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833857PMC
April 2016

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Biophys J 2016 04;110(8):1811-1825

Molecular Biophysics Program, University of Colorado, Boulder, Colorado; Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850241PMC
April 2016

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

Biochem J 2016 Jan 2;473(2):135-44. Epub 2015 Nov 2.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, U.K.

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http://dx.doi.org/10.1042/BJ20150931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700475PMC
January 2016

PTEN regulates cilia through Dishevelled.

Nat Commun 2015 Sep 24;6:8388. Epub 2015 Sep 24.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms9388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598566PMC
September 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
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http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015

Synergy in activating class I PI3Ks.

Trends Biochem Sci 2015 Feb 5;40(2):88-100. Epub 2015 Jan 5.

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tibs.2014.12.003DOI Listing
February 2015

The structural basis for mTOR function.

Semin Cell Dev Biol 2014 Dec 5;36:91-101. Epub 2014 Oct 5.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.09.024DOI Listing
December 2014

PIKKs--the solenoid nest where partners and kinases meet.

Curr Opin Struct Biol 2014 Dec 3;29:134-42. Epub 2014 Dec 3.

Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2014.11.003DOI Listing
December 2014

Progressively reducing regulatory burden.

AAPS J 2014 Jul 17;16(4):621-4. Epub 2014 Apr 17.

, N Potomac, Maryland, 20878, USA,

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http://dx.doi.org/10.1208/s12248-014-9601-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070254PMC
July 2014

Weight-loss study in African-American Women: lessons learned from project take HEED and future, technologically enhanced directions.

Perm J 2013 ;17(2):55-9

Kaiser Permanente Ohio Center of Research and an Internist at the Bedford Medical Center in Ohio, USA.

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http://dx.doi.org/10.7812/TPP/12-094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662279PMC
December 2013

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18862-7. Epub 2013 Nov 4.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1304801110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839701PMC
November 2013

Connecting with an old partner in a new way.

Cancer Cell 2013 May;23(5):559-61

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.ccr.2013.04.023DOI Listing
May 2013

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

Adv Biol Regul 2013 Jan 13;53(1):97-110. Epub 2012 Sep 13.

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.jbior.2012.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613897PMC
January 2013

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Proc Natl Acad Sci U S A 2012 Sep 4;109(38):15259-64. Epub 2012 Sep 4.

Laboratory of Molecular Biology, Medical Research Council, Cambridge, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1205508109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458343PMC
September 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang 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Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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April 2012

Membrane trafficking: Arls squeeze the fat out.

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November 2011

Dietary supplements and regulation.

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JAMA 2011 Oct;306(15):1657; author reply 1657-8

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October 2011

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Sci Signal 2011 Oct 18;4(195):re2. Epub 2011 Oct 18.

Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB20QH, UK.

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October 2011

Ensuring global access to quality medicines: role of the US Pharmacopeia.

J Pharm Sci 2011 Apr 24;100(4):1280-7. Epub 2010 Nov 24.

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April 2011

Kinases charging to the membrane.

Cell 2010 Dec;143(6):865-7

MRC Laboratory of Molecular Biology, Cambridge, UK.

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December 2010

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.

Autophagy 2010 Aug 3;6(6):805-7. Epub 2010 Aug 3.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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August 2010

Measurement science for food and drug monographs: toward a global system.

Pharm Res 2010 Jul 6;27(7):1203-7. Epub 2010 Apr 6.

US Pharmacopeial Convention, Rockville, Maryland, USA.

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July 2010

Metal impurities in food and drugs.

Pharm Res 2010 May 9;27(5):750-5. Epub 2010 Mar 9.

Documentary Standards Division, US Pharmacopeia, Rockville, Maryland 20852-1790, USA.

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May 2010

Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.

Science 2010 Mar;327(5973):1638-42

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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March 2010

Using Medicare administrative data to conduct postmarketing surveillance of follow-on biologics: issues and opportunities.

Food Drug Law J 2008 ;63(4):891-900

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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July 2009

FDA's dietary supplement CGMPs: standards without standardization.

Food Drug Law J 2008 ;63(4):929-42

United States Pharmacopeial Convention, Rockville, MD, USA.

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July 2009

Change in criteria for USP dissolution performance verification tests.

AAPS PharmSciTech 2009 9;10(1):21-6. Epub 2009 Jan 9.

US Pharmacopeial Convention, 12601 Twinbrook Parkway, Rockville, MD 20852, USA.

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June 2009

Evolution and assembly of ESCRTs.

Biochem Soc Trans 2009 Feb;37(Pt 1):151-5

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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February 2009

A role for the ESCRT system in cell division in archaea.

Science 2008 Dec 13;322(5908):1710-3. Epub 2008 Nov 13.

Medical Research Council (MRC) Cancer Cell Unit, Hills Road, Cambridge CB2 0XZ, UK.

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December 2008

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December 2008

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J Pharm Biomed Anal 2008 Nov 9;48(3):1042-5. Epub 2008 Aug 9.

US Pharmacopeia, Documentary Standards Development, 12601 Twinbrook Parkway, Rockville, MD 20852-1790, United States.

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November 2008

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

Nat Chem Biol 2008 Nov 12;4(11):691-9. Epub 2008 Oct 12.

Program in Chemistry and Chemical Biology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA.

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November 2008

The barrier to enantiomerization of N-Boc-2-lithiopyrrolidine: the effect of chiral and achiral diamines.

Chem Commun (Camb) 2008 Jan(1):97-8

Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA.

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January 2008

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

Nature 2007 Oct;449(7163):735-9

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge CB2 0QH, UK.

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October 2007

Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity.

J Biol Chem 2007 Aug 20;282(35):25737-47. Epub 2007 Jun 20.

Department of Chemistry, University of Illinois, Chicago, Illinois 60607-7061, USA.

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August 2007

The structural basis of novel endosome anchoring activity of KIF16B kinesin.

EMBO J 2007 Aug 19;26(15):3709-19. Epub 2007 Jul 19.

Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.

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August 2007

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

Biochem Soc Symp 2007 (74):47-57

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, CB2 2QH, UK.

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July 2007

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.

EMBO J 2007 Jul 14;26(13):3250-9. Epub 2007 Jun 14.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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July 2007

The emerging shape of the ESCRT machinery.

Nat Rev Mol Cell Biol 2007 May;8(5):355-68

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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May 2007

Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.

EMBO J 2007 Jan 11;26(2):600-12. Epub 2007 Jan 11.

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783442PMC
January 2007

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

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Departments of Chemistry and Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60607, USA.

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December 2006

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

J Cell Biol 2006 Jun;173(6):867-77

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK.

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June 2006

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.

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Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2006.03.035DOI Listing
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May 2006

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Cell 2006 Apr;125(1):99-111

MRC Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, CB2 2QH, United Kingdom.

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April 2006

Balancing efficacy and safety in the use of oral sedation in dental outpatients.

J Am Dent Assoc 2006 Apr;137(4):502-13

Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, USA.

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April 2006

Official USP Reference Standards: metrology concepts, overview, and scientific issues and opportunities.

J Pharm Biomed Anal 2006 Jan 21;40(1):3-15. Epub 2005 Nov 21.

United States Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD 20852-1790, USA.

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January 2006

Improving the safety of neuromuscular blocking agents: a statement from the USP Safe Medication Use Expert Committee.

Am J Health Syst Pharm 2006 Jan;63(2):139-42

College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.

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January 2006

A segment of cold shock protein directs the folding of a combinatorial protein.

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Centre for Protein Engineering and Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.

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February 2005

Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.

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Medical Research Council Laboratory of Molecular Biology and Centre for Protein Engineering, Medical Research Council Centre, Cambridge CB2 2QH, United Kingdom.

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July 2004

Selected medication-error data from USP's MEDMARX program for 2002.

Am J Health Syst Pharm 2004 May;61(10):993-1000

Center for the Advancement of Patient Safety, United States Pharmacopeia, Rockville, MD, USA.

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May 2004

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

Mol Cell 2003 Oct;12(4):863-74

MRC Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.

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October 2003