Publications by authors named "Roger B Cohen"

100Publications

Increased rate of recurrence and high rate of salvage in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma with adverse features treated with primary surgery without recommended adjuvant therapy.

Authors:
Ryan M Carey David Shimunov Gregory S Weinstein Steven B Cannady John N Lukens Alexander Lin Samuel Swisher-McClure Joshua M Bauml Charu Aggarwal Roger B Cohen Jason G Newman Ara A Chalian Christopher H Rassekh Devraj Basu Bert W O'Malley Karthik Rajasekaran Robert M Brody

Head Neck 2020 Dec 16. Epub 2020 Dec 16.

Department of Otorhinolaryngology - Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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December 2020

Outcomes in Patients With Non-small-cell Lung Cancer With Brain Metastases Treated With Pembrolizumab-based Therapy.

Authors:
Lova Sun Christiana W Davis Wei-Ting Hwang Seth Jeffries Lydia Frenzel Sulyok Melina E Marmarelis Aditi P Singh Abigail T Berman Steven J Feigenberg William Levin Christine A Ciunci Joshua M Bauml Roger B Cohen Corey J Langer Charu Aggarwal

Clin Lung Cancer 2021 Jan 11;22(1):58-66.e3. Epub 2020 Nov 11.

Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA. Electronic address:

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January 2021

Oncologic Outcomes Following Transoral Robotic Surgery for Human Papillomavirus-Associated Oropharyngeal Carcinoma in Older Patients.

Authors:
Harman S Parhar David Shimunov Jason G Newman Steven B Cannady Karthik Rajasekaran Bert W O' Malley Ara A Chalian Christopher H Rassekh Roger B Cohen Alexander Lin John Lukens Samuel Swisher-McClure Joshua Bauml Charu Aggarwal Gregory S Weinstein Robert M Brody

JAMA Otolaryngol Head Neck Surg 2020 Dec;146(12):1167-1175

Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania, Philadelphia.

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December 2020

Bayesian approach to interpreting somatic cancer sequencing data: a case in point.

Authors:
Ju-Yoon Yoon Jason N Rosenbaum Norge Vergara Roger B Cohen Robert B Wilson

J Clin Pathol 2020 Aug 27. Epub 2020 Aug 27.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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August 2020

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models.

Authors:
Nicole D Facompre Pavithra Rajagopalan Varun Sahu Alexander T Pearson Kathleen T Montone Claire D James Frederico O Gleber-Netto Gregory S Weinstein Jalal Jalaly Alexander Lin Anil K Rustgi Hiroshi Nakagawa Joseph A Califano Curtis R Pickering Elizabeth A White Bradford E Windle Iain M Morgan Roger B Cohen Phyllis A Gimotty Devraj Basu

Int J Cancer 2020 Dec 6;147(11):3236-3249. Epub 2020 Jul 6.

Department of Otorhinolaryngology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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December 2020

Management of Lung Cancer During the COVID-19 Pandemic.

Authors:
Aditi P Singh Abigail T Berman Melina E Marmarelis Andrew R Haas Steven J Feigenberg Jennifer Braun Christine A Ciunci Joshua M Bauml Roger B Cohen John C Kucharczuk Lawrence N Shulman Corey J Langer Charu Aggarwal

JCO Oncol Pract 2020 Sep 26;16(9):579-586. Epub 2020 May 26.

Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

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September 2020

Pembrolizumab for the treatment of programmed death-ligand 1-positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE-028 study.

Authors:
Janice M Mehnert Emily Bergsland Bert H O'Neil Armando Santoro Jan H M Schellens Roger B Cohen Toshihiko Doi Patrick A Ott Michael J Pishvaian Igor Puzanov Kyaw L Aung Chiun Hsu Christophe Le Tourneau Antoine Hollebecque Elena Élez Kenji Tamura Marlena Gould Ping Yang Karen Stein Sarina A Piha-Paul

Cancer 2020 Jul 22;126(13):3021-3030. Epub 2020 Apr 22.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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July 2020

Care of immunocompromised patients with head and neck cancer during the COVID-19 pandemic: Two challenging and informative clinical cases.

Authors:
Alyssa M Civantos Ryan M Carey Gary R Lichtenstein John N Lukens Roger B Cohen Christopher H Rassekh

Head Neck 2020 06 22;42(6):1131-1136. Epub 2020 Apr 22.

Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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June 2020

Baseline Plasma Tumor Mutation Burden Predicts Response to Pembrolizumab-based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.

Authors:
Charu Aggarwal Jeffrey C Thompson Austin L Chien Katie J Quinn Wei-Ting Hwang Taylor A Black Stephanie S Yee Theresa E Christensen Michael J LaRiviere Benjamin A Silva Kimberly C Banks Rebecca J Nagy Elena Helman Abigail T Berman Christine A Ciunci Aditi P Singh Jeffrey S Wasser Joshua M Bauml Corey J Langer Roger B Cohen Erica L Carpenter

Clin Cancer Res 2020 05 26;26(10):2354-2361. Epub 2020 Feb 26.

Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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May 2020

Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis.

Authors:
Charu Aggarwal Roger B Cohen Matthew P Morrow Kimberly A Kraynyak Albert J Sylvester Jocelyn Cheung Kelsie Dickerson Veronique Schulten Dawson Knoblock Elisabeth Gillespie Joshua M Bauml Jian Yan Malissa Diehl Jean Boyer Michael Dallas J Joseph Kim David B Weiner Jeffrey M Skolnik

Vaccines (Basel) 2020 Jan 29;8(1). Epub 2020 Jan 29.

Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA.

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January 2020

A Phase 2 Trial of Alternative Volumes of Oropharyngeal Irradiation for De-intensification (AVOID): Omission of the Resected Primary Tumor Bed After Transoral Robotic Surgery for Human Papilloma Virus-Related Squamous Cell Carcinoma of the Oropharynx.

Authors:
Samuel Swisher-McClure John N Lukens Charu Aggarwal Peter Ahn Devraj Basu Joshua M Bauml Robert Brody Ara Chalian Roger B Cohen Alireza Fotouhi-Ghiam Geoffrey Geiger Jared Gershowitz Virginia Livolsi Nandita Mitra Kathleen Montone Jason Newman Eric Ojerholm Bert O'Malley Karthik Rajasekaran Erik Tan Gregory Weinstein Alexander Lin

Int J Radiat Oncol Biol Phys 2020 03 27;106(4):725-732. Epub 2019 Nov 27.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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March 2020

Quality of Life of Postoperative Photon versus Proton Radiation Therapy for Oropharynx Cancer.

Authors:
Sonam Sharma Olivia Zhou Reid Thompson Peter Gabriel Ara Chalian Christopher Rassekh Gregory S Weinstein Bert W O'Malley Charu Aggarwal Joshua Bauml Roger B Cohen J Nicholas Lukens Samuel Swisher-McClure Alireza F Ghiam Peter H Ahn Alexander Lin

Int J Part Ther 2018 30;5(2):11-17. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

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November 2018

Early Tumor and Nodal Response in Patients with Locally Advanced Non-Small Cell Lung Carcinoma Predict for Oncologic Outcomes in Patients Treated with Concurrent Proton Therapy and Chemotherapy.

Authors:
Amardeep S Grewal Eun Jeong Min Qi Long Sharonjit K Grewal Varsha Jain William P Levin Keith A Cengel Samuel Swisher-McClure Charu Aggarwal Joshua M Bauml Aditi Singh Christine Ciunci Roger B Cohen Corey Langer Steven J Feigenberg Abigail T Berman

Int J Radiat Oncol Biol Phys 2020 02 22;106(2):358-368. Epub 2019 Oct 22.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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February 2020

Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer.

Authors:
Jared Gershowitz Hann-Hsiang Chao Abigail Doucette John N Lukens Samuel Swisher-McClure Gregory S Weinstein Bert W O'Malley Ara A Chalian Christopher H Rassekh Jason G Newman Roger B Cohen Joshua M Bauml Charu Aggarwal Alexander Lin

Br J Radiol 2019 Dec 15;92(1104):20190466. Epub 2019 Oct 15.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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December 2019

Immunotherapy for head and neck cancer: where are we now and where are we going?

Authors:
Joshua M Bauml Charu Aggarwal Roger B Cohen

Ann Transl Med 2019 Jul;7(Suppl 3):S75

Division of Hematology Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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July 2019

Impact of and Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With -Mutated Advanced Non-Small-Cell Lung Cancer.

Authors:
Erin Bange Melina E Marmarelis Wei-Ting Hwang Yu-Xiao Yang Jeffrey C Thompson Jason Rosenbaum Joshua M Bauml Christine Ciunci Evan W Alley Roger B Cohen Corey J Langer Erica Carpenter Charu Aggarwal

JCO Precis Oncol 2019 10;3. Epub 2019 May 10.

University of Pennsylvania, Philadelphia, PA.

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May 2019

The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation.

Authors:
Hann-Hsiang Chao Caitlin A Schonewolf Erik X Tan Samuel Swisher-McClure Alireza F Ghiam Gregory S Weinstein Bert W O'Malley Ara A Chalian Christopher H Rassekh Jason G Newman Roger B Cohen Joshua M Bauml Charu Aggarwal Alexander Lin John N Lukens

Head Neck 2019 11 14;41(11):3858-3868. Epub 2019 Aug 14.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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November 2019

Treatment and Outcomes of Oropharyngeal Cancer in People with Human Immunodeficiency Virus.

Authors:
Cristina E Brickman Kathleen J Propert Jessica S Merlin Jeffrey C Liu Sequoya Eady Amy Mcghee-Jez Camille Ragin Surbhi Grover Roger B Cohen Robert Gross

AIDS Res Hum Retroviruses 2019 10 29;35(10):934-940. Epub 2019 Aug 29.

Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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October 2019

Lung Cancer-Related Mortality With Inhaled Insulin or a Comparator: Follow-Up Study of patients previously enrolled in Exubera Controlled Clinical Trials (FUSE) Final Results.

Authors:
Nicolle M Gatto Daniel O Koralek Michael B Bracken William T Duggan Joanna Lem Sol Klioze Gary G Koch Robert A Wise Roger B Cohen Neville C Jackson

Diabetes Care 2019 09 22;42(9):1708-1715. Epub 2019 Jul 22.

Global Product Development, Pfizer, Groton, CT.

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September 2019

What if Acupuncture Were Covered by Insurance for Pain Management? A Cross-Sectional Study of Cancer Patients at One Academic Center and 11 Community Hospitals.

Authors:
Kevin T Liou Tony K W Hung Salimah H Meghani Andrew S Epstein Q Susan Li Sally A D Romero Roger B Cohen Jun J Mao

Pain Med 2019 10;20(10):2060-2068

Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.

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October 2019

Pembrolizumab After Completion of Locally Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer: A Phase 2 Trial.

Authors:
Joshua M Bauml Rosemarie Mick Christine Ciunci Charu Aggarwal Christiana Davis Tracey Evans Charuhas Deshpande Linda Miller Pooja Patel Evan Alley Christina Knepley Faith Mutale Roger B Cohen Corey J Langer

JAMA Oncol 2019 Jul 11. Epub 2019 Jul 11.

Abramson Cancer Center, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia.

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July 2019

Comparative Effectiveness of Carboplatin/Pemetrexed With Versus Without Bevacizumab for Advanced Nonsquamous Non-Small Cell Lung Cancer.

Authors:
Stephen J Bagley Suzanna Talento Nandita Mitra Neal J Meropol Roger B Cohen Corey J Langer Anil Vachani

J Natl Compr Canc Netw 2019 05;17(5):469-477

Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, and.

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May 2019

Targeting HER2/neu Oncogene Overexpression With Ado-Trastuzumab Emtansine in the Treatment of Metastatic Salivary Gland Neoplasms: A Single-Institution Experience.

Authors:
Brandon L Swed Roger B Cohen Charu Aggarwal

JCO Precis Oncol 2019 15;3. Epub 2019 Feb 15.

University of Pennsylvania, Philadelphia, PA.

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February 2019

First-in-Human Phase I Study of Merestinib, an Oral Multikinase Inhibitor, in Patients with Advanced Cancer.

Authors:
Aiwu Ruth He Roger B Cohen Crystal S Denlinger Ashwin Sama Ariel Birnbaum Jimmy Hwang Takami Sato Nancy Lewis Michelle Mynderse Michele Niland Jennifer Giles Johan Wallin Brian Moser Wei Zhang Richard Walgren Elizabeth R Plimack

Oncologist 2019 09 4;24(9):e930-e942. Epub 2019 Mar 4.

Department of Hematology/Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania, USA.

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September 2019

Influence of Mutation on Survival in Patients With Advanced -Mutant Non-Small-Cell Lung Cancer.

Authors:
Charu Aggarwal Christiana W Davis Rosemarie Mick Jeffrey C Thompson Saman Ahmed Seth Jeffries Stephen Bagley Peter Gabriel Tracey L Evans Joshua M Bauml Christine Ciunci Evan Alley Jennifer J D Morrissette Roger B Cohen Erica L Carpenter Corey J Langer

JCO Precis Oncol 2018 31;2018. Epub 2018 Aug 31.

University of Pennsylvania, Philadelphia, PA.

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August 2018

T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.

Authors:
Patrick A Ott Yung-Jue Bang Sarina A Piha-Paul Albiruni R Abdul Razak Jaafar Bennouna Jean-Charles Soria Hope S Rugo Roger B Cohen Bert H O'Neil Janice M Mehnert Juanita Lopez Toshihiko Doi Emilie M J van Brummelen Razvan Cristescu Ping Yang Kenneth Emancipator Karen Stein Mark Ayers Andrew K Joe Jared K Lunceford

J Clin Oncol 2019 02 13;37(4):318-327. Epub 2018 Dec 13.

Merck & Co., Inc., Kenilworth, NJ.

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February 2019

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

Authors:
Pascale André Caroline Denis Caroline Soulas Clarisse Bourbon-Caillet Julie Lopez Thomas Arnoux Mathieu Bléry Cécile Bonnafous Laurent Gauthier Ariane Morel Benjamin Rossi Romain Remark Violette Breso Elodie Bonnet Guillaume Habif Sophie Guia Ana Ines Lalanne Caroline Hoffmann Olivier Lantz Jérôme Fayette Agnès Boyer-Chammard Robert Zerbib Pierre Dodion Hormas Ghadially Maria Jure-Kunkel Yannis Morel Ronald Herbst Emilie Narni-Mancinelli Roger B Cohen Eric Vivier

Cell 2018 12 29;175(7):1731-1743.e13. Epub 2018 Nov 29.

Innate Pharma, 117 Avenue de Luminy, 13009 Marseille, France; Aix Marseille Université, INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, 13009 Marseille, France; Service d'Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 13005 Marseille, France. Electronic address:

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December 2018

Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of Veterans Health Affairs data.

Authors:
Joshua M Bauml Ravi Vinnakota Yeun-Hee Anna Park Susan E Bates Tito Fojo Charu Aggarwal Jessica Di Stefano Christina Knepley Sewanti Limaye Ronac Mamtani Juan Wisnivesky Nevena Damjanov Corey J Langer Roger B Cohen Keith Sigel

Cancer 2019 02 20;125(3):406-415. Epub 2018 Oct 20.

James J. Peters Veterans Affairs Medical Center, Bronx, New York.

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February 2019

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer.

Authors:
Charu Aggarwal Jeffrey C Thompson Taylor A Black Sharyn I Katz Ryan Fan Stephanie S Yee Austin L Chien Tracey L Evans Joshua M Bauml Evan W Alley Christine A Ciunci Abigail T Berman Roger B Cohen David B Lieberman Krishna S Majmundar Samantha L Savitch Jennifer J D Morrissette Wei-Ting Hwang Kojo S J Elenitoba-Johnson Corey J Langer Erica L Carpenter

JAMA Oncol 2019 02;5(2):173-180

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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February 2019

Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer.

Authors:
Charu Aggarwal Roger B Cohen Matthew P Morrow Kimberly A Kraynyak Albert J Sylvester Dawson M Knoblock Joshua M Bauml Gregory S Weinstein Alexander Lin Jean Boyer Lindsay Sakata Sophie Tan Aubrey Anton Kelsie Dickerson Drishty Mangrolia Russell Vang Michael Dallas Sandra Oyola Susan Duff Mark Esser Rakesh Kumar David Weiner Ildiko Csiki Mark L Bagarazzi

Clin Cancer Res 2019 01 21;25(1):110-124. Epub 2018 Sep 21.

Inovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania.

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January 2019

Cisplatin Every 3 Weeks Versus Weekly With Definitive Concurrent Radiotherapy for Squamous Cell Carcinoma of the Head and Neck.

Authors:
Joshua M Bauml Ravi Vinnakota Yeun-Hee Anna Park Susan E Bates Tito Fojo Charu Aggarwal Sewanti Limaye Nevena Damjanov Jessica Di Stefano Christine Ciunci Eric M Genden Juan P Wisnivesky Rocco Ferrandino Ronac Mamtani Corey J Langer Roger B Cohen Keith Sigel

J Natl Cancer Inst 2019 05;111(5):490-497

Department of Medicine, Division of Hematology/Oncology, James J. Peters VA Medical Center, Bronx, NY.

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May 2019

Barriers to physical activity: a study of academic and community cancer survivors with pain.

Authors:
Sally A D Romero Justin C Brown Joshua M Bauml Jennifer L Hay Q Susan Li Roger B Cohen Jun J Mao

J Cancer Surviv 2018 12 4;12(6):744-752. Epub 2018 Sep 4.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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December 2018

Phase Ib study of pevonedistat, a NEDD8-activating enzyme inhibitor, in combination with docetaxel, carboplatin and paclitaxel, or gemcitabine, in patients with advanced solid tumors.

Authors:
A Craig Lockhart Todd M Bauer Charu Aggarwal Carrie B Lee R Donald Harvey Roger B Cohen Farhad Sedarati Tsz Keung Nip Hélène Faessel Ajeeta B Dash Bruce J Dezube Douglas V Faller Afshin Dowlati

Invest New Drugs 2019 02 21;37(1):87-97. Epub 2018 May 21.

Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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February 2019

Exposure-response relationship for ramucirumab from the randomized, double-blind, phase 3 REVEL trial (docetaxel versus docetaxel plus ramucirumab) in second-line treatment of metastatic non-small cell lung cancer.

Authors:
Egbert F Smit Edward B Garon Martin Reck Federico Cappuzzo Paolo Bidoli Roger B Cohen Ling Gao Lisa M O'Brien Pablo Lee Annamaria Zimmermann David R Ferry Allen S Melemed Maurice Pérol

Cancer Chemother Pharmacol 2018 07 2;82(1):77-86. Epub 2018 May 2.

Département de Cancérologie Médicale Centre Léon-Bérard, Lyon, France.

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July 2018

The association between fatigue and pain symptoms and decreased physical activity after cancer.

Authors:
Sally A D Romero Lee Jones Joshua M Bauml Q Susan Li Roger B Cohen Jun J Mao

Support Care Cancer 2018 Oct 19;26(10):3423-3430. Epub 2018 Apr 19.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2018

Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion.

Authors:
Charu Aggarwal Andrew R Haas Susan Metzger Laura K Aguilar Estuardo Aguilar-Cordova Andrea G Manzanera Gregoria Gómez-Hernández Sharyn I Katz Evan W Alley Tracey L Evans Joshua M Bauml Roger B Cohen Corey J Langer Steven M Albelda Daniel H Sterman

Mol Ther 2018 05 21;26(5):1198-1205. Epub 2018 Feb 21.

New York University Langhorne Medical Center, New York, NY 10016, USA.

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May 2018

Pembrolizumab for the Treatment of Advanced Salivary Gland Carcinoma: Findings of the Phase 1b KEYNOTE-028 Study.

Authors:
Roger B Cohen Jean-Pierre Delord Toshihiko Doi Sarina A Piha-Paul Stephen V Liu Jill Gilbert Alain P Algazi Silvia Damian Ruey-Long Hong Christophe Le Tourneau Daphne Day Andrea Varga Elena Elez John Wallmark Sanatan Saraf Pradeep Thanigaimani Jonathan Cheng Bhumsuk Keam

Am J Clin Oncol 2018 Nov;41(11):1083-1088

*University of Pennsylvania, Philadelphia, PA †Institut Claudius Regaud, Toulouse §§U900 INSERM Research Unit, Saint-Cloud ‡‡Institut Curie, Paris ##Gustave Roussy, Villejuif, France ‡National Cancer Center Hospital East, Chiba, Japan §The University of Texas MD Anderson Cancer Center, Houston, TX ∥Georgetown University Hospital, Washington, DC ¶Vanderbilt University School of Medicine, Nashville, TN #Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA **Fondazione IRCCS Istituto Nazionale dei Tumori Medical Oncology, Milan, Italy ††National Taiwan University Hospital, Taipei, Taiwan ∥∥Princess Margaret Cancer Centre ¶¶Ontario Institute for Cancer Research, Toronto, ON, Canada ***Vall d'Hebron Institute of Oncology, Barcelona, Spain †††Maryland Oncology Hematology PA, Rockville, MD ‡‡‡Merck & Co. Inc., Kenilworth, NJ §§§Seoul National University Hospital, Seoul, Republic of Korea.

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November 2018

Effect of Prophylactic Cranial Irradiation on Overall Survival in Metastatic Small-Cell Lung Cancer: A Propensity Score-Matched Analysis.

Authors:
Sonam Sharma Matthew T McMillan Abigail Doucette Roger B Cohen Abigail Berman William Levin Charles B Simone Jacob Shabason

Clin Lung Cancer 2018 05 14;19(3):260-269.e3. Epub 2017 Dec 14.

Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

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May 2018

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma.

Authors:
Bert H O'Neil John M Wallmark David Lorente Elena Elez Judith Raimbourg Carlos Gomez-Roca Samuel Ejadi Sarina A Piha-Paul Mark N Stein Albiruni R Abdul Razak Katia Dotti Armando Santoro Roger B Cohen Marlena Gould Sanatan Saraf Karen Stein Sae-Won Han

PLoS One 2017 28;12(12):e0189848. Epub 2017 Dec 28.

Division of Hematology and Medical Oncology, Seoul National University Hospital, Seoul, Republic of Korea.

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January 2018

Circulating tumor cells as a predictive biomarker in patients with small cell lung cancer undergoing chemotherapy.

Authors:
Charu Aggarwal Xingmei Wang Anjana Ranganathan Drew Torigian Andrea Troxel Tracey Evans Roger B Cohen Bhavesh Vaidya Chandra Rao Mark Connelly Anil Vachani Corey Langer Steven Albelda

Lung Cancer 2017 10 12;112:118-125. Epub 2017 Aug 12.

Janssen Diagnostics, LLC, Huntingdon Valley, PA, United States; Division of Pulmonary and Critical Care, Thoracic Oncology Group, University of Pennsylvania, Philadelphia, PA, United States.

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October 2017

The Role of Advanced Imaging in Assessing Response to Definitive Chemoradiation Before Prophylactic Cranial Irradiation in Limited-Stage Small-Cell Lung Cancer.

Authors:
Aparna H Kesarwala Diana J Lu Eric Xanthopoulos Smith Apisarnthanarax Keith A Cengel Tracey L Evans Charu Aggarwal Roger B Cohen Corey J Langer Ramesh Rengan Charles B Simone

Clin Lung Cancer 2018 03 12;19(2):e205-e209. Epub 2017 Oct 12.

Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD.

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March 2018

Etirinotecan Pegol (NKTR-102) in Third-line Treatment of Patients With Metastatic or Recurrent Non-Small-cell Lung Cancer: Results of a Phase II Study.

Authors:
Charu Aggarwal Roger B Cohen Eddy Yu Wei-Ting Hwang Joshua M Bauml Evan Alley Tracey L Evans Corey J Langer

Clin Lung Cancer 2018 03 19;19(2):157-162. Epub 2017 Oct 19.

Hematology-Oncology Division, Department of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA.

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March 2018

Emerging uses of circulating tumor DNA in advanced stage non-small cell lung cancer.

Authors:
Melina Marmarelis Jeffrey C Thompson Charu Aggarwal Tracey L Evans Erica Carpenter Roger B Cohen Corey J Langer Joshua Bauml

Ann Transl Med 2017 Sep;5(18):380

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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September 2017

Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study.

Authors:
Chiun Hsu Se-Hoon Lee Samuel Ejadi Caroline Even Roger B Cohen Christophe Le Tourneau Janice M Mehnert Alain Algazi Emilie M J van Brummelen Sanatan Saraf Pradeep Thanigaimani Jonathan D Cheng Aaron R Hansen

J Clin Oncol 2017 Dec 24;35(36):4050-4056. Epub 2017 Aug 24.

Chiun Hsu, National Taiwan University Hospital, Graduate Institute of Oncology, National Taiwan University College of Medicine, and National Taiwan University Cancer Center, Taipei, Taiwan, Republic of China; Se-Hoon Lee, Seoul National University Hospital, Seoul, South Korea; Samuel Ejadi, Virginia G. Piper Cancer Center, Scottsdale, AZ; Roger B. Cohen, University of Pennsylvania, Philadelphia, PA; Janice M. Mehnert, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ; Alain Algazi, University of California, San Francisco, San Francisco, CA; Sanatan Saraf, Pradeep Thanigaimani, and Jonathan D. Cheng, Merck & Co., Inc., Kenilworth, NJ; Caroline Even, Gustave Roussy, Villejuif; Christophe Le Tourneau, Institut Curie, Paris; Christophe Le Tourneau, INSERM U900 Research Unit, Saint-Cloud, France; Emilie M.J. van Brummelen, Netherlands Cancer Institute, Amsterdam, the Netherlands; and Aaron R. Hansen, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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December 2017

Prospective study of proton-beam radiation therapy for limited-stage small cell lung cancer.

Authors:
Jean-Claude M Rwigema Vivek Verma Liyong Lin Abigail T Berman William P Levin Tracey L Evans Charu Aggarwal Ramesh Rengan Corey Langer Roger B Cohen Charles B Simone

Cancer 2017 Nov 5;123(21):4244-4251. Epub 2017 Jul 5.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.

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November 2017

Erratum to: A phase I dose-escalation study of Selumetinib in combination with Erlotinib or Temsirolimus in patients with advanced solid tumors.

Authors:
Jeffrey R Infante Roger B Cohen Kevin B Kim Howard A Burris Gregory Curt Ugochi Emeribe Delyth Clemett Helen K Tomkinson Patricia M LoRusso

Invest New Drugs 2017 10;35(5):669

Yale Cancer Center, 55 Park Street, Ste First Floor, New Haven, CT, 06519, USA.

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October 2017

Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors.

Authors:
Suchit H Patel Andreas Rimner Roger B Cohen

Transl Lung Cancer Res 2017 Apr;6(2):186-195

Division of Hematology-Oncology, Perelman Center for Advanced Medicine, Philadelphia, USA.

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April 2017

Beyond Positive Margins and Extracapsular Extension: Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer.

Authors:
Daniel M Trifiletti Andrew Smith Nandita Mitra Surbhi Grover John N Lukens Roger B Cohen Paul Read William M Mendenhall Alexander Lin Samuel Swisher-McClure

J Clin Oncol 2017 May 13;35(14):1550-1560. Epub 2017 Feb 13.

Daniel M. Trifiletti and Paul Read, University of Virginia, Charlottesville, VA; Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Alexander Lin, and Samuel Swisher-McClure, University of Pennsylvania, Philadelphia, PA; and William M. Mendenhall, University of Florida, Gainesville, FL.

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May 2017

A phase I dose-escalation study of Selumetinib in combination with Erlotinib or Temsirolimus in patients with advanced solid tumors.

Authors:
Jeffrey R Infante Roger B Cohen Kevin B Kim Howard A Burris Gregory Curt Ugochi Emeribe Delyth Clemett Helen K Tomkinson Patricia M LoRusso

Invest New Drugs 2017 10 19;35(5):576-588. Epub 2017 Apr 19.

Yale Cancer Center, 55 Park Street, Ste First Floor, New Haven, CT, 06519, USA.

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October 2017

Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer.

Authors:
Stephen J Bagley Shawn Kothari Charu Aggarwal Joshua M Bauml Evan W Alley Tracey L Evans John A Kosteva Christine A Ciunci Peter E Gabriel Jeffrey C Thompson Susan Stonehouse-Lee Victoria E Sherry Elizabeth Gilbert Beth Eaby-Sandy Faith Mutale Gloria DiLullo Roger B Cohen Anil Vachani Corey J Langer

Lung Cancer 2017 04 25;106:1-7. Epub 2017 Jan 25.

Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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April 2017

A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors.

Authors:
Patricia M LoRusso Jeffrey R Infante Kevin B Kim Howard A Burris Gregory Curt Ugochi Emeribe Delyth Clemett Helen K Tomkinson Roger B Cohen

BMC Cancer 2017 03 6;17(1):173. Epub 2017 Mar 6.

Fox Chase Cancer Center, Philadelphia, PA, USA.

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March 2017

Unsupervised exercise in survivors of human papillomavirus related head and neck cancer: how many can go it alone?

Authors:
Joshua Bauml Jiyoung Kim Xiaochen Zhang Charu Aggarwal Roger B Cohen Kathryn Schmitz

J Cancer Surviv 2017 Aug 13;11(4):462-468. Epub 2017 Feb 13.

Penn State College of Medicine, Hershey, PA, USA.

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August 2017

Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer.

Authors:
Jeffrey R Infante Amita Patnaik Claire F Verschraegen Anthony J Olszanski Montaser Shaheen Howard A Burris Anthony W Tolcher Kyriakos P Papadopoulos Muralidhar Beeram Scott M Hynes Jennifer Leohr Aimee Bence Lin Lily Q Li Anna McGlothlin Daphne L Farrington Eric H Westin Roger B Cohen

Cancer Chemother Pharmacol 2017 Feb 17;79(2):315-326. Epub 2017 Jan 17.

Fox Chase Cancer Center, Philadelphia, PA, USA.

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February 2017

Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries.

Authors:
Kyle M Hatten Bert W O'Malley Andres M Bur Mihir R Patel Christopher H Rassekh Jason G Newman Steven B Cannady Ara A Chalian Benjamin L Hodnett Alexander Lin John N Lukens Roger B Cohen Joshua M Bauml Kathleen T Montone Virginia A Livolsi Gregory S Weinstein

JAMA Otolaryngol Head Neck Surg 2017 03;143(3):267-273

Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia.

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March 2017

Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer.

Authors:
Stephen J Bagley Steven Vitale Suhong Zhang Charu Aggarwal Tracey L Evans Evan W Alley Roger B Cohen Corey J Langer Ian A Blair Anil Vachani Alexander S Whitehead

Clin Lung Cancer 2017 03 26;18(2):e143-e149. Epub 2016 Oct 26.

Center of Excellence in Environmental Toxicology and Center for Cancer Pharmacology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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March 2017

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis.

Authors:
Peter H Ahn Nandita Mitra Michelle Alonso-Basanta James N Palmer Nithin D Adappa Bert W O'Malley Christopher Rassekh Ara Chalian Roger B Cohen Alexander Lin

Acta Oncol 2016 Sep - Oct;55(9-10):1107-1114. Epub 2016 Aug 11.

a Department of Radiation Oncology , University of Pennsylvania , Philadelphia , Pennsylvania , USA.

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January 2018

A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Authors:
Antonio Jimeno Marshall R Posner Lori J Wirth Nabil F Saba Roger B Cohen Elizabeta C Popa Athanassios Argiris Kenneth F Grossmann Ammar Sukari Dawn Wilson Xiaosha Zhang Jade Sun Chad Glasser Kenneth M Attie Matthew L Sherman Susan S Pandya Jared Weiss

Cancer 2016 Dec 20;122(23):3641-3649. Epub 2016 Sep 20.

Department of Hematology and Oncology, University of North Carolina, Chapel Hill, North Carolina.

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December 2016

Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA.

Authors:
Jeffrey C Thompson Stephanie S Yee Andrea B Troxel Samantha L Savitch Ryan Fan David Balli David B Lieberman Jennifer D Morrissette Tracey L Evans Joshua Bauml Charu Aggarwal John A Kosteva Evan Alley Christine Ciunci Roger B Cohen Stephen Bagley Susan Stonehouse-Lee Victoria E Sherry Elizabeth Gilbert Corey Langer Anil Vachani Erica L Carpenter

Clin Cancer Res 2016 Dec 6;22(23):5772-5782. Epub 2016 Sep 6.

Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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December 2016

Scan-associated distress in lung cancer: Quantifying the impact of "scanxiety".

Authors:
Joshua M Bauml Andrea Troxel C Neill Epperson Roger B Cohen Kathryn Schmitz Carrie Stricker Lawrence N Shulman Angela Bradbury Jun J Mao Corey J Langer

Lung Cancer 2016 10 16;100:110-113. Epub 2016 Aug 16.

Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA, United States; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

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October 2016

Immunotherapy for head and neck cancer: latest developments and clinical potential.

Authors:
Joshua M Bauml Roger B Cohen Charu Aggarwal

Ther Adv Med Oncol 2016 May 16;8(3):168-75. Epub 2016 Feb 16.

Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, 624 South Pavilion, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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May 2016

Capecitabine and lapatinib for the first-line treatment of metastatic/recurrent head and neck squamous cell carcinoma.

Authors:
Jared M Weiss Stephen Bagley Wei-Ting Hwang Joshua Bauml Juneko Grilley Olson Roger B Cohen David Neil Hayes Corey Langer

Cancer 2016 08 19;122(15):2350-5. Epub 2016 May 19.

Division of Hematology and Oncology, University of Pennsylvania, Abramson Comprehensive Cancer Center, Philadelphia, Pennsylvania.

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August 2016

Acupuncture for Dyspnea in Lung Cancer: Results of a Feasibility Trial.

Authors:
Joshua Bauml Andrew Haas Charles B Simone Susan Q Li Roger B Cohen Corey J Langer Jun J Mao

Integr Cancer Ther 2016 09 24;15(3):326-32. Epub 2016 Apr 24.

Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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September 2016

Analysis of the Relationship Between Response to Chemotherapy and Response to Radiation Therapy in Patients With Non-Small Cell Lung Cancer Receiving Sequential Treatment.

Authors:
Genevieve Maquilan Surbhi Grover Eric Xanthopoulos Tracey L Evans Charu Aggarwal Corey J Langer Roger B Cohen James P Stevenson Charles B Simone Ramesh Rengan

Am J Clin Oncol 2018 04;41(4):391-395

Perelman Center for Advanced Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.

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April 2018

Cancer Communication in the Social Media Age.

Authors:
Mina S Sedrak Roger B Cohen Raina M Merchant Marilyn M Schapira

JAMA Oncol 2016 Jun;2(6):822-3

Abramson Cancer Center, University of Pennsylvania, Philadelphia3Crescenz VA Medical Center, Philadelphia, Pennsylvania.

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June 2016

A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors.

Authors:
Laura W Goff Roger B Cohen Jordan D Berlin Filippo G de Braud Andrej Lyshchik Cristina Noberasco Francesco Bertolini Marina Carpentieri Corrado Gallo Stampino Antonello Abbattista Erjan Wang Hossein Borghaei

Clin Cancer Res 2016 05 11;22(9):2146-54. Epub 2015 Dec 11.

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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May 2016

Nodal metastasis and elective nodal level treatment in sinonasal small-cell and sinonasal undifferentiated carcinoma: a surveillance, epidemiology and end results analysis.

Authors:
Peter H Ahn Nandita Mitra Michelle Alonso-Basanta Nithin D Adappa James N Palmer Bert W O'Malley Christopher H Rassekh Ara Chalian Roger B Cohen Alexander Lin

Br J Radiol 2016 11;89(1058):20150488. Epub 2015 Nov 11.

1 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

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May 2016

Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy.

Authors:
Anna K Brady Jonathan D McNeill Brendan Judy Joshua Bauml Tracey L Evans Roger B Cohen Corey Langer Anil Vachani Charu Aggarwal

Oncotarget 2015 Oct;6(30):30287-94

Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.

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October 2015

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors.

Authors:
John Sarantopoulos Geoffrey I Shapiro Roger B Cohen Jeffrey W Clark John S Kauh Glen J Weiss James M Cleary Devalingam Mahalingam Michael D Pickard Hélène M Faessel Allison J Berger Kristine Burke George Mulligan Bruce J Dezube R Donald Harvey

Clin Cancer Res 2016 Feb 30;22(4):847-57. Epub 2015 Sep 30.

Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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February 2016

Phase I dose escalation and pharmacokinetic evaluation of two different schedules of LY2334737, an oral gemcitabine prodrug, in patients with advanced solid tumors.

Authors:
Sandrine J Faivre Anthony J Olszanski Karin Weigang-Köhler Hanno Riess Roger B Cohen Xuejing Wang Scott P Myrand Enaksha R Wickremsinhe Candice L Horn Haojun Ouyang Sophie Callies Karim A Benhadji Eric Raymond

Invest New Drugs 2015 Dec 16;33(6):1206-16. Epub 2015 Sep 16.

Department of Medical Oncology, Beaujon University Hospital, Clichy, France.

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December 2015

Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents.

Authors:
George Dranitsaris Roger B Cohen Gary Acton Llew Keltner Melissa Price Eitan Amir Eckhard R Podack Taylor H Schreiber

J Immunother 2015 Sep;38(7):259-66

*Heat Biologics Inc., Durham, NC †Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA ‡Drug Development Office, Cancer Research UK, London, UK §Division of Medical Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada ∥Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.

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September 2015

Total Laryngectomy Versus Larynx Preservation for T4a Larynx Cancer: Patterns of Care and Survival Outcomes.

Authors:
Surbhi Grover Samuel Swisher-McClure Nandita Mitra Jiaqi Li Roger B Cohen Peter H Ahn John N Lukens Ara A Chalian Gregory S Weinstein Bert W O'Malley Alexander Lin

Int J Radiat Oncol Biol Phys 2015 Jul;92(3):594-601

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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July 2015

Phase I dose-escalation study of cabazitaxel administered in combination with gemcitabine in patients with metastatic or unresectable advanced solid malignancies.

Authors:
Olivier Rixe Igor Puzanov Patricia M LoRusso Roger B Cohen John C Morris Olugbenga O Olowokure Jian Y Yin Séverine Doroumian Liji Shen Anthony J Olszanski

Anticancer Drugs 2015 Aug;26(7):785-92

aDivision of Hematology/Oncology, University of New Mexico Cancer Center, Albuquerque, New Mexico bDivision of Hematology-Oncology, Henry-Joyce Cancer Clinic/The Vanderbilt Clinic, Nashville, Tennessee cYale Cancer Center, Yale University, New Haven, Connecticut dFox Chase Cancer Center, Philadelphia, Pennsylvania eDepartment of Medicine, Division of Hematology-Oncology, University of Cincinnati Cancer Institute, Cincinnati, Ohio fSanofi, Bridgewater, New Jersey, USA gSanofi, Montpellier, France.

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August 2015

Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies.

Authors:
Margaret von Mehren Michael Bookman Neal J Meropol Louis M Weiner Eric Sherman Jinhui Li Roland Knoblauch Trilok Parekh Roger B Cohen

Cancer Chemother Pharmacol 2015 May 20;75(5):1047-55. Epub 2015 Mar 20.

Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA,

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May 2015

Evaluating the safety and efficacy of axitinib in the treatment of advanced renal cell carcinoma.

Authors:
Orvar Gunnarsson Nicklas R Pfanzelter Roger B Cohen Stephen M Keefe

Cancer Manag Res 2015 11;7:65-73. Epub 2015 Feb 11.

Department of Medicine, Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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February 2015

HPV-related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery.

Authors:
John M Kaczmar Kay See Tan Daniel F Heitjan Alexander Lin Peter H Ahn Jason G Newman Christopher H Rassekh Ara A Chalian Bert W O'Malley Roger B Cohen Gregory S Weinstein

Head Neck 2016 Jan 6;38(1):59-65. Epub 2015 Apr 6.

Department of Otorhinolaryngology/Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

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January 2016

Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors.

Authors:
Jeffrey R Infante E Claire Dees Anthony J Olszanski Shyeilla V Dhuria Suman Sen Scott Cameron Roger B Cohen

J Clin Oncol 2014 Oct 11;32(28):3103-10. Epub 2014 Aug 11.

Jeffrey R. Infante, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; E. Claire Dees, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC; Antony J. Olszanski, Fox Chase Cancer Center; Roger B. Cohen, Perelman School of Medicine, Philadelphia, PA; Shyeilla V. Dhuria and Suman Sen, Novartis Pharmaceuticals Corp, East Hanover, NJ; and Scott Cameron, Novartis Institutes for Biomedical Research, Cambridge, MA.

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October 2014

Late consequential surgical bed soft tissue necrosis in advanced oropharyngeal squamous cell carcinomas treated with transoral robotic surgery and postoperative radiation therapy.

Authors:
J Nicholas Lukens Alexander Lin Victoria Gamerman Nandita Mitra Surbhi Grover Erin M McMenamin Gregory S Weinstein Bert W O'Malley Roger B Cohen Abimbola Orisamolu Peter H Ahn Harry Quon

Int J Radiat Oncol Biol Phys 2014 Aug 10;89(5):981-988. Epub 2014 Jun 10.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania; Johns Hopkins University, Baltimore, Maryland. Electronic address:

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August 2014

A multicenter phase 1 study of PX-866 and cetuximab in patients with metastatic colorectal carcinoma or recurrent/metastatic squamous cell carcinoma of the head and neck.

Authors:
Daniel W Bowles Neil Senzer Diana Hausman Scott Peterson Alex Vo Luke Walker Roger B Cohen Antonio Jimeno

Invest New Drugs 2014 Dec 12;32(6):1197-203. Epub 2014 Jun 12.

Division of Medical Oncology, University of Colorado School of Medicine, 12801 East 17th Avenue MS 8117 Aurora, Denver, CO, 80045, USA,

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December 2014

A Single-institution Comparison of Cetuximab, Carboplatin, and Paclitaxel Induction Chemotherapy Followed by Chemoradiation (CRT) Versus CRT for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN).

Authors:
Surbhi Grover Nandita Mitra Fei Wan John N Lukens Sonam Sharma Jessica Bauman Farzad Masroor Roger B Cohen Arati Desai Kenneth Algazy Michelle Alonso-Basanta Peter Ahn Boon-Keng Kevin Teo Ara A Chalian Gregory S Weinstein Bert W O'Malley Alexander Lin

Am J Clin Oncol 2016 10;39(5):522-7

Departments of *Radiation Oncology †Biostatistics and Epidemiology ‡Internal Medicine §Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA.

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October 2016

Phase I safety and pharmacokinetic study of the PI3K/mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors.

Authors:
Pasi A Jänne Roger B Cohen A Douglas Laird Sandrine Macé Jeffrey A Engelman Rodrigo Ruiz-Soto Kevin Rockich Jianbo Xu Geoffrey I Shapiro Pablo Martinez Enriqueta Felip

J Thorac Oncol 2014 Mar;9(3):316-23

*Lowe Center for Thoracic Oncology and the Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts; †Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; ‡Translational Medicine, Exelixis, Inc., South San Francisco, San Francisco, California; §Translational and Experimental Medicine, Sanofi, Vitry-sur-Seine, France; ‖Center for Thoracic Centers, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts; ¶Clinical Development Oncology, Sanofi, Cambridge, Massachusetts; #Pharmacokinetic Modeling and Simulation, Sanofi, Cambridge, Massachusetts; **Biostatistics and Programming, Sanofi, Cambridge, Massachusetts; ††Early Drug Development Center, Dana-Farber Cancer Institute, Boston, Massachusetts; ‡‡Department of Medical Oncology, Vall d'ebron University Hospital, Barcelona, Spain.

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March 2014

A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors.

Authors:
Margaret von Mehren Carolyn D Britten Peter Pieslor Wayne Saville Artemios Vassos Sarah Harris Gerald R Galluppi Mohamed Darif Zev A Wainberg Roger B Cohen Stephen Leong

Invest New Drugs 2014 Jun 24;32(3):518-25. Epub 2014 Jan 24.

Fox Chase Cancer Center, Philadelphia, PA, USA,

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June 2014

Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)- and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC).

Authors:
Roger B Cohen

Cancer Treat Rev 2014 May 12;40(4):567-77. Epub 2013 Oct 12.

Abramson Cancer Center, Philadelphia, PA, United States. Electronic address:

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May 2014

Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: integrated analyses of up to 8 years of treatment from the abatacept clinical trial program.

Authors:
Michael E Weinblatt Larry W Moreland Rene Westhovens Roger B Cohen Sheila M Kelly Nader Khan Ramesh Pappu Ingrid Delaet Allison Luo Sheila Gujrathi Marc C Hochberg

J Rheumatol 2013 Jun 15;40(6):787-97. Epub 2013 Apr 15.

Brigham and Women's Hospital, Boston, MA, USA.

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June 2013

A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies.

Authors:
Roger B Cohen Steinar Aamdal Marta Nyakas Maria Cavallin Darron Green Maria Learoyd Ian Smith Razelle Kurzrock

Eur J Cancer 2013 May 21;49(7):1521-9. Epub 2013 Feb 21.

Division of Hematology and Oncology, Department of Medicine, Fox Chase Cancer Center, Philadelphia, PA, USA.

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May 2013

A Web-based communication aid for patients with cancer: the CONNECT Study.

Authors:
Neal J Meropol Brian L Egleston Joanne S Buzaglo Andrew Balshem Al B Benson Donald J Cegala Roger B Cohen Michael Collins Michael A Diefenbach Suzanne M Miller Linda Fleisher Jennifer L Millard Eric A Ross Kevin A Schulman Allison Silver Elyse Slater Nicholas Solarino Daniel P Sulmasy Jonathan Trinastic Kevin P Weinfurt

Cancer 2013 Apr 18;119(7):1437-45. Epub 2013 Jan 18.

University Hospitals Case Medical Center Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

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April 2013

A Phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors.

Authors:
John Marshall Jimmy Hwang Ferry A L M Eskens Herman Burger Shakun Malik Martina Uttenreuther-Fischer Peter Stopfer Mahmoud Ould-Kaci Roger B Cohen Nancy L Lewis

Invest New Drugs 2013 Apr 17;31(2):399-408. Epub 2012 Nov 17.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.

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April 2013

Research participants' high expectations of benefit in early-phase oncology trials: are we asking the right question?

Authors:
Kevin P Weinfurt Damon M Seils Li Lin Daniel P Sulmasy Alan B Astrow Herbert I Hurwitz Roger B Cohen Neal J Meropol

J Clin Oncol 2012 Dec 22;30(35):4396-400. Epub 2012 Oct 22.

Duke University, Durham, NC 27715, USA.

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December 2012

Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.

Authors:
Sapna P Patel Alexander J Lazar Nicholas E Papadopoulos Ping Liu Jeffrey R Infante Michelle R Glass Carol S Vaughn Patricia M LoRusso Roger B Cohen Michael A Davies Kevin B Kim

Cancer 2013 Feb 12;119(4):799-805. Epub 2012 Sep 12.

Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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February 2013

Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations.

Authors:
E Claire Dees Roger B Cohen Margaret von Mehren Thomas E Stinchcombe Hua Liu Karthik Venkatakrishnan Mark Manfredi Howard Fingert Howard A Burris Jeffrey R Infante

Clin Cancer Res 2012 Sep 5;18(17):4775-84. Epub 2012 Jul 5.

UNC Lineberger Comprehensive Cancer Center, 170 Manning Drive, POB 3121, Chapel Hill, NC 27599, USA.

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September 2012

Antiangiogenic therapy for advanced renal cell carcinoma: management of treatment-related toxicities.

Authors:
Roger B Cohen Stéphane Oudard

Invest New Drugs 2012 Oct 12;30(5):2066-79. Epub 2012 Feb 12.

Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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October 2012

Pharmacokinetic evaluation of axitinib.

Authors:
Brian Patson Roger B Cohen Anthony J Olszanski

Expert Opin Drug Metab Toxicol 2012 Feb 17;8(2):259-70. Epub 2012 Jan 17.

Phase I Clinical Trials Fox Chase Cancer Center-Medical Oncology, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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February 2012

Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements.

Authors:
D Neil Hayes Amy S Lucas Tawee Tanvetyanon Monika K Krzyzanowska Christine H Chung Barbara A Murphy Jill Gilbert Ranee Mehra Dominic T Moore Arif Sheikh Janelle Hoskins Michele C Hayward Ni Zhao Wendi O'Connor Karen E Weck Roger B Cohen Ezra E W Cohen

Clin Cancer Res 2012 Apr 12;18(7):2056-65. Epub 2012 Jan 12.

University of North Carolina Lineberger Comprehensive Cancer Center, School of Medicine, Baltimore, Maryland, USA.

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April 2012

Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.

Authors:
Razelle Kurzrock Steven I Sherman Douglas W Ball Arlene A Forastiere Roger B Cohen Ranee Mehra David G Pfister Ezra E W Cohen Linda Janisch Forlisa Nauling David S Hong Chaan S Ng Lei Ye Robert F Gagel John Frye Thomas Müller Mark J Ratain Ravi Salgia

J Clin Oncol 2011 Jul 23;29(19):2660-6. Epub 2011 May 23.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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July 2011

Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.

Authors:
Arijit Chakravarty Vaishali Shinde Josep Tabernero Andres Cervantes Roger B Cohen E Claire Dees Howard Burris Jeffrey R Infante Teresa Macarulla Elena Elez Jordi Andreu Edith Rodriguez-Braun Susana Rosello Margaret von Mehren Neal J Meropol Corey J Langer Bert ONeil Douglas Bowman Mengkun Zhang Hadi Danaee Laura Faron-Yowe Gary Gray Hua Liu Jodi Pappas Lee Silverman Chris Simpson Bradley Stringer Stephen Tirrell Ole Petter Veiby Karthik Venkatakrishnan Katherine Galvin Mark Manfredi Jeffrey A Ecsedy

Cancer Res 2011 Feb 10;71(3):675-85. Epub 2010 Dec 10.

Millennium Pharmaceuticals Inc., Cambridge, Massachusetts 02139, USA.

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February 2011

Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results.

Authors:
Elisabeth I Heath George R Blumenschein Roger B Cohen Patricia M Lorusso Noelle K Loconte Sindy T Kim Ana Ruiz-Garcia Richard C Chao George Wilding

Cancer Chemother Pharmacol 2011 Sep 8;68(3):703-12. Epub 2010 Dec 8.

Karmanos Cancer Institute, Detroit, MI 48201, USA.

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September 2011

Increased recurrences using intensity-modulated radiation therapy in the postoperative setting.

Authors:
Aruna Turaka Tianyu Li Navesh K Sharma Linna Li Nicos Nicolaou Ranee Mehra Barbara Burtness Roger B Cohen Miriam N Lango Eric M Horwitz John A Ridge Steven J Feigenberg

Am J Clin Oncol 2010 Dec;33(6):599-603

Departments of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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December 2010

The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer.

Authors:
Mohamedtaki A Tejani Roger B Cohen Ranee Mehra

Biologics 2010 Aug 9;4:173-85. Epub 2010 Aug 9.

Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

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August 2010

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.

Authors:
E Claire Dees Jeffrey R Infante Roger B Cohen Bert H O'Neil Suzanne Jones Margaret von Mehren Hadi Danaee Yih Lee Jeffrey Ecsedy Mark Manfredi Katherine Galvin Bradley Stringer Hua Liu Omar Eton Howard Fingert Howard Burris

Cancer Chemother Pharmacol 2011 Apr 7;67(4):945-54. Epub 2010 Jul 7.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina, 170 Manning Drive, 3rd floor POB, CB 7305, Chapel Hill, NC 27599, USA.

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April 2011

A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer.

Authors:
Eric B Haura Alejandro D Ricart Timothy G Larson Philip J Stella Lyudmila Bazhenova Vincent A Miller Roger B Cohen Peter D Eisenberg Paulina Selaru Keith D Wilner Shirish M Gadgeel

Clin Cancer Res 2010 Apr 23;16(8):2450-7. Epub 2010 Mar 23.

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

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April 2010

Phase 1 experience with an anti-glycotope monoclonal antibody, RAV12, in recurrent adenocarcinoma.

Authors:
Howard A Burris Lee S Rosen Caio M Rocha-Lima John Marshall Suzanne Jones Roger B Cohen Lori A Kunkel Deryk Loo Jan Baughman Stanford J Stewart Nancy Lewis

Clin Cancer Res 2010 Mar 23;16(5):1673-81. Epub 2010 Feb 23.

Sarah Cannon Research Institute, Nashville, Tenessee 37203-1632, USA.

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March 2010