Publications by authors named "Roger A Greenberg"

79Publications

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.

Cell Rep 2020 Sep;32(9):108080

Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530826PMC
September 2020

Nuclear body phase separation drives telomere clustering in ALT cancer cells.

Mol Biol Cell 2020 08 24;31(18):2048-2056. Epub 2020 Jun 24.

Penn Center for Genome Integrity, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1091/mbc.E19-10-0589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543070PMC
August 2020

Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.

Nature 2019 06 29;570(7760):194-199. Epub 2019 May 29.

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/s41586-019-1232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914362PMC
June 2019

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Dev Cell 2019 06 16;49(6):920-935.e5. Epub 2019 May 16.

Molecular & Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA; Orthopaedic Surgery and Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581604PMC
June 2019

Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models.

Mol Cancer Ther 2019 07 9;18(7):1195-1204. Epub 2019 May 9.

Department of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606392PMC
July 2019

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening.

Genes Dev 2019 02 28;33(3-4):221-235. Epub 2019 Jan 28.

Department of Cancer Biology, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.319723.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362809PMC
February 2019

Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites.

Mol Cell Biol 2019 01 11;39(1). Epub 2018 Dec 11.

Department of Cancer Biology, Basser Center for BRCA, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00209-18
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http://dx.doi.org/10.1128/MCB.00209-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290371PMC
January 2019

Assembling a protective shield.

Nat Cell Biol 2018 08;20(8):862-863

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41556-018-0152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407861PMC
August 2018

Direct Quantitative Monitoring of Homology-Directed DNA Repair of Damaged Telomeres.

Methods Enzymol 2018 1;600:107-134. Epub 2018 Feb 1.

Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373480PMC
March 2019

Mitotic progression following DNA damage enables pattern recognition within micronuclei.

Nature 2017 08 31;548(7668):466-470. Epub 2017 Jul 31.

Department of Cancer Biology, Basser Center for BRCA, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature23470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857357PMC
August 2017

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.

Mol Cell 2017 Jul 6;67(2):252-265.e6. Epub 2017 Jul 6.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580398PMC
July 2017

Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks.

Biol Reprod 2017 May;96(5):1096-1104

Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1093/biolre/iox040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355104PMC
May 2017

As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks.

Biophys J 2017 Feb 27;112(3):446-449. Epub 2016 Oct 27.

Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, Pennsylvania; Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, Pennsylvania; Graduate Group/Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495163088
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http://dx.doi.org/10.1016/j.bpj.2016.09.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300774PMC
February 2017

Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repair.

Genes Dev 2017 01;31(1):3-5

Department of Cancer Biology, Department Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.295923.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287110PMC
January 2017

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.

Curr Biol 2017 Jan 15;27(2):210-223. Epub 2016 Dec 15.

Physical Sciences Oncology Center at Penn (PSOC@Penn), 129 Towne Building, University of Pennsylvania, Philadelphia, PA 19104, USA; Molecular and Cell Biophysics Lab, 129 Towne Building, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Group, Department of Physics and Astronomy, 129 Towne Building, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262636PMC
January 2017

Break-induced telomere synthesis underlies alternative telomere maintenance.

Nature 2016 11 19;539(7627):54-58. Epub 2016 Oct 19.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/nature20099
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http://dx.doi.org/10.1038/nature20099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384111PMC
November 2016

Nuclear constriction segregates mobile nuclear proteins away from chromatin.

Mol Biol Cell 2016 12 26;27(25):4011-4020. Epub 2016 Oct 26.

Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104

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http://www.molbiolcell.org/doi/10.1091/mbc.e16-06-0428
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http://dx.doi.org/10.1091/mbc.E16-06-0428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156542PMC
December 2016

In vivo imaging of DNA double-strand break induced telomere mobility during alternative lengthening of telomeres.

Methods 2017 02 1;114:54-59. Epub 2016 Aug 1.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160, United States; Department of Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378164PMC
February 2017

Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture.

Front Genet 2016 7;7:103. Epub 2016 Jun 7.

Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.

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http://dx.doi.org/10.3389/fgene.2016.00103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894868PMC
July 2016

Noncanonical views of homology-directed DNA repair.

Genes Dev 2016 05;30(10):1138-54

Department of Cancer Biology, Department Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.280545.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888836PMC
May 2016

[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer.

Am J Nucl Med Mol Imaging 2016 28;6(1):94-101. Epub 2016 Jan 28.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania 231 S. 34th Street, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749508PMC
April 2016

ALTernative Telomere Maintenance and Cancer.

Trends Cancer 2015 Oct;1(2):145-156

Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.trecan.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669901PMC
October 2015

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.

Cell Rep 2015 Oct 1;13(2):251-9. Epub 2015 Oct 1.

Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607662PMC
October 2015

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Mol Cell 2015 Sep 3;59(6):970-83. Epub 2015 Sep 3.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 1090, Toronto, ON M5G 1X5, Canada; Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579573PMC
September 2015

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.

Genes Dev 2015 Sep 3;29(18):1955-68. Epub 2015 Sep 3.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Department of Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://dx.doi.org/10.1101/gad.264192.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579352PMC
September 2015

Deciphering the BRCA1 Tumor Suppressor Network.

J Biol Chem 2015 Jul 5;290(29):17724-32. Epub 2015 Jun 5.

From the Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, and Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1074/jbc.R115.667931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505021PMC
July 2015

DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Cell Rep 2015 May 23;11(5):785-797. Epub 2015 Apr 23.

Department of Animal Biology, School of Veterinary Medicine, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 380 S. University Ave, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.celrep.2015.03.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426031PMC
May 2015

DNA repair: Familiar ends with alternative endings.

Nature 2015 Feb 4;518(7538):174-6. Epub 2015 Feb 4.

Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1038/nature14200DOI Listing
February 2015

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas.

Nat Commun 2015 Jan 21;6:6140. Epub 2015 Jan 21.

1] Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/ncomms7140
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http://dx.doi.org/10.1038/ncomms7140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302757PMC
January 2015

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Cancer Discov 2015 Feb 3;5(2):135-42. Epub 2014 Dec 3.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320660PMC
February 2015

Chromatin yo-yo: expansion and condensation during DNA repair.

Trends Cell Biol 2014 Nov 7;24(11):616-618. Epub 2014 Oct 7.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160.

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http://dx.doi.org/10.1016/j.tcb.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254157PMC
November 2014

Interchromosomal homology searches drive directional ALT telomere movement and synapsis.

Cell 2014 Sep;159(1):108-121

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA; Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177039PMC
September 2014

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

Cell Rep 2013 Oct 26;5(1):180-93. Epub 2013 Sep 26.

Department of Animal Biology and Mari Lowe Comparative Oncology Center, School of Veterinary Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813903PMC
October 2013

Conversations between chromatin modifications and DNA double strand break repair: a commentary.

Mutat Res 2013 Oct 27;750(1-2):1-4. Epub 2013 Aug 27.

Department of Oncology, University of Alberta Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827952PMC
October 2013

The dynamics of DNA damage repair and transcription.

Methods Mol Biol 2013 ;1042:227-35

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA1/2, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-62703-526-2_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827964PMC
March 2014

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.

Nat Struct Mol Biol 2013 Mar 3;20(3):317-25. Epub 2013 Feb 3.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nsmb.2499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594358PMC
March 2013

Biallelic deleterious BRCA1 mutations in a woman with early-onset ovarian cancer.

Cancer Discov 2013 Apr 26;3(4):399-405. Epub 2012 Dec 26.

Abramson Cancer Center, Department of Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625496PMC
April 2013

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

Sci Signal 2012 Dec 4;5(253):ra88. Epub 2012 Dec 4.

Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scisignal.2003485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131685PMC
December 2012

DNA damage: placing BRCA1 in the proper context.

Curr Biol 2012 Sep;22(18):R806-8

Department of Cancer Biology, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.cub.2012.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827951PMC
September 2012

Links between genome integrity and BRCA1 tumor suppression.

Trends Biochem Sci 2012 Oct 24;37(10):418-24. Epub 2012 Jul 24.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.tibs.2012.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459146PMC
October 2012

Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism.

Mol Cell Biol 2012 Sep 23;32(18):3790-9. Epub 2012 Jul 23.

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.00049-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430196PMC
September 2012

Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.

Sci Transl Med 2012 Feb;4(122):122ra23

Laboratory of Cancer Genetics, Department of Clinical Genetics, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI-90220 Oulu, Finland.

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http://dx.doi.org/10.1126/scitranslmed.3003223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869525PMC
February 2012

Cancer. BRCA1, everything but the RING?

Science 2011 Oct;334(6055):459-60

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1214057
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http://dx.doi.org/10.1126/science.1214057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827953PMC
October 2011

Histone tails: Directing the chromatin response to DNA damage.

FEBS Lett 2011 Sep 27;585(18):2883-90. Epub 2011 May 27.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.febslet.2011.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172378PMC
September 2011

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.

J Biol Chem 2011 Apr 18;286(15):13669-80. Epub 2011 Feb 18.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.213728
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http://dx.doi.org/10.1074/jbc.M110.213728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075711PMC
April 2011

Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand Breaks.

Genes Cancer 2010 Jul;1(7):787-96

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601910382774
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http://dx.doi.org/10.1177/1947601910382774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989631PMC
July 2010

Neighborly DISCourse: DNA double strand breaks silence transcription.

Cell Cycle 2010 Sep 28;9(18):3635-6. Epub 2010 Sep 28.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.9.18.13171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830114PMC
September 2010

Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.

J Biol Chem 2010 Oct 22;285(40):30971-81. Epub 2010 Jul 22.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1074/jbc.M110.135319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945588PMC
October 2010

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.

Cell 2010 Jun;141(6):970-81

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.cell.2010.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920610PMC
June 2010

The ubiquitin landscape at DNA double-strand breaks.

J Cell Biol 2009 Nov;187(3):319-26

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1083/jcb.200908074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779242PMC
November 2009

Breast cancer gene variants: separating the harmful from the harmless.

J Clin Invest 2009 Oct 21;119(10):2895-7. Epub 2009 Sep 21.

Abramson Cancer Center, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104-6160, USA.

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http://www.jci.org/articles/view/40577
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http://dx.doi.org/10.1172/JCI40577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752087PMC
October 2009

Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.

Breast Cancer Res Treat 2010 Feb 2;120(1):165-8. Epub 2009 Jul 2.

Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, P.O. Box 5000, 90014, Oulu, Finland.

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http://dx.doi.org/10.1007/s10549-009-0453-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863093PMC
February 2010

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Genes Dev 2009 Mar 4;23(6):740-54. Epub 2009 Mar 4.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1739609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661612PMC
March 2009

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks.

Proc Natl Acad Sci U S A 2009 Mar 6;106(9):3166-71. Epub 2009 Feb 6.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0807485106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651241PMC
March 2009

Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication.

J Biol Chem 2009 Mar 28;284(13):8777-85. Epub 2008 Dec 28.

Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806103200
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659236PMC
March 2009

Telomere structural dynamics in genome integrity control and carcinogenesis.

Adv Exp Med Biol 2005 ;570:311-41

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massasuchsetts 02115, USA.

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http://dx.doi.org/10.1007/1-4020-3764-3_11DOI Listing
September 2008

Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network.

Chromosoma 2008 Aug 28;117(4):305-17. Epub 2008 Mar 28.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1007/s00412-008-0154-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692651PMC
August 2008

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Science 2007 May;316(5828):1198-202

Dana-Farber Cancer Institute and Department of Genetics and Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1139516
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706583PMC
May 2007

BRCA mutations and childhood cancer.

Cancer Biol Ther 2006 Sep 24;5(9):1103-4. Epub 2006 Sep 24.

Dana Faber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703724PMC
http://dx.doi.org/10.4161/cbt.5.9.3370DOI Listing
September 2006

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

Genes Dev 2006 Jan;20(1):34-46

Department of Genetics, Harvard Medical School and The Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1381306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356099PMC
January 2006

Constitutive telomerase expression promotes mammary carcinomas in aging mice.

Proc Natl Acad Sci U S A 2002 Jun 28;99(12):8191-6. Epub 2002 May 28.

Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street (M413), Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.112515399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123043PMC
June 2002

Screening for diabetes: is it warranted?

Clin Chim Acta 2002 Jan;315(1-2):61-9

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s0009-8981(01)00722-7DOI Listing
January 2002