Roger G Ptak

Roger G Ptak

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Roger G Ptak

Roger G Ptak

Publications by authors named "Roger G Ptak"

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Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.

Eur J Med Chem 2019 Jan 23;161:533-542. Epub 2018 Oct 23.

Department of Basic Sciences, Touro University-California, Vallejo, CA, 94592, USA; Department of Pharmaceutical Chemistry, University of California San Francisco, CA, 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.10.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264915PMC
January 2019

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

J Drug Des Res 2018 13;5(2). Epub 2018 Aug 13.

Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214487PMC
August 2018

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.

PLoS One 2018 7;13(2):e0192512. Epub 2018 Feb 7.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192512PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802939PMC
April 2018

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

J Med Chem 2017 07 6;60(14):6220-6238. Epub 2017 Jul 6.

Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven , Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00416DOI Listing
July 2017

Enhanced potency of bivalent small molecule gp41 inhibitors.

Bioorg Med Chem 2017 01 19;25(1):408-420. Epub 2016 Nov 19.

Department of Basic Sciences, Touro University-California, Vallejo, CA 94592, United States; Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94143, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260928PMC
January 2017

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.

Antiviral Res 2016 12 5;136:51-59. Epub 2016 Nov 5.

OyaGen, Inc., 77 Ridgeland Rd., Rochester, NY 14623, USA; Department of Biochemistry and Biophysics and Environmental Health Sciences Center, Center for RNA Biology, Center for AIDS Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, NY 14642, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125868PMC
December 2016

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.

J Med Chem 2016 Oct 17;59(20):9513-9531. Epub 2016 Oct 17.

Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01260DOI Listing
October 2016

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.

Org Biomol Chem 2016 Sep;14(37):8743-8757

KU Leuven, Rega Institute, Laboratory of Medicinal Chemistry, Minderbroedersstraat 10, 3000 Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079539PMC
http://dx.doi.org/10.1039/c6ob01189fDOI Listing
September 2016

Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.

Virology 2015 Oct 1;484:276-87. Epub 2015 Jul 1.

Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, United States; Department of Neurology (Microbiology), Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822150029
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http://dx.doi.org/10.1016/j.virol.2015.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567410PMC
October 2015

Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.

J Biol Chem 2015 Apr 27;290(16):10504-17. Epub 2015 Feb 27.

From the Departments of Cancer Immunology and AIDS and Neurology (Microbiology), Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.M114.626903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400358PMC
April 2015

HIV-1, human interaction database: current status and new features.

Nucleic Acids Res 2015 Jan 6;43(Database issue):D566-70. Epub 2014 Nov 6.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA

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http://dx.doi.org/10.1093/nar/gku1126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383939PMC
January 2015

Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication.

J Chem Inf Model 2014 Nov 28;54(11):3080-90. Epub 2014 Oct 28.

Department of Microbiology & Immunology and ‡Department of Biochemistry & Molecular Biology, Drexel University College of Medicine , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/ci500437rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245176PMC
November 2014

Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide.

Antimicrob Agents Chemother 2014 11;58(2):687-97. Epub 2013 Nov 11.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA.

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http://aac.asm.org/content/58/2/687.full.pdf
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http://aac.asm.org/cgi/doi/10.1128/AAC.02000-13
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http://dx.doi.org/10.1128/AAC.02000-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910842PMC
September 2014

Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41.

J Med Chem 2014 Jun 6;57(12):5270-81. Epub 2014 Jun 6.

Department of Basic Sciences, Touro University-California , 1310 Club Drive, Mare Island, Vallejo, California 94592, United States.

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http://dx.doi.org/10.1021/jm500344yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216203PMC
June 2014

Development of real-time PCR array for simultaneous detection of eight human blood-borne viral pathogens.

PLoS One 2012 17;7(8):e43246. Epub 2012 Aug 17.

Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422334PMC
May 2013

Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms.

Viruses 2013 Mar 22;5(3):981-97. Epub 2013 Mar 22.

Department of Immunology & Microbial Science, The Scripps Research Institute, La Jolla 92037, California, USA.

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http://dx.doi.org/10.3390/v5030981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705307PMC
March 2013

Dimeric RNA recognition regulates HIV-1 genome packaging.

PLoS Pathog 2013 Mar 21;9(3):e1003249. Epub 2013 Mar 21.

HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605237PMC
March 2013

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

Bioorg Med Chem Lett 2013 Feb 29;23(4):1132-5. Epub 2012 Nov 29.

Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557583PMC
February 2013

Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41.

J Med Chem 2011 Oct 3;54(20):7220-31. Epub 2011 Oct 3.

Department of Basic Sciences, Touro University-California, 1310 Club Drive, Mare Island, Vallejo, California 94592, United States.

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http://dx.doi.org/10.1021/jm200791zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234170PMC
October 2011

Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners.

J Virol 2011 Aug 25;85(15):7603-12. Epub 2011 May 25.

HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Building 535, Room 336, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1128/JVI.00562-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147938PMC
August 2011

Highly potent chimeric inhibitors targeting two steps of HIV cell entry.

J Biol Chem 2011 Aug 9;286(32):28370-81. Epub 2011 Jun 9.

University of California, Merced, California 95343, USA.

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http://dx.doi.org/10.1074/jbc.M111.234799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151080PMC
August 2011

Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.

Antimicrob Agents Chemother 2011 Jan 18;55(1):264-75. Epub 2010 Oct 18.

Texas A&M University, Department of Biochemistry and Biophysics, College Station, Texas 77843-2128, USA.

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http://dx.doi.org/10.1128/AAC.00376-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019634PMC
January 2011

Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

J Biol Chem 2010 May 9;285(19):14346-55. Epub 2010 Mar 9.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-4320, USA.

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http://dx.doi.org/10.1074/jbc.M110.109314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863248PMC
May 2010

Human immunodeficiency virus type 1, human protein interaction database at NCBI.

Nucleic Acids Res 2009 Jan 15;37(Database issue):D417-22. Epub 2008 Oct 15.

Southern Research Institute, Frederick, MD 21701, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkn708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686594PMC
January 2009

Cataloguing the HIV type 1 human protein interaction network.

AIDS Res Hum Retroviruses 2008 Dec;24(12):1497-502

Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA.

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http://dx.doi.org/10.1089/aid.2008.0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655106PMC
December 2008

Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation.

Virology 2008 Sep 26;379(1):152-60. Epub 2008 Jul 26.

HIV Drug Resistance Program, National Cancer Institute at Frederick, P.O. Box B, Building 535, Room 336, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1016/j.virol.2008.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577075PMC
September 2008

Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination.

J Virol 2007 Apr 31;81(8):4002-11. Epub 2007 Jan 31.

HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Building 535, Room 336, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1128/JVI.02589-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866129PMC
April 2007

Nucleosides with self-complementary hydrogen-bonding motifs: synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system.

Bioorg Med Chem 2006 Sep 9;14(18):6359-67. Epub 2006 Jun 9.

Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.05.043DOI Listing
September 2006

Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants.

J Biol Chem 2006 Sep 1;281(39):28699-711. Epub 2006 Aug 1.

Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M603609200
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http://dx.doi.org/10.1074/jbc.M603609200DOI Listing
September 2006

Broad spectrum antimicrobial activity of leukocyte extracts from the American alligator (Alligator mississippiensis).

Vet Immunol Immunopathol 2006 Apr 18;110(3-4):221-8. Epub 2005 Nov 18.

Department of Chemistry, McNeese State University, Lake Charles, Box 90455, LA 70609, USA.

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http://dx.doi.org/10.1016/j.vetimm.2005.10.001DOI Listing
April 2006

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

J Med Chem 2004 Nov;47(23):5773-82

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48019, USA.

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http://dx.doi.org/10.1021/jm0400606DOI Listing
November 2004

Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.

Antimicrob Agents Chemother 2004 Oct;48(10):3918-27

School of Dentistry, 1011 N. University Ave., University of Michigan, Ann Arbor, MI 48109-1078, USA.

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http://dx.doi.org/10.1128/AAC.48.10.3918-3927.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521925PMC
October 2004

Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs.

Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1725-7

Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USA.

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http://dx.doi.org/10.1081/NCN-120023123DOI Listing
December 2003

Synthesis and antiviral activity of 2-substituted analogs of triciribine.

Nucleosides Nucleotides Nucleic Acids 2003 Dec;22(12):2171-93

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1081/ncn-120026873DOI Listing
December 2003

Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27.

J Virol 2003 Nov;77(21):11499-506

Department of Biologic and Materials Sciences, School of Dentistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC229258PMC
http://dx.doi.org/10.1128/jvi.77.21.11499-11506.2003DOI Listing
November 2003

Molecular evidence of HIV-1 transmission in a criminal case.

Proc Natl Acad Sci U S A 2002 Oct 18;99(22):14292-7. Epub 2002 Oct 18.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.222522599
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http://dx.doi.org/10.1073/pnas.222522599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137877PMC
October 2002

HIV-1 regulatory proteins: targets for novel drug development.

Authors:
Roger G Ptak

Expert Opin Investig Drugs 2002 Aug;11(8):1099-115

Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, USA.

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http://dx.doi.org/10.1517/13543784.11.8.1099DOI Listing
August 2002

Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.

Antimicrob Agents Chemother 2002 Feb;46(2):478-86

Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127035PMC
http://dx.doi.org/10.1128/aac.46.2.478-486.2002DOI Listing
February 2002