Publications by authors named "Roger D Kamm"

100Publications

Rethinking organoid technology through bioengineering.

Nat Mater 2020 Nov 16. Epub 2020 Nov 16.

Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

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http://dx.doi.org/10.1038/s41563-020-00804-4DOI Listing
November 2020

Cysteine cathepsins are altered by flow within an engineered microvascular niche.

APL Bioeng 2020 Dec 4;4(4):046102. Epub 2020 Nov 4.

Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1063/5.0023342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644274PMC
December 2020

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform.

Biomaterials 2021 Jan 19;265:120470. Epub 2020 Oct 19.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.120470DOI Listing
January 2021

Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes.

Angiogenesis 2020 Sep 21. Epub 2020 Sep 21.

The Vascular Biology Program and Department of Surgery, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10456-020-09746-6DOI Listing
September 2020

Biohybrid systems: Borrowing from nature to make better machines.

APL Bioeng 2020 Jun 17;4(2):020401. Epub 2020 Jun 17.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1063/5.0014918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304995PMC
June 2020

Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension.

APL Bioeng 2020 Mar 6;4(1):016106. Epub 2020 Mar 6.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1063/1.5127069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060087PMC
March 2020

Models for Monocytic Cells in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1224:87-115

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-3-030-35723-8_7DOI Listing
February 2020

The bioprinting roadmap.

Biofabrication 2020 02 6;12(2):022002. Epub 2020 Feb 6.

Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United States of America. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, People's Republic of China.

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http://dx.doi.org/10.1088/1758-5090/ab5158DOI Listing
February 2020

The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation.

Adv Healthc Mater 2020 04 29;9(8):e1901410. Epub 2020 Jan 29.

Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Department of Mechanical Engineering, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201901410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274859PMC
April 2020

On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease.

Nat Protoc 2020 02 13;15(2):421-449. Epub 2020 Jan 13.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41596-019-0248-1DOI Listing
February 2020

Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF-Ang-Tie2 Signaling.

Adv Sci (Weinh) 2019 Dec 29;6(23):1900878. Epub 2019 Oct 29.

Massachusetts Institute of Technology Cambridge MA 02139 USA.

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http://dx.doi.org/10.1002/advs.201900878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891921PMC
December 2019

Microphysiological systems.

APL Bioeng 2019 Dec 29;3(4):040401. Epub 2019 Oct 29.

Department of Biological Engineering and Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, MIT Building, Room NE47-321, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1063/1.5130170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819166PMC
December 2019

Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease.

Adv Sci (Weinh) 2019 Oct 12;6(20):1900962. Epub 2019 Aug 12.

Genetics and Aging Research Unit McCance Center for Brain Health Mass General Institute for Neurodegenerative Disease Department of Neurology Massachusetts General Hospital Harvard Medical School Charlestown MA 02129 USA.

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http://dx.doi.org/10.1002/advs.201900962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794630PMC
October 2019

MicroRNA delivery through nanoparticles.

J Control Release 2019 11 14;313:80-95. Epub 2019 Oct 14.

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.

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http://dx.doi.org/10.1016/j.jconrel.2019.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900258PMC
November 2019

Migration of vascular endothelial cells in monolayers under hypoxic exposure.

Integr Biol (Camb) 2019 01;11(1):26-35

Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-aza Aoba, Aoba-ku, Sendai, Miyagi, Japan.

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http://dx.doi.org/10.1093/intbio/zyz002DOI Listing
January 2019

Quantitative screening of the effects of hyper-osmotic stress on cancer cells cultured in 2- or 3-dimensional settings.

Sci Rep 2019 09 24;9(1):13782. Epub 2019 Sep 24.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.1038/s41598-019-50198-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760113PMC
September 2019

Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution.

Small 2019 11 9;15(46):e1902393. Epub 2019 Sep 9.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/smll.201902393DOI Listing
November 2019

Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy.

Nat Commun 2019 08 13;10(1):3652. Epub 2019 Aug 13.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-019-11645-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692322PMC
August 2019

Publisher Correction: Microfluidic assessment of metastatic potential.

Nat Biomed Eng 2019 Aug;3(8):670

Department of Biological Engineering, Massachusetts Institutes of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41551-019-0444-xDOI Listing
August 2019

Microfluidic assessment of metastatic potential.

Nat Biomed Eng 2019 06;3(6):423-424

Department of Biological Engineering, Massachusetts Institutes of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41551-019-0412-5DOI Listing
June 2019

An on-chip model of protein paracellular and transcellular permeability in the microcirculation.

Biomaterials 2019 08 13;212:115-125. Epub 2019 May 13.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.05.022DOI Listing
August 2019

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

PLoS Comput Biol 2019 05 2;15(5):e1006395. Epub 2019 May 2.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497229PMC
May 2019

Self-organization of hepatocyte morphogenesis depending on the size of collagen microbeads relative to hepatocytes.

Biofabrication 2019 04 26;11(3):035007. Epub 2019 Apr 26.

Department of System Design Engineering, Keio University, Japan

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http://dx.doi.org/10.1088/1758-5090/ab145dDOI Listing
April 2019

Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein.

Mol Pharm 2019 06 29;16(6):2838-2844. Epub 2019 Apr 29.

Program in Cellular and Molecular Medicine , Boston Children's Hospital , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00078DOI Listing
June 2019

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices.

PLoS Comput Biol 2019 04 8;15(4):e1006684. Epub 2019 Apr 8.

Yale University, Biomedical Engineering Department, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472805PMC
April 2019

Quantification of human neuromuscular function through optogenetics.

Theranostics 2019 31;9(5):1232-1246. Epub 2019 Jan 31.

Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.

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http://www.thno.org/v09p1232.htm
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http://dx.doi.org/10.7150/thno.25735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401498PMC
January 2020

Biohybrid valveless pump-bot powered by engineered skeletal muscle.

Proc Natl Acad Sci U S A 2019 01 11;116(5):1543-1548. Epub 2019 Jan 11.

Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1817682116
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http://dx.doi.org/10.1073/pnas.1817682116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358718PMC
January 2019

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines.

Sci Rep 2018 12 18;8(1):17949. Epub 2018 Dec 18.

BioSystems and Micromechanics, IRG, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore.

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http://www.nature.com/articles/s41598-018-36381-5
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http://dx.doi.org/10.1038/s41598-018-36381-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298998PMC
December 2018

Cooperative Effects of Vascular Angiogenesis and Lymphangiogenesis.

Regen Eng Transl Med 2018 Sep 23;4(3):120-132. Epub 2018 Apr 23.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/s40883-018-0054-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223658PMC
September 2018

Engineered Models of Metastasis with Application to Study Cancer Biomechanics.

Adv Exp Med Biol 2018;1092:189-207

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://link.springer.com/10.1007/978-3-319-95294-9_10
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http://dx.doi.org/10.1007/978-3-319-95294-9_10DOI Listing
July 2019

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons.

Sci Adv 2018 10 10;4(10):eaat5847. Epub 2018 Oct 10.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA 02139, USA.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aat
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http://dx.doi.org/10.1126/sciadv.aat5847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179377PMC
October 2018

Construction of Continuous Capillary Networks Stabilized by Pericyte-like Perivascular Cells.

Tissue Eng Part A 2019 03 27;25(5-6):499-510. Epub 2018 Oct 27.

1 Department of System Design Engineering, Keio University, Yokohama, Japan.

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http://dx.doi.org/10.1089/ten.TEA.2018.0186DOI Listing
March 2019

Complex mechanics of the heterogeneous extracellular matrix in cancer.

Extreme Mech Lett 2018 May;21:25-34

Departments of Biological Engineering and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.eml.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097546PMC
May 2018

Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling.

Cell Rep 2018 07;24(4):962-972

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Ludwig/MIT Center for Molecular Oncology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181240PMC
July 2018

Hydrogel-incorporating unit in a well: 3D cell culture for high-throughput analysis.

Lab Chip 2018 08;18(17):2604-2613

Biomedical Omics Group, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.

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http://dx.doi.org/10.1039/c8lc00525gDOI Listing
August 2018

Studying TCR T cell anti-tumor activity in a microfluidic intrahepatic tumor model.

Methods Cell Biol 2018 12;146:199-214. Epub 2018 Jul 12.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0091679X183006
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http://dx.doi.org/10.1016/bs.mcb.2018.05.009DOI Listing
December 2018

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes.

Biomaterials 2018 10 12;180:117-129. Epub 2018 Jul 12.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, MIT Building, Room NE47-321, Cambridge, MA, 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 500 Technology Square, MIT Building, Room NE47-321, Cambridge, MA, 02139, USA; Singapore-MIT Alliance for Research&Technology (SMART), BioSytems and Micromechanics (BioSyM), Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201194PMC
October 2018

Interstitial flow promotes macrophage polarization toward an M2 phenotype.

Mol Biol Cell 2018 08 11;29(16):1927-1940. Epub 2018 Jul 11.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-03-0164
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http://dx.doi.org/10.1091/mbc.E18-03-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232969PMC
August 2018

Influence of protein corona and caveolae-mediated endocytosis on nanoparticle uptake and transcytosis.

Nanoscale 2018 Jul;10(26):12386-12397

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.

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http://dx.doi.org/10.1039/c8nr02393jDOI Listing
July 2018

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Proc Natl Acad Sci U S A 2018 07 18;115(27):7022-7027. Epub 2018 Jun 18.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1715932115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142213PMC
July 2018

models of molecular and nano-particle transport across the blood-brain barrier.

Biomicrofluidics 2018 Jul 31;12(4):042213. Epub 2018 May 31.

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.

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http://dx.doi.org/10.1063/1.5027118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980570PMC
July 2018

Evidence from ITIR-FCS Diffusion Studies that the Amyloid-Beta (Aβ) Peptide Does Not Perturb Plasma Membrane Fluidity in Neuronal Cells.

J Mol Biol 2018 09 7;430(18 Pt B):3439-3453. Epub 2018 May 7.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, S637551, Singapore; Singapore-MIT Alliance for Research and Technology, BioSyM IRG, 1 Create Way, S138602, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183034
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http://dx.doi.org/10.1016/j.jmb.2018.04.030DOI Listing
September 2018

Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.

Curr Opin Biotechnol 2018 08 12;52:116-123. Epub 2018 Apr 12.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; BioSystems and Micromechanics (BioSyM), Singapore-MIT Alliance for Research and Technology, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082713PMC
August 2018

Cell contraction induces long-ranged stress stiffening in the extracellular matrix.

Proc Natl Acad Sci U S A 2018 04 4;115(16):4075-4080. Epub 2018 Apr 4.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1722619115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910866PMC
April 2018

Engineered 3D vascular and neuronal networks in a microfluidic platform.

Sci Rep 2018 03 26;8(1):5168. Epub 2018 Mar 26.

Department of Mechanical Engineering, Massachusetts institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41598-018-23512-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979969PMC
March 2018

In Vitro Modeling of Mechanics in Cancer Metastasis.

ACS Biomater Sci Eng 2018 Feb 16;4(2):294-301. Epub 2017 May 16.

Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsbiomaterials.7b00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811931PMC
February 2018

Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration.

Proc Natl Acad Sci U S A 2018 01 2;115(3):E390-E399. Epub 2018 Jan 2.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1717230115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776995PMC
January 2018

Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis.

Biomaterials 2018 02 25;156:65-76. Epub 2017 Nov 25.

Department of Mechanical Engineering, Massachusetts Institutes of Technology, Cambridge, MA, 02139, USA; Department of Biological Engineering, Massachusetts Institutes of Technology, Cambridge, MA, 02139, USA; BioSystems and Micromechanics (BioSyM), Singapore-MIT Alliance for Research and Technology, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.11.041DOI Listing
February 2018

Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.

Nano Lett 2018 01 6;18(1):1-8. Epub 2017 Dec 6.

Department of Mechanical Sciences and Engineering, University of Illinois at Urbana-Champaign , 1206 West Green Street, Urbana, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b04982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842374PMC
January 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

In Vitro Microfluidic Models for Neurodegenerative Disorders.

Adv Healthc Mater 2018 01 7;7(2). Epub 2017 Sep 7.

Department of Mechanical Engineering, Massachusetts Institutes of Technology, 500 Technology Square MIT Building, Room NE47-321, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201700489DOI Listing
January 2018

Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.

ACS Nano 2017 06 19;11(6):5195-5214. Epub 2017 May 19.

Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University , Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.

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http://dx.doi.org/10.1021/acsnano.7b01493DOI Listing
June 2017

Integrated Analysis of Intracellular Dynamics of MenaINV Cancer Cells in a 3D Matrix.

Biophys J 2017 May;112(9):1874-1884

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425400PMC
May 2017

A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation.

Lab Chip 2017 06;17(12):2067-2075

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c6lc01568aDOI Listing
June 2017

Endothelial monolayer permeability under controlled oxygen tension.

Integr Biol (Camb) 2017 06;9(6):529-538

Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, Japan.

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http://dx.doi.org/10.1039/c7ib00068eDOI Listing
June 2017

A Facile Method to Probe the Vascular Permeability of Nanoparticles in Nanomedicine Applications.

Sci Rep 2017 03 31;7(1):707. Epub 2017 Mar 31.

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-017-00750-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429672PMC
March 2017

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics.

Nat Protoc 2017 05 30;12(5):865-880. Epub 2017 Mar 30.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2017.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509465PMC
May 2017

Advances in on-chip vascularization.

Regen Med 2017 04 20;12(3):285-302. Epub 2017 Mar 20.

Department of Mechanical Engineering, MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.2217/rme-2016-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574321PMC
April 2017

A process engineering approach to increase organoid yield.

Development 2017 03 7;144(6):1128-1136. Epub 2017 Feb 7.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA

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http://dx.doi.org/10.1242/dev.142919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358111PMC
March 2017

Morphological Transformation and Force Generation of Active Cytoskeletal Networks.

PLoS Comput Biol 2017 01 23;13(1):e1005277. Epub 2017 Jan 23.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256887PMC
January 2017

Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression.

Converg Sci Phys Oncol 2017 28;3. Epub 2017 Jul 28.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston MA 02215.

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http://dx.doi.org/10.1088/2057-1739/aa7e86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070160PMC
July 2017

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood-brain barrier.

Lab Chip 2017 01;17(3):448-459

Department of Research, National Neuroscience Institute, 20 College Road, 169856 Singapore and Neuroscience Academic Clinical Programme, Duke-NUS Medical School, 169857 Singapore. and Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore and KK Research Center, KK Women's and Children's Hospital, Singapore 229899, Singapore.

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http://dx.doi.org/10.1039/c6lc00638hDOI Listing
January 2017

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.

Biophys J 2016 Oct;111(7):1541-1552

Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052451PMC
October 2016

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment.

Sci Rep 2016 Sep 28;6:34094. Epub 2016 Sep 28.

School of Biological and Health Systems Engineering (SBHSE), Arizona State University, Tempe, Arizona 85287, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039718PMC
http://dx.doi.org/10.1038/srep34094DOI Listing
September 2016

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.

Sci Adv 2016 08 3;2(8):e1501429. Epub 2016 Aug 3.

Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.

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http://dx.doi.org/10.1126/sciadv.1501429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972469PMC
August 2016

Effects of 3D geometries on cellular gradient sensing and polarization.

Phys Biol 2016 06 25;13(3):036008. Epub 2016 Jun 25.

Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston MA 02215, USA. Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1088/1478-3975/13/3/036008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963243PMC
June 2016

Cell adhesion during bullet motion in capillaries.

Am J Physiol Heart Circ Physiol 2016 08 3;311(2):H395-403. Epub 2016 Jun 3.

Graduate School of Biomedical Engineering, Tohoku University, Aoba, Sendai, Japan; School of Engineering, Tohoku University, Aoba, Sendai, Japan;

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http://dx.doi.org/10.1152/ajpheart.00241.2016DOI Listing
August 2016

Engineering a 3D microfluidic culture platform for tumor-treating field application.

Sci Rep 2016 05 24;6:26584. Epub 2016 May 24.

Biosym IRG, Singapore-MIT Alliance for Research and Technology, 1 Create Way, 138602 Singapore, Singapore.

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http://dx.doi.org/10.1038/srep26584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877588PMC
May 2016

Microfluidic models for adoptive cell-mediated cancer immunotherapies.

Drug Discov Today 2016 09 13;21(9):1472-1478. Epub 2016 May 13.

Singapore-MIT Alliance for Research and Technology, BioSyM IRG, 1 Create Way, 138602, Singapore; Massachusetts Institute of Technology, Department of Biological Engineering, 77 Massachusetts Avenue, 02139 Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035566PMC
September 2016

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Cancer Discov 2016 06 12;6(6):630-49. Epub 2016 Apr 12.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Massachusetts Institute of Technology Ludwig Center for Molecular Oncology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918202PMC
June 2016

Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.

Cancer Res 2016 05 17;76(9):2513-24. Epub 2016 Mar 17.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873393PMC
May 2016

Optogenetic skeletal muscle-powered adaptive biological machines.

Proc Natl Acad Sci U S A 2016 Mar 14;113(13):3497-502. Epub 2016 Mar 14.

Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

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http://dx.doi.org/10.1073/pnas.1516139113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822586PMC
March 2016

Impact of the physical microenvironment on tumor progression and metastasis.

Curr Opin Biotechnol 2016 08 2;40:41-48. Epub 2016 Mar 2.

Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, United States; Howard Hughes Medical Institute, Boston University, Boston, MA 00215, United States. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2016.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975620PMC
August 2016

Microfluidics: A new tool for modeling cancer-immune interactions.

Trends Cancer 2016 Jan;2(1):6-19

Department of Mechanical Engineering, MIT, Cambridge, MA, USA; Department of Biological Engineering, MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.trecan.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743529PMC
January 2016

Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks.

Nat Commun 2016 Jan 8;7:10323. Epub 2016 Jan 8.

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1038/ncomms10323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714927PMC
January 2016

Constructive remodeling of a synthetic endothelial extracellular matrix.

Sci Rep 2015 Dec 21;5:18290. Epub 2015 Dec 21.

School of Mechanical Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea.

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http://dx.doi.org/10.1038/srep18290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685304PMC
December 2015

Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform.

Small 2016 Feb 30;12(5):612-22. Epub 2015 Nov 30.

Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/smll.201501905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752442PMC
February 2016

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment.

Oncotarget 2015 Nov;6(34):36603-14

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 138602, Singapore.

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http://dx.doi.org/10.18632/oncotarget.5464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742198PMC
November 2015

Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network.

PLoS Comput Biol 2015 Oct 5;11(10):e1004535. Epub 2015 Oct 5.

BioSystems and Micromechanics IRG, Singapore MIT Alliance for Research and Technology, Singapore; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593642PMC
October 2015

Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy.

Nat Methods 2015 Dec 5;12(12):1132-4. Epub 2015 Oct 5.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nmeth.3616
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http://dx.doi.org/10.1038/nmeth.3616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666809PMC
December 2015

Probabilistic Voxel-Fe model for single cell motility in 3D.

In Silico Cell Tissue Sci 2014 Oct;1

Aragón Institute of Engineering Research (I3A), Department of Mechanical Engineering, University of Zaragoza Campus Rio Ebro, 50018 Zaragoza, Spain.

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http://dx.doi.org/10.1186/2196-050X-1-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538854PMC
October 2014

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions.

Oncotarget 2015 Sep;6(28):25295-307

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 138602, Singapore.

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http://dx.doi.org/10.18632/oncotarget.4716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694832PMC
September 2015

Controlled electromechanical cell stimulation on-a-chip.

Sci Rep 2015 Jul 2;5:11800. Epub 2015 Jul 2.

1] Biosym IRG, Singapore-MIT Alliance for Research and Technology, Singapore [2] Department of Biological Engineering and Department of Mechanical Engineering, Massachusetts Institute of Technology, USA.

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http://dx.doi.org/10.1038/srep11800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488866PMC
July 2015

Multiscale mechanobiology: computational models for integrating molecules to multicellular systems.

Integr Biol (Camb) 2015 Oct 27;7(10):1093-108. Epub 2015 May 27.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1039/c5ib00043bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677065PMC
October 2015

Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks.

Biomech Model Mechanobiol 2015 Oct 24;14(5):1143-55. Epub 2015 Feb 24.

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, corso Duca degli Abruzzi 24, 10129, Turin, Italy.

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http://dx.doi.org/10.1007/s10237-015-0660-6DOI Listing
October 2015

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation.

Proc Natl Acad Sci U S A 2015 Jan 18;112(1):214-9. Epub 2014 Dec 18.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://www.pnas.org/lookup/doi/10.1073/pnas.1417115112
Publisher Site
http://dx.doi.org/10.1073/pnas.1417115112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291627PMC
January 2015

Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments.

PLoS Comput Biol 2014 Nov 20;10(11):e1003959. Epub 2014 Nov 20.

Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pcbi.1003959
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http://dx.doi.org/10.1371/journal.pcbi.1003959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238946PMC
November 2014

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs.

Lab Chip 2015 Jan;15(1):301-10

Departments of Biological Engineering and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c4lc00866aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311754PMC
January 2015