Roger A Barker

Roger A Barker

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Roger A Barker

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DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

Neurobiol Dis 2020 Feb 11;134:104629. Epub 2019 Nov 11.

TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary; Cantabio Pharmaceuticals, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104629DOI Listing
February 2020

Motor complications in Parkinson's disease: 13-year follow-up of the CamPaIGN cohort.

Mov Disord 2020 Jan 11;35(1):185-190. Epub 2019 Nov 11.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/mds.27882DOI Listing
January 2020

Dual modulation of neuron-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons.

FEBS Lett 2019 Dec 10;593(23):3370-3380. Epub 2019 Oct 10.

Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology, Lund Stem Cell Center, Lund University, Sweden.

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http://dx.doi.org/10.1002/1873-3468.13612DOI Listing
December 2019

Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD.

Mov Disord 2019 Nov 23;34(11):1690-1698. Epub 2019 Aug 23.

Faculty of Medical Science, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1002/mds.27813DOI Listing
November 2019

Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.

Mol Psychiatry 2019 Nov 22. Epub 2019 Nov 22.

John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, CB2 0PY, UK.

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http://dx.doi.org/10.1038/s41380-019-0608-9DOI Listing
November 2019

Using Medical Claims Analyses to Understand Interventions for Parkinson Patients.

J Parkinsons Dis 2018 ;8(1):45-58

Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JPD-171277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836412PMC
October 2019

Categorising Visual Hallucinations in Early Parkinson's Disease.

J Parkinsons Dis 2018 ;8(3):447-453

Institute of Neuroscience, Newcastle University, UK.

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http://dx.doi.org/10.3233/JPD-181338DOI Listing
October 2019

Multimorbidity Predicts Quality of Life but not Motor Severity in Early Parkinson's Disease.

J Parkinsons Dis 2018 ;8(4):511-515

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.3233/JPD-181428DOI Listing
October 2019

Huntington's disease patients display progressive deficits in hippocampal-dependent cognition during a task of spatial memory.

Cortex 2019 Oct 13;119:417-427. Epub 2019 Aug 13.

Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.cortex.2019.07.014DOI Listing
October 2019

A Professional Standard for Informed Consent for Stem Cell Therapies.

JAMA 2019 Aug 12. Epub 2019 Aug 12.

University of Wisconsin Law School, Madison.

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http://dx.doi.org/10.1001/jama.2019.11290DOI Listing
August 2019

Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

Neurol Genet 2019 Aug 9;5(4):e348. Epub 2019 Jul 9.

Laboratory of Neurogenetics (H.I., C.B., H.L.L., F.F., D.G.H., A.B.S., M.A.N.), National Institute on Aging, National Institutes of Health, Bethesda; Data Tecnica International (H.I., M.A.N.), Glen Echo, MD; Precision Neurology Program (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Neurogenomics Laboratory (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Ann Romney Center for Neurologic Diseases (G.L., C.R.S.), Brigham and Women's Hospital, Boston, MA; The Norwegian Centre for Movement Disorders (J.M.-G., G.A.), Stavanger University Hospital; Department of Chemistry (J.M.-G., G.A.), Bioscience and Environmental Engineering, University of Stavanger, Norway; Assistance-Publique Hôpitaux de Paris (J.-C.C.), ICM, INSERM UMRS 1127, CNRS 7225, ICM, Department of Neurology and CIC Neurosciences, Pitié-Salpêtrière Hospital, Paris, France; Department of Neurology (L.P., M.T.), Oslo University Hospital, Norway; Department of Neurology (M.N., B.R.B., B.P.W.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Michael J Fox Foundation (S.J.H.), New York; Translational Genome Sciences (K.-D.H.N, K.E.), Biogen, Cambridge, MA; Department of Neurology University of Pennsylvania (J.R.), Philadelphia, PA; Department of Biostatistics and Computational Biology (S.E.), University of Rochester, NY; Department of Computer Science (F.F.), University of Illinois Urbana-Champaign; Department of Neurology (P.A.), Center for Health + Technology, University of Rochester, NY; Department of Clinical Neurosciences (K.M.S., R.W.), University of Cambridge, John van Geest Centre for Brain Repair, UK; Department of Pathology and Laboratory Medicine (V.M.V.D.), Center for Neurodegenerative Disease Research, Parelman School of Medicine at the University of Pennsylvania, Philadelphia; Genetics and Pharmacogenomics (A.G.D.-W.), Merck Research Laboratory, Boston, MA; Statistical Genetics (A.G.D.-W.), Biogen, Cambridge, MA; Institut du cerveau et de la moelle épinière ICM (A.B., F.D.); Sorbonne Université SU (A.B.); INSERM UMR (A.B.), Paris, France; Department of Neurology (G.A.), Stavanger University Hospital, Norway; Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London; Department of Molecular Neuroscience (A.J.N.), UCL Institute of Neurology, London, UK; Department of Neurology (O.-B.T.), Haukeland University Hospital; University of Bergen (O.-B.T.), Bergen, Norway; Department of Neurology (J.R.E.), Nottingham University NHS Trust, UK; Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Medical and Molecular Genetics (C.E.W.), Indiana University, Indianapolis; Department of Neurology (D.K.S.), Beth Israel Deaconess Medical Center; Harvard Medical School (D.K.S.), Boston; Voyager Therapeutics (B.R.), Cambridge, MA; Department of Neurology (B.R.), University of Rochester School of Medicine, NY; Institute of Clinical Medicine (M.T.), University of Oslo, Norway; German Center for Neurodegenerative Diseases-Tubingen (P.H.); HIH Tuebingen (P.H.), Germany; Department of Psychiatry (D.W.), University of Pennsylvania School of Medicine; Department of Veterans Affairs (D.W.), Philadelphia, PA; and Department of Clinical Neurosciences (R.A.B., C.H.W.-G.), University of Cambridge, UK; Department of Neurology (J.J.V.H.), Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1212/NXG.0000000000000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659137PMC
August 2019

Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease.

Authors:
Roger A Barker

Nat Med 2019 07 1;25(7):1045-1053. Epub 2019 Jul 1.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41591-019-0507-2DOI Listing
July 2019

Parkinson disease and growth factors - is GDNF good enough?

Nat Rev Neurol 2019 Jun;15(6):312-314

Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41582-019-0180-6DOI Listing
June 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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http://dx.doi.org/10.1056/NEJMoa1900907DOI Listing
June 2019

The clinical heterogeneity of Parkinson's disease and its therapeutic implications.

Eur J Neurosci 2019 Feb 14;49(3):328-338. Epub 2018 Oct 14.

Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/ejn.14094DOI Listing
February 2019

Hyperosmotic stress induces cell-dependent aggregation of α-synuclein.

Sci Rep 2019 Feb 19;9(1):2288. Epub 2019 Feb 19.

John van Geest Centre for Brain Repair, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-38296-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381101PMC
February 2019

Disease-Modification in Huntington's Disease: Moving Away from a Single-Target Approach.

J Huntingtons Dis 2019 ;8(1):9-22

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/JHD-180320DOI Listing
January 2019

Platelet-derived extracellular vesicles in Huntington's disease.

J Neurol 2018 Nov 12;265(11):2704-2712. Epub 2018 Sep 12.

Centre de Recherche du CHU de Québec, Québec, QC, Canada.

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http://dx.doi.org/10.1007/s00415-018-9022-5DOI Listing
November 2018

Tackling Ethical Challenges of Premature Delivery of Stem Cell-Based Therapies: ISSCR 2018 Annual Meeting Focus Session Report.

Stem Cell Reports 2018 11;11(5):1021-1025

The Centre for Stem Cell Systems (ELSI program), The University of Melbourne, Parkville, VIC, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183044
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http://dx.doi.org/10.1016/j.stemcr.2018.10.020DOI Listing
November 2018

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease.

Front Neurol 2018 20;9:946. Epub 2018 Nov 20.

John van Geest Center for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.3389/fneur.2018.00946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256248PMC
November 2018

Emerging Treatment Approaches for Parkinson's Disease.

Front Neurosci 2018 8;12:693. Epub 2018 Oct 8.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.3389/fnins.2018.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186796PMC
October 2018

Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis.

Front Neurol 2018 16;9:870. Epub 2018 Oct 16.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.3389/fneur.2018.00870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198066PMC
October 2018

iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia.

Exp Neurobiol 2018 Oct 31;27(5):350-364. Epub 2018 Oct 31.

CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seongnam 13488, Korea.

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http://dx.doi.org/10.5607/en.2018.27.5.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221836PMC
October 2018

Regenerative Therapies for Parkinson's Disease: An Update.

BioDrugs 2018 Aug;32(4):357-366

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.

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http://dx.doi.org/10.1007/s40259-018-0294-1DOI Listing
August 2018

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.

Cell Rep 2018 08;24(6):1397-1406

Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.017DOI Listing
August 2018

Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD).

Prog Brain Res 2017 7;230:165-190. Epub 2017 Feb 7.

Wallenberg Neuroscience Center, Lund University, Lund, Sweden; Wellcome Trust-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2016.11.011DOI Listing
May 2018

New approaches for brain repair-from rescue to reprogramming.

Nature 2018 05 16;557(7705):329-334. Epub 2018 May 16.

Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1038/s41586-018-0087-1DOI Listing
May 2018

Predicting clinical diagnosis in Huntington's disease: An imaging polymarker.

Ann Neurol 2018 03 13;83(3):532-543. Epub 2018 Mar 13.

The Computational, Cognitive & Clinical Neuroimaging Laboratory (CNL), Division of Brain Sciences, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1002/ana.25171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900832PMC
March 2018

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts.

J Vis Exp 2018 02 5(132). Epub 2018 Feb 5.

Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University;

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http://dx.doi.org/10.3791/56904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912349PMC
February 2018

C-PE2I and F-Dopa PET for assessing progression rate in Parkinson's: A longitudinal study.

Mov Disord 2018 01 30;33(1):117-127. Epub 2017 Oct 30.

Centre for Neurodegeneration and Neuroinflammation, Division of Brain Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/mds.27183DOI Listing
January 2018

Spatial structure normalises working memory performance in Parkinson's disease.

Cortex 2017 11 1;96:73-82. Epub 2017 Sep 1.

Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK; The Brain and Mind Institute, University of Western Ontario, Canada.

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http://dx.doi.org/10.1016/j.cortex.2017.08.023DOI Listing
November 2017

Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

Cell Stem Cell 2017 Nov;21(5):569-573

Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 606-8507, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.stem.2017.09.014DOI Listing
November 2017

CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.

PLoS One 2017 9;12(2):e0171748. Epub 2017 Feb 9.

John van Geest Centre for Brain Repair, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, England.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171748PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300212PMC
September 2017

Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?

Front Neurosci 2017 28;11:530. Epub 2017 Sep 28.

Department of Experimental Medical Science, Division of Neurobiology and Lund Stem Cell Center, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

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http://dx.doi.org/10.3389/fnins.2017.00530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625013PMC
September 2017

Stability of mild cognitive impairment in newly diagnosed Parkinson's disease.

J Neurol Neurosurg Psychiatry 2017 08 1;88(8):648-652. Epub 2017 Mar 1.

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/jnnp-2016-315099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537517PMC
August 2017

Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

Lancet Neurol 2017 08 16;16(8):620-629. Epub 2017 Jun 16.

Neurogenomics Laboratory and Parkinson Personalized Medicine Program of Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761650PMC
August 2017

Parkinson disease: Defining PD subtypes - a step toward personalized management?

Nat Rev Neurol 2017 Aug 7;13(8):454-455. Epub 2017 Jul 7.

John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK.

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http://dx.doi.org/10.1038/nrneurol.2017.98DOI Listing
August 2017

Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment.

Hum Brain Mapp 2017 03 13;38(3):1702-1715. Epub 2017 Jan 13.

Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1002/hbm.23499DOI Listing
March 2017

A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS.

Sci Rep 2017 03 21;7:44899. Epub 2017 Mar 21.

Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1038/srep44899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359595PMC
March 2017

Neural grafting for Parkinson's disease: challenges and prospects.

Neural Regen Res 2017 Mar;12(3):389-392

John van Geest Center for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.4103/1673-5374.202935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399709PMC
March 2017

Neuroendocrine abnormalities in Parkinson's disease.

J Neurol Neurosurg Psychiatry 2017 Feb 31;88(2):176-185. Epub 2016 Oct 31.

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1136/jnnp-2016-314601DOI Listing
February 2017

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

J Parkinsons Dis 2016 ;6(1):57-63

Center for Neurodegenerative Science, Van Andel Research Institute, MI, USA.

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http://dx.doi.org/10.3233/JPD-160798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927930PMC
January 2017

Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

Neurobiol Aging 2016 12 9;48:153-160. Epub 2016 Sep 9.

Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096886PMC
December 2016

Cell therapies for Parkinson's disease: how far have we come?

Regen Med 2016 12 25;11(8):777-786. Epub 2016 Nov 25.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge, CB2 0PY, UK.

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http://dx.doi.org/10.2217/rme-2016-0102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221268PMC
December 2016

α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

Exp Neurol 2016 Nov 12;285(Pt A):72-81. Epub 2016 Sep 12.

John van Geest Centre for Brain Repair and Department of Clinical Neuroscience, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, United Kingdom; Department of Neurology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.expneurol.2016.09.003DOI Listing
November 2016

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.

Cell 2016 Oct;167(2):566-580.e19

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden; Science for Life Laboratory, 17121 Solna, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055122PMC
October 2016

Learning to be inflexible: Enhanced attentional biases in Parkinson's disease.

Cortex 2016 09 24;82:24-34. Epub 2016 May 24.

Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK; The Brain and Mind Institute, University of Western Ontario, CA, USA.

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http://dx.doi.org/10.1016/j.cortex.2016.05.005DOI Listing
September 2016

Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's disease.

Mov Disord 2016 08 19;31(8):1163-72. Epub 2016 Apr 19.

Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, UK.

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http://dx.doi.org/10.1002/mds.26631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988382PMC
August 2016

Exogenous melatonin for Parkinson's disease: 'Waking up' to the need for further trials.

Parkinsonism Relat Disord 2016 08 13;29:121-2. Epub 2016 May 13.

John van Geest Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.05.012DOI Listing
August 2016

Atomoxetine restores the response inhibition network in Parkinson's disease.

Brain 2016 08 24;139(Pt 8):2235-48. Epub 2016 Jun 24.

1 Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK 2 Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK 4 Behavioural and Clinical Neuroscience Institute, Cambridge, CB2 3EB, UK

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http://dx.doi.org/10.1093/brain/aww138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958901PMC
August 2016

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD).

Mov Disord 2016 07 21;31(7):995-1003. Epub 2016 Mar 21.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/mds.26563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957620PMC
July 2016

Aberrant nigral diffusion in Parkinson's disease: A longitudinal diffusion tensor imaging study.

Mov Disord 2016 07 22;31(7):1020-6. Epub 2016 Apr 22.

Neurology Imaging Unit, Hammersmith Hospital, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/mds.26606DOI Listing
July 2016

Making it personal: the prospects for autologous pluripotent stem cell-derived therapies.

Regen Med 2016 07 27;11(5):423-5. Epub 2016 Jun 27.

Wellcome Trust - MRC Cambridge Stem Cell Institute, University of Cambridge, UK.

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http://dx.doi.org/10.2217/rme-2016-0057DOI Listing
July 2016

Novel targets for Huntington's disease: future prospects.

Degener Neurol Neuromuscul Dis 2016 4;6:25-36. Epub 2016 May 4.

John van Geest Centre for Brain Repair,

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http://dx.doi.org/10.2147/DNND.S83808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053088PMC
May 2016