Roderick T Bronson

Roderick T Bronson

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Roderick T Bronson

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Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.

Mol Ther Methods Clin Dev 2019 Dec 16;15:18-26. Epub 2019 Aug 16.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Neurodiscovery Center, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.omtm.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745533PMC
December 2019

Increased PHGDH expression promotes aberrant melanin accumulation.

BMC Cancer 2019 Jul 22;19(1):723. Epub 2019 Jul 22.

Koch Institute for Integrative Cancer Research, Cambridge, 02139, MA, USA.

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http://dx.doi.org/10.1186/s12885-019-5933-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647269PMC
July 2019

Neutralization of BCL-2/X Enhances the Cytotoxicity of T-DM1 .

Mol Cancer Ther 2019 06 8;18(6):1115-1126. Epub 2019 Apr 8.

Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758547PMC
June 2019

The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice.

Mol Nutr Food Res 2019 04 4;63(8):e1801097. Epub 2019 Feb 4.

Vitamins & Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111.

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http://dx.doi.org/10.1002/mnfr.201801097DOI Listing
April 2019

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.

J Clin Invest 2019 Jan 26;129(1):215-222. Epub 2018 Nov 26.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI99699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307955PMC
January 2019

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366450PMC
December 2018

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.

Cell Rep 2018 12;25(12):3504-3518.e6

Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK; Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183184
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http://dx.doi.org/10.1016/j.celrep.2018.11.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315111PMC
December 2018

Neural blastocyst complementation enables mouse forebrain organogenesis.

Nature 2018 11 10;563(7729):126-130. Epub 2018 Oct 10.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-018-0586-0
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http://dx.doi.org/10.1038/s41586-018-0586-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588192PMC
November 2018

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Nat Commun 2018 11 23;9(1):4945. Epub 2018 Nov 23.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-018-07472-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251888PMC
November 2018

E-Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma.

Am J Respir Cell Mol Biol 2018 08;59(2):237-245

1 Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston Massachusetts.

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http://dx.doi.org/10.1165/rcmb.2017-0210OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096341PMC
August 2018

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.

Cell 2018 06 14;174(1):156-171.e16. Epub 2018 Jun 14.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089614PMC
June 2018

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Cancer Metab 2018 31;6. Epub 2018 May 31.

1David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977456PMC
May 2018

Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4228-4233. Epub 2018 Apr 2.

Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1718414115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910837PMC
April 2018

γδ T Cells Contribute to Injury in the Developing Brain.

Am J Pathol 2018 03 15;188(3):757-767. Epub 2017 Dec 15.

Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840494PMC
March 2018

FOXO protects against age-progressive axonal degeneration.

Aging Cell 2018 02 26;17(1). Epub 2017 Nov 26.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/acel.12701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771393PMC
February 2018

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Stem Cell Reports 2017 11 26;9(5):1706-1720. Epub 2017 Oct 26.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829328PMC
November 2017

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

JCI Insight 2017 10 5;2(19). Epub 2017 Oct 5.

Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.94298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841868PMC
October 2017

Ontak-like human IL-2 fusion toxin.

J Immunol Methods 2017 09 24;448:51-58. Epub 2017 May 24.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00221759173014
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http://dx.doi.org/10.1016/j.jim.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576150PMC
September 2017

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

NPJ Breast Cancer 2017 22;3:38. Epub 2017 Sep 22.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 USA.

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http://dx.doi.org/10.1038/s41523-017-0031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610185PMC
September 2017

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

NPJ Breast Cancer 2017 1;3:18. Epub 2017 May 1.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115 MA USA.

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http://dx.doi.org/10.1038/s41523-017-0020-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460247PMC
May 2017

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.

Cell Metab 2017 03 2;25(3):661-672. Epub 2017 Feb 2.

Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA; Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342925PMC
March 2017

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.

Nature 2017 03 8;543(7645):428-432. Epub 2017 Mar 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature21409DOI Listing
March 2017

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.

Nat Commun 2017 02 13;8:14431. Epub 2017 Feb 13.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms14431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316831PMC
February 2017

Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.

Sci Rep 2016 11 7;6:36696. Epub 2016 Nov 7.

Department of Surgery, University of Michigan Hospital, Ann Arbor, MI, 48019, USA.

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http://dx.doi.org/10.1038/srep36696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098180PMC
November 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Histopathology of the human inner ear in Alström's syndrome.

Audiol Neurootol 2015 24;20(4):267-72. Epub 2015 Jun 24.

Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000381935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540704PMC
June 2016

Unrecognized "AIDS" in Monkeys, 1969-1980: Explanations and Implications.

Am J Public Health 2016 Jun 14;106(6):1015-22. Epub 2016 Apr 14.

Theodore M. Hammett is with Abt Associates, Cambridge, MA. Roderick T. Bronson is with Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2105/AJPH.2016.303085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880232PMC
June 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

Oncotarget 2016 May;7(22):31681-8

Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.18632/oncotarget.9426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077968PMC
May 2016

Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.

Cancer Res 2016 04 15;76(7):1869-81. Epub 2016 Feb 15.

Division of Genetics, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873435PMC
April 2016

Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.

PLoS One 2015 17;10(3):e0120628. Epub 2015 Mar 17.

Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364018PMC
December 2015

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Oncotarget 2015 Dec;6(40):42445-67

Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.6442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767444PMC
December 2015

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.

Comp Med 2015 Oct;65(5):429-43

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617335PMC
October 2015

Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo.

Pigment Cell Melanoma Res 2015 Sep 20;28(5):603-6. Epub 2015 Jun 20.

Graduate Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1111/pcmr.12384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539285PMC
September 2015

Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.

Biochem Biophys Res Commun 2015 Sep 28;465(2):167-73. Epub 2015 Jul 28.

Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine. Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594872PMC
September 2015

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

Immunity 2015 Sep 1;43(3):579-90. Epub 2015 Sep 1.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826619PMC
September 2015

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Genes Dev 2015 Sep;29(17):1850-62

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.267393.115
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http://dx.doi.org/10.1101/gad.267393.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573857PMC
September 2015

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Cancer Discov 2015 Jul 16;5(7):740-51. Epub 2015 Apr 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497843PMC
July 2015

CD11c+ Dendritic Cells Accelerate the Rejection of Older Cardiac Transplants via Interleukin-17A.

Circulation 2015 Jul 8;132(2):122-31. Epub 2015 May 8.

From Transplantation Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.O., T.H., H.R.C.B., K.H., K.E., H.U., M.Q., F.V., F.K., B.S., A.E., S.G.T.); Department of Visceral, Transplant, and Thoracic Surgery, Center for Operative Medicine, Innsbruck Medical University, Austria (R.O.); Institute of Medical Immunology (T.H.) and Department for General, Visceral, Transplant, Vascular, and Thorax Surgery (J.P.), Charité-Universitätsmedizin Berlin, Germany; Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland (H.R.C.B., M.J.W.); Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA (O.B., R.A.); Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (O.B.); Division of Transplantation, Department of Surgery, Medical University of Vienna, Austria (K.H.); Rodent Histopathology Core, Harvard Medical School, Boston, MA (R.T.B.); Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan (R.T.B.); Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, University Hospital of Leipzig, Germany (M.Q., F.K.); and Division of Transplant Surgery, Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands (B.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503506PMC
July 2015

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

Cancer Discov 2015 Apr 22;5(4):396-409. Epub 2015 Jan 22.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418175PMC
April 2015

A vascular model of Tsc1 deficiency accelerates renal tumor formation with accompanying hemangiosarcomas.

Mol Cancer Res 2015 Mar 29;13(3):548-55. Epub 2014 Dec 29.

Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369160PMC
March 2015

Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.

Cancer Res 2015 Mar 16;75(6):1068-79. Epub 2015 Jan 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359959PMC
March 2015

Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Front Oncol 2015 24;5:50. Epub 2015 Feb 24.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338657PMC
March 2015

Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis.

J Trauma Acute Care Surg 2014 Dec;77(6):913-9; discussion 919

From the Department of Surgery (T.Z.), Division of Trauma, Emergency Surgery & Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Department of Surgery (Y.L., B.L., I.H., H.B.A.), University of Michigan Hospital, Ann Arbor, Michigan; and Department of Microbiology and Immunobiology (R.T.B.), Harvard Medical School, Boston, Massachusetts.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TA.0000000000000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824316PMC
December 2014

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Nature 2014 Dec 22;516(7531):428-31. Epub 2014 Oct 22.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292871PMC
December 2014

Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.

Endocrinology 2014 Oct 8;155(10):4061-8. Epub 2014 Jul 8.

Thyroid Program of the Division of Endocrinology (L.A.C., R.H.J., M.A.M., J.S.L., A.J.W., C.C.G., H.D.S., N.Y.L., S.A.H.), Clinical Research Center (H.A.F), and Department of Laboratory Medicine (R.W.P., C.H., M.D.K), Boston Children's Hospital; Thyroid Section of the Division of Endocrinology, Diabetes, and Hypertension (S.A.H.), Department of Pathology (D.D., A.T.A.), and Division of Gastroenterology (C.U., V.D., A.D.), Brigham and Women's Hospital; Harvard Neurodiscovery Center (L.D.); Dana Farber Cancer Institute (R.T. B., S.A.H.); Division of Endocrinology (K.R.V.), Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115; and Department of Molecular and Clinical Endocrinology and Oncology (C.L., D.S., M.D.), University of Naples Federico II, 80131 Naples, Italy.

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http://dx.doi.org/10.1210/en.2013-2028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164928PMC
October 2014

DOK2 inhibits EGFR-mutated lung adenocarcinoma.

PLoS One 2013 8;8(11):e79526. Epub 2013 Nov 8.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079526PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821857PMC
September 2014

ROS1 signaling regulates epithelial differentiation in the epididymis.

Endocrinology 2014 Sep 27;155(9):3661-73. Epub 2014 Jun 27.

Molecular Oncology Research Institute (H.J.J., S.W., D.P., A.C), Tufts Medical Center, Boston, Massachusetts 02111; Center for Cancer Research (K.L., A.C.), Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Program in Membrane Biology and Division of Nephrology and Center for Systems Biology (J.R., T.B.S., S.B.) and Molecular Pathology Unit (L.B.W., K.M.H.), Massachusetts General Hospital, Boston, Massachusetts 02114; Department of Pathology (R.T.B), Harvard Medical School, Boston, Massachusetts 02115; and Department of Neurosurgery and Program in Genetics (A.C), Tufts University School of Medicine, Boston, Massachusetts 02111.

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http://dx.doi.org/10.1210/en.2014-1341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138574PMC
September 2014

Repair of endogenous DNA base lesions modulate lifespan in mice.

DNA Repair (Amst) 2014 Sep 30;21:78-86. Epub 2014 Jun 30.

Biological Engineering Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Biology Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Rodent Histopathology Core, Harvard Medical School, 126 Goldenson Building, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125484PMC
September 2014

Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC.

Cancer Res 2014 Sep 17;74(17):4676-84. Epub 2014 Jul 17.

Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Ludwig Institute for Cancer, Cambridge, Massachusetts. Belfer Institute for Applied Cancer Science, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154986PMC
September 2014

Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.

Cancer Res 2014 Sep 29;74(18):5336-47. Epub 2014 Jul 29.

Department of Molecular Biology, Princeton University, Princeton, New Jersey. Tumor Progression and Genomic Instability Program, The Cancer Institute of New Jersey, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167565PMC
September 2014

Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model.

Surgery 2014 Aug 16;156(2):235-42. Epub 2014 Jun 16.

Department of Surgery, University of Michigan Hospital, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267495PMC
August 2014

MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.

Cancer Cell 2014 Jul 26;26(1):92-105. Epub 2014 Jun 26.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101059PMC
July 2014

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10299-304. Epub 2014 Jun 30.

Stem Cell Program, Boston Children's Hospital, Boston MA 02115;Harvard Stem Cell Institute, Cambridge, MA 02138;Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1404399111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104911PMC
July 2014

A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers.

Kidney Int 2014 Jun 12;85(6):1461-8. Epub 2014 Feb 12.

Renal Division, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ki.2013.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040157PMC
June 2014

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.

Cancer Lett 2014 Jun 14;347(2):191-5. Epub 2014 Mar 14.

Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418438PMC
June 2014

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Cell 2014 Apr;157(3):595-610

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098792PMC
April 2014

Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

Stem Cells 2014 Feb;32(2):338-48

Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.1554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442493PMC
February 2014

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

Cancer Cell 2014 Feb 30;25(2):196-209. Epub 2014 Jan 30.

Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Liver Cancer Program/Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951208PMC
February 2014

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.

Cancer Res 2014 Jan 9;74(1):15-23. Epub 2013 Dec 9.

Authors' Affiliations: Department of Cancer Biology; Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of Biological Chemistry and Molecular Pharmacology and Systems Biology; Rodent Histopathology Core, DF/HCC, Harvard Medical School; Department of Surgery, Brigham and Women's Hospital; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston; Novartis Institutes for Biomedical Research, Cambridge, Massacheusetts; Department of System Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Novartis Institutes for Biomedical Research, Oncology Disease Area, Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982380PMC
January 2014

Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease.

J Nutr Biochem 2013 Dec 2;24(12):2138-43. Epub 2013 Oct 2.

Vitamin Metabolism, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.

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http://dx.doi.org/10.1016/j.jnutbio.2013.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199223PMC
December 2013