Roderick MacKinnon

Roderick MacKinnon

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Roderick MacKinnon

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Structural Basis of Human KCNQ1 Modulation and Gating.

Cell 2020 01 26;180(2):340-347.e9. Epub 2019 Dec 26.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083075PMC
January 2020

Voltage Sensor Movements during Hyperpolarization in the HCN Channel.

Cell 2019 12 28;179(7):1582-1589.e7. Epub 2019 Nov 28.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911011PMC
December 2019

Molecular structures of the human Slo1 K channel in complex with β4.

Elife 2019 12 9;8. Epub 2019 Dec 9.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, New York, United States.

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http://dx.doi.org/10.7554/eLife.51409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934384PMC
December 2019

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.

Elife 2019 11 1;8. Epub 2019 Nov 1.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.50403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824864PMC
November 2019

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.

Elife 2019 11 22;8. Epub 2019 Nov 22.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, New York, United States.

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http://dx.doi.org/10.7554/eLife.52164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882556PMC
November 2019

Force-induced conformational changes in PIEZO1.

Nature 2019 09 21;573(7773):230-234. Epub 2019 Aug 21.

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.

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http://www.nature.com/articles/s41586-019-1499-2
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http://dx.doi.org/10.1038/s41586-019-1499-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258172PMC
September 2019

Regulation of Eag1 gating by its intracellular domains.

Elife 2019 09 6;8. Epub 2019 Sep 6.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, New York, United States.

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http://dx.doi.org/10.7554/eLife.49188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731095PMC
September 2019

Molecular basis of signaling specificity between GIRK channels and GPCRs.

Elife 2018 12 10;7. Epub 2018 Dec 10.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.42908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335053PMC
December 2018

Piezo's membrane footprint and its contribution to mechanosensitivity.

Elife 2018 11 27;7. Epub 2018 Nov 27.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.41968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317911PMC
November 2018

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.

Elife 2018 08 22;7. Epub 2018 Aug 22.

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, New York, United States.

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https://elifesciences.org/articles/33149
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http://dx.doi.org/10.7554/eLife.33149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128688PMC
August 2018

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.

Science 2018 05;360(6388):508-513

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aas9466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241251PMC
May 2018

Structure of the CLC-1 chloride channel from .

Elife 2018 05 29;7. Epub 2018 May 29.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.36629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019066PMC
May 2018

Structure-based membrane dome mechanism for Piezo mechanosensitivity.

Elife 2017 12 12;6. Epub 2017 Dec 12.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.33660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788504PMC
December 2017

Molecular structure of human KATP in complex with ATP and ADP.

Elife 2017 12 29;6. Epub 2017 Dec 29.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.32481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790381PMC
December 2017

Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.

Cell 2017 Jun;169(6):1042-1050.e9

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562354PMC
June 2017

Cryo-EM Structure of the Open Human Ether-à-go-go-Related K Channel hERG.

Cell 2017 04;169(3):422-430.e10

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484391PMC
April 2017

Cryo-EM structure of the open high-conductance Ca-activated K channel.

Nature 2017 01 14;541(7635):46-51. Epub 2016 Dec 14.

Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature20608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500982PMC
January 2017

Structural basis for gating the high-conductance Ca-activated K channel.

Nature 2017 01 14;541(7635):52-57. Epub 2016 Dec 14.

Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature20775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513477PMC
January 2017

Structure of a CLC chloride ion channel by cryo-electron microscopy.

Nature 2017 01 21;541(7638):500-505. Epub 2016 Dec 21.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature20812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576512PMC
January 2017

Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Cell 2017 Jan 12;168(1-2):111-120.e11. Epub 2017 Jan 12.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496774PMC
January 2017

Structural Titration of Slo2.2, a Na-Dependent K Channel.

Cell 2017 01 19;168(3):390-399.e11. Epub 2017 Jan 19.

Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382815PMC
January 2017

Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism.

Science 2016 Aug;353(6300):664-9

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aaf8070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477842PMC
August 2016

Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.

Proc Natl Acad Sci U S A 2016 May 18;113(20):5748-53. Epub 2016 Apr 18.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1602815113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878532PMC
May 2016

Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.

Elife 2016 04 13;5. Epub 2016 Apr 13.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, New York, United States.

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https://elife-publishing-cdn.s3.amazonaws.com/15751/elife-15
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http://elifesciences.org/lookup/doi/10.7554/eLife.15751
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http://dx.doi.org/10.7554/eLife.15751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866826PMC
April 2016

The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.

Elife 2016 04 13;5. Epub 2016 Apr 13.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.15750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866825PMC
April 2016

Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.

Nature 2015 Nov 5;527(7577):198-203. Epub 2015 Oct 5.

Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886347PMC
November 2015

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.

Nature 2014 Dec;516(7529):126-30

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682367PMC
December 2014

Phosphatidic acid modulation of Kv channel voltage sensor function.

Elife 2014 Oct 6;3. Epub 2014 Oct 6.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.04366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212207PMC
October 2014

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system.

Elife 2014 Jul 20;3:e03671. Epub 2014 Jul 20.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States

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http://dx.doi.org/10.7554/eLife.03671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135351PMC
July 2014

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.

Proc Natl Acad Sci U S A 2014 Mar 18;111(9):3614-9. Epub 2014 Feb 18.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1320768111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948252PMC
March 2014

X-ray structure of the mammalian GIRK2-βγ G-protein complex.

Nature 2013 Jun 5;498(7453):190-7. Epub 2013 Jun 5.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature12241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654628PMC
June 2013

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.

Elife 2013 May 21;2:e00594. Epub 2013 May 21.

Laboratory of Molecular Neurobiology and Biophysics , Rockefeller University , New York , United States ; Howard Hughes Medical Institute, Rockefeller University , New York , United States.

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http://dx.doi.org/10.7554/eLife.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660741PMC
May 2013

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.

Proc Natl Acad Sci U S A 2013 Feb 22;110(6):2129-34. Epub 2013 Jan 22.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1218950110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568379PMC
February 2013

Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.

Proc Natl Acad Sci U S A 2012 Nov 5;109(47):19274-9. Epub 2012 Nov 5.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1215078109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511096PMC
November 2012

Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters.

Proc Natl Acad Sci U S A 2012 Jul 2;109(29):11699-704. Epub 2012 Jul 2.

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1205764109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406864PMC
July 2012

Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels.

Proc Natl Acad Sci U S A 2012 Jun 6;109(26):10352-7. Epub 2012 Jun 6.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1204700109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387069PMC
June 2012

Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.

Science 2012 Jan;335(6067):436-41

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1213808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329120PMC
January 2012

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.

Nature 2011 Dec 4;481(7379):94-7. Epub 2011 Dec 4.

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature10670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319005PMC
December 2011

Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.

Cell 2011 Sep;147(1):199-208

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2011.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243363PMC
September 2011

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2.

Nature 2011 Aug 28;477(7365):495-8. Epub 2011 Aug 28.

Laboratory of Molecular Neurobiology & Biophysics, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature10370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324908PMC
August 2011

Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP.

J Mol Biol 2010 Nov 21;403(4):591-606. Epub 2010 Sep 21.

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971526PMC
November 2010

Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.

Science 2010 Oct 30;330(6004):635-41. Epub 2010 Sep 30.

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1195230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079386PMC
October 2010

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.

Science 2010 Jul 27;329(5988):182-6. Epub 2010 May 27.

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1190414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022345PMC
July 2010

A gating charge transfer center in voltage sensors.

Science 2010 Apr;328(5974):67-73

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1185954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869078PMC
April 2010

Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.

Science 2009 Dec;326(5960):1668-74

Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1180310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819303PMC
December 2009

Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA.

J Am Chem Soc 2009 Oct;131(42):15246-50

Institute of Physical and Theoretical Chemistry and Center of Biomolecular Magnetic Resonance, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1021/ja904808nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779547PMC
October 2009

A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers.

J Mol Biol 2009 Jul 27;390(5):902-12. Epub 2009 May 27.

Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.05.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778279PMC
July 2009

Functional reconstitution of purified human Hv1 H+ channels.

J Mol Biol 2009 Apr 21;387(5):1055-60. Epub 2009 Feb 21.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778278PMC
April 2009

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane.

Proc Natl Acad Sci U S A 2008 Dec 2;105(49):19276-81. Epub 2008 Dec 2.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0810187105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614752PMC
December 2008

Inferred motions of the S3a helix during voltage-dependent K+ channel gating.

J Mol Biol 2008 Sep 10;381(3):569-80. Epub 2008 Jun 10.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, Box 47, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819426PMC
September 2008

Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers.

J Mol Biol 2008 Sep 7;382(1):24-33. Epub 2008 Jul 7.

Howard Hughes Medical Institute, Department of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.06.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825521PMC
September 2008

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1.

Proc Natl Acad Sci U S A 2008 Jun 28;105(22):7692-5. Epub 2008 May 28.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.0803277105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409406PMC
June 2008

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.

Nature 2007 Nov;450(7168):376-82

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature06265DOI Listing
November 2007

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.

EMBO J 2007 Sep 16;26(17):4005-15. Epub 2007 Aug 16.

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994128PMC
September 2007

Structural and thermodynamic properties of selective ion binding in a K+ channel.

PLoS Biol 2007 May;5(5):e121

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858713PMC
May 2007

Phospholipids and the origin of cationic gating charges in voltage sensors.

Nature 2006 Dec 29;444(7120):775-9. Epub 2006 Nov 29.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature05416DOI Listing
December 2006

Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation.

Science 2006 Nov;314(5801):1004-7

Laboratories of Molecular Neurobiology and Biophysics and Synthetic Protein Chemistry, Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1133415DOI Listing
November 2006

Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.

J Am Chem Soc 2006 Sep;128(35):11591-9

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/ja0631955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546570PMC
September 2006

Principles of selective ion transport in channels and pumps.

Science 2005 Dec;310(5753):1461-5

Vollum Institute and Howard Hughes Medical Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1126/science.1113666DOI Listing
December 2005

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel.

Cell 2005 Nov;123(3):463-75

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, New York 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2005.08.041DOI Listing
November 2005

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.

Proc Natl Acad Sci U S A 2005 Oct 13;102(43):15441-6. Epub 2005 Oct 13.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0507651102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253646PMC
October 2005

Voltage sensor of Kv1.2: structural basis of electromechanical coupling.

Science 2005 Aug 7;309(5736):903-8. Epub 2005 Jul 7.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1116270DOI Listing
August 2005

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.

Science 2005 Aug 7;309(5736):897-903. Epub 2005 Jul 7.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1116269DOI Listing
August 2005

Construction of a cyclic nucleotide-gated KcsA K+ channel.

J Mol Biol 2005 Jul;350(5):857-65

Howard Hughes Medical Institute, The Laboratory of Molecular Neurobiology and Biophysics, Box 47, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.05.050DOI Listing
July 2005

Structural biology. Membrane protein insertion and stability.

Science 2005 Mar;307(5714):1425-6

Howard Hughes Medical Institute, Rockefeller University, New York, NY 11021, USA.

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http://dx.doi.org/10.1126/science.1110525DOI Listing
March 2005

Glycine as a D-amino acid surrogate in the K(+)-selectivity filter.

Proc Natl Acad Sci U S A 2004 Dec 24;101(49):17045-9. Epub 2004 Nov 24.

Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, Box 47, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0407820101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535378PMC
December 2004

Structural biology. Voltage sensor meets lipid membrane.

Science 2004 Nov;306(5700):1304-5

Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1105528DOI Listing
November 2004

Localization of the voltage-sensor toxin receptor on KvAP.

Biochemistry 2004 Aug;43(31):10071-9

Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/bi049463yDOI Listing
August 2004

Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation.

Nature 2004 Aug;430(7001):806-10

Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021,USA.

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http://dx.doi.org/10.1038/nature02735DOI Listing
August 2004

Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture).

Angew Chem Int Ed Engl 2004 Aug;43(33):4265-77

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/anie.200400662DOI Listing
August 2004

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom.

Nature 2004 Jul;430(6996):232-5

The Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature02632DOI Listing
July 2004

A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.

J Mol Biol 2004 May;338(4):839-46

Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.03.020DOI Listing
May 2004

Ion binding affinity in the cavity of the KcsA potassium channel.

Biochemistry 2004 May;43(17):4978-82

Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/bi049876zDOI Listing
May 2004

Semisynthesis of a functional K+ channel.

Angew Chem Int Ed Engl 2004 May;43(19):2504-7

Howard Hughes Medical Institute, The Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, Box 47, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/anie.200453849DOI Listing
May 2004

Nobel Lecture. Potassium channels and the atomic basis of selective ion conduction.

Biosci Rep 2004 Apr;24(2):75-100

Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, NY 10021, USA.

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http://dx.doi.org/10.1007/s10540-004-7190-2DOI Listing
April 2004

The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates.

J Mol Biol 2003 Nov;333(5):965-75

Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.jmb.2003.09.022DOI Listing
November 2003

Potassium channels.

FEBS Lett 2003 Nov;555(1):62-5

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0014-5793(03)01104-9DOI Listing
November 2003

X-ray structure of a voltage-dependent K+ channel.

Nature 2003 May;423(6935):33-41

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature01580DOI Listing
May 2003

The principle of gating charge movement in a voltage-dependent K+ channel.

Nature 2003 May;423(6935):42-8

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature01581DOI Listing
May 2003

Gating the selectivity filter in ClC chloride channels.

Science 2003 Apr 20;300(5616):108-12. Epub 2003 Mar 20.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1082708DOI Listing
April 2003

Functional analysis of an archaebacterial voltage-dependent K+ channel.

Nature 2003 Mar 2;422(6928):180-5. Epub 2003 Mar 2.

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature01473DOI Listing
March 2003

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.

Cell 2002 Dec;111(7):957-65

Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)01227-8DOI Listing
December 2002

Energetics of pore opening in a voltage-gated K(+) channel.

Cell 2002 Oct;111(2):231-9

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)01013-9DOI Listing
October 2002

Lipids in the structure, folding, and function of the KcsA K+ channel.

Biochemistry 2002 Sep;41(35):10771-7

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/bi026215yDOI Listing
September 2002

Semisynthesis and folding of the potassium channel KcsA.

J Am Chem Soc 2002 Aug;124(31):9113-20

Howard Hughes Medical Institute, The Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/ja0266722DOI Listing
August 2002

Crystal structure and mechanism of a calcium-gated potassium channel.

Nature 2002 May;417(6888):515-22

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/417515aDOI Listing
May 2002

The open pore conformation of potassium channels.

Nature 2002 May;417(6888):523-6

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/417523aDOI Listing
May 2002

Nothing automatic about ion-channel structures.

Nature 2002 Mar;416(6878):261-2

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http://dx.doi.org/10.1038/416261bDOI Listing
March 2002

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.

Nature 2002 Jan;415(6869):287-94

Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/415287aDOI Listing
January 2002