Publications by authors named "Roderick L Beijersbergen"

54Publications

The RECQL helicase prevents replication fork collapse during replication stress.

Life Sci Alliance 2020 Oct 20;3(10). Epub 2020 Aug 20.

Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26508/lsa.202000668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441523PMC
October 2020

High-throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells.

Eur J Immunol 2020 01 14;50(1):73-85. Epub 2019 Nov 14.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201948241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972998PMC
January 2020

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.

Gut 2020 Apr 13;69(4):727-736. Epub 2019 Sep 13.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2019-318506DOI Listing
April 2020

Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.

J Hepatol 2018 Nov 18;69(5):1057-1065. Epub 2018 Jul 18.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01688278183218
Publisher Site
http://dx.doi.org/10.1016/j.jhep.2018.07.004DOI Listing
November 2018

Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines.

Cancer Res 2018 08 29;78(15):4396-4410. Epub 2018 May 29.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-2698DOI Listing
August 2018

ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors.

Oncogene 2018 08 15;37(33):4611-4625. Epub 2018 May 15.

Division of Molecular Carcinogenesis and Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0300-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095834PMC
August 2018

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.

Cell Res 2018 06 5;28(6):690-692. Epub 2018 Mar 5.

Division of Molecular Carcinogenesis, Oncode Institute, Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41422-018-0020-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993748PMC
June 2018

PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma.

Mol Cancer Ther 2018 04 13;17(4):849-857. Epub 2018 Feb 13.

Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-17-0868DOI Listing
April 2018

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.

Cell Rep 2017 Oct;21(3):773-783

Division of Molecular Carcinogenesis, Cancer Genomics Centre, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.09.085DOI Listing
October 2017

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma.

Eur Urol 2017 06 17;71(6):858-862. Epub 2017 Jan 17.

Division of Molecular Carcinogenesis, Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2017.01.021DOI Listing
June 2017

Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform.

Methods Mol Biol 2016 ;1470:49-73

Division of Molecular Carcinogenesis and NKI Robotics and Screening Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6337-9_5DOI Listing
December 2017

Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.

Mol Cancer Ther 2016 07 11;15(7):1545-56. Epub 2016 May 11.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Cancer Systems Biology Center (CSBC), The Netherlands Cancer Institute, Amsterdam, the Netherlands. The NKI Robotics and Screening Center (NRSC), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-15-0865DOI Listing
July 2016

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

Nat Biotechnol 2016 Jun 25;34(6):631-3. Epub 2016 Apr 25.

Division of Molecular Carcinogenesis, Cancer Systems Biology Centre and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nbt.3536
Publisher Site
http://dx.doi.org/10.1038/nbt.3536DOI Listing
June 2016

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

Cell Rep 2015 Sep 10;12(12):1978-85. Epub 2015 Sep 10.

Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.08.037DOI Listing
September 2015

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference.

Nucleic Acids Res 2015 Apr 23;43(7):3407-19. Epub 2015 Mar 23.

Dharmacon, part of GE Healthcare, Lafayette, CO 80026, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402539PMC
April 2015

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.

Cell Res 2015 Apr 6;25(4):445-58. Epub 2015 Feb 6.

Department of Biochemistry, The Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2015.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387553PMC
April 2015

The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality.

Mol Syst Biol 2014 Jul 1;10:738. Epub 2014 Jul 1.

Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299495PMC
http://dx.doi.org/10.15252/msb.20145372DOI Listing
July 2014

Functional subtyping of breast cancer.

Cancer Discov 2011 Aug;1(3):205-6

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-11-0163DOI Listing
August 2011

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

Nature 2012 Jan 26;483(7387):100-3. Epub 2012 Jan 26.

Division of Molecular Carcinogenesis, Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature10868DOI Listing
January 2012

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

J Cell Mol Med 2012 Sep;16(9):2140-9

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1582-4934.2012.01524.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822984PMC
September 2012

Screening for modulators of cisplatin sensitivity: unbiased screens reveal common themes.

Cell Cycle 2011 Feb 1;10(3):380-6. Epub 2011 Feb 1.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/cc.10.3.14642
Publisher Site
http://dx.doi.org/10.4161/cc.10.3.14642DOI Listing
February 2011

Exploration of synthetic lethal interactions as cancer drug targets.

Future Oncol 2010 Nov;6(11):1789-802

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon.10.131DOI Listing
November 2010

Using large-scale RNAi screens to identify novel drug targets for cancer.

IDrugs 2010 Nov;13(11):772-7

Netherlands Cancer Institute, Division of Molecular Carcinogenesis and NKI Robotics and Screening Center, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
November 2010

Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.

Mol Cancer Res 2010 Apr 23;8(4):592-603. Epub 2010 Mar 23.

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-09-0386DOI Listing
April 2010

Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.

Clin Cancer Res 2009 Sep 1;15(18):5811-9. Epub 2009 Sep 1.

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/content/early/2009/08/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-09-0261DOI Listing
September 2009

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

Cancer Cell 2009 Apr;15(4):328-40

Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2009.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693316PMC
April 2009

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

PLoS One 2009 11;4(3):e4798. Epub 2009 Mar 11.

Division of Molecular Carcinogenesis, Centre for Biomedical Genetics and Cancer Genomics Centre, Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653142PMC
July 2009

shRNA libraries and their use in cancer genetics.

Nat Methods 2006 Sep;3(9):701-6

Division of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth921DOI Listing
September 2006

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

Nat Chem Biol 2006 Apr 13;2(4):202-6. Epub 2006 Feb 13.

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio774DOI Listing
April 2006

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

Cell 2005 Jun;121(6):849-58

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2005.04.017DOI Listing
June 2005

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

Nature 2004 Mar;428(6981):431-7

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature02371DOI Listing
March 2004