Roel Verhaak

Roel Verhaak

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BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma.

Sci Rep 2019 Oct 10;9(1):14569. Epub 2019 Oct 10.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Kids, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-019-51270-1DOI Listing
October 2019

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.

Nat Rev Cancer 2019 05;19(5):283-288

Ludwig Institute for Cancer Research, San Diego, La Jolla, CA, USA.

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http://www.nature.com/articles/s41568-019-0128-6
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http://dx.doi.org/10.1038/s41568-019-0128-6DOI Listing
May 2019

Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma.

Cancer Cell 2019 Apr;35(4):542-544

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193015
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http://dx.doi.org/10.1016/j.ccell.2019.03.009DOI Listing
April 2019

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults.

Neurol Clin 2018 08;36(3):421-437

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322909PMC
August 2018

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

Cell Rep 2018 07;24(2):463-478.e5

Cellular and Molecular Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Gilbert Family Neurofibromatosis Institute, Children's National Medical Center, Washington, DC 20010, USA; Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010, USA; Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116735PMC
July 2018

Reconstructing the molecular life history of gliomas.

Acta Neuropathol 2018 05 3;135(5):649-670. Epub 2018 Apr 3.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.

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http://dx.doi.org/10.1007/s00401-018-1842-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904231PMC
May 2018

Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States.

Cell Syst 2017 08;5(2):90-92

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.08.006DOI Listing
August 2017

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

Neuro Oncol 2017 06;19(6):786-795

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

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http://dx.doi.org/10.1093/neuonc/now285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464432PMC
June 2017

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Mol Cancer Res 2017 05 1;15(5):532-540. Epub 2017 Feb 1.

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0322DOI Listing
May 2017

Glioma: experimental models and reality.

Acta Neuropathol 2017 02 10;133(2):263-282. Epub 2017 Jan 10.

Department of Pathology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00401-017-1671-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250671PMC
February 2017

Targeting tyrosine receptor kinase B in gliomas.

Neuro Oncol 2017 01 14;19(1):138-139. Epub 2016 Sep 14.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, Brazil (K.V.P., C.A., M.B., M.S.G., A.T., G.S., C.B.F., R.R.); Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (K.V.P., C.A., M.B., M.S.G., A.T., R.R.); Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (G.S.), Children's Cancer Institute, Porto Alegre, Brazil (C.B.F.).

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http://dx.doi.org/10.1093/neuonc/now199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193030PMC
January 2017

GlioVis data portal for visualization and analysis of brain tumor expression datasets.

Neuro Oncol 2017 01 9;19(1):139-141. Epub 2016 Nov 9.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA (R.L.B.); Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W., R.G.V.); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W.); Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (Q.W., R.G.V.); Bioinformatics unit, Structural Biology and Biocomputing Programme, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain (A.C.); Department of Computational Biology, The Jackson Laboratory, Farmington, Connecticut, USA (R.G.V.); Seve Ballesteros Foundation Brain Tumor Group, Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain (M.S.)

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http://dx.doi.org/10.1093/neuonc/now247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193031PMC
January 2017

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

Cell Rep 2016 12;17(12):3407

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.celrep.2016.12.026DOI Listing
December 2016

Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies.

Neuro Oncol 2016 10 1;18(10):1357-66. Epub 2016 Jul 1.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (S.T.G., Y.H., A.B.H.); Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (S.-P.W., J.d.G.); Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (R.G.W.V.); Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (S.Z.); Department of Neuropathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (G.N.F.); Caris Life Sciences, Phoenix, Arizona, USA (J.X., Z.G., S.K.R., D.S.); The University of Sydney, Sydney, Australia (M.K.)

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http://dx.doi.org/10.1093/neuonc/now132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035527PMC
October 2016

Longitudinal genomic characterization of brain tumors for identification of therapeutic vulnerabilities.

Neuro Oncol 2016 08 28;18(8):1037-9. Epub 2016 May 28.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas (E.E., R.G.W.V.); Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (R.G.W.V.).

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http://dx.doi.org/10.1093/neuonc/now064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933487PMC
August 2016

Moving the needle: Optimizing classification for glioma.

Authors:
Roel G W Verhaak

Sci Transl Med 2016 08;8(350):350fs14

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aah4740DOI Listing
August 2016

MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.

Mol Cancer Ther 2016 07 22;15(7):1656-68. Epub 2016 Apr 22.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936927PMC
July 2016

A Molecular Take on Malignant Rhabdoid Tumors.

Trends Cancer 2016 05 28;2(5):217-218. Epub 2016 Apr 28.

Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.04.003DOI Listing
May 2016

A Molecular Take on Malignant Rhabdoid Tumors.

Trends Cancer 2016 May;2(5):217-218

Department of Genomic Medicine, Computational Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics, Computational Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.trecan.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035037PMC
May 2016

Novel kinase fusion transcripts found in endometrial cancer.

Sci Rep 2015 Dec 22;5:18657. Epub 2015 Dec 22.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1038/srep18657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687039PMC
December 2015

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

Cell Rep 2015 Jul 2;12(2):258-71. Epub 2015 Jul 2.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.celrep.2015.06.012DOI Listing
July 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Transcriptional mimicry by tumor-associated stroma.

Nat Genet 2015 Apr;47(4):307-9

1] Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/ng.3255DOI Listing
April 2015

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.

Genome Res 2015 Mar 3;25(3):316-27. Epub 2015 Feb 3.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;

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http://dx.doi.org/10.1101/gr.180612.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352879PMC
March 2015

Seek and destroy: relating cancer drivers to therapies.

Cancer Cell 2015 Mar;27(3):319-21

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.02.011DOI Listing
March 2015

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):E4214-23. Epub 2014 Sep 22.

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908

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http://dx.doi.org/10.1073/pnas.1414389111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210043PMC
October 2014

PRADA: pipeline for RNA sequencing data analysis.

Bioinformatics 2014 Aug 1;30(15):2224-6. Epub 2014 Apr 1.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, The Eli and Edythe L. Broad Institute of Harvard University and MIT, Cambridge, MA 02142 and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10015, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103589PMC
August 2014

Inferring tumour purity and stromal and immune cell admixture from expression data.

Nat Commun 2013 ;4:2612

1] Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, Texas 77030, USA [2] Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

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http://dx.doi.org/10.1038/ncomms3612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826632PMC
May 2014

Silent mutations make some noise.

Cell 2014 Mar;156(6):1129-1131

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.037DOI Listing
March 2014

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Cell Rep 2014 Jan 16;6(2):313-24. Epub 2014 Jan 16.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041390PMC
January 2014

Intragenic breakpoint: a marker of genome instability in glioblastoma.

Cell Cycle 2013 Dec 21;12(24):3705-6. Epub 2013 Oct 21.

Department of Bioinformatics and Computational Biology; The University of Texas MD Anderson Cancer Center; Houston TX USA; Department of Genomic Medicine; The University of Texas MD Anderson Cancer Center; Houston TX USA.

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http://dx.doi.org/10.4161/cc.26874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905055PMC
December 2013

The somatic genomic landscape of glioblastoma.

Cell 2013 Oct;155(2):462-77

Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

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https://www.genome.gov/Multimedia/Slides/TCGA2/27_Verhaak.pd
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301208
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http://dx.doi.org/10.1016/j.cell.2013.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910500PMC
October 2013

Predicting time to ovarian carcinoma recurrence using protein markers.

J Clin Invest 2013 Sep 15;123(9):3740-50. Epub 2013 Aug 15.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1172/JCI68509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754259PMC
September 2013

Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.

Nat Struct Mol Biol 2013 Jul 2;20(7):908-13. Epub 2013 Jun 2.

Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China.

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http://liulab.dfci.harvard.edu/publications/NSMB13_Jun%202%2
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http://www.nature.com/doifinder/10.1038/nsmb.2591
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http://dx.doi.org/10.1038/nsmb.2591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702647PMC
July 2013

Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.

Clin Cancer Res 2012 Nov 15;18(21):5911-23. Epub 2012 Aug 15.

Braman Family Breast Cancer Institute and Division of Biostatistics, Department of Epidemiology and Public Health, University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698880PMC
November 2012

Studying a complex tumor: potential and pitfalls.

Cancer J 2012 Jan-Feb;18(1):107-14

Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PPO.0b013e3182431c57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342695PMC
May 2012

The cellular origin for malignant glioma and prospects for clinical advancements.

Expert Rev Mol Diagn 2012 May;12(4):383-94

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.

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http://dx.doi.org/10.1586/erm.12.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368274PMC
May 2012

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Nature 2012 Feb 15;483(7390):484-8. Epub 2012 Feb 15.

Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.

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http://www.nature.com/articles/nature10898
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http://dx.doi.org/10.1038/nature10898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656605PMC
February 2012

Unifying gene expression measures from multiple platforms using factor analysis.

PLoS One 2011 Mar 11;6(3):e17691. Epub 2011 Mar 11.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059153PMC
March 2011

Genes predictive of outcome and novel molecular classification schemes in adult acute myeloid leukemia.

Cancer Treat Res 2010 ;145:67-83

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://link.springer.com/10.1007/978-0-387-69259-3_5
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http://dx.doi.org/10.1007/978-0-387-69259-3_5DOI Listing
October 2010

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling.

Haematologica 2009 Jan 6;94(1):131-4. Epub 2008 Oct 6.

Erasmus University Medical Center Rotterdam, Department of Hematology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625407PMC
January 2009

Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.

Cancer Res 2006 Jan;66(2):622-6

Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, the Netherlands.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2908DOI Listing
January 2006