Roger A H Adan

Roger A H Adan

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Roger A H Adan

Roger A H Adan

Publications by authors named "Roger A H Adan"

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Emotion-driven impulsiveness but not decision-making ability and cognitive inflexibility predicts weight status in adults.

Appetite 2019 Nov 11;142:104367. Epub 2019 Jul 11.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, the Netherlands; Institute for Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.appet.2019.104367DOI Listing
November 2019

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Authors:
Hunna J Watson Zeynep Yilmaz Laura M Thornton Christopher Hübel Jonathan R I Coleman Héléna A Gaspar Julien Bryois Anke Hinney Virpi M Leppä Manuel Mattheisen Sarah E Medland Stephan Ripke Shuyang Yao Paola Giusti-Rodríguez Ken B Hanscombe Kirstin L Purves Roger A H Adan Lars Alfredsson Tetsuya Ando Ole A Andreassen Jessica H Baker Wade H Berrettini Ilka Boehm Claudette Boni Vesna Boraska Perica Katharina Buehren Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Roger D Cone Philippe Courtet Scott Crow James J Crowley Unna N Danner Oliver S P Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E DeSocio Danielle M Dick Dimitris Dikeos Christian Dina Monika Dmitrzak-Weglarz Elisa Docampo Laramie E Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández-Aranda Manfred M Fichter Krista Fischer Manuel Föcker Lenka Foretova Andreas J Forstner Monica Forzan Christopher S Franklin Steven Gallinger Ina Giegling Johanna Giuranna Fragiskos Gonidakis Philip Gorwood Monica Gratacos Mayora Sébastien Guillaume Yiran Guo Hakon Hakonarson Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G Helder Stefan Herms Beate Herpertz-Dahlmann Wolfgang Herzog Laura M Huckins James I Hudson Hartmut Imgart Hidetoshi Inoko Vladimir Janout Susana Jiménez-Murcia Antonio Julià Gursharan Kalsi Deborah Kaminská Jaakko Kaprio Leila Karhunen Andreas Karwautz Martien J H Kas James L Kennedy Anna Keski-Rahkonen Kirsty Kiezebrink Youl-Ri Kim Lars Klareskog Kelly L Klump Gun Peggy S Knudsen Maria C La Via Stephanie Le Hellard Robert D Levitan Dong Li Lisa Lilenfeld Bochao Danae Lin Jolanta Lissowska Jurjen Luykx Pierre J Magistretti Mario Maj Katrin Mannik Sara Marsal Christian R Marshall Morten Mattingsdal Sara McDevitt Peter McGuffin Andres Metspalu Ingrid Meulenbelt Nadia Micali Karen Mitchell Alessio Maria Monteleone Palmiero Monteleone Melissa A Munn-Chernoff Benedetta Nacmias Marie Navratilova Ioanna Ntalla Julie K O'Toole Roel A Ophoff Leonid Padyukov Aarno Palotie Jacques Pantel Hana Papezova Dalila Pinto Raquel Rabionet Anu Raevuori Nicolas Ramoz Ted Reichborn-Kjennerud Valdo Ricca Samuli Ripatti Franziska Ritschel Marion Roberts Alessandro Rotondo Dan Rujescu Filip Rybakowski Paolo Santonastaso André Scherag Stephen W Scherer Ulrike Schmidt Nicholas J Schork Alexandra Schosser Jochen Seitz Lenka Slachtova P Eline Slagboom Margarita C T Slof-Op 't Landt Agnieszka Slopien Sandro Sorbi Beata Świątkowska Jin P Szatkiewicz Ioanna Tachmazidou Elena Tenconi Alfonso Tortorella Federica Tozzi Janet Treasure Artemis Tsitsika Marta Tyszkiewicz-Nwafor Konstantinos Tziouvas Annemarie A van Elburg Eric F van Furth Gudrun Wagner Esther Walton Elisabeth Widen Eleftheria Zeggini Stephanie Zerwas Stephan Zipfel Andrew W Bergen Joseph M Boden Harry Brandt Steven Crawford Katherine A Halmi L John Horwood Craig Johnson Allan S Kaplan Walter H Kaye James E Mitchell Catherine M Olsen John F Pearson Nancy L Pedersen Michael Strober Thomas Werge David C Whiteman D Blake Woodside Garret D Stuber Scott Gordon Jakob Grove Anjali K Henders Anders Juréus Katherine M Kirk Janne T Larsen Richard Parker Liselotte Petersen Jennifer Jordan Martin Kennedy Grant W Montgomery Tracey D Wade Andreas Birgegård Paul Lichtenstein Claes Norring Mikael Landén Nicholas G Martin Preben Bo Mortensen Patrick F Sullivan Gerome Breen Cynthia M Bulik

Nat Genet 2019 Aug 15;51(8):1207-1214. Epub 2019 Jul 15.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41588-019-0439-2DOI Listing
August 2019

Effects of GABA and Leptin Receptor-Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis.

Obesity (Silver Spring) 2019 Jul 14;27(7):1123-1132. Epub 2019 May 14.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht and University Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/oby.22495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617814PMC
July 2019

Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice.

Neuroimage 2019 Jul 13;201:116016. Epub 2019 Jul 13.

Image Sciences Institute, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Division of Human Nutrition & Health, Wageningen University & Research, Wageningen, the Netherlands.

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http://dx.doi.org/10.1016/j.neuroimage.2019.116016DOI Listing
July 2019

Rats that are predisposed to excessive obesity show reduced (leptin-induced) thermoregulation even in the preobese state.

Physiol Rep 2019 Jul;7(14):e14102

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.14102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656864PMC
July 2019

Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.

Neuropsychopharmacology 2019 Jun 29. Epub 2019 Jun 29.

Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/s41386-019-0454-0DOI Listing
June 2019

Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment.

J Neurosci 2019 May 22;39(22):4353-4364. Epub 2019 Mar 22.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, 3584CG Utrecht, The Netherlands,

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http://dx.doi.org/10.1523/JNEUROSCI.2814-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538860PMC
May 2019

Insensitivity to Losses: A Core Feature in Patients With Anorexia Nervosa?

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 May 13. Epub 2019 May 13.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands; Altrecht Eating Disorders Rintveld, Zeist, The Netherlands; Institute of Physiology and Neuroscience, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2019.05.001DOI Listing
May 2019

Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats.

Obesity (Silver Spring) 2019 Mar 30;27(3):409-419. Epub 2019 Jan 30.

Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/oby.22381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590171PMC
March 2019

How Reward and Aversion Shape Motivation and Decision Making: A Computational Account.

Neuroscientist 2019 Mar 13:1073858419834517. Epub 2019 Mar 13.

2 Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1177/1073858419834517DOI Listing
March 2019

Pathophysiology and Individualized Treatment of Hypothalamic Obesity Following Craniopharyngioma and Other Suprasellar Tumors: A Systematic Review.

Endocr Rev 2019 02;40(1):193-235

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

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https://academic.oup.com/edrv/advance-article/doi/10.1210/er
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http://dx.doi.org/10.1210/er.2018-00017DOI Listing
February 2019

Reinforcement learning across the rat estrous cycle.

Psychoneuroendocrinology 2019 02 24;100:27-31. Epub 2018 Sep 24.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2018.09.016DOI Listing
February 2019

Limbic control over the homeostatic need for sodium.

Sci Rep 2019 Jan 31;9(1):1050. Epub 2019 Jan 31.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-37405-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355778PMC
January 2019

Is leptin resistance the cause or the consequence of diet-induced obesity?

Int J Obes (Lond) 2018 08 22;42(8):1445-1457. Epub 2018 May 22.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CG, The Netherlands.

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http://dx.doi.org/10.1038/s41366-018-0111-4DOI Listing
August 2018

Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note.

Physiol Rep 2018 07;6(14):e13807

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.13807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060107PMC
July 2018

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states.

Nat Commun 2018 02 21;9(1):731. Epub 2018 Feb 21.

Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-03087-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821846PMC
February 2018

Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation.

Eur Neuropsychopharmacol 2018 01 17;28(1):171-184. Epub 2017 Nov 17.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Centre Utrecht, Universiteitsweg 100, 3585 CG Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2017.11.005DOI Listing
January 2018

Considering healthiness promotes healthier choices but modulates medial prefrontal cortex differently in children compared with adults.

Neuroimage 2017 10 4;159:325-333. Epub 2017 Aug 4.

Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands; Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands; Division of Human Nutrition, Wageningen University and Research Centre, 6703 HD Wageningen, The Netherlands.

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http://dx.doi.org/10.1016/j.neuroimage.2017.08.007DOI Listing
October 2017

The determinants of food choice.

Proc Nutr Soc 2017 08 1;76(3):316-327. Epub 2016 Dec 1.

Division of Human Nutrition,Wageningen University & Research Centre,Wageningen,Stippeneng 4,6708 WE,The Netherlands.

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http://dx.doi.org/10.1017/S002966511600286XDOI Listing
August 2017

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system.

Neuroimage 2017 08 11;156:109-118. Epub 2017 May 11.

Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Bolognalaan 50, 3584 CJ Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2017.05.021DOI Listing
August 2017

Genetic predisposition to obesity affects behavioural traits including food reward and anxiety-like behaviour in rats.

Behav Brain Res 2017 06 5;328:95-104. Epub 2017 Apr 5.

Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.02.037DOI Listing
June 2017

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats.

Eur Neuropsychopharmacol 2016 11 4;26(11):1784-1793. Epub 2016 Oct 4.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2016.09.003DOI Listing
November 2016

Associations between neural correlates of visual stimulus processing and set-shifting in ill and recovered women with anorexia nervosa.

Psychiatry Res Neuroimaging 2016 Sep 9;255:35-42. Epub 2016 Jul 9.

Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, Q02.4.45, 3584 CX Utrecht, The Netherlands; Division of Human Nutrition, Wageningen University & Research Center, Wageningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pscychresns.2016.07.004DOI Listing
September 2016

Central melanocortins regulate the motivation for sucrose reward.

PLoS One 2015 26;10(3):e0121768. Epub 2015 Mar 26.

Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374756PMC
February 2016

Overview of genetic research in anorexia nervosa: The past, the present and the future.

Int J Eat Disord 2015 Nov 14;48(7):814-25. Epub 2015 Jul 14.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/eat.22400DOI Listing
November 2015

Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring.

Anal Chem 2015 Oct;87(19):9966-73

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre , Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.5b03334DOI Listing
October 2015

Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation.

Neuropsychopharmacology 2015 Aug 4;40(9):2085-95. Epub 2015 Mar 4.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/npp.2015.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613606PMC
August 2015

Towards an animal model of food addiction.

Obes Facts 2012 19;5(2):180-95. Epub 2012 Apr 19.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1159/000338292DOI Listing
June 2015

Dietary factors affect food reward and motivation to eat.

Obes Facts 2012 20;5(2):221-42. Epub 2012 Apr 20.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1159/000338073DOI Listing
June 2015

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.

PLoS One 2014 15;9(4):e95392. Epub 2014 Apr 15.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988196PMC
May 2015

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa.

Front Behav Neurosci 2015 27;9:46. Epub 2015 Feb 27.

Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute , Utrecht , Netherlands ; Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht , Netherlands.

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http://dx.doi.org/10.3389/fnbeh.2015.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342866PMC
March 2015

Longitudinal changes in the physical activity of adolescents with anorexia nervosa and their influence on body composition and leptin serum levels after recovery.

PLoS One 2013 21;8(10):e78251. Epub 2013 Oct 21.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804495PMC
February 2015

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood.

PLoS One 2014 23;9(5):e97639. Epub 2014 May 23.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032260PMC
February 2015

What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents.

Neuroimage 2015 Jan 5;104:35-43. Epub 2014 Oct 5.

Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Division of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The Netherlands.

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http://dx.doi.org/10.1016/j.neuroimage.2014.09.069DOI Listing
January 2015

FTO knockdown in rat ventromedial hypothalamus does not affect energy balance.

Physiol Rep 2014 Dec 11;2(12). Epub 2014 Dec 11.

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.12152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332191PMC
December 2014

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.

Physiol Rep 2014 Jul 30;2(7). Epub 2014 Jul 30.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.12083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187548PMC
July 2014

Low control over palatable food intake in rats is associated with habitual behavior and relapse vulnerability: individual differences.

PLoS One 2013 10;8(9):e74645. Epub 2013 Sep 10.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769238PMC
June 2014

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.

Obesity (Silver Spring) 2014 May 19;22(5):1216-9. Epub 2014 Feb 19.

Department of Translational Neuroscience Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/oby.20718DOI Listing
May 2014

Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum.

Front Neuroanat 2014 26;8:14. Epub 2014 Mar 26.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fnana.2014.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972466PMC
April 2014

Feelings about food: the ventral tegmental area in food reward and emotional eating.

Trends Pharmacol Sci 2014 Jan 11;35(1):31-40. Epub 2013 Dec 11.

Brain Center Rudolf Magnus Department of Translational Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2013.11.003DOI Listing
January 2014

Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats.

Obesity (Silver Spring) 2013 Dec 5;21(12):E700-8. Epub 2013 Sep 5.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/oby.20581DOI Listing
December 2013

Repeated agouti related peptide (83-132) injections inhibit cocaine-induced locomotor sensitisation, but not via the nucleus accumbens.

Eur J Pharmacol 2013 Nov 19;719(1-3):187-191. Epub 2013 Jul 19.

Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2013.04.052DOI Listing
November 2013

Melanocortin MC(4) receptor-mediated feeding and grooming in rodents.

Eur J Pharmacol 2013 Nov 18;719(1-3):192-201. Epub 2013 Jul 18.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2013.04.060DOI Listing
November 2013

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis.

World J Biol Psychiatry 2013 Aug 21;14(6):441-51. Epub 2011 Sep 21.

Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.3109/15622975.2011.605470DOI Listing
August 2013

Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry.

Anal Chem 2013 May 26;85(9):4594-604. Epub 2013 Apr 26.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/ac400232yDOI Listing
May 2013

Hyperactivity in anorexia nervosa: warming up not just burning-off calories.

PLoS One 2012 27;7(7):e41851. Epub 2012 Jul 27.

Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407098PMC
April 2013

Mechanisms underlying current and future anti-obesity drugs.

Authors:
Roger A H Adan

Trends Neurosci 2013 Feb 8;36(2):133-40. Epub 2013 Jan 8.

Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tins.2012.12.001DOI Listing
February 2013

Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.

Obesity (Silver Spring) 2012 Dec 7;20(12):2420-5. Epub 2012 May 7.

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2012.128DOI Listing
December 2012

Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.

J Neurosci 2012 Nov;32(46):16120-8

Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1523/JNEUROSCI.1572-12.2012DOI Listing
November 2012

Neuropsychological weaknesses in anorexia nervosa: set-shifting, central coherence, and decision making in currently ill and recovered women.

Int J Eat Disord 2012 Jul 13;45(5):685-94. Epub 2012 Feb 13.

Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, The Netherlands.

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http://doi.wiley.com/10.1002/eat.22007
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http://dx.doi.org/10.1002/eat.22007DOI Listing
July 2012

Animal models of eating disorder traits.

Curr Top Behav Neurosci 2011 ;6:209-27

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/7854_2010_84DOI Listing
May 2012

Ghrelin mediates anticipation to a palatable meal in rats.

Obesity (Silver Spring) 2012 May 26;20(5):963-71. Epub 2012 Jan 26.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://doi.wiley.com/10.1038/oby.2011.389
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http://dx.doi.org/10.1038/oby.2011.389DOI Listing
May 2012

Olanzapine and sibutramine have opposing effects on the motivation for palatable food.

Behav Pharmacol 2012 Apr;23(2):198-204

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/FBP.0b013e3283512ca1DOI Listing
April 2012

Role of ghrelin in the pathophysiology of eating disorders: implications for pharmacotherapy.

CNS Drugs 2012 Apr;26(4):281-96

Utrecht Research Group Eating Disorders, Utrecht, The Netherlands.

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http://dx.doi.org/10.2165/11599890-000000000-00000DOI Listing
April 2012

Mandometer treatment not superior to treatment as usual for anorexia nervosa.

Int J Eat Disord 2012 Mar 25;45(2):193-201. Epub 2011 Apr 25.

Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands.

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http://dx.doi.org/10.1002/eat.20918DOI Listing
March 2012

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.

Obesity (Silver Spring) 2012 Mar 28;20(3):612-21. Epub 2011 Apr 28.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2011.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286758PMC
March 2012

Recombinant adeno-associated viral vectors.

Methods Mol Biol 2011 ;789:357-76

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/978-1-61779-310-3_24DOI Listing
February 2012

Anticipation of meals during restricted feeding increases activity in the hypothalamus in rats.

Eur J Neurosci 2011 Nov;34(9):1485-91

Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07880.xDOI Listing
November 2011

Inverse agonism at α2A adrenoceptors augments the hypophagic effect of sibutramine in rats.

Obesity (Silver Spring) 2011 Oct 7;19(10):1979-86. Epub 2011 Apr 7.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2011.51DOI Listing
October 2011

A meta-analysis of circulating BDNF concentrations in anorexia nervosa.

World J Biol Psychiatry 2011 Sep 12;12(6):444-54. Epub 2011 Apr 12.

Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.3109/15622975.2011.562244DOI Listing
September 2011

An overview on how components of the melanocortin system respond to different high energy diets.

Eur J Pharmacol 2011 Jun 3;660(1):207-12. Epub 2011 Jan 3.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2010.12.019DOI Listing
June 2011

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner.

Eur J Pharmacol 2011 Jun 3;660(1):148-55. Epub 2011 Jan 3.

Rudolf Magnus Institute of Neuroscience, Department Neuroscience and Pharmacology, Utrecht University Medical Centre, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2010.12.021DOI Listing
June 2011

Neurobiology of overeating and obesity: the role of melanocortins and beyond.

Eur J Pharmacol 2011 Jun 2;660(1):28-42. Epub 2011 Feb 2.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2011.01.034DOI Listing
June 2011

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.

Eur Neuropsychopharmacol 2011 May;21(5):384-92

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S0924977X1000118
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http://dx.doi.org/10.1016/j.euroneuro.2010.06.005DOI Listing
May 2011

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area.

Eur Neuropsychopharmacol 2011 Mar 28;21(3):274-81. Epub 2010 Dec 28.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht,University of Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2010.11.006DOI Listing
March 2011

Olanzapine affects locomotor activity and meal size in male rats.

Pharmacol Biochem Behav 2010 Nov 15;97(1):130-7. Epub 2010 May 15.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.pbb.2010.05.009DOI Listing
November 2010

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.

BMC Neurosci 2010 Aug 11;11:94. Epub 2010 Aug 11.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Utrecht University Medical Centre Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/1471-2202-11-94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928777PMC
August 2010

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector.

BMC Neurosci 2010 Jul 13;11:81. Epub 2010 Jul 13.

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/1471-2202-11-81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912914PMC
July 2010

Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus.

Hum Gene Ther 2010 Jun;21(6):673-82

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands.

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http://dx.doi.org/10.1089/hum.2009.169DOI Listing
June 2010

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

Am J Med Genet B Neuropsychiatr Genet 2010 Mar;153B(2):695-699

Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.b.31026DOI Listing
March 2010

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.

Obesity (Silver Spring) 2009 Jul 19;17(7):1448-50. Epub 2009 Feb 19.

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2008.670DOI Listing
July 2009

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.

Eur Neuropsychopharmacol 2009 May 31;19(5):309-16. Epub 2009 Jan 31.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2008.12.008DOI Listing
May 2009

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa.

Eur Neuropsychopharmacol 2009 Mar 1;19(3):153-60. Epub 2008 Nov 1.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience & Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2008.09.005DOI Listing
March 2009

Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis.

J Proteome Res 2009 Feb;8(2):870-6

Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/pr800449nDOI Listing
February 2009

Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression.

BMC Neurosci 2009 Jan 13;10. Epub 2009 Jan 13.

Medical Pharmacology Department, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, the Netherlands.

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http://dx.doi.org/10.1186/1471-2202-10-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647928PMC
January 2009

Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction.

Endocrinology 2008 Jul 27;149(7):3617-25. Epub 2008 Mar 27.

Department of Pediatrics, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/en.2007-1388DOI Listing
July 2008

Multimeric alpha-MSH has increased efficacy to activate the melanocortin MC4 receptor.

Eur J Pharmacol 2008 May 26;585(1):24-30. Epub 2008 Feb 26.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2008.02.046DOI Listing
May 2008

Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution.

Eur J Pharmacol 2008 May 4;585(1):130-6. Epub 2008 Mar 4.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2007.11.078DOI Listing
May 2008

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.

Eur J Endocrinol 2008 May;158(5):669-76

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room STR 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1530/EJE-07-0834DOI Listing
May 2008

Anti-obesity drugs and neural circuits of feeding.

Trends Pharmacol Sci 2008 Apr 18;29(4):208-17. Epub 2008 Mar 18.

Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tips.2008.01.008DOI Listing
April 2008

Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior.

J Neurosci 2007 Dec;27(51):14139-46

Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1523/JNEUROSCI.3280-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673500PMC
December 2007

Difference in susceptibility to activity-based anorexia in two inbred strains of mice.

Eur Neuropsychopharmacol 2007 Feb 2;17(3):199-205. Epub 2006 Jun 2.

Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2006.04.007DOI Listing
February 2007

AgRP(83-132) and SHU9119 differently affect activity-based anorexia.

Eur Neuropsychopharmacol 2006 Aug 15;16(6):403-12. Epub 2005 Dec 15.

Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2005.11.004DOI Listing
August 2006

To eat or not to eat; regulation by the melanocortin system.

Physiol Behav 2006 Aug 6;89(1):97-102. Epub 2006 Mar 6.

Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.physbeh.2006.01.034DOI Listing
August 2006

Melanocortin receptors as drug targets for disorders of energy balance.

CNS Neurol Disord Drug Targets 2006 Jun;5(3):251-61

Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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June 2006

Constitutive receptor activity series: endogenous inverse agonists and constitutive receptor activity in the melanocortin system.

Authors:
Roger A H Adan

Trends Pharmacol Sci 2006 Apr 28;27(4):183-6. Epub 2006 Feb 28.

Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tips.2006.02.002DOI Listing
April 2006

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry.

Anal Chem 2006 Feb;78(3):734-42

FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1021/ac0513111DOI Listing
February 2006

Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.

Psychiatr Genet 2005 Dec;15(4):237

Rudolf Magnus Institute of Neuroscience, UMCU, Utrecht, The Netherlands.

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December 2005