Roger D Cone

Roger D Cone

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Roger D Cone

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Obesity-associated mutant melanocortin-4 receptors with normal Gα coupling frequently exhibit other discoverable pharmacological and biochemical defects.

J Neuroendocrinol 2019 Oct 15;31(10):e12795. Epub 2019 Oct 15.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1111/jne.12795DOI Listing
October 2019

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Authors:
Hunna J Watson Zeynep Yilmaz Laura M Thornton Christopher Hübel Jonathan R I Coleman Héléna A Gaspar Julien Bryois Anke Hinney Virpi M Leppä Manuel Mattheisen Sarah E Medland Stephan Ripke Shuyang Yao Paola Giusti-Rodríguez Ken B Hanscombe Kirstin L Purves Roger A H Adan Lars Alfredsson Tetsuya Ando Ole A Andreassen Jessica H Baker Wade H Berrettini Ilka Boehm Claudette Boni Vesna Boraska Perica Katharina Buehren Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Roger D Cone Philippe Courtet Scott Crow James J Crowley Unna N Danner Oliver S P Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E DeSocio Danielle M Dick Dimitris Dikeos Christian Dina Monika Dmitrzak-Weglarz Elisa Docampo Laramie E Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández-Aranda Manfred M Fichter Krista Fischer Manuel Föcker Lenka Foretova Andreas J Forstner Monica Forzan Christopher S Franklin Steven Gallinger Ina Giegling Johanna Giuranna Fragiskos Gonidakis Philip Gorwood Monica Gratacos Mayora Sébastien Guillaume Yiran Guo Hakon Hakonarson Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G Helder Stefan Herms Beate Herpertz-Dahlmann Wolfgang Herzog Laura M Huckins James I Hudson Hartmut Imgart Hidetoshi Inoko Vladimir Janout Susana Jiménez-Murcia Antonio Julià Gursharan Kalsi Deborah Kaminská Jaakko Kaprio Leila Karhunen Andreas Karwautz Martien J H Kas James L Kennedy Anna Keski-Rahkonen Kirsty Kiezebrink Youl-Ri Kim Lars Klareskog Kelly L Klump Gun Peggy S Knudsen Maria C La Via Stephanie Le Hellard Robert D Levitan Dong Li Lisa Lilenfeld Bochao Danae Lin Jolanta Lissowska Jurjen Luykx Pierre J Magistretti Mario Maj Katrin Mannik Sara Marsal Christian R Marshall Morten Mattingsdal Sara McDevitt Peter McGuffin Andres Metspalu Ingrid Meulenbelt Nadia Micali Karen Mitchell Alessio Maria Monteleone Palmiero Monteleone Melissa A Munn-Chernoff Benedetta Nacmias Marie Navratilova Ioanna Ntalla Julie K O'Toole Roel A Ophoff Leonid Padyukov Aarno Palotie Jacques Pantel Hana Papezova Dalila Pinto Raquel Rabionet Anu Raevuori Nicolas Ramoz Ted Reichborn-Kjennerud Valdo Ricca Samuli Ripatti Franziska Ritschel Marion Roberts Alessandro Rotondo Dan Rujescu Filip Rybakowski Paolo Santonastaso André Scherag Stephen W Scherer Ulrike Schmidt Nicholas J Schork Alexandra Schosser Jochen Seitz Lenka Slachtova P Eline Slagboom Margarita C T Slof-Op 't Landt Agnieszka Slopien Sandro Sorbi Beata Świątkowska Jin P Szatkiewicz Ioanna Tachmazidou Elena Tenconi Alfonso Tortorella Federica Tozzi Janet Treasure Artemis Tsitsika Marta Tyszkiewicz-Nwafor Konstantinos Tziouvas Annemarie A van Elburg Eric F van Furth Gudrun Wagner Esther Walton Elisabeth Widen Eleftheria Zeggini Stephanie Zerwas Stephan Zipfel Andrew W Bergen Joseph M Boden Harry Brandt Steven Crawford Katherine A Halmi L John Horwood Craig Johnson Allan S Kaplan Walter H Kaye James E Mitchell Catherine M Olsen John F Pearson Nancy L Pedersen Michael Strober Thomas Werge David C Whiteman D Blake Woodside Garret D Stuber Scott Gordon Jakob Grove Anjali K Henders Anders Juréus Katherine M Kirk Janne T Larsen Richard Parker Liselotte Petersen Jennifer Jordan Martin Kennedy Grant W Montgomery Tracey D Wade Andreas Birgegård Paul Lichtenstein Claes Norring Mikael Landén Nicholas G Martin Preben Bo Mortensen Patrick F Sullivan Gerome Breen Cynthia M Bulik

Nat Genet 2019 Aug 15;51(8):1207-1214. Epub 2019 Jul 15.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41588-019-0439-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779477PMC
August 2019

Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System.

Curr Biol 2019 Jun 6;29(12):2009-2019.e7. Epub 2019 Jun 6.

School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, 6997801 Tel Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, 6997801 Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.05.021DOI Listing
June 2019

G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1.

J Biol Chem 2018 11 26;293(46):17739-17753. Epub 2018 Sep 26.

From the Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232,

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http://dx.doi.org/10.1074/jbc.RA118.003238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240878PMC
November 2018

Regulation of energy rheostasis by the melanocortin-3 receptor.

Sci Adv 2018 08 22;4(8):eaat0866. Epub 2018 Aug 22.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1126/sciadv.aat0866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105298PMC
August 2018

Characterization of MC4R Regulation of the Kir7.1 Channel Using the Tl Flux Assay.

Methods Mol Biol 2018 ;1684:211-222

Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/978-1-4939-7362-0_16DOI Listing
July 2018

Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.

Elife 2017 08 22;6. Epub 2017 Aug 22.

Departments of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.

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http://dx.doi.org/10.7554/eLife.28118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577919PMC
August 2017

Functional variants of the melanocortin-4 receptor associated with the Odontoceti and Mysticeti suborders of cetaceans.

Sci Rep 2017 07 18;7(1):5684. Epub 2017 Jul 18.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1038/s41598-017-05962-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515947PMC
July 2017

Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish.

Sci Rep 2017 03 20;7:44777. Epub 2017 Mar 20.

Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1038/srep44777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357965PMC
March 2017

Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach.

Horm Behav 2016 06 5;82:87-100. Epub 2016 May 5.

Control of Food Intake Group, Department of Fish Physiolgy and Biotechnology, Instituto de Acuicultura de Torre de la Sal (IATS-CSIC), Castellón, Spain, 12595. Electronic address:

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http://dx.doi.org/10.1016/j.yhbeh.2016.04.011DOI Listing
June 2016

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.

J Mol Endocrinol 2016 05 3;56(4):T157-74. Epub 2016 Mar 3.

Department of Molecular Physiology and BiophysicsVanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1530/JME-16-0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027135PMC
May 2016

Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.

Proc Natl Acad Sci U S A 2016 Mar 22;113(11):3084-9. Epub 2016 Feb 22.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232

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http://dx.doi.org/10.1073/pnas.1513212113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801292PMC
March 2016

Regulation of orexigenic AgRP neurons: A third way?

Trends Endocrinol Metab 2015 Jul 29;26(7):339-40. Epub 2015 May 29.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.tem.2015.05.008DOI Listing
July 2015

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.

J Clin Endocrinol Metab 2015 Apr 12;100(4):1639-45. Epub 2015 Feb 12.

Diabetes, Endocrinology, and Obesity Branch (K.Y.C., R.M., B.S.A., K.P.M., P.S., R.J.B., X.Z., M.R., T.L.P., M.L.R., M.C.S.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Department of Molecular Physiology and Biophysics (R.D.C., B.L.P.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232; and Rhythm Pharmaceuticals (K.M.G., L.H.T.V.d.P.), Boston, Massachusetts 02116.

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http://rhythmpharmaceutical.com/pdfs/Chen%202015%20JCEM.pdf
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http://press.endocrine.org/doi/10.1210/jc.2014-4024
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http://dx.doi.org/10.1210/jc.2014-4024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399297PMC
April 2015

Neuroscience: a cellular basis for the munchies.

Nature 2015 Mar 18;519(7541):38-40. Epub 2015 Feb 18.

Vanderbilt University Medical Center, Department of Molecular Physiology and Biophysics, Nashville, Tennessee 37232-0615, USA.

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http://dx.doi.org/10.1038/nature14206DOI Listing
March 2015

Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.

Endocrinology 2014 May 26;155(5):1718-27. Epub 2014 Feb 26.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0165.

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http://dx.doi.org/10.1210/en.2013-2049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990839PMC
May 2014

Development of an assay for high-throughput energy expenditure monitoring in the zebrafish.

Zebrafish 2013 Sep 25;10(3):343-52. Epub 2013 May 25.

Department of Animal Science, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1089/zeb.2012.0841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806375PMC
September 2013

Zebrafish ghrelin is expressed in pancreatic endocrine cells and regulated by metabolic state.

Biochem Biophys Res Commun 2013 Sep 13;439(1):115-20. Epub 2013 Aug 13.

Department of Biomedical Sciences, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2013.08.017DOI Listing
September 2013

Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.

Science 2013 Jul;341(6143):278-81

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1126/science.1232995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255277PMC
July 2013

QnAs with Roger D. Cone.

Authors:
Roger D Cone

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9618. Epub 2013 May 28.

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http://dx.doi.org/10.1073/pnas.1308417110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683786PMC
June 2013

Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.

Proc Natl Acad Sci U S A 2013 Apr 8;110(17):7050-5. Epub 2013 Apr 8.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.1304707110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637712PMC
April 2013

Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

J Clin Endocrinol Metab 2012 Jun 6;97(6):E1023-31. Epub 2012 Apr 6.

Massachusetts General Hospital, 149 13th Street, Room 8219, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1210/jc.2011-3432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387412PMC
June 2012

Melanocortin-3 receptor regulates the normal fasting response.

Proc Natl Acad Sci U S A 2012 Jun 9;109(23):E1489-98. Epub 2012 May 9.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.1201994109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384161PMC
June 2012

AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.

Cell Metab 2012 Feb 12;15(2):256-64. Epub 2012 Jan 12.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332529PMC
February 2012

Leptin grows up and gets a neural network.

Neuron 2011 Jul;71(1):4-6

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37205, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175484PMC
July 2011

Physiological roles of the melanocortin MC₃ receptor.

Eur J Pharmacol 2011 Jun 3;660(1):13-20. Epub 2011 Jan 3.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.ejphar.2010.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095771PMC
June 2011

Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Eur J Pharmacol 2011 Jun 4;660(1):139-47. Epub 2011 Feb 4.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.ejphar.2011.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175485PMC
June 2011

Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.

Endocrinology 2011 Mar 14;152(3):890-902. Epub 2011 Jan 14.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, Thailand.

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http://dx.doi.org/10.1210/en.2010-0716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040060PMC
March 2011

Shining a light on energy homeostasis.

Cell Metab 2011 Mar;13(3):235-6

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073614PMC
March 2011

Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.

Proc Natl Acad Sci U S A 2011 Jan 15;108(1):355-60. Epub 2010 Dec 15.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.

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http://dx.doi.org/10.1073/pnas.1016785108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017160PMC
January 2011

Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.

Mol Endocrinol 2010 Dec 13;24(12):2366-81. Epub 2010 Oct 13.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1210/me.2010-0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999480PMC
December 2010

Pineal-specific agouti protein regulates teleost background adaptation.

Proc Natl Acad Sci U S A 2010 Nov 27;107(47):20164-71. Epub 2010 Oct 27.

Department of Molecular Physiology and Biophysics, The Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1014941107
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http://dx.doi.org/10.1073/pnas.1014941107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996689PMC
November 2010

Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.

Endocrinology 2010 May 26;151(5):2200-10. Epub 2010 Feb 26.

Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan.

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http://dx.doi.org/10.1210/en.2009-1153DOI Listing
May 2010

Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.

Endocrine 2009 Jun 11;35(3):312-24. Epub 2009 Apr 11.

The Center for the Study of Weight Regulation and Associated Disorders and The Vollum Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1007/s12020-008-9141-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714906PMC
June 2009

The melanocortin-3 receptor is required for entrainment to meal intake.

J Neurosci 2008 Nov;28(48):12946-55

Neuropeptides Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3615-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613653PMC
November 2008

Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling.

Endocrinology 2007 Dec 27;148(12):6186-94. Epub 2007 Sep 27.

Center for the Study of Weight Regulation and Associated Disorders (L481), Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1210/en.2007-0699DOI Listing
December 2007

Conserved neurochemical pathways involved in hypothalamic control of energy homeostasis.

J Comp Neurol 2007 Nov;505(3):235-48

Center for the Study of Weight Regulation and Associated Disorders and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1002/cne.21447DOI Listing
November 2007

Creation of a genetic model of obesity in a teleost.

FASEB J 2007 Jul 6;21(9):2042-9. Epub 2007 Mar 6.

Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1096/fj.06-7503comDOI Listing
July 2007

Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue.

Endocrinology 2007 Apr 28;148(4):1550-60. Epub 2006 Dec 28.

Center for the Study of Weight Regulation and Associated Disorders and Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239-3098, and Division of Endocrinology, Rhode Island Hospital, Providence 02903, USA.

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http://dx.doi.org/10.1210/en.2006-1389DOI Listing
April 2007

Studies on the physiological functions of the melanocortin system.

Authors:
Roger D Cone

Endocr Rev 2006 Dec 31;27(7):736-49. Epub 2006 Oct 31.

Center for the Study of Weight Regulation and Associated Disorders, and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1210/er.2006-0034DOI Listing
December 2006

Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones.

J Hypertens 2006 Nov;24(11):2239-46

Division of Nephrology, San Francisco General Hospital and University of California San Francisco, San Francisco, California 94143-1341, USA.

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http://dx.doi.org/10.1097/01.hjh.0000249702.49854.faDOI Listing
November 2006

Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia.

Nat Clin Pract Nephrol 2006 Sep;2(9):527-34

Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://www.nature.com/articles/ncpneph0273
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http://dx.doi.org/10.1038/ncpneph0273DOI Listing
September 2006

Characterization of leptin-responsive neurons in the caudal brainstem.

Endocrinology 2006 Jul 6;147(7):3190-5. Epub 2006 Apr 6.

Center for the Study of Weight Regulation and Associated Disorders and Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, 97239-3098, USA.

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http://dx.doi.org/10.1210/en.2005-0877DOI Listing
July 2006

The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models.

Philos Trans R Soc Lond B Biol Sci 2006 Jul;361(1471):1265-74

Vollum Institute and The Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, 97239, USA.

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http://dx.doi.org/10.1098/rstb.2006.1861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1642695PMC
July 2006

Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression.

Behav Genet 2006 Mar 12;36(2):291-300. Epub 2006 Jan 12.

Vollum Institute for Advanced Biomedical Research, Oregon Health and Science University, Portland, 97239, USA.

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http://link.springer.com/10.1007/s10519-005-9024-9
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http://dx.doi.org/10.1007/s10519-005-9024-9DOI Listing
March 2006

The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R).

Peptides 2006 Feb 4;27(2):259-64. Epub 2005 Nov 4.

Department of Pediatric Endocrinology, Oregon Health & Sciences University, Portland, OR 97201, USA.

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http://dx.doi.org/10.1016/j.peptides.2005.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679957PMC
February 2006

Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis.

Peptides 2006 Feb 22;27(2):340-9. Epub 2005 Nov 22.

Vollum Institute and The Center for Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1016/j.peptides.2005.02.031DOI Listing
February 2006

PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors.

Cell Metab 2005 Sep;2(3):191-9

Vollum Institute and Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041310500231
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http://dx.doi.org/10.1016/j.cmet.2005.08.003DOI Listing
September 2005

Role of leptin and melanocortin signaling in uremia-associated cachexia.

J Clin Invest 2005 Jun;115(6):1659-65

Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1172/JCI22521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136984PMC
June 2005

Anatomy and regulation of the central melanocortin system.

Authors:
Roger D Cone

Nat Neurosci 2005 May;8(5):571-8

Vollum Institute and the Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1038/nn1455DOI Listing
May 2005

Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons.

Endocrinology 2005 Mar 9;146(3):1043-7. Epub 2004 Dec 9.

Vollum Institute and The Center for the Study of Weight Regulation and Associated Disorders, Oregon Health & Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1210/en.2004-1397DOI Listing
March 2005

Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease.

Pediatr Nephrol 2005 Mar 21;20(3):427-31. Epub 2005 Jan 21.

Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC5, Portland, OR, 97239, USA.

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http://dx.doi.org/10.1007/s00467-004-1789-1DOI Listing
March 2005

Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.

Cell Metab 2005 Mar;1(3):159-68

Vollum Institute and Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.02.003DOI Listing
March 2005

Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse.

Endocrinology 2004 Nov 15;145(11):4816-21. Epub 2004 Jul 15.

Ph.D, Professor of Medicine, Division of Endocrinology, Box No. 268, Tufts-New England Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1210/en.2004-0476DOI Listing
November 2004

Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.

Endocrinology 2004 Jun 11;145(6):2585-90. Epub 2004 Mar 11.

Ph.D, Vollum Institute, Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1210/en.2003-1754DOI Listing
June 2004

The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis.

Recent Prog Horm Res 2004 ;59:395-408

Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1210/rp.59.1.395DOI Listing
April 2004

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.

Nat Neurosci 2004 Apr 14;7(4):335-6. Epub 2004 Mar 14.

Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1038/nn1214DOI Listing
April 2004

Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

Am J Med Genet A 2004 Apr;126A(3):267-71

Department of Pediatrics, Oregon Health & Science University, Portland, USA.

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http://dx.doi.org/10.1002/ajmg.a.20600DOI Listing
April 2004

De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.

J Med Chem 2004 Mar;47(6):1514-26

Departments of Chemistry and Anatomy, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/jm030452xDOI Listing
March 2004

Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis.

Brain Res 2004 Mar;1000(1-2):64-71

Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Mail Code: L474, Portland, OR 97201, USA.

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http://dx.doi.org/10.1016/j.brainres.2003.10.041DOI Listing
March 2004

Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice.

Chem Senses 2004 Feb;29(2):111-5

Vollum Institute for Advanced Biomedical Research, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1093/chemse/bjh011DOI Listing
February 2004

The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator.

Endocrinology 2004 Jan 25;145(1):184-93. Epub 2003 Sep 25.

Vollum Institute, Oregon Health and Science University, Portland Oregon 97239, USA.

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http://dx.doi.org/10.1210/en.2003-0337DOI Listing
January 2004

Melanocortin-5 receptor deficiency promotes defensive behavior in male mice.

Horm Behav 2004 Jan;45(1):58-63

Vollum Institute for Advanced Biomedical Research, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.yhbeh.2003.08.004DOI Listing
January 2004

Agouti-related protein (AGRP) is conserved and regulated by metabolic state in the zebrafish, Danio rerio.

Endocrine 2003 Dec;22(3):257-65

Vollum Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA.

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http://link.springer.com/10.1385/ENDO:22:3:257
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http://dx.doi.org/10.1385/ENDO:22:3:257DOI Listing
December 2003

Pheromone-induced anorexia in male Syrian hamsters.

Am J Physiol Endocrinol Metab 2003 Nov 29;285(5):E1028-38. Epub 2003 Jul 29.

Vollum Institute for Advanced Biomedical Research and Oregon National Primate Research Center, Oregon Health and Science University, Portland, USA.

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http://dx.doi.org/10.1152/ajpendo.00010.2003DOI Listing
November 2003

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.

Nat Neurosci 2003 Jul;6(7):736-42

Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nn1073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710100PMC
July 2003

Central serotonin and melanocortin pathways regulating energy homeostasis.

Ann N Y Acad Sci 2003 Jun;994:169-74

Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb03177.xDOI Listing
June 2003

Electrophysiological actions of peripheral hormones on melanocortin neurons.

Ann N Y Acad Sci 2003 Jun;994:175-86

Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb03178.xDOI Listing
June 2003

Knockout studies defining different roles for melanocortin receptors in energy homeostasis.

Ann N Y Acad Sci 2003 Jun;994:240-5

Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb03186.xDOI Listing
June 2003

The role of the melanocortin-3 receptor in cachexia.

Ann N Y Acad Sci 2003 Jun;994:258-66

Department of Pediatric Endocrinology, Oregon Health and Sciences University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb03188.xDOI Listing
June 2003

A role for the endogenous opioid beta-endorphin in energy homeostasis.

Endocrinology 2003 May;144(5):1753-60

Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1210/en.2002-221096DOI Listing
May 2003

Differential role of melanocortin receptor subtypes in cachexia.

Endocrinology 2003 Apr;144(4):1513-23

Department of Pediatric Endocrinology, Oregon Health and Science University, Portland, Oregon 97201, USA.

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http://dx.doi.org/10.1210/en.2002-221099DOI Listing
April 2003

Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.

J Clin Invest 2003 Apr;111(8):1251-8

Division of Nephrology, San Francisco General Hospital, University of California-San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1172/JCI16993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152936PMC
April 2003

Gut hormone PYY(3-36) physiologically inhibits food intake.

Nature 2002 Aug;418(6898):650-4

Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/nature00887DOI Listing
August 2002

Activation of central melanocortin pathways by fenfluramine.

Science 2002 Jul;297(5581):609-11

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1072327
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http://dx.doi.org/10.1126/science.1072327DOI Listing
July 2002